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市場調査レポート
商品コード
1493561
タンパク質精製・分離市場 - 世界の産業規模、シェア、動向、機会、予測:用途別、製品別、技術別、地域別、競合、2019-2029年Protein Purification and Isolation Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Application, By Product, By Technology Region and Competition, 2019-2029F |
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タンパク質精製・分離市場 - 世界の産業規模、シェア、動向、機会、予測:用途別、製品別、技術別、地域別、競合、2019-2029年 |
出版日: 2024年05月15日
発行: TechSci Research
ページ情報: 英文 182 Pages
納期: 2~3営業日
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タンパク質精製・分離の世界市場規模は2023年に82億1,000万米ドルとなり、予測期間では2029年までCAGR 9.89%で着実な成長が予測されています。
世界のタンパク質精製・分離市場は、研究、診断、治療、工業プロセスにおける様々な用途のためのタンパク質の抽出と精製に焦点を当てた、バイオテクノロジーと製薬産業における重要な分野です。創薬、バイオ医薬品生産、診断目的の高品質タンパク質への需要が高まる中、市場は近年大幅な成長を遂げています。
市場概要 | |
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予測期間 | 2025-2029 |
市場規模:2023年 | 82億1,000万米ドル |
市場規模:2029年 | 144億米ドル |
CAGR:2024年-2029年 | 9.89% |
急成長セグメント | 機器 |
最大市場 | 北米 |
プロテオミクス研究の進展、医薬品研究開発への投資の増加、標的タンパク質を用いた治療が必要とされる慢性疾患の増加などが、この成長を牽引する主な要因です。同市場は、細胞溶解液、組織、培養液などの複雑な生物学的サンプルからタンパク質を分離・精製するために設計された幅広い技術と製品を包含しています。クロマトグラフィー、電気泳動、沈殿法のような伝統的な方法は、効率、自動化、スループットにおいて著しい進歩を遂げたとはいえ、広く使用され続けています。
アフィニティーベースの精製、膜ろ過、タンパク質結晶化などの新しい技術は、その特異性、拡張性、より高い収率と純度でタンパク質を精製する能力により、人気を集めています。同市場はまた、様々な治療用途で組換えタンパク質の採用が増加しており、製品の品質と安全性に関する厳しい規制要件を満たすための効率的な精製プロセスに対するニーズが高まっていることも影響しています。北米と欧州は、確立されたバイオ医薬品産業、強固な研究インフラ、プロテオミクス研究への多額の投資により、従来から世界市場で突出した地位を占めてきました。
自動精製システム、ハイスループットプラットフォーム、統合ソフトウェアソリューションなどの技術的進歩は、タンパク質精製ワークフローに革命をもたらし、研究者が実験においてより高いスループット、再現性、効率を達成することを可能にしています。個別化医療と精密治療に対する需要の高まりは、特定のタンパク質標的、疾患適応、治療様式に合わせた革新的な精製技術の開発を促進しています。市場はまた、高度な精製システムに伴う高額な初期費用、特定のクラスのタンパク質を精製することの複雑さ、精製プロセスの検証と標準化に関連する規制上のハードルといった課題にも直面しています。
バイオ医薬品産業の成長
技術の進歩
慢性疾患の増加
複雑なサンプルマトリックスと不均一性
コストと時間のかかるプロセス
拡張性と再現性
プロテオミクス研究の拡大
個別化医療への注目の高まり
Global Protein Purification and Isolation Market was valued at USD 8.21 Billion in 2023 and is anticipated to project steady growth in the forecast period with a CAGR of 9.89% through 2029. The global protein purification and isolation market is a vital sector within the biotechnology and pharmaceutical industries, focused on the extraction and purification of proteins for various applications in research, diagnostics, therapeutics, and industrial processes. With an increasing demand for high-quality proteins for drug discovery, biopharmaceutical production, and diagnostic purposes, the market has witnessed substantial growth in recent years.
