FYARRO市場：市場規模、予測、市場洞察-2032年

FYARRO（注射用シロリムス蛋白結合粒子懸濁液）（アルブミン結合）は、成人患者の切除不能または転移性の局所進行性悪性黒色腫の治療に使用される処方薬です。FYARROはがん細胞と闘うように設計されています。進行した悪性PEComaでは、血管周囲上皮細胞が制御不能に増殖します。FYARROは、がん細胞が制御不能に増殖する原因となるシグナルのひとつをブロックし、がんの増殖や転移を阻止するのに役立ちます。これは標的がん治療であり、化学療法ではないです。FYARROが他のmTOR阻害剤と異なるのは、ナノ粒子技術を使用し、FYARROが腫瘍内に薬剤をより多く取り込み、より多くのmTORスイッチをオフにするのを助ける点です。

推奨用量は100mg/m2で、21日間サイクルの1日目と8日目に30分かけて点滴静注します。

FYARROに含まれるシロリムスは、mTOR（mechanism target of rapamycin kinase、以前はmammalian target of rapamycinとして知られていた）の阻害剤です。mTORはセリン-スレオニンキナーゼであり、PI3K/ACT経路の下流に位置し、細胞の生存、成長、増殖などの重要な細胞プロセスを制御し、いくつかのヒトがんにおいて一般的に発現が調節されています。細胞内では、シロリムスはイムノフィリンであるFK Binding Protein-12（FKBP-12）と結合し、免疫抑制複合体を形成します。シロリムス-FKBP-12複合体はラパマイシン複合体1（mTORC1）に結合し、その活性化を阻害します。シロリムスによるmTORの阻害は、in vitroおよびin vivo試験において、細胞増殖、血管新生、グルコース取り込みを抑制することが示されています。

今後数年間で、血管周囲上皮細胞腫（PEComa）の市場シナリオは、世界中の広範な調査と医療支出の増加により変化します。

各社は、病状を治療／改善するための新たなアプローチに焦点を当てた治療法を開発し、課題を評価し、FYARROの優位性に影響を与える可能性のある機会を模索しています。

PEComaに対する他の新興製品は、FYARROに厳しい市場競争をもたらすと予想され、近い将来、後発の新興治療薬が発売されれば、市場に大きな影響を与えると思われます。

規制上のマイルストーンと開発活動の詳細な説明は、PEComaにおけるFYARROの現在の開発シナリオを提供します。

当レポートでは、主要7ヶ国における血管周囲上皮細胞腫治療薬のFYARRO市場について調査し、市場の概要とともに、競合情勢、2032年までの市場規模予測、および国別市場分析などを提供しています。

目次

第1章 レポートのイントロダクション

第2章 血管周囲上皮細胞腫（PEComa）におけるFYARROの概要

• 製品の詳細
• 臨床開発
  • 臨床研究
  • 臨床試験情報
  • 安全性と有効性
• 規制のマイルストーン
• その他の発達活動
• 製品プロファイル

第3章 競合情勢（上市済み治療法）

第4章 競合情勢（後期段階の新興治療法）

第5章 FYARRO市場評価

• 血管周囲上皮細胞腫（PEComa）におけるFYARROの市場の見通し
• 主要7ヶ国分析
  • 主要7ヶ国の血管周囲上皮細胞腫（PEComa）におけるFYARROの市場規模
• 国別市場分析
  • 米国
  • ドイツ
  • 英国

第6章 SWOT分析

第7章 アナリストの見解

第8章 付録

第9章 DelveInsightのサービス内容

第10章 免責事項

第11章 DelveInsightについて

第12章 レポート購入オプション

List of Tables

• Table 1: FYARRO, Clinical Trial Description, 2023
• Table 2: FYARRO, General Description
• Table 3: Competitive Landscape (Marketed Therapies)
• Table 4: Competitive Landscape (Late-stage Emerging Therapies)
• Table 5: FYARRO Market Size in the 7MM, in USD million (2019-2032)
• Table 6: FYARRO Market Size in the US, in USD million (2019-2032)
• Table 7: FYARRO Market Size in Germany, in USD million (2019-2032)
• Table 8: FYARRO Market Size in France, in USD million (2019-2032)
• Table 9: FYARRO Market Size in Italy, in USD million (2019-2032)
• Table 10: FYARRO Market Size in Spain, in USD million (2019-2032)
• Table 11: FYARRO Market Size in the UK, in USD million (2019-2032)
• Table 12: FYARRO Market Size in Japan, in USD million (2019-2032)

List of Figures

• Figure 1: FYARRO Market Size in the 7MM, USD million (2019-2032)
• Figure 2: FYARRO Market Size in the United States, USD million (2019-2032)
• Figure 3: FYARRO Market Size in Germany, USD million (2019-2032)
• Figure 4: FYARRO Market Size in France, USD million (2019-2032)
• Figure 5: FYARRO Market Size in Italy, USD million (2019-2032)
• Figure 6: FYARRO Market Size in Spain, USD million (2019-2032)
• Figure 7: FYARRO Market Size in the United Kingdom, USD million (2019-2032)
• Figure 8: FYARRO Market Size in Japan, USD million (2019-2032)

"FYARRO Market Size, Forecast, and Market Insight - 2032" report provides comprehensive insights about FYARRO for Perivascular Epithelioid Cell Neoplasm (PEComa) in the seven major markets. A detailed picture of the FYARRO for PEComa in the 7MM, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan for the study period 2019 -2032 is provided in this report along with a detailed description of the FYARRO for PEComa. The report provides insights about mechanism of action, dosage and administration, as well as research and development including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the FYARRO market forecast analysis for PEComa in the 7MM, SWOT, analysts' views, comprehensive overview of market competitors, and brief about other emerging therapies in PEComa.

Drug Summary:

FYARRO (sirolimus protein-bound particles for injectable suspension) (albumin-bound) is a prescription medicine used to treat locally advanced unresectable or metastatic malignant PEComa in adult patients. FYARRO had been designed to fight cancer cells. In advanced malignant PEComa, perivascular epithelioid cells grow out of control. FYARRO blocks one of the signals in the cancer cells causing it to grow out of control, helping to stop cancer from growing or spreading. It is a targeted cancer treatment and not a chemotherapy treatment. FYARRO is different from other mTOR inhibitors because it uses nanoparticle technology to help FYARRO get more of the drug inside tumors to help turn more mTOR switches off.

The recommended dosage of FYARRO is 100 mg/m2 administered as an intravenous infusion over 30 minutes on Days 1 and 8 of each 21-day cycle until disease progression or unacceptable toxicity.

Mechanism of action

Sirolimus in FYARRO is an inhibitor of the mechanistic target of rapamycin kinase (mTOR, previously known as the mammalian target of rapamycin). mTOR, a serine-threonine kinase, is downstream of the PI3K/AKT pathway, controls key cellular processes such as cell survival, growth, and proliferation, and is commonly dysregulated in several human cancers. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus-FKBP-12 complex binds to and inhibits the activation of the mechanistic target of rapamycin complex 1 (mTORC1). Inhibition of mTOR by sirolimus has been shown to reduce cell proliferation, angiogenesis, and glucose uptake in vitro and in vivo studies.

Scope of the Report:

The report provides insights into:

• A comprehensive product overview including the FYARRO description, mechanism of action, dosage and administration, research and development activities in Perivascular Epithelioid Cell Neoplasm (PEComa).
• Elaborated details on FYARRO regulatory milestones and other development activities have been provided in this report.
• The report also highlights the FYARRO research and development activities in PEComa across the United States, Europe and Japan.
• The report also covers the patents information with expiry timeline around FYARRO.
• The report contains forecasted sales of FYARRO for PEComa till 2032.
• Comprehensive coverage of the late-stage emerging therapies for PEComa.
• The report also features the SWOT analysis with analyst views for FYARRO in PEComa.

Methodology:

The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by DelveInsight's team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.

