酵素補充療法の市場規模、シェア、動向分析レポート：製品別、治療疾患別、投与経路別、最終用途別、地域別、セグメント別予測、2025年～2030年

酵素補充療法市場の成長と動向

Grand View Research, Inc.の最新レポートによると、世界の酵素補充療法市場規模は2030年までに172億6,000万米ドルに達し、2025～2030年にかけてCAGR 9.0％で成長すると推定されています。

Genetic and Rare Diseases Information Center（GARD）によると、希少疾患とは20万人以下に発症する疾患と定義されています。これらの疾患は、以前は製薬会社によるサポートがなかったため、希少疾病とも呼ばれています。米国で1983年に希少疾病用医薬品法が成立して以来、いくつかの大手製薬会社やバイオ医薬品会社は希少疾病用医薬品の開発に多額の投資を行ってきました。このように、認知度の向上、研究開発投資の増加、ライソゾーム貯蔵症や遺伝性疾患の増加、容易な医薬品承認プロセスが、予測期間中の市場成長を促進する要因となっています。

米国国立衛生ラボのデータによると、希少疾患を患う米国人は2,500万人を超えると推定されています。これらの事実は、これらの疾病の数は少ないもの、罹患者数は多いという事実を示しています。酵素補充療法を利用する最も一般的なライソゾーム貯蔵障害には、ゴーシェ、ファブリー、ポンペ、MPS、SCID、シュワックマン・ダイヤモンド症候群などがあります。

近年、これらの疾患は大きな注目を集め、成長にプラスの影響を与えています。医薬品メーカーが希少疾病用医薬品の開発に投資できるよう、さまざまな助成金や法律が設けられています。希少医薬品審査指定プログラム、希少小児疾患優先審査バウチャー・プログラム、人道的使用機器（HUD）プログラム、希少製品臨床検査助成プログラムは、希少医薬品の開発を支援するプログラムです。

在宅医療や輸液センターでの酵素補充療法の利用が増加しており、市場の牽引役となっています。このような専門的な輸液センターは、予測期間中に最も高いCAGRを記録すると予測されています。病院は、アクセスが容易で幅広い疾患の治療が可能であることから、最大のセグメントシェアを占めています。

酵素補充療法市場レポートハイライト

• 市場ではゴーシェ病が支配的な地位を占め、2024年には32.6%の最大売上シェアを占めました。
• イミグルセラーゼは市場を席巻し、2024年には20.2%の最大売上シェアを占めました。これは、ゴーシェ病の有病率が上昇し、効果的な治療オプションが必要とされているためです。さらに、認知度と診断率が向上するにつれて、より多くの患者が特定され、イミグルセラーゼの需要が増加しています。
• 非経口が市場を独占し、2024年には80.9%の最大売上シェアを占めました。この成長は、迅速な吸収と効果的なドラッグデリバリーを促進する能力に起因しています。さらに、この方法では点滴が可能であり、酵素のような大きな分子を血流に直接送り込み、即効的な治療効果を確保するために不可欠です。
• 点滴センターは市場をリードし、2024年には40.8%の最大売上シェアを占めました。これらのセンターは、ERTを投与するための管理された環境を提供し、輸液中の患者の安全性と快適性を確保しています。

目次

第1章 調査手法と範囲

第2章 エグゼクティブサマリー

第3章 酵素補充療法市場の変数、動向、範囲

• 市場系統の展望
• 市場力学
  • 市場促進要因分析
  • 市場抑制要因分析
• ビジネス環境分析
  • 産業分析-ポーターのファイブフォース分析
  • PESTLE分析

第4章 酵素補充療法市場：製品ビジネス分析

• 製品市場シェア、2024年と2030年
• 製品セグメントダッシュボード
• 市場規模と予測と動向分析、製品別、2018～2030年
• イミグルセラーゼ
• アガルシダーゼベータ
• タリグルセラーゼ
• ベラグルセラーゼアルファ
• ペガデマーゼ
• ラロニダーゼ
• 膵臓酵素
• イデュルスルファーゼ
• ガルスルファーゼ
• その他

第5章 酵素補充療法市場：治療疾患ビジネス分析

• 治療疾患市場シェア、2024年と2030年
• 治療疾患セグメントダッシュボード
• 市場規模と予測と動向分析、治療疾患別、2018～2030年
• ゴーシェ病
• ムルティフェ
• SCID
• ポンペ病
• ファブリー病
• その他

