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市場調査レポート
商品コード
1439638
次世代シーケンシング(NGS)- 世界市場の考察、競合情勢、市場予測(2030年)Next Generation Sequencing - Market Insights, Competitive Landscape, and Market Forecast - 2030 |
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次世代シーケンシング(NGS)- 世界市場の考察、競合情勢、市場予測(2030年) |
出版日: 2024年02月01日
発行: DelveInsight
ページ情報: 英文 150 Pages
納期: 2~10営業日
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世界の次世代シーケンシング(NGS)の市場規模は、2023年に92億8,000万米ドル、2030年までに263億米ドルに達し、2024年~2030年の予測期間にCAGRで18.96%の成長が見込まれます。次世代シーケンシング(NGS)に対する需要の増加は主に、COVID-19の突然の発生などの感染症の症例の増加や、世界のがんの負担の増大に起因しています。さらに、臨床診断や科学研究におけるNGS技術の応用の増加、NGS技術が示す効率的なターンアラウンド結果、高速性、正確性などの利点は、今後数年間の世界の次世代シーケンシング(NGS)市場の成長に寄与する要因です。
次世代シーケンシング(NGS)の市場力学
次世代シーケンシング(NGS)市場は、世界中でCOVID-19感染者が急増しているため、現在急成長しています。これは、COVIDウイルスが発生時から進化しており、PCR検査ではウイルスの存在しか判定できないためです。一方、NGS技術はCOVID-19ウイルスの新型株の判定や監視に使用されます。
世界保健機関(WHO)の2022年12月22日のデータによると、COVID-19の確定症例は世界中で約2億7,523万3,892件報告されています。
さらに、世界のがん患者の負担の増大も次世代シーケンシング(NGS)市場に寄与すると予測されています。これは、がんバイオマーカーの検出におけるNGS技術ベースのプラットフォームの重要性が高まっているためです。GLOBOCAN directoryが2020年に発表したデータによると、同年には世界で約1,929万2,789件の新たながん症例が検出されました。
さらに、感染症や遺伝性疾患などのさまざまな疾患の検出に向けたNGS技術ベースの製品の承認が、予測期間に次世代シーケンシング(NGS)市場に寄与すると見込まれます。例えば、2020年09月08日、米国FDAはBlueprint Medicinesが開発した標的治療薬GAVRETO(TM)(pralsetinib)の候補となるRET融合遺伝子陽性の転移性非小細胞肺がん(NSCLC)患者を同定するコンパニオン診断薬(CDx)として、Thermo Fisher Scientificが開発したOncomine Dx Target検査に市販前承認を与えました。GAVRETO(TM)は、FDAが承認した3つのNSCLC治療薬に関連するバイオマーカーを対象とした、初の次世代シーケンシング(NGS)ベースのCDxです。
しかし、NGS技術における短いリード長や器具とサービスの高いコストといった特定の要因が、次世代シーケンシング(NGS)市場の成長を阻害する可能性が高いです。
前例のないCOVID-19パンデミックは、次世代シーケンシング(NGS)市場にプラスの効果をもたらしています。NGS技術は、COVID-19の診断に向けた費用対効果の高い分子検査であり、シングルステップのRNA抽出を使用し、ゴールドスタンダードであるRT-qPCRと比較して高いスケーラビリティと精度を示すからです。さらに、SARS-CoV-2に対する次世代シーケンシング(NGS)検査の緊急使用認可(EUA)が増加したことも、パンデミック危機における市場成長につながっています。例えば、2020年6月10日、Illumina, Inc.は米国FDAからSARS-CoV-2の検出を可能にするハイスループット、次世代シーケンシング(NGS)ベースの体外診断(IVD)ワークフローであるIllumina COVID-19Seq(TM)Testの緊急使用認可(EUA)を取得しました。さらに、次世代シーケンシング(NGS)技術を臨床診断検査として取り入れたことや、特にCOVID-19パンデミックがさまざまな検査機関で発生したことも、パンデミック中の市場を強化しました。例えば、2020年8月、Helix Laboratoryは、COVID-19が疑われる人の上気道検体中のSARS-CoV-2由来の核酸の定性的な検出に向けて開発されたアンプリコンベースの次世代シーケンシング(NGS)検査であるCOVID-19 NGS検査のFDA承認を取得しました。
当レポートでは、世界の次世代シーケンシング(NGS)市場について調査分析し、市場規模と予測、促進要因と課題、企業と製品のプロファイルなどを提供しています。
Next-Generation Sequencing Market By Product Type (Instruments, Reagents & Consumables And Services), By Sequencing Type (Whole-Genome Sequencing, Whole-Exome Sequencing, Rna Sequencing, Targeted Sequencing, De-Novo Sequencing, Others), By Application (Diagnostic, Drug Discovery, Agriculture & Animal Research, Others), By End-User (Pharmaceutical & Biotechnology Companies, Hospitals & Clinics, Academic & Research Institute), by geography, is expected to grow at a significant CAGR forecast till 2030 owing to the rising application of next-generation sequencing (NGS) technology in clinical diagnosis and advancement in NGS platforms
The global Next-Generation Sequencing market was valued at USD 9.28 billion in 2023, growing at a CAGR of 18.96% during the forecast period from 2024 to 2030, to reach USD 26.30 billion by 2030. The increase in demand for Next-Generation Sequencing is primarily attributed to the rising cases of infectious diseases such as the sudden outbreak of COVID-19 and the escalating burden of cancer, worldwide. Moreover, the rising application of NGS technology in clinical diagnosis and scientific research, and advantages such as efficient turnaround results, high speed, and accuracy exhibited by the NGS technology, among others are some of the factors that would contribute to the global Next-Generation Sequencing market growth in the forthcoming years.
