市場調査レポート
商品コード
1319258
コンジュゲーション・ラベリングサービスの世界市場、タンパク質・ペプチドラベリング、低分子・抗体コンジュゲーション:分子タイプ別の分布、主要地域、業界動向と予測(2023年~2035年)Conjugation & Labeling Services Market: Focus on Protein & Peptide Labeling, Small Molecule & Antibody Conjugation-Distribution by Type of Molecule, Key Geographical Regions: Industry Trends & Global Forecasts, 2023-2035 |
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コンジュゲーション・ラベリングサービスの世界市場、タンパク質・ペプチドラベリング、低分子・抗体コンジュゲーション:分子タイプ別の分布、主要地域、業界動向と予測(2023年~2035年) |
出版日: 2023年04月04日
発行: Roots Analysis
ページ情報: 英文 191 Pages
納期: 即日から翌営業日
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世界のコンジュゲーション・ラベリングサービスの市場規模は、予測期間(2023年~2035年)にCAGRで最大10%の成長が予測されています。
現在、多くの医薬品開発企業や研究機関は、バイオコンジュゲーション化学に関する技術の専門知識を欠いており、また、コンジュゲーションプロセスの実施に不可欠な先進のバイオコンジュゲーション技術も社内で扱えるものは限られています。サービスプロバイダーの関連する経験や専門知識を活用するために、いくつかの組織は抗体コンジュゲーションサービスやタンパク質ラベリング業務を外注することを好みます。サービスプロバイダーは、さまざまな生体分子の化学修飾に必要な幅広い試薬システムやコンジュゲートとともに、確立された手法を備えている傾向があります。これらの要因が相まって、タンパク質ラベリング、抗体ラベリング、抗体コンジュゲーション業務のCROへのアウトソーシングが増加し、市場成長の要因となっています。
現在の市場情勢は、抗体コンジュゲーションサービスを提供する企業が170社以上、タンパク質ラベリングサービスを提供する企業が120社以上存在し、世界中に広がっています。全体として、市場は非常に断片化されており、タンパク質、抗体、ペプチド、低分子など、さまざまな種類の生体分子に対してバイオコンジュゲーションサービスを提供するために必要な専門知識を有する超大手、大手、中堅、中小企業が存在しています。特筆すべきは、サービスプロバイダーの78%がハプテンとの抗体コンジュゲーションを提供していることです。特筆すべき例(当レポートでも取り上げています)としては、AAT Bioquest、Abzena、Fina Biosolutions、Life Tein、ProSci、Synaptic Systems、ViroGenなどがあります。
研究目的のカスタム抗体コンジュゲーションは、この市場でもっとも求められているサービスです。各社が提供する抗体コンジュゲーションサービスには、HRPコンジュゲーション、ビオチンコンジュゲーション、蛍光ラベリングサービスなどがあります。抗体ラベリングは抗体コンジュゲーションとも呼ばれ、タグを抗体に結合させます。当レポートでは、研究/診断用途に関連する抗体コンジュゲーションサービスをすべて取り上げました。
蛍光タグはプロテオミクスの分野で、タンパク質の位置や量を検出するために広く採用されています。これらはまた、タンパク質複合体形成中のコンフォメーション変化の同定や生物学的プロセスの追跡にもつながります。また、蛍光プローブに抗体やペプチドをタグ付けして研究目的に利用する企業もあります。
ここ数年、タンパク質ラベリング、ペプチドラベリング、低分子コンジュゲーション、抗体コンジュゲーションサービスを提供する企業が着実に増加しています。このうち、バイオコンジュゲーションサービスプロバイダーの大半は北米を拠点としています。
さまざまなステークホルダーが、その他の工業/非工業企業との提携を結ぶために統合的な努力を行っています。2018年以降、70を超える戦略的提携が結ばれていることは注目に値します。これは、サービスプロバイダーがコンジュゲーション関連の能力を積極的にアップグレードし、バイオコンジュゲートの現在と予想される需要に対応していることを示しています。この分野は絶えず進化しており、ステークホルダーはバイオコンジュゲーションや生体分子のラベリングに関連するイベント(ウェビナー/会議/セミナー/ミーティング/シンポジウム/サミット)に積極的に参加しています。これらのイベントは、企業が自社のアイデアや革新的なバイオコンジュゲーションの方法論/技術を発表し、バイオコンジュゲートのさまざまな応用についてより多くの聴衆と議論するために必要なプラットフォームを提供する可能性が高いです。生体分子を調整する革新的なアプローチと最先端技術への傾倒を考慮すると、市場は予測期間の2023年~2035年に急速なペースで発展する可能性があります。
当レポートでは、世界のコンジュゲーション・ラベリングサービス市場について調査分析し、現在の市場情勢、市場規模、現在と将来の機会などの情報を提供しています。
Conjugate(s) / Label(s) Used
Conjugate(s) / Label(s) Used
Conjugation is the process of formation of a single, stable hybrid, wherein one of the entities is a molecule, such as protein, antibody, peptide and small molecule. These molecules can be conjugated with various modalities, such as haptens, enzymes, isotopes, fluorescent tags, carrier proteins, polymers, particle conjugates and photoreactive molecules. Bioconjugation is a subset of conjugation where one of the entity is a biomolecule, such as protein or an antibody. The synergistic combination of the conjugates and biomolecules confer desired functions, which otherwise are difficult to achieve with individual counterparts. These functionalities offer increased membrane permeability, target specificity, circulation time and enhanced pharmacokinetic properties. It is interesting to highlight that when the modification with conjugates lead to detection (direct / indirect) in bioimaging and immunoassays, bioconjugation is also referred to as biomolecule labeling. Presently, industry stakeholders employ various labeling approaches (fluorescent labeling and isotopic labeling) for protein profiling in order to quantify the compounds, and monitor and visualize the biological processes. Over the last couple of years, the pharmaceutical industry has also witnessed the utility of these complex entities across several application areas, such as development of conjugated drug therapeutics, drug delivery systems, disease diagnosis, invention of diagnostic tools, and high-throughput screening. Presently, a number of players across the globe are actively engaged in providing efficient antibody conjugation services for research purposes. Further, given the rising demand for conjugated biomolecules in the field of research and development, the conjugation and labeling services market is anticipated to witness substantial growth in the foreseen future.