第6章 酵素補充療法市場：投与経路ビジネス分析

• 投与経路市場シェア、2024年と2030年
• 投与経路セグメントダッシュボード
• 市場規模と予測と動向分析、投与経路別、2018～2030年
• 非経口
• 経口

第7章 酵素補充療法市場：最終用途ビジネス分析

• 最終用途市場シェア、2024年と2030年
• 最終用途セグメントダッシュボード
• 市場規模と予測と動向分析、最終用途別、2018～2030年
• 点滴センター
• 病院
• その他

第8章 酵素補充療法市場：製品、治療疾患、最終用途、地域別、推定・動向分析

• 地域別市場シェア分析、2024年と2030年
• 地域別市場ダッシュボード
• 市場規模、予測動向分析、2018～2030年
• 北米
  • 米国
  • カナダ
  • メキシコ
• 欧州
  • 英国
  • ドイツ
  • フランス
  • イタリア
  • スペイン
  • ノルウェー
  • デンマーク
  • スウェーデン
• アジア太平洋
  • 日本
  • 中国
  • インド
  • 韓国
  • オーストラリア
  • タイ
• ラテンアメリカ
  • ブラジル
  • アルゼンチン
• 中東・アフリカ
  • 南アフリカ
  • サウジアラビア
  • アラブ首長国連邦
  • クウェート

第9章 競合情勢

• 参加者概要
• 企業の市況分析
• 企業分類
• 戦略マッピング
• 企業プロファイル/上場企業
  • Carl Zeiss Meditec, Inc.
  • Shire Plc、
  • Sanofi SA
  • Biomarin Pharmaceutical Inc.
  • AbbVie
  • Alexion Pharmaceuticals Inc.
  • Allergan plc
  • Horizon Pharma Public Limited Company
  • Actelion（Janssen）
  • Recordati Rare Diseases
  • Protalix BIoTherapeutics
  • Amicus Therapeutics, Inc.

List of Tables

• Table 1. List of Secondary Sources
• Table 2. List of Abbreviations
• Table 3. Global Enzyme Replacement Therapy Market, by Region, 2018 - 2030 (USD Million)
• Table 4. Global Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 5. Global Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 6. Global Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 7. Global Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 8. North America Enzyme Replacement Therapy Market, by Country, 2018 - 2030 (USD Million)
• Table 9. North America Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 10. North America Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 11. North America Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 12. North America Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 13. U.S. Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 14. U.S. Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 15. U.S. Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 16. U.S. Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 17. Canada Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 18. Canada Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 19. Canada Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 20. Canada Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 21. Mexico Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 22. Mexico Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 23. Mexico Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 24. Mexico Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 25. Europe Enzyme Replacement Therapy Market, by Country, 2018 - 2030 (USD Million)
• Table 26. Europe Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 27. Europe Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 28. Europe Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 29. Europe Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 30. UK Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 31. UK Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 32. UK Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 33. UK Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 34. Germany Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 35. Germany Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 36. Germany Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 37. Germany Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 38. France Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 39. France Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 40. France Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 41. France Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 42. Italy Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 43. Italy Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 44. Italy Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 45. Italy Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 46. Spain Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 47. Spain Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 48. Spain Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 49. Spain Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 50. Norway Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 51. Norway Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 52. Norway Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 53. Norway Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 54. Denmark Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 55. Denmark Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 56. Denmark Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 57. Denmark Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 58. Sweden Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 59. Sweden Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 60. Sweden Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 61. Sweden Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 62. Asia Pacific Enzyme Replacement Therapy Market, by Country, 2018 - 2030 (USD Million)
• Table 63. Asia Pacific Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 64. Asia Pacific Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 65. Asia Pacific Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 66. Asia Pacific Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 67. Japan Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 68. Japan Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 69. Japan Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 70. Japan Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 71. China Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 72. China Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 73. China Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 74. China Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 75. India Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 76. India Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 77. India Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 78. India Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 79. Australia Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 80. Australia Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 81. Australia Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 82. Australia Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 83. South Korea Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 84. South Korea Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 85. South Korea Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 86. South Korea Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 87. Thailand Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 88. Thailand Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 89. Thailand Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 90. Thailand Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 91. Latin America Enzyme Replacement Therapy Market, by Country, 2018 - 2030 (USD Million)
• Table 92. Latin America Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 93. Latin America Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 94. Latin America Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 95. Latin America Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 96. Brazil Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 97. Brazil Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 98. Brazil Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 99. Brazil Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 100. Argentina Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 101. Argentina Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 102. Argentina Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 103. Argentina Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 104. Middle East & Africa Enzyme Replacement Therapy Market, by Country, 2018 - 2030 (USD Million)
• Table 105. Middle East & Africa Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 106. Middle East & Africa Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 107. Middle East & Africa Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 108. Middle East & Africa Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 109. South Africa Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 110. South Africa Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 111. South Africa Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 112. South Africa Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 113. Saudi Arabia Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 114. Saudi Arabia Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 115. Saudi Arabia Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 116. Saudi Arabia Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 117. UAE Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 118. UAE Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 119. UAE Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 120. UAE Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)
• Table 121. Kuwait Enzyme Replacement Therapy Market, by Product, 2018 - 2030 (USD Million)
• Table 122. Kuwait Enzyme Replacement Therapy Market, by Therapeutic Condition, 2018 - 2030 (USD Million)
• Table 123. Kuwait Enzyme Replacement Therapy Market, by Route of Administration, 2018 - 2030 (USD Million)
• Table 124. Kuwait Enzyme Replacement Therapy Market, by End Use, 2018 - 2030 (USD Million)

