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吸入一酸化窒素市場レポート:2030年までの動向、予測、競合分析

Inhaled Nitric Oxide Market Report: Trends, Forecast and Competitive Analysis to 2030


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Lucintel
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英文 150 Pages
納期
3営業日
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吸入一酸化窒素市場レポート:2030年までの動向、予測、競合分析
出版日: 2024年11月29日
発行: Lucintel
ページ情報: 英文 150 Pages
納期: 3営業日
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概要

吸入一酸化窒素の動向と予測

世界の吸入一酸化窒素市場の将来は、新生児呼吸器治療、喘息とCOPD、急性呼吸窮迫症候群、マラリア治療、結核治療市場の機会で有望視されています。世界の吸入一酸化窒素市場は、2024年から2030年までのCAGRが5.1%で、2030年までに推定11億米ドルに達すると予想されています。この市場の主な促進要因は、進行中の研究開発活動とともに、呼吸器疾患やその他の関連疾患の有病率の増加です。

  • Lucintel社は、製品タイプ別では、コンパクトで携帯可能な送達システムのイントロダクションより、様々なヘルスケア用途で一酸化窒素療法を容易に投与できるようになるため、送達システムが予測期間中に高い成長を遂げると予測しています。
  • この用途分類の中では、喘息やCOPDの症状の一因となるタバコの消費量の増加により、喘息とCOPDが最も高い成長を遂げると予想されています。
  • 地域別では、COPDや喘息のような疾病の急増、高齢化人口の増加、同地域における大手企業の存在により、北米が予測期間中に最も高い成長を示すと予想されます。

吸入一酸化窒素市場の戦略的成長機会

吸入一酸化窒素市場は、様々な用途において戦略的成長機会を提供しています。注目すべき機会には、技術の進歩、適応症の臨床使用の増加、効率的な呼吸療法へのニーズの高まりなどがあります。

  • 新興市場への進出:新興市場への進出は、高度な呼吸療法に対する需要の高まりによる成長の可能性を示します。これらの地域は吸入一酸化窒素療法を促進し、アクセシビリティを向上させる機会を提供します。
  • 高度な送達システムの開発:新しく精密で快適な送達システムは、より良い治療結果をもたらし、より多くの顧客を惹きつけることができます。革新的な技術は、活況を呈する吸入一酸化窒素市場において競争優位に立つ機会を提供します。
  • 新たな臨床応用の開拓:肺高血圧症や慢性呼吸器疾患などの症状に対する吸入一酸化窒素の地理的用途の拡大は成長機会を提供し、治療の価値を高める。
  • 遠隔地と連携したケアのための吸入一酸化窒素の経済性:硝酸血管拡張薬光学系と線量測定ツールを組み合わせることで、遠隔患者管理と健康データの取得が可能になります。この統合はケアの質を向上させ、市場の成長を支えます。
  • コスト削減の機会:手ごろな価格の一酸化窒素吸入システムを開発することは、資源が限られた地域における呼吸療法への需要に応えるものです。より手頃な価格の製品は市場シェアを拡大し、吸入一酸化窒素の幅広い使用を促します。

新たな地域への拡大、新たな送達デバイスの開発、臨床応用の拡大、デジタルヘルスプラットフォームとの統合、費用対効果の高いソリューションへの注力は、戦略的な成長機会です。これらの取り組みが市場成長に寄与し、吸入一酸化窒素療法の有効性を向上させると期待されています。

吸入一酸化窒素市場の促進要因・課題

吸入一酸化窒素市場は、主に新技術、規制枠組みの変化、社会の健康状態の変化などの影響を受けています。これらの要因は市場の成長を促進し、吸入一酸化窒素療法の採用と開発を形成します。

吸入一酸化窒素市場を牽引する要因は以下の通りである:

  • 技術開発:遠隔測定と遠隔患者モニタリングの進歩は遠隔医療ソリューションをより効果的にし、吸入一酸化窒素療法をそのようなシステムに組み込むことを可能にします。消費者が新しいデバイスを提案することで、より良い医療を提供できるようになります。
  • 呼吸器疾患の増加:呼吸器疾患の罹患率の増加は、吸入一酸化窒素のような効果的な治療に対する需要を増加させる。この動向は経済的持続性を促進し、吸入一酸化窒素分野における新しい治療法や技術の開発を促進する可能性があります。
  • 規制支援:支援的な規制の枠組みは、吸入一酸化窒素市場における新製品や新技術のイントロダクションを促進します。円滑な製品承認と技術革新の魅力が市場の成長と新製品の開発に寄与します。
  • ヘルスケア施設の発展:特に発展途上地域におけるヘルスケア施設の拡大は、吸入一酸化窒素療法の供給と受容を増加させる。これは、ヘルスケアサービスとアクセシビリティの向上により、市場成長にプラスの影響を与えます。
  • 迅速かつ成功する治療の重要性:早期診断と治療の成功は、吸入一酸化窒素のような高度な治療法の開発を促進します。早期介入は患者の転帰を改善し、市場の成長を支えます。

吸入一酸化窒素市場における課題は以下の通りである:

  • 高コスト:吸入一酸化窒素技術のコストは、特に低所得国にとっては法外であり、その普及を制限しています。吸入一酸化窒素療法へのアクセスを拡大するには、コストに対処することが極めて重要です。
  • 規制上のハードル:規制上の問題は、新製品の進歩と市場参入を遅らせる可能性があります。企業が吸入一酸化窒素市場に新技術を導入するには、こうしたハードルを乗り越えなければならないです。
  • 限られた認識と訓練:限られた認識とトレーニングは、吸入一酸化窒素療法の効果的な投与に影響を与える可能性があります。吸入一酸化窒素の正しい使用法についてヘルスケア担当者を教育することは、患者の転帰を改善するために不可欠です。

研究活動、呼吸困難に対する新しいデバイスの導入、規制の有効化、医療システムの改善、予防治療などの市場促進要因が吸入一酸化窒素市場を推進しています。市場はまた、高コスト、規制の制限、認知度の欠如に関連する課題にも直面しており、市場と患者ケアを支えるためにはこれらを克服しなければならないです。吸入一酸化窒素療法を拡大し、呼吸器医療におけるその役割を広げるためには、これらの促進要因と課題のバランスをとることが不可欠です。

目次

第1章 エグゼクティブサマリー

第2章 世界の吸入一酸化窒素市場:市場力学

  • イントロダクション、背景、分類
  • サプライチェーン
  • 業界の促進要因と課題

第3章 2018年から2030年までの市場動向と予測分析

  • マクロ経済動向(2018~2023年)と予測(2024~2030年)
  • 世界の吸入一酸化窒素市場の動向(2018~2023年)と予測(2024~2030年)
  • 吸入一酸化窒素の世界市場:製品タイプ別
    • ガス
    • 配送システム
  • 吸入一酸化窒素の世界市場:用途別
    • 新生児呼吸器治療
    • 喘息とCOPD
    • 急性呼吸促拍症候群
    • マラリア治療
    • 結核治療
    • その他

第4章 2018年から2030年までの地域別市場動向と予測分析

  • 地域別吸入一酸化窒素の世界市場
  • 北米の吸入一酸化窒素市場
  • 欧州の吸入一酸化窒素市場
  • アジア太平洋地域の吸入一酸化窒素市場
  • その他地域の吸入一酸化窒素市場

第5章 競合分析

  • 製品ポートフォリオ分析
  • 運用統合
  • ポーターのファイブフォース分析

第6章 成長機会と戦略分析

  • 成長機会分析
    • 製品タイプ別の世界の吸入一酸化窒素市場の成長機会
    • 用途別の世界の吸入一酸化窒素市場の成長機会
    • 地域別の世界の吸入一酸化窒素市場の成長機会
  • 世界の吸入一酸化窒素市場の新たな動向
  • 戦略分析
    • 新製品開発
    • 世界の吸入一酸化窒素市場の能力拡大
    • 世界の吸入一酸化窒素市場における合併、買収、合弁事業
    • 認証とライセンシング

第7章 主要企業の企業プロファイル

  • Air Liquide Healthcare
  • BOC Healthcare
  • Matheson Tri-Gas
  • Merck
  • Mallinckrodt Pharmaceuticals
  • Nu-Med Plus
  • Perma Pure
目次

Inhaled Nitric Oxide Trends and Forecast

The future of the global inhaled nitric oxide market looks promising with opportunities in neonatal respiratory treatment, asthma and COPD, acute respiratory distress syndrome, malaria treatment, and tuberculosis treatment markets. The global inhaled nitric oxide market is expected to reach an estimated $1.1 billion by 2030 with a CAGR of 5.1% from 2024 to 2030. The major drivers for this market are the increasing prevalence of respiratory and other associated diseases along with ongoing research and development activities.

  • Lucintel forecasts that, within the product type category, delivery systems are expected to witness higher growth over the forecast period due to the introduction of the compact and portable delivery system, which enables easier administration of nitric oxide therapy in various healthcare applications.
  • Within this application category, asthma and COPD are expected to witness the highest growth due growing consumption of cigarettes, which contributes to asthma and COPD symptoms.
  • In terms of regions, North America is expected to witness the highest growth over the forecast period due to the surging incidence of diseases like COPD and asthma, the increasing aging population, and the presence of major players in the region.

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Emerging Trends in the Inhaled Nitric Oxide Market

Inhaled nitric oxide is driving new developments and influencing the growth of the modality. These trends highlight advancements in technology, expanding applications, and increasing practices in healthcare.

  • Improved Delivery Devices: New delivery systems allow for more accurate dosing and increased patient comfort. Device improvements also help maximize ileum activity, meaning the therapy could be integrated into neonatal and adult care by clinicians.
  • Expanding Clinical Uses: The indications for inhaled nitric oxide treatment are expanding to ARDS, respiratory complications of COVID-19, and pulmonary hypertension. Research has shown that inhaled nitric oxide is effective in treating various respiratory illnesses.
  • Synergy with Other Development Approaches: The use of conventional therapeutics such as mechanized respiratory support or pharmacological agents enhances inhaled nitric oxide therapy, playing a key role in patient management. This integrated approach improves therapy outcomes and helps manage more complex respiratory conditions.
  • Focus on Cost-Effectiveness: While the benefits of inhaled nitric oxide therapy are gaining credibility, efforts are also being made to make delivery systems more affordable. Inexpensive solutions bring the therapy closer to patients, allowing a broader group to benefit from treatment.
  • Advances in Research and Development: Ongoing research is advancing inhaled nitric oxide technology and broadening its use in medicine. With these efforts in R&D, it is reasonable to assume that other therapies are improving, including those where inhaled nitric oxide plays a role.

As demonstrated, emerging trends such as improved delivery mechanisms, wider clinical use, synergy with other therapies, emphasis on technological efficiency, and increased research activities are transforming the inhaled nitric oxide market. These trends are driving novel designs and improvements in treatments, expanding the scope of action, and enhancing the quality of patient care.

Recent Developments in the Inhaled Nitric Oxide Market

Recent trends in the inhaled nitric oxide market reflect advancements in technology, clinical applications, and patient treatment. These developments are shaping the industry's future in respiratory therapies.

  • New Inhaled Nitric Oxide Delivery Systems: New delivery systems ensure careful administration of inhaled nitric oxide, improving patient outcomes. Advanced device technology has been shown to enhance the effectiveness and safety of inhaled nitric oxide, making it applicable in diverse clinical settings.
  • Expanded Clinical Indications: Inhaled nitric oxide is used to improve outcomes in ARDS and acute SARS-CoV-2-induced respiratory failure. The extended use suggests that clinical evidence for improved therapeutic response has accumulated for a range of respiratory conditions.
  • Cost-Effective Solutions: Affordable inhaled nitric oxide solutions improve accessibility, particularly in low-resource settings. These innovations encourage wider use of inhaled nitric oxide therapy, helping bridge gaps in respiratory care.
  • Integration with Telemedicine: Telemedicine integration enables remote monitoring and management of inhaled nitric oxide therapy. This improves the quality of care by allowing necessary changes and communication throughout treatment.
  • Increased Research and Clinical Trials: The growing number of research studies and clinical trials seeks to fully understand the benefits and uses of inhaled nitric oxide. These initiatives stimulate innovation and help create new treatment modalities and indications.

Recent developments such as new delivery systems, expanded clinical indications, cost-effective solutions, telemedicine integration, and increased research are significantly impacting the inhaled nitric oxide market. These factors enhance the efficiency, availability, and utilization of inhaled nitric oxide therapy.

Strategic Growth Opportunities for Inhaled Nitric Oxide Market

The inhaled nitric oxide market offers strategic growth opportunities in various applications. Notable opportunities include technological advancements, the growing clinical use of indications, and the rising need for efficient respiratory therapies.

  • Expanding into Emerging Markets: Expanding into emerging markets presents growth potential due to the increasing demand for advanced respiratory therapies. These regions offer opportunities to promote inhaled nitric oxide therapy and improve accessibility.
  • Developing Advanced Delivery Systems: New, precise, and comfortable delivery systems can lead to better treatment outcomes and attract more customers. Innovative technologies present opportunities for competitive advantage in the booming inhaled nitric oxide market.
  • Exploring New Clinical Applications: Expanding the geographical use of inhaled nitric oxide for conditions such as pulmonary hypertension and chronic respiratory diseases offers growth opportunities and enhances the therapeutic value of the treatment.
  • Economics of Inhaled Nitric Oxide for Remote and Connected Care: The use of nitro vasodilator optics combined with dosimetry tools allows remote patient management and health data capture. This integration improves care quality and supports market growth.
  • Cost Reduction Opportunities: Developing affordable inhaled nitric oxide delivery systems responds to the demand for respiratory therapies in resource-limited regions. More affordable products increase market share and encourage wider use of inhaled nitric oxide.

Expanding to new geographies, developing new delivery devices, extending clinical applications, integrating with digital health platforms, and focusing on cost-effective solutions are strategic growth opportunities. These initiatives are expected to contribute to market growth and improve the effectiveness of inhaled nitric oxide therapy.

Inhaled Nitric Oxide Market Driver and Challenges

The inhaled nitric oxide market is influenced mainly by new technologies, changing regulatory frameworks, and shifts in societal health. These factors drive the market's growth and shape the adoption and development of inhaled nitric oxide therapies.

The factors responsible for driving the inhaled nitric oxide market include:

  • Technological Developments: Advances in telemetry and remote patient monitoring make telehealth solutions more effective, enabling inhaled nitric oxide therapy to be integrated into such systems. Public feedback is also valuable, as consumers suggest new devices for improved delivery and better patient care.
  • Increasing Respiratory Conditions: The rising incidence of respiratory conditions increases the demand for effective therapies like inhaled nitric oxide. This trend could drive economic sustainability and enhance the development of new treatments and technologies in the inhaled nitric oxide sector.
  • Regulatory Support: Supportive regulatory frameworks facilitate the introduction of new products and technologies in the inhaled nitric oxide market. Smooth product approvals and attraction of innovation contribute to market growth and the development of new products.
  • Development of Healthcare Facilities: The expansion of healthcare facilities, especially in developing regions, increases the supply and acceptance of inhaled nitric oxide therapy. This positively affects market growth by improving healthcare services and accessibility.
  • Importance of Prompt and Successful Treatment: Early diagnosis and successful treatment drive the development of sophisticated therapies like inhaled nitric oxide. Early interventions improve patient outcomes, supporting market growth.

Challenges in the inhaled nitric oxide market are:

  • High Costs: The cost of inhaled nitric oxide technology can be prohibitive, particularly for low-income countries, limiting its adoption. Addressing costs is crucial to expanding access to inhaled nitric oxide therapy.
  • Regulatory Hurdles: Regulatory issues can slow the progress of new products and their market entry. Companies must overcome these hurdles to introduce new technologies in the inhaled nitric oxide market.
  • Limited Awareness and Training: Limited awareness and training can affect the effective administration of inhaled nitric oxide therapy. Educating healthcare personnel on the correct use of inhaled nitric oxide is essential for better patient outcomes.

Drivers such as research activities, the introduction of new devices for respiratory difficulties, enabling regulation, healthcare system improvements, and preventive treatments are propelling the inhaled nitric oxide market. The market also faces challenges related to high costs, regulatory limitations, and a lack of awareness, which must be overcome to support the market and patient care. Achieving a balance between these drivers and challenges is essential for expanding inhaled nitric oxide therapy and broadening its role in respiratory medicine.

List of Inhaled Nitric Oxide Companies

Companies in the market compete on the basis of product quality offered. Major players in this market focus on expanding their manufacturing facilities, R&D investments, infrastructural development, and leverage integration opportunities across the value chain. With these strategies inhaled nitric oxide companies cater increasing demand, ensure competitive effectiveness, develop innovative products & technologies, reduce production costs, and expand their customer base. Some of the inhaled nitric oxide companies profiled in this report include-

  • Air Liquide Healthcare
  • BOC Healthcare
  • Matheson Tri-Gas
  • Merck
  • Mallinckrodt Pharmaceuticals
  • Nu-Med Plus
  • Perma Pure

Inhaled Nitric Oxide by Segment

The study includes a forecast for the global inhaled nitric oxide by product type, application, and region.

Inhaled Nitric Oxide Market by Product Type [Analysis by Value from 2018 to 2030]:

  • Gas
  • Delivery Systems

Inhaled Nitric Oxide Market by Application [Analysis by Value from 2018 to 2030]:

  • Neonatal Respiratory Treatment
  • Asthma and COPD
  • Acute Respiratory Distress Syndrome
  • Malaria Treatment
  • Tuberculosis Treatment
  • Others

Inhaled Nitric Oxide Market by Region [Shipment Analysis by Value from 2018 to 2030]:

  • North America
  • Europe
  • Asia Pacific
  • The Rest of the World

Country Wise Outlook for the Inhaled Nitric Oxide Market

The corporate achievements in the inhaled nitric oxide market have been significant, particularly with the increase in technological advancements and understanding of its therapeutic value. Inhaled nitric oxide is primarily used to treat various respiratory disorders, enhancing oxygenation while minimizing pulmonary arterial pressure. As research and healthcare systems evolve, market trends are changing in countries like the United States, China, Germany, India, and Japan.

  • United States: Recent improvements in the United States have not only focused on new formulations but also on advanced delivery systems. An important development has been FDA approvals for next-generation inhaled nitric oxide devices with improved safety and usability.
  • China: In China, the inhaled nitric oxide segment has grown through the development of new treatment centers and the expansion of technology. Other trends include collaborations with international companies to introduce modern inhaled nitric oxide equipment in hospitals and research centers.
  • Germany: Germany has introduced several innovations in the inhaled nitric oxide market, focusing on device safety and efficiency. Recent trends include the introduction of advanced delivery systems with better monitoring and ergonomics.
  • India: The respiratory distress therapeutic market for inhaled nitric oxide is growing in India, with efforts to make this important therapy more accessible. Recent developments include the creation of affordable delivery systems, making treatment easier for individuals in both rural and urban areas.
  • Japan: Japan has made strides in integrating inhaled nitric oxide into standard treatment protocols for respiratory diseases. Recent innovations include new devices with advanced features that enhance patient comfort.

Features of the Global Inhaled Nitric Oxide Market

Market Size Estimates: Inhaled nitric oxide market size estimation in terms of value ($B).

Trend and Forecast Analysis: Market trends (2018 to 2023) and forecast (2024 to 2030) by various segments and regions.

Segmentation Analysis: Inhaled nitric oxide market size by product type, application, and region in terms of value ($B).

Regional Analysis: Inhaled nitric oxide market breakdown by North America, Europe, Asia Pacific, and Rest of the World.

Growth Opportunities: Analysis of growth opportunities in different product types, applications, and regions for the inhaled nitric oxide market.

Strategic Analysis: This includes M&A, new product development, and competitive landscape of the inhaled nitric oxide market.

Analysis of competitive intensity of the industry based on Porter's Five Forces model.

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This report answers following 11 key questions:

  • Q.1. What are some of the most promising, high-growth opportunities for the inhaled nitric oxide market by product type (gas and delivery systems), application (neonatal respiratory treatment, asthma and COPD, acute respiratory distress syndrome, malaria treatment, tuberculosis treatment, and others), and region (North America, Europe, Asia Pacific, and the Rest of the World)?
  • Q.2. Which segments will grow at a faster pace and why?
  • Q.3. Which region will grow at a faster pace and why?
  • Q.4. What are the key factors affecting market dynamics? What are the key challenges and business risks in this market?
  • Q.5. What are the business risks and competitive threats in this market?
  • Q.6. What are the emerging trends in this market and the reasons behind them?
  • Q.7. What are some of the changing demands of customers in the market?
  • Q.8. What are the new developments in the market? Which companies are leading these developments?
  • Q.9. Who are the major players in this market? What strategic initiatives are key players pursuing for business growth?
  • Q.10. What are some of the competing products in this market and how big of a threat do they pose for loss of market share by material or product substitution?
  • Q.11. What M&A activity has occurred in the last 5 years and what has its impact been on the industry?