The study presents an in-depth analysis, highlighting the capabilities of various stakeholders engaged in this domain, across different geographies. Amongst other elements, the report features:
One of the key objectives of the report was to evaluate the current opportunity and future potential associated with conjugation and labeling services market, over the forecast period. We have provided informed estimates of the likely evolution of the market in the short to mid-term and long term, for the period 2023-2035. Our year-wise projections of the current and future opportunity have further been segmented based on relevant parameters, such as type of molecule supported (proteins, peptides, small molecules, antibodies and other molecules), type of molecular conjugate / label (polymers, haptens, enzymes, fluorescent tags, bead coupling / particle conjugates, quantum dots, isotopes and other molecular conjugates / labels), and key geographical regions (North America, Europe, Asia-Pacific, Middle East and North Africa, and Latin America). In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the market growth.
The opinions and insights presented in the report were influenced by discussions held with stakeholders in this domain. The report features detailed transcripts of interviews held with the following industry stakeholders:
All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.
The Conjugation and Labeling Services Market: Focus on Protein Labeling, Peptide Labeling, Small Molecule Conjugation and Antibody Conjugation: Distribution by Type of Molecule Supported (Proteins, Peptides, Small Molecules, Antibodies and Other Molecules), Type of Molecular Conjugate / Label (Polymers, Haptens, Enzymes, Fluorescent Tags, Bead Coupling / Particle Conjugates, Quantum Dots, Isotopes and Other Molecular Conjugates / Labels), and Key Geographical Regions (North America, Europe, Asia-Pacific, Middle East and North Africa, and Latin America): Industry Trends and Global Forecasts, 2023-2035 report features an extensive study of the current market landscape, market size and the likely future potential of the conjugation and labeling services market, during the forecast period. Further, it highlights the efforts of several stakeholders engaged in this rapidly emerging domain of the pharmaceutical industry. Key inclusions of the report are briefly discussed below.
A number of drug developers and research institutes currently lack the technical expertise related to bioconjugation chemistries, along with limited in-house capabilities and scarcity of advanced bioconjugation technologies, which are essential to carry out the process of conjugation. In order to leverage the relevant experience and expertise of service providers, several organizations prefer to outsource their antibody conjugation services and protein labeling operations. The service providers tend to be equipped with established methodologies, along with a wide range of reagent systems and conjugates required for the chemical modification of different biomolecules. These factors together will be responsible for market growth through increased outsourcing of protein labeling, antibody labeling and antibody conjugation services to the CROs.
