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市場調査レポート
商品コード
1276458
多発性骨髄腫の世界市場規模、シェア、産業動向分析レポート:エンドユーザー別、疾患タイプ別(症候性多発性骨髄腫、くすぶり型(無症候性)多発性骨髄腫)、薬剤タイプ別、地域別展望・予測、2023~2029年Global Multiple Myeloma Market Size, Share & Industry Trends Analysis Report By End User, By Disease Type (Active Multiple Myeloma and Smoldering Multiple Myeloma), By Drug Type, By Regional Outlook and Forecast, 2023 - 2029 |
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多発性骨髄腫の世界市場規模、シェア、産業動向分析レポート:エンドユーザー別、疾患タイプ別(症候性多発性骨髄腫、くすぶり型(無症候性)多発性骨髄腫)、薬剤タイプ別、地域別展望・予測、2023~2029年 |
出版日: 2023年04月28日
発行: KBV Research
ページ情報: 英文 213 Pages
納期: 即納可能
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多発性骨髄腫市場規模は、2029年には375億米ドルに達し、予測期間中にCAGR9.8%の市場成長率で上昇すると予測されています。
多発性骨髄腫は、悪性腫瘍を発症し、制御不能なまでに増殖している形質細胞を指す言葉です。モノクローナル免疫グロブリン、またはMタンパク質、Mスパイク、パラプロテインは、形質細胞が作り出す異常なタンパク質(抗体)です。健康な形質細胞が作る免疫グロブリンは、細菌を認識して排除することができるので、感染症との戦いに有効です。
しかし、多発性骨髄腫の患者さんの骨髄にはがん化した形質細胞が集まり、健康な血球を破壊します。その結果、体内でパラプロテインという異常なタンパク質が生成され、それが蓄積して組織や臓器に害を及ぼす可能性があります。多発性骨髄腫には、頻繁な感染症、貧血、骨の痛み、腎臓の問題など、いくつかの副作用があります。治療の選択肢として、標的療法、化学療法、放射線療法、幹細胞移植があります。
COVID-19影響度分析
パンデミックにより研究開発業務に大きな支障をきたしたため、多発性骨髄腫の新薬や治療法の開発も大幅に遅れました。さらに、2021年12月のBlood Cancer Journalによると、2020年に新たに確認された多発性骨髄腫の症例は2019年と比較して少なく、その症例の生存率も同時に低下しています。多発性骨髄腫の患者は、2020年に死亡率とCOVID-19感染リスクが高くなっています。したがって、パンデミックは多発性骨髄腫市場に有害な影響を及ぼしました。
市場の成長要因
世界的に増加する政府支援の取り組み
政府および組織は、医療行為と並行して、医療提供者との関係で現在発生している他の問題(料金体系と償還、医療施設、薬剤投与経路、政治、および他のネットワーク問題など)についても支援を拡大しています。これらの問題は、プライマリケア医が専門医や他の専門家とケアを調整する患者ケア型医療施設の受け入れや、商業施設とメディケア/メディケイドの両方の領域で安価な腫瘍医療機関の設立など、腫瘍診療をより多くの支払者と提供者の共同イニシアチブへと押し上げつつあります。したがって、政府による支援の増加は、多発性骨髄腫の治療薬や薬剤の需要を増加させ、市場の拡大に拍車をかけると予測されます。
世界の多発性骨髄腫の症例の増加
多発性骨髄腫を含むいくつかの種類の血液悪性腫瘍の発生率が上昇していることは、市場を牽引する主要な要因の1つです。多発性骨髄腫は珍しいがんの一種と考えられていますが、世界中でかなりの数のがん患者がおり、効果的で最先端の治療法に対する需要が高まっています。効果的な最先端治療が行われることで、患者さんはより良い臨床結果を得ることができます。このことは、MMの有病率が世界的に増加する傾向にあることから、極めて重要です。また、研究開発の結果、治療法が進歩し、予後を改善するために、より複雑な医薬品が必要になっています。
市場抑制要因
永久的な解決策がなく、多くの既存の治療法に副作用がある
カイプロリスの一般的な副作用には、疲労、血球数と血小板数の低下、下痢、便秘、吐き気、息切れ、発熱、四肢の腫れ、上気道感染、気管支炎、肺炎があります。さらに、特定の副作用として、血中カリウムの低下、高血糖、血中カルシウムの低下、筋肉の痙攣、四肢のしびれや麻痺、高血圧などがあります。また、放射線療法では、疲労、皮膚の炎症、吐き気、下痢、治療部位の脱毛、不妊症、感染症のリスクの上昇、食欲不振、その後のがんのリスクの上昇、治療部位近傍の臓器への害などの副作用があります。
薬剤タイプの展望
薬剤タイプにより、多発性骨髄腫市場は化学療法、プロテアーゼ阻害剤、モノクローナル抗体、その他に分類されます。モノクローナル抗体セグメントは、2022年の多発性骨髄腫市場でかなりの成長率を調達しました。多発性骨髄腫の治療選択肢は、近年のモノクローナル抗体(mAb)の導入により、根本的に変化しました。再発・難治性患者に対するエロツズマブやダラツムマブの有効性は、この疾患に対するmAbに多くの関心を呼び起こしました。
エンドユーザーの展望
エンドユーザー別に見ると、多発性骨髄腫市場は病院、診療所、その他に分けられます。病院セグメントは、2022年の多発性骨髄腫市場において最大の収益シェアを獲得しました。病院セグメントは、患者の入院数の増加、多発性骨髄腫の有病率の上昇、患者サービスの向上を可能にするこれらの施設に有能な医療スタッフがいることなどの要因によって成長しています。治療に使用される薬剤が病院で日常的に処方され、投与されるという事実が、このセグメントの優位性のかなりの部分を占めています。
疾患タイプ別の展望
多発性骨髄腫市場は、疾患タイプによって症候性多発性骨髄腫とくすぶり型(無症候性)多発性骨髄腫に分類されます。2022年の多発性骨髄腫市場では、くすぶり型(無症候性)多発性骨髄腫のセグメントが顕著な成長率を獲得しました。このセグメントの成長は、この病気に対する認識の高まりに起因しています。くすぶり型(無症候性)多発性骨髄腫は、活動型になるまでに数年かかることがあります。その結果、この症候群を持つ人の中には、症候性のMMを経験しない人もいます。ヘルスケア専門家は、症候性多発性骨髄腫に移行しつつある症状を観察することで、SMMをコントロールします。
地域別展望
地域別に見ると、多発性骨髄腫市場は、北米、欧州、アジア太平洋、LAMEAで分析されています。北米セグメントは、2022年に多発性骨髄腫市場で最も高い収益シェアを調達しました。主要な競合他社の存在感が強く、多発性骨髄腫薬の発売や製品承認の増加により、北米の多発性骨髄腫市場は予測期間中に大きく拡大すると予測されます。さらに、多発性骨髄腫の有病率が上昇していることから、市場の発展が予想されています。例えば、米国がん協会は、2023年までに米国で35,730件の多発性骨髄腫の発生が発見されると予測しています。
市場参入企業がとる主な戦略は、買収です。カーディナルマトリックスで提示された分析に基づくと、Novartis AG、Johnson &Johnson、Pfizer, Inc.が多発性骨髄腫市場の先駆者です。Amgen, Inc.、Sanofi S.A.、Bristol Myers Squibb Companyなどの企業は、多発性骨髄腫市場における主要な革新者の一部です。
List of Figures
The Global Multiple Myeloma Market size is expected to reach $37.5 billion by 2029, rising at a market growth of 9.8% CAGR during the forecast period.
Multiple myeloma or plasma cell cancer is a disease. The immune system is significantly dependent on healthy plasma cells, which are located in the bone marrow. In order to combat infections and other diseases, the immune system is composed of various cell types. T cells and B cells are two of the most common types of lymphocytes (lymph cells) in the immune system. The lymph nodes, bone marrow, intestines, and circulation are just a few of the organs where lymphocytes can be found.
B cells develop into plasma cells due to the immune system's response to an infection. Antibodies, also known as immunoglobulins, are produced by plasma cells and aid the body's defense against pathogens. Bone marrow contains the majority of plasma cells. Soft tissue found inside bones is called bone marrow. Other blood cells, including red, white, and platelets, are also found in the normal bone marrow and plasma cells.
Multiple myeloma is the term used to describe plasma cells that have developed malignancy and are growing uncontrollably. Monoclonal immunoglobulin, or M-protein, M-spike, or paraprotein, is an aberrant protein (antibody) produced by plasma cells. Immunoglobulins made by healthy plasma cells can recognize and eliminate germs, which is helpful in the fight against infections.
However, cancerous plasma cells gather in the bone marrow of patients with multiple myeloma and destroy healthy blood cells. As a result, the body produces paraproteins, aberrant proteins that can accumulate and harm tissues and organs. Multiple myeloma has several side effects, including frequent infections, anemia, bone pain, and renal problems. Targeted therapy, chemotherapy, radiation therapy, and stem cell transplantation are available as alternatives for treatment.
COVID-19 Impact Analysis
Since R&D operations were substantially hampered by the pandemic, developing novel medicines and treatments for multiple myeloma also slowed considerably. Moreover, the Blood Cancer Journal reported in December 2021 that fewer new instances of multiple myeloma were identified in 2020 in comparison with 2019 and that the survival rate for those cases declined concurrently. Patients with multiple myeloma had a higher mortality rate and COVID-19 infection risk in 2020. Therefore, the pandemic had a detrimental effect on the multiple myeloma market.
Market Growth Factors
Increasing government support initiatives worldwide
Along with care practices, governments and organizations are also extending support for other current problems in provider relations include fee schedules & reimbursement, sites of care, route of drug administration, and politics as well as other network issues. These problems are pushing oncology practices into more payer-provider collaborative initiatives, including accepting patient-care medical homes, where primary care doctors coordinate care with experts and other specialists and creating affordable oncology healthcare institutions in both the commercial and Medicare/Medicaid spaces. Hence, the increasing support of governments is projected to increase demand for treatments or medications for multiple myeloma, thereby fueling market expansion.
Rising cases of multiple myeloma worldwide
The rising incidence of several types of blood malignancies, including multiple myeloma, is one of the major market-driving factors. Although MM is regarded as a more uncommon cancer kind, there are a sizable number of cases of cancer worldwide, and the demand for effective and cutting-edge therapies is rising. Patients frequently experience better and more favorable clinical results when effective and cutting-edge therapies are administered. This is crucial because current trends point to an increase in the prevalence of MM around the globe. In addition, as a result of ongoing R&D, treatment has advanced, necessitating more complex medicines to improve prognosis.
Market Restraining Factors
Lack of permanent solutions and side effects of many existing treatments
Common side effects of Kyprolis include fatigue, a low blood cell count and blood platelet levels, diarrhea, constipation, nausea, shortness of breath, fever, swelling of the extremities, upper respiratory tract infection, bronchitis, and pneumonia. Additionally, certain side effects of the drug include low blood potassium, high blood sugar, low blood calcium, muscle spasms, numbness and tingling in the extremities, and high blood pressure. In addition, radiation therapy can cause adverse effects such as fatigue, irritation of the skin, nausea, diarrhea, loss of hair in the treatment area, infertility, higher risk of infection, loss of appetite, increased risk of subsequent cancer, and harm to organs located near the treatment area.
Drug Type Outlook
Based on drug type, the multiple myeloma market is categorized into chemotherapy, protease inhibitors, monoclonal antibody, and others. The monoclonal antibodies segment procured a considerable growth rate in the multiple myeloma market in 2022. The therapeutic options for multiple myeloma have radically changed due to the recent introduction of monoclonal antibodies (mAbs). The effectiveness of elotuzumab and daratumumab in relapsed/refractory patients has sparked much interest in mAbs for this condition.
End User Outlook
On the basis of end user, the multiple myeloma market is divided into hospitals, clinics, and others. The hospitals segment acquired the largest revenue share in the multiple myeloma market in 2022. The hospital segment is growing due to factors including an increase in patient admissions, a rise in the prevalence of multiple myeloma, and the availability of qualified medical staff in these facilities that enable improved patient services. The fact that the medications used in treatment can be routinely prescribed and given in hospital settings accounts for a significant portion of this segment's dominance.
Disease Type Outlook
Based on disease type, the multiple myeloma market is segmented into active multiple myeloma and smoldering multiple myeloma. The smoldering multiple myeloma segment garnered a remarkable growth rate in the multiple myeloma market in 2022. The growth of the segment is owed to the increasing awareness of the disease. It may take years for smoldering multiple myeloma to develop into an active form. As a result, some individuals with this syndrome never experience active MM. Healthcare professionals' control SMM by watching for symptoms that it's turning into active multiple myeloma.
Regional Outlook
On the basis of region, the multiple myeloma market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The North America segment procured the highest revenue share in the multiple myeloma market in 2022. Due to the strong presence of key competitors and the rise in multiple myeloma drug launches and product approvals, the North American multiple myeloma market is predicted to expand considerably over the forecast period. Moreover, the market is anticipated to develop because of the rising prevalence of multiple myeloma. For instance, the American Cancer Society forecasted that by 2023, 35,730 incidences of multiple myeloma would have been discovered in the United States.
The major strategies followed by the market participants are Acquisitions. Based on the Analysis presented in the Cardinal matrix; Novartis AG, Johnson & Johnson, and Pfizer, Inc. are the forerunners in the Multiple Myeloma Market. Companies such as Amgen, Inc., Sanofi S.A., and Bristol Myers Squibb Company are some of the key innovators in Multiple Myeloma Market.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Novartis AG, Bristol Myers Squibb Company, Amgen, Inc., AbbVie, Inc., Sanofi S.A., Johnson & Johnson, Baxter International, Inc., Takeda Pharmaceutical Company Limited, Teva Pharmaceuticals Industries Ltd., and Pfizer, Inc.
Recent Strategies Deployed in Multiple Myeloma Market
Partnerships, Collaborations and Agreements:
Mar-2022: Sanofi came into collaboration with Blackstone Life Sciences, a US-based private equity firm focused on investing in pharmaceutical, life science, and medical research companies. The collaboration involves the private equity firm contributing up to 300 million euros to advance studies and clinical development programs for the development and delivery of the anti-CD38 antibody Sarclisa focused on treating patients with multiple myeloma.
Jan-2020: Sanofi partnered with Sebia, a France-based provider of clinical protein electrophoresis equipment. The partnership focuses on co-developing treatment for multiple myeloma. The agreement includes, Sebia developing in vitro diagnostic (IVD) tests and acting as its supplier.
Acquisitions and Mergers:
Dec-2022: Johnson & Johnson took over Abiomed, a US-based medical device technology company. The addition of Abiomed advances the acquiring company's MedTech business division, by providing innovational medical technologies. Further, the acquisition broadens Johnson & Johnson's cardiovascular product offerings.
Dec-2021: Baxter acquired Hillrom, a US-based medical device company. The acquisition advances the company's mission to transform healthcare and patient care.
Nov-2021: Pfizer acquired Trillium Therapeutics, a Canada-based clinical-stage immuno-oncology company. The acquisition strengthens the acquiring company's devotion to seeking scientific breakthroughs. Further, the addition of Trillium expands Pfizer's hematology product offerings.
Oct-2021: Amgen completed the acquisition of Teneobio, a US-based biotechnology company. The acquisition of Teneobio broadens the acquiring company's skills and further accelerates its aim to design, build and bring innovations to the markets to better serve their patients. Further, the addition of Teneobio's proprietary bispecific and multispecific antibody technologies perfectly complements Amgen's BiTE platform and its already existing antibody capabilities.
Product Launches and Expansions:
Mar-2023: Teva and Natco together launched extra strengths for the generic version of Revlimid. The medicine is intended to use by adult patients for the cure of multiple myeloma, specific myelodysplastic syndromes, and mantle cell lymphoma. The added strengths reflect the company's devotion to making generic drugs accessible to patients who need them.
Feb-2022: Sandoz, part of Novartis introduced lenalidomide, a generic oncology medicine. The medicine is intended for various haemato-oncology conditions and is available in the form of hard capsules. Lenalidomide is a cost-saving treatment, thereby increasing the treatment's accessibility amongst patients.
Dec-2021: Novartis introduced T-Charge, a CAR-T platform that would act as a base for multiple investigational CAR-T cell therapies. The T-Charge eradicates the need for extended culture time outside the body (ex-vivo), as it primarily happens within a patient's body.
Trials and Approvals:
Oct-2022: The US FDA issued clearance for Johnson & Johnson's Tecvayli, a BCMA-targeted bispecific drug intended for treating patients with refractory or relapsed multiple myeloma. The conditions to be met to use the recently approved drug, patients must have undergone a minimum of four lines of therapy.
Jan-2022: Bristol Myers Squibb received approval for Abecma in Japan. Abecma is a CAR T therapy intended for adult patients with refractory or relapsed (R/R) multiple myeloma. The adult patient should have already received a minimum of three therapies and should have experienced disease progression on the last therapy. Further, the approval demonstrates the company's devotion to catering to the unmet medical needs in Japan.
Dec-2021: U.S. Food and Drug Administration (FDA) approved Amgen's expansion of KYPROLIS to use it in combination with DARZALEX FASPRO, and dexamethasone. The new combination is intended for adult patients with refractory or relapsed multiple myeloma, who have undergone one to three lines of therapy. Further, the combination provides enhanced flexibility and easiness to the patients.
Mar-2020: Sanofi announced FDA approved the use of Sarclisa in combination with dexamethasone and pomalidomide. The combination is intended for the treatment of adults with relapsed refractory multiple myeloma (RRMM), who have already received two therapies. The approval provides patients with hard-to-treat multiple myeloma with a new treatment option.
Market Segments covered in the Report:
By End User
By Disease Type
By Drug Type
By Geography
Companies Profiled
Unique Offerings from KBV Research