Next-Generation Sequencing Market Dynamics:
The market for Next-Generation Sequencing is gaining pace at present due to the surge in COVID-19 infected people across the globe. This is because the Covid virus has evolved from the time of its outbreak and PCR testing only determines the presence of the virus. Whereas, NGS technology is used in determining the novel strains of the COVID-19 virus as well as its surveillance.
According to the World Health Organization (WHO), 22 December 2022 data, approximately 275,233,892 confirmed cases of COVID-19 were reported across the globe.
In addition, the increasing burden of cancer cases worldwide is also anticipated to contribute to the Next-Generation Sequencing market. This is because of the rising significance of NGS technology-based platforms for the detection of cancer biomarkers. According to the data published by the GLOBOCAN directory in the year 2020, approximately 19,292,789 new cases of cancer were detected, globally in the same year.
Furthermore, NGS technology-based product approvals for the detection of various disorders such as infectious diseases, genetic disorders, among others are expected to contribute to the market for Nex Generation Sequencing during the forecasted period. For instance, on September 08, 2020, the US FDA granted pre-market approval to the Oncomine Dx Target test, developed by Thermo Fisher Scientific, as a companion diagnostic (CDx) to identify RET fusion-positive, metastatic non-small cell lung cancer (NSCLC) patients who are candidates for GAVRETO(TM) (pralsetinib), a targeted therapy developed by Blueprint Medicines. It is the first targeted next-generation sequencing (NGS)-based CDx for biomarkers associated with three FDA-approved NSCLC therapies.
However, certain factors such as short read lengths in NGS technology and the high cost of the instruments & services are likely to impede the Next-Generation Sequencing market growth.
The unprecedented COVID-19 pandemic has had a positive effect on the Next-Generation Sequencing market. This is because NGS technology is a cost-effective molecular test for the diagnosis of COVID19, which uses a single-step RNA extraction and presents high scalability and accuracy when compared to the gold-standard RT-qPCR. Furthermore, the rise in emergency use authorizations (EUAs) for Next-Generation Sequencing tests for SARS-CoV-2 has also led to market growth during the pandemic crisis. For instance, on June 10, 2020, Illumina, Inc. received an Emergency Use Authorization (EUA) for the Illumina COVIDSeq(TM) Test, a high-throughput, next-generation sequencing-based, in vitro diagnostic (IVD) workflow enabling the detection of SARS-CoV-2 by the US FDA. In addition, the inclusion of Next-generation sequencing (NGS) technology as a clinical diagnostic test, particularly with the COVID-19 pandemic by various laboratories has also bolstered the market during the pandemic. For instance, in August 2020, Helix Laboratory obtained the FDA approval for its COVID-19 NGS test, an amplicon-based next-generation sequencing (NGS) test developed for the qualitative detection of nucleic acid from the SARS-CoV-2 in upper respiratory specimens for COVID-19 suspected individuals.
Next-Generation Sequencing Market Segment Analysis:
Next-Generation Sequencing Market By Product Type (Instruments, Reagents & Consumables And Services), By Sequencing Type (Whole Genome Sequencing, Whole Exome Sequencing, RNA Sequencing, Targeted Sequencing, De-Novo Sequencing, Others), By Application (Diagnostic, Drug Discovery, Agriculture & Animal Research, Others), By End-User (Pharmaceutical & Biotechnology Companies, Hospitals & Clinics, Academic & Research Institute), and By Geography (North America, Europe, Asia-Pacific, and Rest of the World).
In the Next-Generation Sequencing sequencing type segment, the whole genome sequencing (WGS) type is anticipated to hold a significant market share during the forecasted period. This is because whole-genome sequencing provides the most comprehensive data related to any organism in a short duration of time. Moreover, WGS is extensively used to develop precision medicines and personalized treatment.
For instance, on December 03, 2020, Weill Cornell Medicine, New York-Presbyterian Hospital, and Illumina, Inc. entered into a collaboration to sequence the complete human genomes of thousands of consenting patients seeking to advance the scope of precision medicine.
In addition, shifting the focus of market players towards the development of NGS-based whole genome sequencing panels for the detection of causative agents of various infections such as COVID-19 would also contribute to the segmental growth of the Next-generation Sequencing market in the upcoming years. For instance, in March 2020, the Paragon Genomics team quickly developed and launched an amplicon-based NGS panel: CleanPlex® SARS-CoV-2 Panel for sequencing the whole genome of SARS-CoV-2 (the virus responsible for COVID-19) on both Illumina and MGI Tech Sequencing platforms. The panels are designed to obtain complete viral genomes even from samples with very low SARS-CoV-2 viral content.
Thus, the aforementioned factors are projected to propel the market for next-generation based whole genome sequencing type during the forecasted period.
North America is expected to dominate the overall Next-Generation Sequencing Market:
Among all the regions, North America is expected to occupy a major share in the overall Next-Generation Sequencing market during the forecasted period. This domination is owing to the rising cases of infectious disease in the region. Furthermore, the spike in the new cancer cases, the presence of key market players and leading national clinical laboratories, and favorable reimbursement policies for the NGS technology, among others are expected to fuel the overall Next-Generation Sequencing market in the region.
For instance, on January 27, 2020, the Centers for Medicare & Medicaid Services (CMS), announced to cover FDA approved or cleared laboratory diagnostic tests using Next Generation Sequencing (NGS) for patients with germline (inherited) ovarian or breast cancer.
Moreover, a rise in research and development activities to develop advanced NGS-based instruments would contribute to the regional market. For instance, in the year 2020, DNA Script and its Molecular Encoding Consortium partners were awarded a USD 23 million multi-phase contract from the Intelligence Advanced Research Projects Activity's (IARPA) Molecular Information Storage (MIST) program. The consortium will explore the possibility of integrating a novel enzymatic DNA synthesis technology and next-generation sequencing into a single instrument throughout the program.
In addition, the rise in cancer cases in the country would also lead to an increased demand for NGS sequencing technology to provide a molecular rationale for appropriate targeted therapy. For instance, according to the data published by the GLOBOCAN directory in the year 2020, approximately, 2,281,658 new cases of cancer were reported in the US in the same year.
Additionally, strategic business activities in the region to use NGS technology to enhance the diagnostic capabilities will also contribute to the NGS market in the country during the forthcoming years. For instance, on August 12, 2020, GeneDx, Inc., a subsidiary of BioReference Laboratories, Inc., an OPKO Health company agreed with Pediatrix Medical Group to offer state-of-the-art, next-generation genomic sequencing to contribute to the clinical diagnosis in neonatal intensive care units ("NICUs") staffed by Pediatrix's affiliated neonatologists.
Hence, all the above-mentioned factors are projected to fuel the Next-Generation Sequencing market in the country.
Further, the Asia Pacific region has the future potential for the Next-Generation Sequencing market. This is predominantly due to the burgeoning cases of various infectious diseases, and the growing cancer burden in the region. Moreover, the presence of regional companies focused on developing and manufacturing advanced NGS-based systems would propel the market during the forecasted period. For instance, in 2019, Longas Technologies Pty Ltd launched Morphoseq(TM), a disruptive technology designed to improve the performance of industry-standard NGS platforms by increasing effective read lengths, with benefits in accuracy and cost-efficiency. Also, the presence of several NGS service providers in the region would contribute to the market. For instance, MedGenome offers Next Generation Sequencing services to more than 8000 clinicians with over 1600 hospitals across South Asia and India.
Moreover, rising cases of Covid-19 in the region will escalate the demand for Next-Generation Sequencing. For instance, about 34,765,976 confirmed COVID-19 cases, and 7,495 new cases were reported in India till December 23, 2022, as per the WHO report. Also, improving healthcare infrastructure, and government initiatives in raising awareness regarding molecular diagnosis will contribute to the Next-Generation Sequencing market growth in these regions.