The current market landscape features the presence of over 170 companies providing antibody conjugation services and 120 companies providing service for protein labeling, spread across the globe. Overall, the market seems to be well-fragmented, featuring the presence of very large, large, mid-sized and small companies, which have the required expertise to offer bioconjugation services across different types of biomolecules, such as proteins, antibodies, peptides and small molecules. It is worth mentioning that 78% of the service providers offer antibody conjugation with haptens; notable examples (which have also been captured in this report) include AAT Bioquest, Abzena, Fina Biosolutions, Life Tein, ProSci, Synaptic Systems and ViroGen.
Custom antibody conjugation for research purposes is the most sought service in this market. Some of the antibody conjugation services offered by the companies include conjugation with HRP conjugation, Biotin Conjugation and Fluorescent labeling services. Antibody labeling, which is also known as antibody conjugation, involves conjugating a tag to an antibody. In this report, we have captured all the antibody conjugation services that are relevant to research / diagnostic applications.
Fluorescent tags are widely employed in the field of proteomics in order to detect the location of protein and quantity of the protein. These also lead to identification of conformational changes during protein complex formation and tracking the biological processes. Some of the companies also offer tagging of fluorescent probes with antibodies and peptides for research purposes.
Over the past few years, there has been a steady increase in the companies offering protein labeling, peptide labeling, small molecule conjugation and antibody conjugation services. Of these, majority of the bioconjugation service providers are based in North America.
Various stakeholders have been making consolidated efforts to forge alliance with other industry / non-industry players. It is worth highlighting that, since 2018, over 70 strategic partnerships have been inked, indicating that service providers are actively upgrading their conjugation related capabilities and accommodating the current and anticipated demand for bioconjugates. The field is continuously evolving; stakeholders are actively participating in events (webinars / conferences / seminars / meetings / symposiums / summits) related to bioconjugation and labeling of biomolecules. These events are likely to provide the necessary platform for companies to present their ideas, innovative bioconjugation methodologies / techniques and discuss various applications of bioconjugates to a wider audience. Given the inclination towards cutting-edge technologies, along with innovative approaches to tailor the biomolecules, we believe that the conjugation and labeling services market is likely to evolve at a rapid pace, during the forecast period 2023-2035.
The data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews / surveys with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market will evolve across different regions and technology segments. Wherever possible, the available data has been checked for accuracy from multiple sources of information.
While the focus has been on forecasting the market till 2035, the report also provides our independent views on various non-commercial trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information.
Answer: The global antibody conjugation services market is anticipated to be worth USD 0.51.9 million by 2030.
Answer: Presently, more than 170 companies are engaged in offering antibody conjugation services, worldwide. The top players engaged in this domain (which have also been captured in this report) include Affinity Biologicals, BioLegend, Cell Signalling Technology, FAGUS Antibody Services, Novus Biologicals and ProteoGenix.
Answer: More than 150 service providers possess the capabilities to offer peptide conjugation services.
Answer: Close to 50% of the companies claim to offer conjugation and labeling of biomolecules using both fluorescent tags and enzymes; examples include Affigenix Biosolutions, Designer BioScience, Diatheva, GenPro Biotech and LAMPIRE.
Answer: Nearly 45% of the service providers claim to have the requisite capabilities to aid in the bioconjugation of antibodies with various enzymes.
Answer: The factors driving the conjugation and labeling services market include the surge in demand for novel bioconjugate drugs, advanced drug delivery systems, and enhanced biomedical imaging and biomolecular detection.
Answer: In terms of type of molecular conjugate / label, polymers currently account for the largest share (close to 25%) of the global conjugation and labeling services market. This can be attributed to several advantages offered by these conjugates to the biomolecules, including increased therapeutic potential, better stability, improved physicochemical properties and structural integrity. Further, in terms of type of molecule supported, proteins are likely to capture 45% of the current and future market.
Answer: Presently, the conjugation and labeling services market is dominated by North America, capturing around 45% of the overall market, followed by Europe (29%).
Answer: The conjugation and labeling services market is projected to grow at a CAGR of ~10% during the forecast period 2023-2035.