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結核治療市場- 世界の産業規模、シェア、動向、機会、および予測、2018-2028年Tuberculosis Therapeutics Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028F Segmented By Disease Type, By Therapy, By Route of Administration, By Dosage Form, By Distribution Channel, By Region and Competition |
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結核治療市場- 世界の産業規模、シェア、動向、機会、および予測、2018-2028年 |
出版日: 2023年08月01日
発行: TechSci Research
ページ情報: 英文 113 Pages
納期: 2~3営業日
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結核治療の世界市場は、結核の蔓延と闘い、患者の予後を改善するための新たな治療法を見出す必要性が高まっていることから、予測期間中に目覚ましい成長が見込まれています。
結核は、結核菌によって引き起こされる感染性の高い致死的な疾患です。結核は主に肺を侵すが、脳、腎臓、脊椎など、身体の他の部位を侵すこともあります。世界保健機関(WHO)によると、結核は世界の死因トップ10のひとつであり、2019年には1,000万人がこの病気にかかると推定されています。このような高い罹患率を背景に、結核治療に対する需要は今後も増加すると予想され、予測期間中の世界の結核治療市場の成長を牽引します。
結核は、急速に変異する可能性のある細菌によって引き起こされ、治療が困難な薬剤耐性株につながります。多剤耐性結核(MDR-TB)と広範囲薬剤耐性結核(XDR-TB)は、世界保健に重大な課題をもたらす薬剤耐性結核の2つの形態です。薬剤耐性結核菌の出現により、これらの治療困難な結核菌を効果的に治療できる新規結核治療の需要が高まっています。その結果、結核に関連する薬剤耐性の問題に対処できる新規治療薬に対する需要が増加し、今後数年間の世界の結核治療市場の成長を促進すると予想されます。過去10年間で、ベダキリン、デラマニド、プレトマニドなど、いくつかの新しい結核治療が開発されました。ベダキリンは、多剤耐性(MDR)結核や広範囲薬剤耐性(XDR)結核を含む薬剤耐性結核に有効であることが示されている新規薬剤です。デラマニドも、特に他の結核治療と併用した場合に、薬剤耐性結核に有効であることが示されています。プレトマニドは3剤の中で最も新しい薬剤で、広範囲薬剤耐性結核の治療薬として承認されています。
診断ツールの進歩も結核治療を改善してきました。その一例が、わずか2時間で結核と薬剤耐性を検出できる迅速分子診断検査であるXpert MTB/RIFの使用です。もう一つの診断ツールは、90分以内に結核と薬剤耐性を検出できるGeneXpert Omniです。これらのツールは、臨床医がより正確な診断を下し、患者に最も適切な治療レジメンを選択するのに役立ちます。結核の診断法の開拓は、効果的な治療法の開発にもつながっており、その結果、今後数年間の世界の結核治療市場の成長に新たな展望が開かれることになります。
さまざまな慢性疾患や感染症の治療における併用療法の使用は年々増加しており、新規治療薬の成長と開発に新たな機会がもたらされています。結核の治療においても、併用療法の使用はますます一般的になってきています。併用療法は結核の治療に複数の薬剤を使用するもので、治療成績を向上させ、薬剤耐性のリスクを軽減することができます。併用療法の一例として、MDR-TBの治療におけるベダキリンとデラマニドの使用が挙げられます。BPaMZレジメンと呼ばれる別の併用療法では、薬剤感受性結核の治療にベダキリン、プレトマニド、モキシフロキサシン、ピラジナミドを使用しています。結核治療における併用療法の使用は、今後数年間、世界の結核治療市場の成長を牽引すると予想されます。
近年、結核の研究開発に再び注目が集まっています。これにより、結核患者の治療成績を改善する可能性のある新薬や治療法が発見されています。結核の研究開発への注目の高まりは、新しく革新的な結核治療への需要も高めています。clinicaltrials.govによると、結核と闘うための治療法を開発するためのさまざまな段階の研究が世界中で約1092件行われています。
さらに、より短いレジメンで効果的な治療法を見つけるための研究も進められています。従来、結核の治療には抗生物質の長期投与が必要で、その期間は2年に及ぶこともあっています。しかし、最近の調査では、より短い治療レジメンでも同様の効果があることが示されています。その一例がBPaLレジメンで、これは薬剤耐性結核の治療にベダキリン、プレトマニド、リネゾリドを使用するものです。このレジメンは、わずか6ヵ月で結核を治療する効果があることが示されています。このことは、今後数年間、世界の結核治療市場の成長を支えるものと期待されます。
このような新薬やレジメンに加えて、研究者たちは既存の薬剤を結核治療に再利用する可能性も模索しています。例えば、2020年にScience誌に発表された研究では、現在腸内感染症の治療に使用されているニクロサミドという薬剤が、実験室での実験で結核菌の死滅に有望な結果を示したことが明らかになっています。研究者らは現在、ヒトでの結核治療におけるニクロサミドの有効性を検証する臨床試験を計画しています。これにより、今後数年間、世界の結核治療市場の成長に新たな展望が開けると期待されています。
HIVは、体があらゆる種類の感染症と闘うのを助ける細胞を攻撃するウイルスであり、HIVに感染した患者は他の病気や感染症にかかりやすくなります。WHOによると、2021年現在、HIV感染者は世界で約3,840万人に上ります。HIV感染者は免疫力が低下しているため、結核を発症するリスクが非常に高いです。WHOによると、結核患者の約8%がHIV陽性者です。結核とHIVの重複感染が多いことから、両方の病気を効果的に治療できる結核治療の需要が高まっており、世界の結核治療市場の成長を支えています。
TechSci Researchは、所定の市場データを使用して、企業固有のニーズに応じたカスタマイズを提供します。レポートでは以下のカスタマイズが可能です:
Global Tuberculosis Therapeutics Market is expected to grow at an impressive rate during the forecast period on account of the growing need to find new therapeutic solutions to combat the spread of tuberculosis and improve patient outcomes. Tuberculosis (TB) is a highly infectious and potentially fatal disease caused by the bacteria Mycobacterium tuberculosis. It primarily affects the lungs but can also target other parts of the body, including the brain, kidneys, and spine. According to the World Health Organization (WHO), TB is one of the top 10 causes of death worldwide, with an estimated 10 million people falling ill with the disease in 2019. With such a high incidence rate, the demand for tuberculosis therapeutics is expected to continue to rise, thereby driving the growth of global tuberculosis therapeutics market during the forecast period.
Tuberculosis is a global health issue that affects people of all ages and from all walks of life. Despite the availability of effective treatments, the disease continues to be a major public health concern, particularly in low and middle-income countries. According to the WHO, over 90% of TB cases occur in developing countries, where access to proper healthcare and diagnostic tools is limited. As a result, there is an urgent need for effective, affordable, and accessible TB therapeutics to address the global burden of the disease. This, in turn, is expected to drive the growth of global tuberculosis therapeutics market in the coming years.
Additionally, global population is aging, and older adults are more susceptible to TB due to age-related declines in immune function. As the population continues to age, the demand for TB therapeutics that are safe and effective in older adults is expected to increase, thereby driving the growth of global tuberculosis therapeutics market.
Tuberculosis is caused by a bacterium that can mutate rapidly, leading to drug-resistant strains that are difficult to treat. Multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) are two forms of drug-resistant TB that pose a significant challenge to global health. The emergence of drug-resistant strains of TB has increased the demand for novel TB therapeutics that can effectively treat these difficult-to-treat strains. This, in turn, is expected to increase the demand for novel therapeutics that can address the issue of drug resistance related to tuberculosis, thereby fuelling the growth of global tuberculosis therapeutics market in the coming years. In the past decade, several new TB drugs have been developed, including bedaquiline, delamanid, and pretomanid. Bedaquiline is a novel drug that has been shown to be effective against drug-resistant TB, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB. Delamanid has also been shown to be effective against drug-resistant TB, particularly when used in combination with other TB drugs. Pretomanid, the newest of the three drugs, has been approved for the treatment of extensively drug-resistant TB.
Advances in diagnostic tools have also improved the treatment of TB. One example is the use of Xpert MTB/RIF, a rapid molecular diagnostic test that can detect TB and drug resistance in just two hours. Another diagnostic tool is the GeneXpert Omni, which can detect TB and drug resistance in less than 90 minutes. These tools can help clinicians make more accurate diagnoses and choose the most appropriate treatment regimen for their patients. The development in diagnostic methods for tuberculosis is leading to the development of effective therapeutic solutions as well, thereby opening new prospects for the growth of global tuberculosis therapeutics market in the coming years.
