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市場調査レポート
商品コード
1380398
細胞株開発の世界市場:2023-2030年Global Cell Line Development Market 2023-2030 |
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カスタマイズ可能
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細胞株開発の世界市場:2023-2030年 |
出版日: 2023年09月27日
発行: Orion Market Research
ページ情報: 英文 210 Pages
納期: 2~3営業日
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世界の細胞株開発市場は、予測期間(2023-2030年)にCAGR 9.6%で成長すると予測されています。細胞株開発は、バイオテクノロジーや製薬研究において重要なプロセスであり、治療用タンパク質、抗体、ワクチン、その他のバイオ医薬品を生産するための安定した高収量の細胞株を作製することを目的としています。最初のステップでは、適切な宿主細胞株を選択する必要があり、多くの場合、製品の特定の要件に応じて、哺乳類、昆虫、または微生物由来の宿主細胞株を選択します。
ソースタイプのうち、哺乳類サブセグメントは世界の細胞株開発市場でかなりのシェアを占めると予想されます。このセグメントの成長は、モノクローナル抗体の作製に哺乳類細胞ソースが使用されているなどのいくつかの要因に起因しています。これらの細胞株は、人体内のタンパク質を彷彿とさせる複雑なタンパク質を産生し、カスタマイズされた医薬品の作製に役立っています。さらに、ヒトの組織やその他の生物学的成分は哺乳類の細胞株に容易に適応することができ、感染のリスクを下げることができます。例えば、2023年6月、Synthego社は、非営利の世界の生物学的材料および標準リソースセンターであるATCCとの画期的な提携を発表し、遺伝子編集アプリケーション用の哺乳類およびマウス細胞株の広範なコレクションを研究者に提供します。この提携は、ゲノム工学の専門知識と、信頼できる生物学的材料と標準のプロバイダーとして名高いATCCの評判を結びつけるものです。
世界の細胞株開発市場は、北米(米国、カナダ)、欧州(英国、イタリア、スペイン、ドイツ、フランス、その他欧州地域)、アジア太平洋地域(インド、中国、日本、韓国、その他アジア地域)、その他アジア太平洋地域(中東とアフリカ、その他南米)を含む地域別にさらに細分化されています。なかでもアジア太平洋地域は、ヘルスケアインフラの改善や同地域の政府による好意的な取り組みにより、世界市場で突出したシェアを占めると予想されています。
すべての地域の中で、北米地域は予測期間中にかなりのCAGRで成長すると予測されています。同地域の成長は、医療インフラの改善と、同地域におけるより良い研究と製品開発のための市場プレイヤーの戦略的イニシアチブの増加に起因しています。例えば、Lineage Cell Therapeutics, Inc.は2023年9月、Eterna Therapeutics Inc.との独占的オプション契約およびライセンス契約に基づき、新規の低免疫性人工多能性幹細胞(iPSC)株を作製するための特定の開発活動を開始すると発表しました。これは、2023年2月に発表された戦略的提携の次のステップとなるもので、エテルナは、中枢神経系(CNS)疾患およびその他の神経学的適応症を対象とした細胞移植製品候補への分化をリネージが評価する革新的な工学的低免疫iPSC株を開発しています。リネージュは、今回の買収を発表して以来、米国内外の神経学の専門家グループと開発戦略を検討してきました。これらの議論や競合情勢の評価の結果、情勢はエテルナが開発する初期細胞株に対する特定の遺伝子編集の選択を最終決定しました。これらの遺伝子編集には、CD8+T細胞による拒絶反応を抑制することで細胞株由来の製品候補の免疫原性を低下させることを目的としたB2M遺伝子の標的欠失、HLA-Eを過剰発現させ同種NK細胞反応を阻止することを目的としたHLA-E遺伝子の標的挿入、適応症における臨床的差別化と競争優位性を付与することを目的とした3つ目の非公開の編集が含まれます。リネージュは、これらの編集により、非免疫特権または非ヒト白血球抗原(HLA)適合の適応症を含め、編集細胞株の全体的な有用性が拡大し、競合他社が現在使用している他の細胞株との差別化がさらに進むと期待しています。
Title: Global Cell Line Development Market Size, Share & Trends Analysis Report by Product Type (Reagent and Media, Equipment and Accessories and Consumables), by Source Type (Mammalian and Non-mammalian), by End User (Biopharmaceutical and Biotechnology Companies, Contract Research Organizations and Academics and Research Institutes) and by Cell Line (Recombinant, Hybridomas, Continuous and Primary),Forecast Period (2023-2030).