Next-Generation Sequencing Market Key Players:
Some of the key market players operating in the Next-Generation Sequencing market include Agilent Technologies, Inc., Illumina Inc., Bio-Rad Laboratories, Inc., F. Hoffmann-La Roche Ltd, QIAGEN, Thermo Fisher Scientific, PerkinElmer Inc., MedGenome, BGI, Pacific Biosciences, GENEWIZ, Oxford Nanopore Technologies plc., Psomagen, Inc., 10x Genomics, Takara Bio Inc., Zymo Research Corporation., NuGEN Technologies, Inc. (Tecan Trading AG), Vela Diagnostics, CD Genomics., HTG Molecular Diagnostics, Inc., and others.
Recent Developmental Activities in the Next-Generation Sequencing Market:
In December 2022, Roche launched the AVENIO Edge System to simplify and automate next-generation sequencing sample preparation, reduce human error and advance precision medicine.
In May 2022, Illumina, Inc. and Next-Generation Genomics Co., Ltd. launched VeriSeq(TM) NIPT Solution v2 in Thailand, a CE-IVD, next-generation sequencing (NGS)-based approach to noninvasive prenatal testing (NIPT).
In February 2022, INOVIO and QIAGEN expanded collaboration to develop next-generation sequencing (NGS) companion diagnostic for INOVIO's VGX-3100 for advanced cervical dysplasia.
Key Takeaways from the Next-Generation Sequencing Market Report Study
Market size analysis for current market size (2023), and market forecast for 5 years (2024-2030)
The effect of the COVID-19 pandemic on this market is significant. To capture and analyze suitable indicators, our experts are closely watching the Next-Generation Sequencing market.
Top key product/services/technology developments, merger, acquisition, partnership, joint venture happened for last 3 years
Key companies dominating the Global Next-Generation Sequencing Market.
Various opportunities available for the other competitor in the Next-Generation Sequencing Market space.
What are the top-performing segments in 2023? How these segments will perform in 2030.
Which are the top-performing regions and countries in the current market scenario?
Which are the regions and countries where companies should have concentrated on opportunities for Next-Generation Sequencing market growth in the coming future?
Target Audience who can be benefited from the Next-Generation Sequencing Market Report Study
Next-Generation Sequencing providers
Research organizations and consulting companies
Next-Generation Sequencing-related organization, association, forum, and other alliances
Government and corporate offices
Start-up companies, venture capitalists, and private equity firms
Distributors and Traders in Next-Generation Sequencing
Various End-users who want to know more about the Next-Generation Sequencing Market and the latest technological developments in the Next-Generation Sequencing market.
Frequently Asked Questions for the Next-Generation Sequencing Market:
Next-Generation Sequencing is a massively parallel technology for determining the RNA or DNA sequence to provide information regarding genetic variation associated with diseases or other biological phenomena. The technology offers scalability, high throughput, and speed thereby allowing labs to perform a wide variety of applications.
The global Next-Generation Sequencing market was valued at USD 9.28 billion in 2023, growing at a CAGR of 18.96% during the forecast period from 2024 to 2030, to reach USD 26.30 billion by 2030.
The major factors driving the demand for Next-Generation Sequencing are the rising cases of infectious diseases such as the COVID-19 pandemic, and others. In addition, technological advancement, increasing incidence of cancer across the globe, and rapid product approvals in the Next-Generation Sequencing product arena are expected to augment the global Next-Generation Sequencing market.
Some of the key market players operating in the Next-Generation Sequencing market include Agilent Technologies, Inc., Illumina Inc., Bio-Rad Laboratories, Inc., F. Hoffmann-La Roche Ltd, QIAGEN, Thermo Fisher Scientific, PerkinElmer Inc., MedGenome, BGI, Pacific Biosciences, GENEWIZ, Oxford Nanopore Technologies plc., Psomagen, Inc., 10x Genomics, Takara Bio Inc., Zymo Research Corporation., NuGEN Technologies, Inc. (Tecan Trading AG), Vela Diagnostics, CD Genomics., HTG Molecular Diagnostics, Inc., and others.
Among all the regions, North America is expected to occupy a major share in the overall Next-Generation Sequencing market during the forecasted period, 2024-2030. This domination is owing to the rising cases of infectious disease in the region. Furthermore, the spike in the new cancer cases, the presence of key market players and leading national clinical laboratories, and favorable reimbursement policies for the NGS technology, among others are expected to fuel the overall Next-Generation Sequencing market in the region.