Market Overview | |
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Forecast Period | 2025-2029 |
Market Size 2023 | USD 8.21 Billion |
Market Size 2029 | USD 14.40 Billion |
CAGR 2024-2029 | 9.89% |
Fastest Growing Segment | Instruments |
Largest Market | North America |
Key factors driving this growth include advancements in proteomics research, rising investments in pharmaceutical R&D, and the growing prevalence of chronic diseases necessitating targeted protein-based therapies. The market encompasses a wide range of techniques and products designed to isolate and purify proteins from complex biological samples, such as cell lysates, tissues, or culture media. Traditional methods like chromatography, electrophoresis, and precipitation techniques continue to be widely used, albeit with significant advancements in efficiency, automation, and throughput.
Novel techniques such as affinity-based purification, membrane filtration, and protein crystallization have gained traction due to their specificity, scalability, and ability to purify proteins with higher yields and purity. The market is also influenced by the increasing adoption of recombinant proteins in various therapeutic applications, driving the need for efficient purification processes to meet stringent regulatory requirements for product quality and safety. North America and Europe have traditionally held prominent positions in the global market, owing to established biopharmaceutical industries, robust research infrastructure, and substantial investments in proteomics research.
Technological advancements such as automated purification systems, high-throughput platforms, and integrated software solutions are revolutionizing protein purification workflows, enabling researchers to achieve higher throughput, reproducibility, and efficiency in their experiments. The increasing demand for personalized medicine and precision therapies is driving the development of innovative purification technologies tailored to specific protein targets, disease indications, and therapeutic modalities. The market also faces challenges such as high upfront costs associated with sophisticated purification systems, the complexity of purifying certain classes of proteins, and regulatory hurdles related to the validation and standardization of purification processes.
Key Market Drivers
Growing Biopharmaceutical Industry
The growing biopharmaceutical industry is a significant driver behind the expansion of the global protein purification and isolation market. Biopharmaceuticals, including monoclonal antibodies, recombinant proteins, and vaccines, have emerged as key therapeutic modalities for treating various diseases, including cancer, autoimmune disorders, and infectious diseases. As a result, the demand for advanced protein purification and isolation technologies has surged, fueling market growth.
One of the primary reasons for the increasing demand for protein purification and isolation technologies within the biopharmaceutical sector is the complexity of biologics manufacturing. Unlike traditional small-molecule drugs, biopharmaceuticals are produced using living organisms or biological systems, such as bacteria, yeast, mammalian cells, or transgenic animals. The purification of these biomolecules from complex biological mixtures requires sophisticated techniques capable of isolating the target protein with high yield, purity, and activity.
Stringent regulatory requirements governing the production of biopharmaceuticals necessitate the use of robust purification and isolation processes to ensure product safety, efficacy, and consistency. Protein purification plays a critical role in removing impurities, such as host cell proteins, DNA, endotoxins, and aggregates, which could compromise the quality and safety of the final drug product. Biopharmaceutical companies prioritize investing in state-of-the-art purification technologies to meet regulatory standards and ensure the production of high-quality biologics.
The expanding pipeline of biopharmaceutical products further drives the demand for protein purification and isolation solutions. With advancements in biotechnology and genetic engineering, researchers are developing an increasing number of biologics targeting various diseases and therapeutic areas. Each new biopharmaceutical candidate requires customized purification strategies tailored to its unique properties and production system, creating opportunities for companies offering innovative purification technologies and services.
Technological Advancements
Technological advancements have been pivotal in driving the growth of the global protein purification and isolation market, revolutionizing the efficiency, scalability, and purity levels of these processes. As the demand for purified proteins continues to grow across various industries such as biopharmaceuticals, academic research, and biotechnology, innovative technologies play a crucial role in meeting these evolving needs. One significant advancement in protein purification and isolation is the development of chromatography techniques. High-performance liquid chromatography (HPLC), affinity chromatography, ion exchange chromatography, and size exclusion chromatography are among the widely used chromatographic methods for protein separation. Continuous improvements in column design, stationary phases, and detection systems have led to enhanced resolution, selectivity, and throughput, allowing researchers to isolate proteins with higher purity and yield.