FYARRO Analytical Perspective by DelveInsight

• In-depth FYARRO Market Assessment

This report provides a detailed market assessment of FYARRO for Perivascular Epithelioid Cell Neoplasm (PEComa) in the seven major markets, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. This segment of the report provides forecasted sales data from 2024 to 2032.

• FYARRO Clinical Assessment

The report provides the clinical trials information of FYARRO for Perivascular Epithelioid Cell Neoplasm (PEComa) covering trial interventions, trial conditions, trial status, start and completion dates.

Report Highlights:

• In the coming years, the market scenario for Perivascular Epithelioid Cell Neoplasm (PEComa) is set to change due to the extensive research and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
• The companies are developing therapies that focus on novel approaches to treat/improve the disease condition, assess challenges, and seek opportunities that could influence FYARRO dominance.
• Other emerging products for PEComa are expected to give tough market competition to FYARRO and launch of late-stage emerging therapies in the near future will significantly impact the market.
• A detailed description of regulatory milestones, and developmental activities, provide the current development scenario of FYARRO in PEComa.
• Our in-depth analysis of the forecasted sales data of FYARRO from 2024 to 2032 will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the FYARRO in PEComa.

Key Questions:

• What is the product type, route of administration and mechanism of action of FYARRO?
• What is the clinical trial status of the study related to FYARRO in Perivascular Epithelioid Cell Neoplasm (PEComa) and study completion date?
• What are the key collaborations, mergers and acquisitions, licensing and other activities related to the FYARRO development?
• What are the key designations that have been granted to FYARRO for PEComa?
• What is the forecasted market scenario of FYARRO for PEComa?
• What are the forecasted sales of FYARRO in the seven major countries, including the United States, Europe (Germany, France, Italy, Spain, and the United Kingdom), and Japan?
• What are the other emerging products available and how are these giving competition to FYARRO for PEComa?
• Which are the late-stage emerging therapies under development for the treatment of PEComa?

Table of Contents

1. Report Introduction

2. FYARRO Overview in Perivascular Epithelioid Cell Neoplasm (PEComa)

• 2.1. Product Detail
• 2.2. Clinical Development
  • 2.2.1. Clinical studies
  • 2.2.2. Clinical trials information
  • 2.2.3. Safety and Efficacy
• 2.3. Regulatory Milestones
• 2.4. Other Developmental Activities
• 2.5. Product Profile

3. Competitive Landscape (Marketed Therapies)

4. Competitive Landscape (Late-stage Emerging Therapies)

5. FYARRO Market Assessment

• 5.1. Market Outlook of FYARRO in Perivascular Epithelioid Cell Neoplasm (PEComa)
• 5.2. 7MM Analysis
  • 5.2.1. Market Size of FYARRO in the 7MM for Perivascular Epithelioid Cell Neoplasm (PEComa)
• 5.3. Country-wise Market Analysis
  • 5.3.1. Market Size of FYARRO in the United States for Perivascular Epithelioid Cell Neoplasm (PEComa)
  • 5.3.2. Market Size of FYARRO in Germany for Perivascular Epithelioid Cell Neoplasm (PEComa)
  • 5.3.3. Market Size of FYARRO in France for Perivascular Epithelioid Cell Neoplasm (PEComa)
  • 5.3.4. Market Size of FYARRO in Italy for Perivascular Epithelioid Cell Neoplasm (PEComa)
  • 5.3.5. Market Size of FYARRO in Spain for Perivascular Epithelioid Cell Neoplasm (PEComa)
  • 5.3.6. Market Size of FYARRO in the United Kingdom for Perivascular Epithelioid Cell Neoplasm (PEComa)
  • 5.3.7. Market Size of FYARRO in Japan for Perivascular Epithelioid Cell Neoplasm (PEComa)

6. SWOT Analysis

7. Analysts' Views

8. Appendix

• 8.1. Bibliography
• 8.2. Report Methodology

9. DelveInsight Capabilities

10. Disclaimer

11. About DelveInsight

12. Report Purchase Options