The global Cell Line Development market is anticipated to grow at a CAGR of 9.6% during the Forecast Period (2023-2030). Cell line development is a critical process in biotechnology and pharmaceutical research, aimed at creating stable and high-yielding cell lines to produce therapeutic proteins, antibodies, vaccines, and other biopharmaceuticals. The initial step involves choosing a suitable host cell line, often derived from mammalian, insect, or microbial sources, depending on the specific requirements of the product.
The global Cell Line Development market is segmented on the product type, Source type, End user, and cell line. Based on the product type, the market is sub-segmented into Reagent and Media, Equipment and Accessories and Consumables. Based on source type, the market is sub-segmented into Mammalian and Non-mammalian. Based on the end user, the market is sub-segmented into Biopharmaceutical and Biotechnology Companies, Contract Research Organizations and Academics and Research Institutes. And based on cell line, the market is segmented into Recombinant, Hybridomas, Continuous and Primary. Among the cell line, the Recombinant sub-segment is anticipated to hold a considerable share of the market, owing to rising demand for biologics to treat cancer and autoimmune illnesses.
Among the Source Type, the Mammalian sub-segment is expected to hold a considerable share of the global Cell Line Development market. This segmental growth is attributed to several factors such as, mammalian cell sources are being used to create monoclonal antibodies. These cell lines produce intricate proteins that are reminiscent of those in the human body, aiding in the creation of customized medications. Additionally, human tissues and other biological components can easily adapt to mammalian cell lines, lowering the risk of infection. For instance, In June 2023, Synthego, announced a groundbreaking partnership with ATCC, the premier non-profit global biological materials and standards resource center, to provide researchers with an extensive collection of mammalian and mouse cell lines for gene editing applications, including Express Cell Pools to increase speed to results. This alliance brings together its expertise in genome engineering and ATCC's renowned reputation as a trusted provider of authenticated biological materials and standards.
The global Cell Line Development market is further segmented based on geography including North America (the US, and Canada), Europe (UK, Italy, Spain, Germany, France, and the Rest of Europe), Asia-Pacific (India, China, Japan, South Korea, and Rest of Asia), and the Rest of the World (the Middle East & Africa, and Latin America). Among these, Asia pacific is anticipated to hold a prominent share of the market across the globe, owing to improving healthcare infrastructure, and favorable initiatives by government in the region.
Among all regions, the North America regions is anticipated to grow at a considerable CAGR over the forecast period. Regional growth is attributed to improving medical infrastructure and increasing strategic initiatives by market players for better research and product development in the regions. For instance, in September 2023, Lineage Cell Therapeutics, Inc., announced the initiation of certain development activities to generate a novel hypoimmune induced pluripotent stem cell (iPSC) line under the Company's exclusive option and license agreement with Eterna Therapeutics Inc. This marks the next step under the strategic collaboration announced in February 2023, under which Eterna is developing innovative engineered hypoimmune iPSC lines that Lineage will evaluate for differentiation into cell transplant product candidates for central nervous system (CNS) diseases and other neurology indications. Since announcing the deal earlier, Lineage has evaluated its development strategy with a group of leading neurology experts in the US and abroad. As a result of these and other discussions, and an assessment of the competitive landscape, Lineage finalized its selection of specific gene edits for the initial cell lines to be developed by Eterna. The edits include the targeted deletion of the B2M gene, designed to reduce the immunogenicity of product candidates derived from the lines by inhibiting rejection by CD8+ T cells; the targeted insertion of the HLA-E gene, designed to overexpress HLA-E and prevent the allogeneic NK cell response, and a third undisclosed edit intended to confer clinical differentiation and a competitive advantage in the applicable indications. Lineage expects that these edits would expand the edited cell lines' overall utility, including for non-immune privileged or non-human leukocyte antigen (HLA) matched indications and will further differentiate the cell line from others currently in use by competitors.
The major companies serving the Cell Line Development market include: Advanced Instruments, Berkeley Lights, Boehringer Ingelheim International GmbH, Creative BioLabs., Danaher, Fujifilm Holdings Corp, Horizon Discovery Ltd., JSR Corp, Lonza, Merck KGaA Corning Inc., and others. The market players are considerably contributing to the market growth by the adoption of various strategies including mergers and acquisitions, partnerships, collaborations, funding, and new product launches, to stay competitive in the market. For instance, in April 2019, Solentim, the cell line development (CLD) imaging instrumentation producer, and SAL Scientific, a provider of growth-enhancing animal-free cell culture reagents, announced a new strategic partnership. The collaboration will further optimise CLD workflow by supplying novel supplements which substantially improve cell growth. Solentim will act as the exclusive distributor for the SAL Scientific 'Insti' product range. Cells grown in chemically defined, animal component-free media can be susceptible to impaired growth and viability, especially when subjected to stress.