List of Figures

• Fig. 1 Enzyme Replacement Therapy Market Segmentation
• Fig. 2 Market Research Process
• Fig. 3 Data Triangulation Techniques
• Fig. 4 Primary Research Pattern
• Fig. 5 Market Research Approaches
• Fig. 6 Value-Chain-Based Sizing & Forecasting
• Fig. 7 Market Formulation & Validation
• Fig. 8 Market Snapshot
• Fig. 9 Product, Therapeutic Condition, Route of Administration and End Use Outlook (USD Million)
• Fig. 10 Product, Therapeutic Condition, Route of Administration, and End Use Outlook
• Fig. 11 Competitive Landscape
• Fig. 12 Enzyme Replacement Therapy Market Dynamics
• Fig. 13 Enzyme Replacement Therapy Market: Porter's Five Forces Analysis
• Fig. 14 Enzyme Replacement Therapy Market: PESTLE analysis
• Fig. 15 Enzyme Replacement Therapy Market: Product Segment Dashboard
• Fig. 16 Enzyme Replacement Therapy Market: Product Market Share Analysis, 2024 & 2030
• Fig. 17 Imiglucerase Market, 2018 - 2030 (USD Million)
• Fig. 18 Agalsidase Beta Market, 2018 - 2030 (USD Million)
• Fig. 19 Alglucosidase Alfa Market, 2018 - 2030 (USD Million)
• Fig. 20 Taliglucerase Market, 2018 - 2030 (USD Million)
• Fig. 21 Velaglucerase Alfa Market, 2018 - 2030 (USD Million)
• Fig. 22 Pegademase Market, 2018 - 2030 (USD Million)
• Fig. 23 Laronidase Market, 2018 - 2030 (USD Million)
• Fig. 24 Pancreatic Enzymes Market, 2018 - 2030 (USD Million)
• Fig. 25 Idursulfase Market, 2018 - 2030 (USD Million)
• Fig. 26 Galsulfase Market, 2018 - 2030 (USD Million)
• Fig. 27 Others Market, 2018 - 2030 (USD Million)
• Fig. 28 Enzyme Replacement Therapy Market: Therapeutic Condition Segment Dashboard
• Fig. 29 Enzyme Replacement Therapy Market: Therapeutic Condition Market Share Analysis, 2024 & 2030
• Fig. 30 Gaucher Disease Market, 2018 - 2030 (USD Million)
• Fig. 31 MPS Market, 2018 - 2030 (USD Million)
• Fig. 32 SCID Market, 2018 - 2030 (USD Million)
• Fig. 33 Pompe Disease Market, 2018 - 2030 (USD Million)
• Fig. 34 Fabry Disease Market, 2018 - 2030 (USD Million)
• Fig. 35 Other Market, 2018 - 2030 (USD Million)
• Fig. 36 Enzyme Replacement Therapy Market: Route of Administration Segment Dashboard
• Fig. 37 Enzyme Replacement Therapy Market: Route of Administration Market Share Analysis, 2024 & 2030
• Fig. 38 Parenteral Market, 2018 - 2030 (USD Million)
• Fig. 39 Oral Market, 2018 - 2030 (USD Million)
• Fig. 40 Enzyme Replacement Therapy Market: End Use Segment Dashboard
• Fig. 41 Enzyme Replacement Therapy Market: End Use Market Share Analysis, 2024 & 2030
• Fig. 42 Infusion Centers Market, 2018 - 2030 (USD Million)
• Fig. 43 Hospitals Market, 2018 - 2030 (USD Million)
• Fig. 44 Other Market, 2018 - 2030 (USD Million)
• Fig. 45 Enzyme Replacement Therapy Market Revenue, By Region
• Fig. 46 Regional Marketplace: Key Takeaways
• Fig. 47 Regional Marketplace: Key Takeaways
• Fig. 48 North America Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 49 U.S. Country Dynamics
• Fig. 50 U.S. Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 51 Canada Country Dynamics
• Fig. 52 Canada Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 53 Mexico Country Dynamics
• Fig. 54 Mexico Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 55 Europe Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 56 UK Country Dynamics
• Fig. 57 UK Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 58 Germany Country Dynamics
• Fig. 59 Germany Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 60 France Country Dynamics
• Fig. 61 France Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 62 Italy Country Dynamics
• Fig. 63 Italy Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 64 Spain Country Dynamics
• Fig. 65 Spain Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 66 Norway Country Dynamics
• Fig. 67 Norway Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 68 Sweden Country Dynamics
• Fig. 69 Sweden Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 70 Denmark Country Dynamics
• Fig. 71 Denmark Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 72 Asia Pacific Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 73 Japan Country Dynamics
• Fig. 74 Japan Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 75 China Country Dynamics
• Fig. 76 China Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 77 India Country Dynamics
• Fig. 78 India Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 79 Australia Country Dynamics
• Fig. 80 Australia Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 81 South Korea Country Dynamics
• Fig. 82 South Korea Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 83 Thailand Country Dynamics
• Fig. 84 Thailand Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 85 Latin America Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 86 Brazil Country Dynamics
• Fig. 87 Brazil Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 88 Argentina Country Dynamics
• Fig. 89 Argentina Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 90 MEA Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 91 South Africa Country Dynamics
• Fig. 92 South Africa Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 93 Saudi Arabia Country Dynamics
• Fig. 94 Saudi Arabia Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 95 UAE Country Dynamics
• Fig. 96 UAE Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 97 Kuwait Key Country Dynamics
• Fig. 98 Kuwait Enzyme Replacement Therapy Market, 2018 - 2030 (USD Million)
• Fig. 99 Company Categorization
• Fig. 100 Company Market Position Analysis
• Fig. 101 Strategic Framework

Enzyme Replacement Therapy Market Growth & Trends:

The global enzyme replacement therapy market size is estimated to reach USD 17.26 billion by 2030, registering to grow at a CAGR of 9.0% from 2025 to 2030 according to a new report by Grand View Research, Inc. As per the Genetic and Rare Diseases Information Center or GARD, a rare disease is defined as a condition that affects lesser than 200,000 individuals. These disorders are also called orphan diseases due to the lack of support exhibited by pharmaceutical companies previously. Since the passing of the Orphan Drug Act of 1983 in the U.S., several large pharmaceutical and biopharmaceutical companies have invested heavily in the development of orphan drugs. Thus, rising awareness, increasing R&D investment, growth in the number of lysosomal storage and genetic disorders, and easy drug approval process are factors propelling the market growth during the forecast period.

According to data from the National Institutes of Health, it is estimated that over 25 million Americans suffer from rare diseases. These facts are indicative of the fact that although the number of these ailments is low, individuals suffering from these are large. Some of the most common lysosomal storage disorders that make use of enzyme replacement therapy are Gaucher, Fabry, Pompe, MPS, SCID, and Shwachman-Diamond Syndrome among others.

In the recent past, these disorders have been gaining significant attention, impacting growth positively. Various grants and acts are in place to accommodate drug makers to invest in the development of orphan drugs. Orphan Drug Designation Program, Rare Pediatric Disease Priority Review Voucher Program, Humanitarian Use Device (HUD) Program, and Orphan Products Clinical Trials Grants Program are programs that aid in the development of orphan drugs.

The rising use of enzyme replacement therapy in home care and infusion centers are gaining traction in the market. Specialized infusion centers such as these are anticipated to witness the highest CAGR during the forecast period. Hospitals held the largest segmental share owing to easy accessibility and ability to treat a wide range of ailments.

Enzyme Replacement Therapy Market Report Highlights:

• Gaucher disease held the dominant position in the market and accounted for the largest revenue share of 32.6% in 2024, driven by the increasing prevalence and awareness of the condition, leading to more patients being diagnosed and treated.
• Imiglucerase dominated the market and accounted for the largest revenue share of 20.2% in 2024, owing to the rising prevalence of Gaucher disease, which necessitates effective treatment options. In addition, as awareness and diagnosis rates improve, more patients are being identified, increasing demand for imiglucerase.
• The parenteral route of administration dominated the market and accounted for the largest revenue share of 80.9% in 2024. This growth is attributed to its ability to facilitate rapid absorption and effective drug delivery. In addition, this method allows for intravenous infusions, which are essential for delivering large molecules such as enzymes directly into the bloodstream, ensuring immediate therapeutic effects
• Infusion centers led the market and accounted for the largest revenue share of 40.8% in 2024, driven by their specialized focus on intravenous treatments. These centers provide a controlled environment for administering ERT, ensuring patient safety and comfort during infusions.

