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市場調査レポート
商品コード
1447721
腫瘍内癌治療市場の評価:癌タイプ・技術・エンドユーザー・地域別の機会および予測 (2017~2031年)Intratumoral Cancer Therapies Market Assessment, By Type of Cancer, By Technology, By End-user, By Region, Opportunities and Forecast, 2017-2031F |
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カスタマイズ可能
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腫瘍内癌治療市場の評価:癌タイプ・技術・エンドユーザー・地域別の機会および予測 (2017~2031年) |
出版日: 2024年03月11日
発行: Market Xcel - Markets and Data
ページ情報: 英文 233 Pages
納期: 3~5営業日
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世界の腫瘍内癌治療の市場規模は、2023年の2,026億7,000万米ドルから、2024年から2031年の予測期間中は10.33%のCAGRで推移し、2031年には4,448億2,000万米ドルの規模に成長すると予測されています。
世界のさまざまな地域での癌の有病率の拡大、製薬業界の拡大、R&D活動の活発化が市場の成長を後押ししています。American Cancer Societyによると、米国では2023年に195万8,310人が新たに癌に罹患し、60万9,820人が死亡すると推定されています。
予後を改善するために患者の個々の要件に合わせ、遺伝子プロファイルに合わせてカスタマイズできる免疫療法薬の採用が増加していることが、市場に有利な成長機会をもたらしています。mRNA癌ワクチンの有効性を調査するためのR&D活動の活発化も市場成長をさらに後押ししています。2023年には、治療用ワクチンが手術による腫瘍摘出後の膵臓癌の再発リスクを低減するかどうかを調査する第2相臨床試験が開始されました。この試験には、Memorial Sloan Kettering Cancer Center (MSK) および世界の約80施設で260人の患者が登録される予定です。この試験では、mRNAのアプローチが現在の標準的な治療法よりも優れているかどうかについての洞察が得られると期待されています。
投資の増加による事業機会の到来
世界のさまざまな地域で癌の有病率が高まっているため、いくつかの政府は新規治療ソリューションのR&D活動への投資を増やしています。癌は、患者やその家族だけでなく、社会の生活にも大きな経済的影響を及ぼすため、患者の迅速な治療や検査を支援するさまざまな対策への投資は、経済的な側面が強いです。癌研究に投資することで、さまざまな種類の癌の早期発見を支援することを目指しています。
戦略的提携が市場拡大をサポート
戦略的提携や協力関係を通じて、さまざまなバイオテクノロジー企業や製薬企業が、それぞれのリソースや専門知識を結集し、開発プロセスを迅速に進めるためのアイデア、経験、知識を組み合わせることができます。2022年2月、BioNTech SEは、癌に対するTCRベースの免疫療法を推進するため、Medigene AGと世界な戦略的提携を締結しました。この共同研究には、複数の標的構造が含まれる見通しです。
当レポートでは、世界の腫瘍内癌治療の市場を調査し、市場の定義と概要、市場規模の推移・予測、各種区分・地域別の詳細分析、産業構造、市場成長への影響因子の分析、ケーススタディ、競合情勢、主要企業のプロファイルなどをまとめています。
Global intratumoral cancer therapies market is projected to witness a CAGR of 10.33% during the forecast period 2024-2031, growing from USD 202.67 billion in 2023 to USD 444.82 billion in 2031F. The growing prevalence of cancer in various regions across the globe, expansion of the pharmaceutical industry, and rising research and development activities are bolstering the market growth. As per the American Cancer Society, 1,958,310 new cases and 609,820 deaths related to cancer were estimated to occur in the United States in 2023.
The growing adoption of immunotherapy drugs that can be tailored to the individual requirements of the patients and customized to their genetic profile for improving outcomes is providing lucrative growth opportunities to the market. Increasing research and development activities for investigating the efficacy of mRNA cancer vaccines is further supporting the market expansion. In 2023, a phase 2 clinical trial was opened to investigate whether therapeutic vaccines reduce the risk of return of pancreatic cancer after the removal of tumors by surgery. The study is expected to enroll 260 patients at Memorial Sloan Kettering Cancer Center (MSK) and approximately 80 sites across the globe. The trial will be open to individuals who recently received pancreatic cancer diagnosis and who have not yet had treatments including radiation therapy, immunotherapy, and chemotherapy or surgery. During phase 1 the vaccine was well tolerated by most patients, with phase 2 expected to offer clarity on the vaccine and various potential benefits. The trial is expected to offer insights into whether the mRNA approach performs better as compared to the current standards of the treatment.
Increasing Investments Anticipated to Offer Opportunities
Due to the growing prevalence of cancer in various regions across the globe, several governments are increasing investment in research and development activities for novel treatment solutions. Cancer has a significant economic impact on the lives of the patients and their families as well as the society, therefore there is a strong economic front for investing in various measures that will support the faster treatment and testing of patients. By investing in cancer research, they aim to support early detection of different types of cancers. For 2023, the American Institute for Cancer Research joined One Voice Against Cancer for requesting USD 49 billion in base funding for the National Institutes of Health.
Furthermore, various leading market players are investing in cancer research activities. According to Novartis India MD, the company invests 20% of its revenue towards research activities, including cancer research. With the help of dedicated research activities, the recognition and unraveling of cancer complexities will become much easier.
Strategic Collaborations Support Market Expansion
Through strategic partnerships and collaborations different biotechnology and pharmaceutical companies can pool their resources and expertise to combine their ideas, experience, and knowledge for fast-tracking the development process. In February 2022, BioNTech SE entered a global strategic partnership with Medigene AG to advance TCR-based immunotherapies against cancer. The research collaboration is expected to encompass several target structures. BioNTech SE is expected to hold exclusive worldwide commercialization rights and will be responsible for developing TCR therapies that result from the collaboration.
Amgen Inc., one of the leading American multinational biopharmaceutical companies committed to easing patient suffering by manufacturing, delivering, discovering, and developing innovative human therapeutics launched Amgen Partners of Choice. The network aims to bring together the company's clinical leaders and research and development experts from eight research centers around the globe. The network expects to create various collaboration channels to expedite the transformational programs that are focused on selected tumor types and disease areas.
North America Accounts for Significant Market Share
The strong presence of various leading market players, the increasing prevalence of cancer in the region, and rising investments in research and development activities are supporting the expansion of the market in the region. According to the Canadian Cancer Society, it was estimated that there would be 239,100 new cancer cases and 86,700 cancer-related deaths in Canada in 2023. Increasing public-private research collaborations are expected to offer the advancement of new therapies, supporting the market expansion in North America. For instance, the Partnership for Accelerating Cancer Therapies (PACT), a five-year public-private research collaboration, is expected to facilitate uniform and systemic clinical testing of biomarkers for advancing the understanding of resistance to immunotherapies and mechanisms of treatment response.
Meanwhile, Europe is expected to witness significant growth in the coming years. The growth can be attributed to the rising research and development activities by the regional market players. Sanofi is conducting an interventional study to determine maximum administered dose or maximum tolerated dose and tolerability and safety of SAR441000 when administered intratumorally. The study is estimated to conclude in February 2024.
Rising Incidences of Lung Cancer Support Market Growth
According to the World Health Organization (WHO) lung cancer is the leading cause of cancer related to deaths across the globe and smoking is the leading cause of lung cancer, resulting in approximately 85% of all cases. The growth of the smoking populace is one of the major factors bolstering the demand for lung cancer therapies. Current technologies provide two approaches for intratumoral therapy in lung cancer, namely percutaneous and bronchoscopic. Bronchoscopic approaches are more suitable for tumors that grow deeper in the lungs and are more likely to obstruct or crush larger airways whereas percutaneous approaches are used for treating peripheral lung tumors that are present near the chest wall. Various research activities are underway to evaluate the efficacy of bronchoscopic intratumoral injection. For instance, a team of researchers from Hiser Medical Center of Qingdao, Shandong, China is conducting a study to evaluate the adverse reactions and therapeutic effects of cisplatin and endostar in patients suffering from lung squamous cell carcinoma.
Checkpoint Inhibitors Account for Significant Market Share
Due to various benefits associated with checkpoint inhibitors, the segment is anticipated to account for a significant share of the market over the forecast period. Rising product approvals by different regulatory bodies including FDA is further supporting the segmental growth. In 2023, GlaxoSmithKline Pharmaceuticals Ltd. won the first PD-1 approval.
Jemperli was cleared as an add-on for patients undergoing chemotherapy with recurrent or primary advanced endometrial cancer. For being eligible for the therapy, the tumor of the patient must be microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR). In phase 3 RUBY trial, it was observed that the addition of Jemperli to chemotherapy reduced death or risk of progression by 72% among patients with mismatch repair deficient or microsatellite instability-high tumors, while showing a progression-free survival improvement of 24%.
Future Market Scenario (2024 - 2031F)
Intratumoral immunotherapy is expected to bolster the effectiveness of cancer immunotherapies across a broad spectrum of malignancies. Addressing the barriers to intratumoral delivery can aid in maximizing the effectiveness of these therapies. Abundant opportunities are available to support the integration of novel biomaterials for providing sustained release and improved delivery of immunotherapies within tumors.
With the help of continuous advancements towards the development of intratumoral drug-releasing interventional implants and devices that facilitate tumor approach, intratumoral nanoDDS administrations are expected to offer a suitable alternative to conventional systemic drug delivery.
Key Players Landscape and Outlook
Key participants in the intratumoral cancer therapies market are GlaxoSmithKline Pharmaceuticals Ltd., BioNTech SE, Pfizer, Inc., F. Hoffmann-La Roche Ltd., and Amgen Inc. Increasing investments towards research and development activities and strategic collaborations are supporting the market expansion.
In 2023, BioNTech SE announced a partnership with the United Kingdom government to provide personalized mRNA cancer immunotherapies to up to 10,000 patients by 2030. The multi-year collaboration is expected to focus on cancer immunotherapies and the expansion of BioNTech's footprint in the country. The company aims to roll out and design randomized clinical trials with the potential for registration for the personalized mRNA cancer immunotherapies provided by the company in the United Kingdom.
All segments will be provided for all regions and countries covered
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work