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市場調査レポート
商品コード
1519769
嚢胞性線維症治療薬市場レポート:薬剤クラス別、薬剤分子タイプ別、投与経路別、エンドユーザー別、地域別、2024年~2032年Cystic Fibrosis Therapeutics Market Report by Drug Class, Drug Molecule Type, Route of Administration, End-User, and Region 2024-2032 |
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嚢胞性線維症治療薬市場レポート:薬剤クラス別、薬剤分子タイプ別、投与経路別、エンドユーザー別、地域別、2024年~2032年 |
出版日: 2024年07月01日
発行: IMARC
ページ情報: 英文 147 Pages
納期: 2~3営業日
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世界の嚢胞性線維症治療薬の市場規模は2023年に72億米ドルに達しました。今後、IMARC Groupは、市場は2032年までに147億米ドルに達し、2024年から2032年の間に7.9%の成長率(CAGR)を示すと予測しています。嚢胞性線維症の有病率の上昇、遺伝的要因に基づく個別化治療アプローチに対する個人の嗜好の高まり、遺伝子治療における最近の進歩の広範な利用は、市場成長を推進する主な要因の一部です。
嚢胞性線維症治療薬は、呼吸器系や消化器系に影響を及ぼす遺伝性疾患の症状管理を可能にします。CFTRモジュレーターや遺伝子治療を含む様々な薬剤が含まれ、オーダーメイドの治療オプションを提供しています。CFTRモジュレーターは、CFTRタンパク質の機能を強化することにより、CFの原因となる根本的な遺伝子異常を改善します。症状を改善し、病気の進行を遅らせることで、生活の質の向上に貢献します。肺機能を強化し、CF患者の呼吸を楽にし、呼吸器症状を軽減することができます。
遺伝的要因に基づく個別化治療に対する個人の嗜好の高まりが、市場の成長を強化しています。これとは別に、各国の行政当局がCFの研究開発や治療開発のための政策や資金を導入しており、これが良好な市場見通しをもたらしています。さらに、希少疾病用医薬品開発に対する規制上の優遇措置の継続的な増加が、製薬会社のCF治療薬への投資を促しています。さらに、製薬会社、研究機関、ヘルスケアプロバイダー間の協力関係の高まりは、新しい治療法の開発を加速させています。さらに、ウェアラブルデバイスや遠隔医療などのテクノロジーの普及により、患者のモニタリングや治療の提供が強化されています。
CFTRモジュレーターの進歩
CFTR調節薬の開発と継続的な改良は、市場成長の主な要因の一つです。これらの薬剤は、CF患者における濃い粘液産生とそれに続く健康合併症の原因である欠陥CFTRタンパク質を直接標的とします。これとは別に、製薬会社は、より高い有効性と幅広い適用性を提供する新世代のCFTRモジュレーターを導入するために、研究開発(R&D)活動に継続的に投資しています。これらの進歩は、より包括的な解決策を提供し、患者の全体的な健康を改善します。また、特定のCF患者集団における粘液クリアランスの改善、呼吸器症状の軽減、肺機能の向上もサポートしています。
遺伝子ベースの治療法の開発
遺伝子ベースの治療法の開発も、市場開拓を促進する大きな要因です。これらの革新的な治療は、CFTR遺伝子の機能不全コピーを罹患細胞に導入することにより、CFの根本原因に対処し、CFの治癒や長期管理を容易にします。さらに、KaftrioやTrikaftaのような遺伝子ベースの治療がCFの症状を治療するために承認されるなど、遺伝子治療における最近の進歩の利用が増加していることも、良好な市場見通しをもたらしています。これとは別に、遺伝子ベースの治療法の進化が市場の成長を強化しています。これらの治療法は、より効果的で的を絞った治療を提供し、治療の選択肢を広げ、潜在的な治療法の研究を促進するのに役立っています。
有病率の増加と早期診断
いくつかの要因により、特にミレニアル世代の間でCFの有病率が上昇していることが、治療薬に対する需要を押し上げています。これに伴い、診断能力の向上が市場の見通しを明るいものにしています。さらに、ヘルスケアシステムは、新生児スクリーニングプログラムや遺伝子検査を通じて、CF症例の特定に習熟しつつあります。これとは別に、早期診断により若年齢での治療開始が可能となり、疾患の進行に大きな影響を与え、長期的な転帰を改善することができます。さらに、遺伝子検査や新生児スクリーニングプログラムの進歩により、乳幼児におけるCFの診断がより迅速かつ確実に行われるようになってきています。
The global cystic fibrosis therapeutics market size reached US$ 7.2 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 14.7 Billion by 2032, exhibiting a growth rate (CAGR) of 7.9% during 2024-2032. The rising prevalence of cystic fibrosis, increasing preferences of individuals for personalized treatment approaches based on genetic factors, and the widespread utilization of recent advancements in gene therapy are some of the major factors propelling the market growth.
Cystic fibrosis therapeutics enables management of the symptoms of a genetic disease affecting the respiratory and digestive systems. It encompasses a range of drugs, including CFTR modulators and gene therapy, offering tailored treatment options. It helps correct the underlying genetic defect responsible for CF by enhancing the function of the CFTR protein. It contributes to a better quality of life by managing symptoms and slowing disease progression. It can enhance lung function, helping individuals with CF breathe more easily and reducing respiratory symptoms.
Rising preferences of individuals for personalized treatment approaches based on genetic factors is strengthening the growth of the market. Apart from this, governing authorities of various countries are introducing policies and funding for CF research and treatment development, which is offering a favorable market outlook. Additionally, a continuous rise in regulatory incentives for orphan drug development is encouraging pharmaceutical companies to invest in CF therapeutics. Moreover, the rising collaborative efforts between pharmaceutical companies, research institutions, and healthcare providers are accelerating the development of new therapies. Furthermore, the widespread use of technology, such as wearable devices and telemedicine, is enhancing patient monitoring and treatment delivery.
Advancements in CFTR modulators
The development and continued improvement of CFTR modulator drugs represent one of the primary factors contributing to the market growth. These medications directly target the defective CFTR protein, which is responsible for the thick mucus production and subsequent health complications in individuals with CF. Apart from this, pharmaceutical companies are continuously investing in research and development (R&D) activities to introduce new generations of CFTR modulators that offer greater effectiveness and broader applicability. These advancements provide more comprehensive solutions and improve the overall well-being of individuals. They also support improved mucus clearance, reduced respiratory symptoms, and enhanced lung function in specific CF patient populations.
Development of gene-based therapies
The development of gene-based therapies is another major factor facilitating the market growth. These innovative treatments help address the root cause of CF by introducing functional copies of the defective CFTR gene into affected cells and facilitating a cure or long-term management of CF. Additionally, the rising utilization of recent advancements in gene therapy, such as the approval of gene-based treatments like Kaftrio and Trikafta for treating CF symptoms is offering a favorable market outlook. Apart from this, the evolution of gene-based therapies is strengthening the growth of the market. These therapies aid in providing more effective and targeted treatments, expanding treatment options, and fostering research into potential curative approaches.
Increasing prevalence and early diagnosis
The rising prevalence of CF, especially among the millennial population due to several factors, is driving the demand for therapeutics. Along with this, improved diagnostic capabilities are creating a positive market outlook. Additionally, healthcare systems are becoming more adept at identifying CF cases through newborn screening programs and genetic testing. Apart from this, early diagnosis allows for the initiation of treatment at a younger age, which can significantly impact disease progression and improve long-term outcomes. Furthermore, ongoing advancements in genetic testing and newborn screening programs are allowing for quicker and more reliable diagnosis of CF in infants and young children.
IMARC Group provides an analysis of the key trends in each segment of the market report, along with forecasts at the global, regional, and country levels from 2024-2032. Our report has categorized the market based on drug class, drug molecule type, route of administration, and end-user.
Pancreatic Enzyme Supplements
Mucolytics
Bronchodilators
CFTR Modulators
Antibiotics
Others
CFTR modulators hold the largest market share
A detailed breakup and analysis of the market based on the drug class has also been provided in the report. This includes pancreatic enzyme supplements, mucolytics, bronchodilators, CFTR modulators, antibiotics, and others. According to the report, CFTR modulators accounted for the largest market share as they offer a highly targeted treatment approach. They address the root cause of CF at the molecular level, focusing on the defective CFTR protein. They work by improving the function of the defective CFTR protein and regulate the flow of salt and fluids in and out of cells. Additionally, the expanded approval for use in various CF patient populations, including those with specific genetic mutations drives its demand across the globe. Apart from this, pharmaceutical companies continue to invest heavily in research activities to create new generations of CFTR modulators. These efforts aim to improve the effectiveness of existing drugs and develop new ones, ensuring a competitive edge in the market.
Small Molecule Drugs
Biologics
Small molecule drugs account for the majority of the market share
The report has provided a detailed breakup and analysis of the market based on the drug molecule type. This includes small molecule drugs and biologics. According to the report, small molecule drugs represented the largest segment as they have excellent bioavailability and get efficiently absorbed into the bloodstream after oral administration. This ensures that a significant portion of the drug reaches its target site, enhancing therapeutic efficacy. Apart from this, they are generally cost-effective to manufacture, making them attractive to pharmaceutical companies. The production processes for these drugs are well-established, allowing for economies of scale and efficient mass production. Moreover, regulatory agencies, such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), have established clear guidelines for the development and approval of small molecule drugs. This regulatory support ensures their safety, quality, and efficacy, bolstering confidence among healthcare professionals and patients.
Oral Drugs
Inhaled Drugs
Oral drugs dominate the market
A detailed breakup and analysis of the market based on the route of administration has also been provided in the report. This includes oral drugs and inhaled drugs. According to the report, oral drugs accounted for the largest market share as they are often more cost-effective than other forms of medication delivery. They require less infrastructure for administration and reduce the need for healthcare professionals' involvement, leading to lower overall healthcare costs. Additionally, they do not involve needles or invasive procedures, making them more tolerable for a broader patient population. Apart from this, they are usually administered in the form of tablets or capsules, offering a level of accessibility and convenience. Apart from this, patients can take these medications easily without the need for specialized medical personnel or equipment. This convenience supports long-term treatments, chronic conditions, and self-administered therapies for several chronic diseases.
Hospitals
Clinics
Others
Hospitals dominate the market
The report has provided a detailed breakup and analysis of the market based on the end-user. This includes hospitals, clinics, and others. According to the report, hospitals represented the largest segment as they provide comprehensive healthcare services under one roof. They offer a wide range of medical specialties, including emergency care, surgery, radiology, pathology, and specialized clinics. Apart from this, they are primarily associated with acute care, which involves the treatment of severe and life-threatening conditions. Moreover, they are equipped with state-of-the-art medical equipment and technology. This includes advanced diagnostic tools, imaging systems, surgical robots, and intensive care units. These resources enable hospitals to deliver cutting-edge medical treatments and procedures. Furthermore, many hospitals are affiliated with medical schools and research institutions, fostering an environment of continuous learning and innovation. This research-driven approach leads to the development of new medical treatments, therapies, and best practices.
North America
United States
Canada
Asia Pacific
China
Japan
India
South Korea
Australia
Indonesia
Others
Europe
Germany
France
United Kingdom
Italy
Spain
Russia
Others
Latin America
Brazil
Mexico
Others
Middle East and Africa
Europe leads the market, accounting for the largest cystic fibrosis therapeutics market share
The market research report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa. According to the report, Europe accounted for the largest market share since the region has a well-developed healthcare infrastructure with widespread access to medical facilities and specialized CF centers. Additionally, Europe has a relatively high prevalence of CF. This increased prevalence drives research and development (R&D) efforts as well as market demand for CF therapeutics. Apart from this, Europe is home to some of the largest pharmaceutical companies in the world. These companies invest heavily in CF therapeutics, leading to the development of innovative treatments. Furthermore, the European Medicines Agency (EMA) provides a clear regulatory pathway for the approval of CF drugs. Moreover, many European governments allocate substantial funding to support CF research and treatment. This funding accelerates the development of new therapies and promotes market growth.
Companies are investing heavily in research and development (R&D) activities to discover new treatments and medications that target the underlying causes of cystic fibrosis. Additionally, they are working on therapies tailored to specific genetic mutations associated with cystic fibrosis. This ensures a more effective and targeted approach to treatment. Apart from this, many companies are forming partnerships with academic institutions, research organizations, and other pharma companies to accelerate drug development and bring new therapies to market more quickly. Furthermore, they are continuously conducting and investing in phase I, II, and III clinical trials to test the efficacy and safety of new cystic fibrosis therapies.
AbbVie Inc.
Alaxia
Alcresta Therapeutics Inc.
Allergan
AstraZeneca
F. Hoffmann-La Roche Ltd.
Gilead Sciences Inc.
Merck & Co. Inc.
Novartis AG
Teva Pharmaceutical Industries Ltd.
Vertex Pharmaceuticals Inc.
(Please note that this is only a partial list of the key players, and the complete list is provided in the report.)
In December 2022, Vertex Pharmaceuticals Inc. announced that the U.S. Food and Drug Administration cleared its Investigational New Drug (IND) application for VX-522, a messenger ribonucleic acid (mRNA) therapy targeted at treating the underlying cause of cystic fibrosis (CF) lung disease.
In October 2020, AbbVie Inc. announced the partnership with Roche and the acquisition of the TMEM16A potentiators portfolio. The relationship influenced the expansion of the company's product line.