Electrophoresis techniques, including gel electrophoresis and capillary electrophoresis, have also undergone significant advancements, enabling precise separation and characterization of proteins based on their size, charge, and mobility. The introduction of technologies such as SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis) and 2D electrophoresis has facilitated the analysis of complex protein mixtures, paving the way for proteomic studies and biomarker discovery.
The integration of automation and robotics into protein purification workflows has streamlined the process, reducing manual labor and increasing throughput. Automated liquid handling systems, robotic sample preparation platforms, and high-throughput purification systems enable researchers to process large numbers of samples efficiently while maintaining reproducibility and accuracy. These advancements have not only improved productivity but also reduced operational costs and minimized the risk of human error.
Another notable technological advancement driving the protein purification and isolation market is the development of novel affinity ligands and resins. Affinity chromatography, which relies on specific interactions between a target protein and its ligand, has gained popularity due to its high selectivity and purity. The discovery and design of new affinity ligands, such as antibodies, aptamers, and engineered peptides, have expanded the range of proteins that can be effectively purified, contributing to market growth.
Rising Prevalence of Chronic Diseases
The rising prevalence of chronic diseases worldwide is a significant driver behind the growth of the global protein purification and isolation market. Chronic diseases such as cancer, diabetes, cardiovascular disorders, and autoimmune diseases have become leading causes of morbidity and mortality globally, posing significant challenges to healthcare systems. In response to this growing health burden, there is an increasing emphasis on developing targeted therapeutics and personalized treatment approaches, driving the demand for purified proteins for research, diagnosis, and drug development.
Proteins play crucial roles in the pathogenesis, diagnosis, and treatment of chronic diseases. Understanding the structure, function, and interactions of disease-related proteins is essential for elucidating disease mechanisms and identifying potential therapeutic targets. Protein purification and isolation techniques enable researchers to isolate and study specific proteins implicated in chronic diseases, facilitating the discovery and development of novel therapeutics.
Biomarker discovery is a key area where protein purification and isolation technologies are instrumental in addressing the challenges associated with chronic diseases. Biomarkers are measurable indicators of biological processes or disease states and play essential roles in disease diagnosis, prognosis, and monitoring. Proteomic studies aimed at identifying disease-specific biomarkers require sophisticated purification techniques to isolate low-abundance proteins from complex biological samples such as blood, urine, or tissue extracts.
The growing demand for personalized medicine and precision oncology further drives the need for purified proteins in diagnostic and therapeutic applications. Proteomic profiling of patient samples enables the identification of molecular signatures associated with specific diseases or patient subgroups, facilitating personalized treatment strategies. Protein purification technologies play a crucial role in isolating and characterizing disease-specific biomarkers and therapeutic targets, thereby supporting the development of targeted therapies tailored to individual patients.
Key Market Challenges
Complex Sample Matrices and Heterogeneity
One of the primary challenges faced by protein purification and isolation processes is the complexity of sample matrices and the heterogeneity of protein mixtures. Biological samples, such as cell lysates, tissue extracts, and blood plasma, contain a diverse array of proteins with varying sizes, charges, and abundances. This complexity makes it challenging to isolate target proteins of interest while effectively removing contaminants and impurities.
The heterogeneity of protein mixtures poses challenges in achieving high purity and yield during purification processes. Variations in protein expression levels, post-translational modifications, and isoform differences further complicate purification strategies, leading to decreased efficiency and reproducibility. Overcoming these challenges requires the development of innovative purification technologies capable of selectively isolating target proteins from complex biological samples while minimizing non-specific binding and interference from impurities.
Cost and Time Intensive Processes
Protein purification and isolation processes are often time-consuming and cost-intensive, presenting significant challenges for researchers and biopharmaceutical companies. Traditional purification methods, such as chromatography and electrophoresis, require expensive equipment, consumables, and specialized reagents, contributing to high operational costs. These processes involve multiple steps, including sample preparation, chromatographic separation, and purification optimization, prolonging the time required to obtain purified proteins.
The cost and time constraints associated with protein purification and isolation hinder research progress and drug development timelines, limiting the scalability and commercialization of biopharmaceutical products. To address these challenges, there is a growing need for the development of cost-effective and time-efficient purification technologies that streamline workflows, reduce resource consumption, and improve process productivity.
Scalability and Reproducibility
Scalability and reproducibility are critical challenges in protein purification and isolation, particularly for biopharmaceutical manufacturing and large-scale production. Many purification techniques that work effectively at the laboratory scale may not be easily scalable to industrial production levels due to limitations in equipment capacity, column size, and process optimization.
Achieving consistent purification results across different scales is essential for ensuring product quality, regulatory compliance, and manufacturing efficiency. Variations in protein yields, purity levels, and process performance between laboratory and large-scale production settings can pose significant challenges for biopharmaceutical companies.
Key Market Trends
Expansion of Proteomics Research
Proteomics research, the large-scale study of proteins and their functions, has witnessed exponential growth in recent years, driven by advancements in technology, increased funding, and growing interest in understanding the molecular basis of diseases. This expansion of proteomics research is not only reshaping our understanding of biology but also fueling the demand for advanced protein purification and isolation technologies, thus driving the growth of the global protein purification and isolation market.
One of the key drivers behind the expansion of proteomics research is the advent of high-throughput technologies such as mass spectrometry, protein microarrays, and next-generation sequencing. These technologies enable researchers to analyze thousands of proteins simultaneously, allowing for comprehensive profiling of cellular proteomes and identification of protein biomarkers associated with diseases. As proteomics studies become more complex and data-intensive, there is a growing need for reliable and efficient protein purification and isolation methods to obtain high-quality samples for analysis.
The increasing adoption of proteomics research in various fields, including biomedical research, drug discovery, and personalized medicine, is driving the demand for purified proteins. Proteomics studies play a crucial role in identifying disease biomarkers, elucidating disease mechanisms, and discovering potential drug targets. Protein purification and isolation technologies are essential for isolating specific proteins of interest from complex biological samples, enabling researchers to study their structure, function, and interactions in detail.
The expansion of proteomics research is also fueled by the growing availability of genomic and proteomic databases, as well as bioinformatics tools for data analysis and interpretation. These resources facilitate the integration of proteomics data with other omics data, such as genomics and transcriptomics, enabling researchers to gain deeper insights into biological systems and disease processes. However, to fully leverage the wealth of information generated by proteomics studies, researchers require high-quality purified proteins for downstream analysis, highlighting the importance of protein purification and isolation technologies.
Increased Focus on Personalized Medicine
Personalized medicine, also known as precision medicine, has emerged as a revolutionary approach to healthcare, aiming to tailor medical treatments to individual patients based on their genetic makeup, lifestyle, and environmental factors. This paradigm shift in medicine is not only transforming patient care but also driving the demand for advanced protein purification and isolation technologies, thereby boosting the growth of the global protein purification and isolation market.
One of the key drivers behind the increased focus on personalized medicine is the growing recognition of the heterogeneity of diseases and treatment responses among patients. Traditional one-size-fits-all approaches to drug development and treatment may not always be effective, as individual patients may exhibit different genetic variations, molecular profiles, and disease pathways. Personalized medicine seeks to address these complexities by identifying biomarkers, therapeutic targets, and treatment strategies tailored to each patient's unique characteristics.
Proteomics research plays a crucial role in personalized medicine by elucidating the molecular basis of diseases and identifying biomarkers that can inform treatment decisions. Protein biomarkers are indicators of biological processes or disease states and can be used for disease diagnosis, prognosis, and monitoring. Protein purification and isolation technologies are essential for isolating specific proteins of interest from patient samples, such as blood, urine, or tissue biopsies, for biomarker discovery and validation.