The use of combination therapies in the treatment of various chronic and infectious diseases has increased over the years, significantly opening new opportunities for the growth and development of novel therapeutics. The use of combination therapies is becoming increasingly common in the treatment of TB. Combination therapies involve the use of multiple drugs to treat TB, which can improve treatment outcomes and reduce the risk of drug resistance. One example of combination therapy is the use of bedaquiline and delamanid in the treatment of MDR-TB. Another combination therapy, called the BPaMZ regimen, uses the drugs bedaquiline, pretomanid, moxifloxacin, and pyrazinamide to treat drug-sensitive TB. The use of combination therapies in the treatment of tuberculosis is expected to drive the growth of global tuberculosis therapeutics market in the coming years.
In recent years, there has been a renewed focus on TB research and development. This has led to the discovery of new drugs and therapies that have the potential to improve treatment outcomes for patients with TB. The increased focus on TB research and development has also increased the demand for new and innovative TB therapeutics. According to clinicaltrials.gov, there are around 1,092 studies in different phases of development across the globe for developing a treatment for combating tuberculosis.
Additionally, studies are going on to find effective treatments with shorter regimens. Traditionally, TB treatment has involved a long course of antibiotics that can last for up to two years. However, recent research has shown that shorter treatment regimens may be just as effective. One example is the use of the BPaL regimen, which uses the drugs bedaquiline, pretomanid, and linezolid to treat drug-resistant TB. This regimen has been shown to be effective in treating TB in as little as six months. This, in turn, is expected to support the growth of global tuberculosis therapeutics market in the coming years.
In addition to these new drugs and regimens, researchers are also exploring the potential of repurposing existing drugs for the treatment of TB. For example, a study published in the journal Science in 2020 found that a drug called niclosamide, which is currently used to treat intestinal infections, showed promising results in killing Mycobacterium tuberculosis in laboratory experiments. The researchers are now planning to conduct clinical trials to test niclosamide's effectiveness in treating TB in humans. This is further expected to open new prospects for the growth of global tuberculosis therapeutics market in the coming years.
HIV is a virus that attacks cells that help the body fight any kind of infection, making the patient suffering from HIV more vulnerable to other diseases and infections. According to WHO, as of 2021, there are around 38.4 million people living with HIV worldwide. People who are infected with HIV are at a much higher risk of developing TB due to their weakened immune systems. According to the WHO, around 8% of all TB cases are HIV-positive. The high prevalence of TB/HIV co-infection has increased the demand for TB therapeutics that can effectively treat both diseases, thereby supporting the growth of global tuberculosis therapeutics market.
Global Tuberculosis Therapeutics Market can be segmented by disease type, therapy, route of administration, dosage form, distribution channel, and by region. Based on disease type, global tuberculosis therapeutics market can be split into active tuberculosis and latent tuberculosis. By therapy, the global tuberculosis therapeutics market can be divided into first-line therapy and second-line therapy. Based on the route of administration, global tuberculosis therapeutics can be categorized into oral, parenteral, and others. By dosage form, the global tuberculosis therapeutics market can be segmented into tablets, capsules, injections, and others. In terms of distribution channels, the global tuberculosis therapeutics market can be grouped into hospital pharmacy, retail pharmacy, and online pharmacy. Regionally, the global tuberculosis therapeutics market can be segmented into North America, Europe, Asia Pacific, South America, and Middle East & Africa.
AstraZeneca, Plc., Johnson & Johnson, Eli Lilly And Company, Mylan N.V., Teva Pharmaceutical Industries Ltd., Sanofi SA, Novartis AG, Sun Pharmaceutical Industries Ltd., Pfizer Inc., among others, are some of the leading players operating in the global Tuberculosis Therapeutics market.
In this report, Global Tuberculosis Therapeutics Market has been segmented into the following categories, in addition to the industry trends, which have also been detailed below:
Company Profiles: Detailed analysis of the major companies present in Global Tuberculosis Therapeutics Market.
With the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report: