![]() |
市場調査レポート
商品コード
1541074
蛍光in situハイブリダイゼーションプローブ市場レポート:タイプ、プローブタイプ、技術、用途、エンドユーザー、地域別 2024-2032Fluorescent in Situ Hybridization Probe Market Report by Type, Probe Type, Technology, Application, End-User, and Region 2024-2032 |
||||||
カスタマイズ可能
|
蛍光in situハイブリダイゼーションプローブ市場レポート:タイプ、プローブタイプ、技術、用途、エンドユーザー、地域別 2024-2032 |
出版日: 2024年08月10日
発行: IMARC
ページ情報: 英文 137 Pages
納期: 2~3営業日
|
世界の蛍光in situハイブリダイゼーション(FISH)プローブ市場規模は、2023年に8億7,290万米ドルに達しました。今後、IMARC Groupは、市場は2032年までに15億1,270万米ドルに達し、2024年から2032年の間に6.1%の成長率(CAGR)を示すと予測しています。遺伝性疾患の有病率の増加、疾患の早期発見とスクリーニングの重視の高まり、広範な研究開発(R&D)活動は、市場を推進する主な要因の一部です。
蛍光in situハイブリダイゼーション(FISH)プローブは、細胞や組織内の特定のデオキシリボ核酸(DNA)またはリボ核酸(RNA)配列を可視化し、マッピングするために使用される分子生物学的手法です。FISHプローブは、オリゴヌクレオチド、蛍光色素、リンカーやスペーサー、ブロッキング試薬、ハイブリダイゼーションバッファーなど様々な材料から構成されています。FISHプローブは、染色体異常検出、遺伝子コピー数変動解析、腫瘍学研究、微生物同定、遺伝子発現解析、出生前診断などに広く用いられています。FISHプローブは高感度で高分解能であるため、コピー数の少ない標的配列も検出することができます。
FISHプローブは個々の患者の遺伝子プロファイルに関する貴重な洞察を提供し、特定の遺伝子変化に基づいたオーダーメイドの治療戦略を可能にするためです。さらに、遺伝子異常に関する高解像度の視覚的・定量的情報を提供するため、臨床医や研究者がFISHプローブを広く利用していることも、市場成長の原動力となっています。さらに、先進的な診断検査の費用を患者に払い戻し、質の高いヘルスケア施設へのアクセスを提供するために、いくつかの政府が支援政策を実施していることが、市場の成長を強化しています。その他の要因としては、高齢者人口の増加、ヘルスケア産業の急速な拡大、広範な研究開発(R&D)活動、標的治療への注目の高まり、高度なFISHプローブの開発への投資の増加などが挙げられ、市場成長の原動力になると予想されます。
遺伝性疾患の増加
FISHプローブは、欠失、重複、逆位、転座などの遺伝性疾患に伴う構造異常の検出に広く使用されています。さらに、標準的な顕微鏡では検出が極めて困難な微小欠失症候群や微小重複症候群の診断にも重要な役割を果たしています。さらに、FISHプローブは反復拡大を検出することができ、ハンチントン病、脆弱X症候群、筋強直性ジストロフィーの同定に役立ちます。これとは別に、FISHプローブは遺伝子コピー数の変化を評価することができるため、医療従事者の疾病分類、治療効果の予測、個別化治療の決定に役立ち、ひいては市場の成長に寄与しています。さらに、FISHプローブは保因状態に関する情報を提供するため、個人は十分な情報に基づいた生殖に関する決定を下し、適切な遺伝カウンセリングを受けることができます。
疾患の早期発見とスクリーニングの重要性の高まり
FISHプローブは、遺伝子の増幅、欠失、転座、染色体再配列など、さまざまながんによく見られる特定の遺伝子変化を標的とすることができるため、がんの早期発見と診断において重要な役割を果たしています。これとは別に、寄生虫、細菌、ウイルスによる感染症の早期診断にも応用されています。さらに、FISHプローブは、ダウン症候群、ターナー症候群、デュシェンヌ型筋ジストロフィーなどの遺伝的疾患の適時検出にも広く使用されています。さらに、発育中の胎児の染色体異常を検出する出生前診断にも広く使用されており、これにより両親は妊娠や医療介入の可能性について十分な情報を得た上で決断することができます。
広範な研究開発(R&D)活動
マルチプレックスFISHプローブのイントロダクションは、1つのサンプル内で複数の遺伝子ターゲットを同時に検出することを可能にし、研究者や臨床医が1回の実験で複数のゲノム領域を分析することを可能にするため、時間とリソースを節約することができ、市場成長にプラスの影響を与えています。さらに、最近のプロキシミティFISHプローブの市場開拓は、細胞または組織サンプル内の2つ以上の遺伝的標的間の空間的近接を検出することを可能にし、その結果、細胞内の空間的相互作用、遺伝子クラスター、クロマチン組織に関する貴重な情報を提供することができ、市場成長に寄与しています。さらに、FISHプローブデータの急速なデジタル化により、データの共有が強化され、自動画像解析、保存、リモートアクセスが可能になり、市場の成長を支えています。
The global fluorescent in situ hybridization (FISH) probe market size reached US$ 872.9 Million in 2023. Looking forward, IMARC Group expects the market to reach US$ 1,512.7 Million by 2032, exhibiting a growth rate (CAGR) of 6.1% during 2024-2032. The increasing prevalence of genetic disorders, growing emphasis on early disease detection and screening, and extensive research and development (R&D) activities are some of the major factors propelling the market.
Fluorescent in situ hybridization (FISH) probe is a molecular biology technique used to visualize and map specific deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sequences within cells and tissues. They are composed of various materials, such as oligonucleotides, fluorophores, linkers and spacers, blocking reagents, and hybridization buffers. FISH probes are widely used in chromosomal abnormality detection, gene copy number variation analysis, oncology research, microbial identification, gene expression analysis, and prenatal diagnosis. They offer high sensitivity and resolution, allowing for the detection of even low-copy-number target sequences.
The increasing demand for personalized medicine is facilitating the adoption of FISH probes, as they provide valuable insights into individual patients' genetic profiles, enabling tailored treatment strategies based on their specific genetic alterations. Furthermore, the widespread utilization of FISH probes by clinicians and researchers to provide high-resolution visual and quantitative information about genetic abnormalities is providing an impetus to the market growth. Additionally, the implementation of supportive policies by several governments to reimburse patients for advanced diagnostic tests and provide access to high-quality healthcare facilities is strengthening the market growth. Other factors, including the rising geriatric population, the rapid expansion of the healthcare industry, extensive research and development (R&D) activities, rising focus on targeted therapies and increasing investment in the development of advanced FISH probes, are anticipated to drive the market growth.
The increasing prevalence of genetic disorders
FISH probes are extensively used to detect structural abnormalities associated with genetic disorders, such as deletions, duplications, inversions, and translocations. Furthermore, they play a crucial role in the diagnosis of microdeletion and microduplication syndromes that are extremely difficult to detect under a standard microscope. Moreover, FISH probes enable the detection of repeat expansions, which aids in identifying Huntington's disease, fragile X syndrome, and myotonic dystrophy. Apart from this, they allow the assessment of gene copy number changes, thus aiding healthcare professionals in disease classification, predicting treatment response, and guiding personalized therapy decisions, which in turn is contributing to the market growth. Additionally, FISH probes provide information about carrier status, which allow individuals to make informed reproductive decisions and receive appropriate genetic counseling.
The growing emphasis on early disease detection and screening
FISH probes play a critical role in early cancer detection and diagnosis, as they can target specific genetic alterations commonly found in various cancers, including gene amplifications, deletions, translocations, and chromosomal rearrangements. Apart from this, they find applications in early diagnosis of infectious diseases caused by parasites, bacteria, or viruses. Moreover, FISH probes are extensively used in the timely detection of genetic conditions, such as Down syndrome, Turner syndrome, or Duchenne muscular dystrophy. Additionally, they are widely employed in prenatal diagnosis to detect chromosomal abnormalities in developing fetuses, which allows parents to make informed decisions about pregnancy and potential medical interventions.
Extensive research and development (R&D) activities
The introduction of multiplex FISH Probes, which allows the simultaneous detection of multiple genetic targets within a single sample, enabling researchers and clinicians to analyze multiple genomic regions in a single experiment, thus saving time and resources, is positively influencing the market growth. Furthermore, the recent development of proximity-FISH probes that enables the detection of spatial proximity between two or more genetic targets within a cell or tissue sample, thus providing valuable information about spatial interactions, gene clustering, and chromatin organization within cells, is contributing to the market growth. Moreover, the rapid digitalization of FISH Probe data, allowing for enhanced data sharing and automated image analysis, storage, and remote access, is supporting the market growth.
IMARC Group provides an analysis of the key trends in each segment of the global fluorescent in situ hybridization (FISH) probe market report, along with forecasts at the global, regional and country levels from 2024-2032. Our report has categorized the market based on type, probe type, technology, application, and end-user.
DNA
RNA
mRNA
miRNA
Others
RNA dominates the market
The report has provided a detailed breakup and analysis of the market based on the type. This includes DNA and RNA (mRNA, miRNA, and others). According to the report, RNA represented the largest market segment.
RNA is dominating the market, as RNA FISH probes enable researchers to investigate gene expression patterns at the single-cell level, which provides valuable insights into cellular heterogeneity, developmental processes, and disease mechanisms. Furthermore, they enable the detection and visualization of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs), which aids in improving the understanding of the functions and regulatory networks of these important RNA molecules. Apart from this, RNA FISH Probes facilitate the real-time observation and tracking of RNA dynamics, such as RNA synthesis, degradation, and turnover rates, thus enabling researchers to study RNA biology and cellular response. Moreover, they offer high sensitivity and specificity in detecting RNA molecules by reducing background noise and false-positive signals.
Locus Specific Probes
Alphoid/Centromeric Repeat Probes
Whole Chromosome Probes
Locus specific probes hold the largest share in the market
The report has provided a detailed breakup and analysis of the market based on the probe type. This includes locus specific probes, alphoid/centromeric repeat probes, and whole chromosome probes. According to the report, locus specific probes accounted for the largest market share.
Locus-specific probes are designed to hybridize to specific genetic loci or regions of interest in the genome, which allows researchers and clinicians to focus on specific genes and chromosomal abnormalities associated with particular diseases and conditions. They also offer high diagnostic accuracy and precision by enabling the detection of specific genetic abnormalities with great specificity. Apart from this, Locus-specific probes are extensively used to detect and characterize genetic variations in patients, including chromosomal aberrations, microdeletions, and gene mutations.
Flow FISH
Q FISH
Others
Flow FISH dominates the market
The report has provided a detailed breakup and analysis of the market based on the technology. This includes flow FISH, Q FISH, and others. According to the report, flow FISH represented the largest market segment.
Flow FISH is dominating the market as it allows for rapid processing of a large number of cells, thus offering more data in a shorter amount of time compared to traditional FISH methods. Furthermore, it is known for its high sensitivity, which makes it ideal for detecting even low-abundance targets in medical diagnostics and research. In addition, flow FISH can be easily integrated with automation technologies to reduce manual errors and increase the throughput. Besides this, it provides quantitative data, which is crucial in fields such as healthcare, where precise measurements are required for diagnosis and treatment plans. Moreover, the cost per sample in flow FISH is less than traditional FISH methods, especially when analyzing large samples, making it highly appealing for both research and clinical settings.
Cancer
Genetic Diseases
Others
Cancer dominates the market
The report has provided a detailed breakup and analysis of the market based on the application. This includes cancer, genetic diseases, and others. According to the report, cancer represented the largest market segment.
FISH probes are widely used in cancer treatment as they help to detect specific genetic abnormalities. It also enables healthcare professionals to identify and classify cancer cells, which further assist in diagnosis, prognosis, and treatment decision-making. Furthermore, they offer high specificity and sensitivity in detecting genetic aberrations and chromosomal rearrangements that are characteristic of various types of cancer. Apart from this, FISH probes aid oncologists in selecting the most appropriate targeted therapies and monitoring treatment response. They also assist in cancer research by improving the understanding of the underlying mechanism associated with cancer. Additionally, FISH probes are widely used in liquid biopsies to offer a non-invasive approach for cancer detection, monitoring, and treatment response assessment.
Research Organizations
Diagnostic Centers
Others
The report has provided a detailed breakup and analysis of the market based on the end-user. This includes flow research organizations, diagnostic centers, and others.
FISH probes are widely used in research organizations to enable the visualization and detection of specific DNA or RNA sequences within cells or tissues. They are used in gene mapping and chromosomal analysis, which aids in studying cancer genetics and identifying chromosomal rearrangements associated with specific malignancies. Furthermore, the FISH probe is extensively utilized in developmental biology and neurobiology to provide valuable insights into gene regulation, cellular development, and disease mechanisms.
Diagnostic centers extensively utilize FISH probes to identify genetic alterations in patient samples, which aids in diagnosing cancer, determining prognosis, and guiding treatment decisions. They also assist in genetic disease screening by detecting specific genetic abnormalities, such as aneuploidies and microdeletion syndromes. Apart from this, FISH probes are widely used in prenatal testing to screen for chromosomal abnormalities in developing fetuses.
North America
United States
Canada
Asia Pacific
China
Japan
India
South Korea
Australia
Indonesia
Others
Europe
Germany
France
United Kingdom
Italy
Spain
Russia
Others
Latin America
Brazil
Mexico
Others
Middle East and Africa
North America exhibits a clear dominance in the market, accounting for the largest fluorescent in situ hybridization (FISH) probe market share
The report has also provided a comprehensive analysis of all the major regional markets, which includes North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa. According to the report, North America represented the largest market segment.
North America is dominating the FISH probe market owing to the strong focus on biomedical research in the region aimed at developing new diagnostic tools and molecular technologies. Additionally, the presence of a robust healthcare infrastructure comprising well-established hospitals, clinical laboratories, and diagnostic facilities is favoring the market growth. Moreover, the growing incidences of genetic disorders and cancer are facilitating the demand for accurate and reliable molecular diagnostic tools, such as FISH probes. Furthermore, the implementation of strict policies by regional governments to maintain the safety, efficacy, and quality of medical products and instruments is contributing to the market growth. Along with this, the presence of key players in the region that are equipped with resources and expertise to drive product development, marketing, and sales is positively influencing the market growth.
The top companies in the FISH probe market are actively engaged in developing new products by incorporating advanced technologies to improve the accuracy and reliability of results. In line with this, the significant investment in research and development (R&D) projects to expand their portfolio, gain competitive advantages, and meet rising consumer demand is favoring the market growth. Furthermore, several key players are adopting targeted marketing strategies by designing customized products that meet the unique requirements of users. Additionally, the increasing collaboration between leading companies, research institutions, and academic centers to jointly develop new FISH probe technologies, validate products through clinical studies, and strengthen market presence is contributing to the market growth. Moreover, several product manufacturers are establishing distribution channels, partnerships, and subsidiaries across the globe to expand their business and attract a new customer base.
Abnova Corporation
Agilent Technologies Inc.
Biocare Medical LLC
Biosearch Technologies (LGC Ltd.)
Creative Biolabs
F. Hoffmann-La Roche Ltd. (Roche Holding AG)
Genemed Biotechnologies Inc. (Sakura Finetek USA Inc.)
Merck KGaA
Oxford Gene Technology (Sysmex Corporation)
PerkinElmer Inc.
ThermoFisher Scientific Inc.
In November 2022, Biocare Medical LLC announced the acquisition of Empire Genomics, a company that produces fluorescence in situ hybridization (FISH) probes designed and optimized for specific genes, diseases, or regions across the entire mouse and human genomes.
In March 2023, Oxford Gene Technology (Sysmex Corporation) announced that eight of its CytoCell FISH probes had been certified for clinical use in line with Europe's In Vitro Diagnostics Regulation (IVDR).
In April 2023, Agilent Technologies Inc. expanded its portfolio of SureFISH probes. This move was aimed at creating the largest offering of oligonucleotide-based fluorescent in situ hybridization (FISH) assays on the market.