Segmental Insights
Application Insights
Based on the application, protein-protein segment emerged as the dominant segment in the Global Protein Purification and Isolation market in 2023. Protein-protein interactions play a fundamental role in numerous biological processes, including signal transduction, gene regulation, and metabolic pathways. Understanding these interactions is essential for elucidating disease mechanisms, identifying therapeutic targets, and developing novel drugs. Protein purification and isolation are critical steps in studying protein-protein interactions, as they enable researchers to isolate individual proteins or protein complexes for detailed characterization and analysis. Also, advancements in proteomics technologies, such as mass spectrometry, protein microarrays, and yeast two-hybrid assays, have facilitated large-scale detection and analysis of protein-protein interactions.
Product Insights
Based on the product, consumables segment emerged as the dominant segment in the Global Protein Purification and Isolation market in 2023. Consumables, integral to protein purification and isolation processes, encompassed essential components like columns, resins, membranes, and reagents. These consumables, in tandem with purification instruments and systems, facilitated the separation, purification, and analysis of proteins from intricate biological samples. The demand for consumables remains steadfast across diverse domains including research, academic institutions, and biopharmaceutical sectors, propelling the segment's growth trajectory. Within laboratories, consumables are indispensable tools wielded by scientists and researchers in their quest to unravel the mysteries of proteins and their functions.
Columns, serving as the foundation of chromatographic separations, enable the isolation of specific proteins based on various characteristics such as size, charge, and affinity. Complementary to columns, resins play a pivotal role in capturing target proteins while membranes aid in filtration and concentration processes, ensuring the purity and integrity of protein samples. The significance of reagents cannot be overstated, as they catalyze specific biochemical reactions crucial for protein purification. These consumables collectively constitute the backbone of protein purification workflows, enabling researchers to extract, refine, and characterize proteins with precision and efficiency.
The prominence of the consumables segment underscores the indispensability of these materials in advancing scientific endeavors and biopharmaceutical innovations. As research endeavors intensify and biopharmaceutical development surges, the demand for consumables is poised to persist, underpinning the continued expansion of the Global Protein Purification and Isolation market.
Regional Insights
North America emerged as the dominant player in the Global Protein Purification and Isolation Market in 2023, holding the largest market share. This leadership position stems from a confluence of factors that fortify the region's prominence. Foremost among these is North America's robust biopharmaceutical industry, which serves as a cornerstone of innovation and development in protein purification and isolation technologies. The region boasts a well-established research infrastructure, comprising world-renowned academic institutions, research centers, and biotechnology hubs. This ecosystem fosters collaboration and drives advancements in protein purification methodologies, enhancing the competitiveness of North American enterprises on the global stage.
North America upholds stringent regulatory standards governing the biopharmaceutical sector, ensuring the safety, efficacy, and quality of protein-based therapeutics. Compliance with these standards instills confidence among stakeholders and bolsters North America's reputation as a reliable source of high-quality protein purification and isolation solutions. The presence of key market players within North America further cements its position as a dominant force in the global protein purification and isolation landscape. These industry leaders leverage their expertise, resources, and strategic partnerships to spearhead innovation, expand market reach, and drive growth within the region and beyond.
These factors culminate in North America's leadership in the Global Protein Purification and Isolation Market, underscoring the region's pivotal role in shaping the trajectory of this dynamic industry. As North America continues to foster innovation, collaboration, and regulatory compliance, its influence on the global protein purification and isolation market is expected to endure and evolve in the years to come.
Thermo Fisher Scientific, Inc.
Merck KGaA
QIAGEN N.V
Bio-Rad Laboratories, Inc.
Agilent Technologies, Inc.
GE HealthCare Technologies Inc.
Promega Corporation
Norgen Biotek Corp.
Abcam Limited
Danaher Corporation
In this report, the Global Protein Purification and Isolation Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:
United States
Canada
Mexico
France
United Kingdom
Italy
Germany
Spain
China
India
Japan
Australia
South Korea
Brazil
Argentina
Colombia
South Africa
Saudi Arabia
UAE
Egypt
Company Profiles: Detailed analysis of the major companies present in the Global Protein Purification and Isolation Market.
Global Protein Purification and Isolation Market report with the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report:
Detailed analysis and profiling of additional market players (up to five).