Table of Contents

1. Executive Summary

2. Global Inhaled Nitric Oxide Market: Market Dynamics

  • 2.1: Introduction, Background, and Classifications
  • 2.2: Supply Chain
  • 2.3: Industry Drivers and Challenges

3. Market Trends and Forecast Analysis from 2018 to 2030

  • 3.1. Macroeconomic Trends (2018-2023) and Forecast (2024-2030)
  • 3.2. Global Inhaled Nitric Oxide Market Trends (2018-2023) and Forecast (2024-2030)
  • 3.3: Global Inhaled Nitric Oxide Market by Product Type
    • 3.3.1: Gas
    • 3.3.2: Delivery Systems
  • 3.4: Global Inhaled Nitric Oxide Market by Application
    • 3.4.1: Neonatal Respiratory Treatment
    • 3.4.2: Asthma and COPD
    • 3.4.3: Acute Respiratory Distress Syndrome
    • 3.4.4: Malaria Treatment
    • 3.4.5: Tuberculosis Treatment
    • 3.4.6: Others

4. Market Trends and Forecast Analysis by Region from 2018 to 2030

  • 4.1: Global Inhaled Nitric Oxide Market by Region
  • 4.2: North American Inhaled Nitric Oxide Market
    • 4.2.1: North American Inhaled Nitric Oxide Market by Product Type: Gas and Delivery Systems
    • 4.2.2: North American Inhaled Nitric Oxide Market by Application: Neonatal Respiratory Treatment, Asthma and COPD, Acute Respiratory Distress Syndrome, Malaria Treatment, Tuberculosis Treatment, and Others
  • 4.3: European Inhaled Nitric Oxide Market
    • 4.3.1: European Inhaled Nitric Oxide Market by Product Type: Gas and Delivery Systems
    • 4.3.2: European Inhaled Nitric Oxide Market by Application: Neonatal Respiratory Treatment, Asthma and COPD, Acute Respiratory Distress Syndrome, Malaria Treatment, Tuberculosis Treatment, and Others
  • 4.4: APAC Inhaled Nitric Oxide Market
    • 4.4.1: APAC Inhaled Nitric Oxide Market by Product Type: Gas and Delivery Systems
    • 4.4.2: APAC Inhaled Nitric Oxide Market by Application: Neonatal Respiratory Treatment, Asthma and COPD, Acute Respiratory Distress Syndrome, Malaria Treatment, Tuberculosis Treatment, and Others
  • 4.5: ROW Inhaled Nitric Oxide Market
    • 4.5.1: ROW Inhaled Nitric Oxide Market by Product Type: Gas and Delivery Systems
    • 4.5.2: ROW Inhaled Nitric Oxide Market by Application: Neonatal Respiratory Treatment, Asthma and COPD, Acute Respiratory Distress Syndrome, Malaria Treatment, Tuberculosis Treatment, and Others

5. Competitor Analysis

  • 5.1: Product Portfolio Analysis
  • 5.2: Operational Integration
  • 5.3: Porter's Five Forces Analysis

6. Growth Opportunities and Strategic Analysis

  • 6.1: Growth Opportunity Analysis
    • 6.1.1: Growth Opportunities for the Global Inhaled Nitric Oxide Market by Product Type
    • 6.1.2: Growth Opportunities for the Global Inhaled Nitric Oxide Market by Application
    • 6.1.3: Growth Opportunities for the Global Inhaled Nitric Oxide Market by Region
  • 6.2: Emerging Trends in the Global Inhaled Nitric Oxide Market
  • 6.3: Strategic Analysis
    • 6.3.1: New Product Development
    • 6.3.2: Capacity Expansion of the Global Inhaled Nitric Oxide Market
    • 6.3.3: Mergers, Acquisitions, and Joint Ventures in the Global Inhaled Nitric Oxide Market
    • 6.3.4: Certification and Licensing

7. Company Profiles of Leading Players

  • 7.1: Air Liquide Healthcare
  • 7.2: BOC Healthcare
  • 7.3: Matheson Tri-Gas
  • 7.4: Merck
  • 7.5: Mallinckrodt Pharmaceuticals
  • 7.6: Nu-Med Plus
  • 7.7: Perma Pure