Table of Contents

Chapter 1. Methodology and Scope

• 1.1. Market Segmentation & Scope
• 1.2. Segment Definitions
  • 1.2.1. Product
  • 1.2.2. Therapeutic Condition
  • 1.2.3. Route of Administration
  • 1.2.4. End Use
• 1.3. Estimates and Forecast Timeline
• 1.4. Research Methodology
• 1.5. Information Procurement
  • 1.5.1. Purchased Database
  • 1.5.2. GVR's Internal Database
  • 1.5.3. Secondary Sources
  • 1.5.4. Primary Research
• 1.6. Information Analysis
  • 1.6.1. Data Analysis Models
• 1.7. Market Formulation & Data Visualization
• 1.8. Model Details
  • 1.8.1. Commodity Flow Analysis
• 1.9. List of Secondary Sources
• 1.10. Objectives

Chapter 2. Executive Summary

• 2.1. Market Snapshot
• 2.2. Segment Snapshot
• 2.3. Competitive Landscape Snapshot

Chapter 3. Enzyme Replacement Therapy Market Variables, Trends, & Scope

• 3.1. Market Lineage Outlook
• 3.2. Market Dynamics
  • 3.2.1. Market Driver Analysis
  • 3.2.2. Market Restraint Analysis
• 3.3. Business Environment Analysis
  • 3.3.1. Industry Analysis - Porter's Five Forces Analysis
    • 3.3.1.1. Supplier power
    • 3.3.1.2. Buyer power
    • 3.3.1.3. Substitution threat
    • 3.3.1.4. Threat of new entrant
    • 3.3.1.5. Competitive rivalry
  • 3.3.2. PESTLE Analysis

Chapter 4. Enzyme Replacement Therapy Market: Product Business Analysis

• 4.1. Product Market Share, 2024 & 2030
• 4.2. Product Segment Dashboard
• 4.3. Market Size & Forecasts and Trend Analysis, by Product, 2018 to 2030 (USD Million)
• 4.4. Imiglucerase
  • 4.4.1. Imiglucerase Market, 2018 - 2030 (USD Million)
• 4.5. Agalsidase Beta
  • 4.5.1. Agalsidase Beta Market, 2018 - 2030 (USD Million)
  • 4.5.2. Alglucosidase Alfa
  • 4.5.3. Alglucosidase Alfa Market, 2018 - 2030 (USD Million)
• 4.6. Taliglucerase
  • 4.6.1. Taliglucerase Market, 2018 - 2030 (USD Million)
• 4.7. Velaglucerase Alfa
  • 4.7.1. Velaglucerase Alfa Market, 2018 - 2030 (USD Million)
• 4.8. Pegademase
  • 4.8.1. Pegademase Market, 2018 - 2030 (USD Million)
• 4.9. Laronidase
  • 4.9.1. Laronidase Market, 2018 - 2030 (USD Million)
• 4.10. Pancreatic Enzymes
  • 4.10.1. Pancreatic Enzymes Market, 2018 - 2030 (USD Million)
• 4.11. Idursulfase
  • 4.11.1. Idursulfase Market, 2018 - 2030 (USD Million)
• 4.12. Galsulfase
  • 4.12.1. Galsulfase Market, 2018 - 2030 (USD Million)
• 4.13. Others
  • 4.13.1. Others Market, 2018 - 2030 (USD Million)

Chapter 5. Enzyme Replacement Therapy Market: Therapeutic Condition Business Analysis

• 5.1. Therapeutic Condition Market Share, 2024 & 2030
• 5.2. Therapeutic Condition Segment Dashboard
• 5.3. Market Size & Forecasts and Trend Analysis, by Therapeutic Condition, 2018 to 2030 (USD Million)
• 5.4. Gaucher Disease
  • 5.4.1. Gaucher Disease Market, 2018 - 2030 (USD Million)
• 5.5. MPS
  • 5.5.1. MPS Market, 2018 - 2030 (USD Million)
• 5.6. SCID
  • 5.6.1. SCID Market, 2018 - 2030 (USD Million)
• 5.7. Pompe Disease
  • 5.7.1. Pompe Disease Market, 2018 - 2030 (USD Million)
• 5.8. Fabry Disease
  • 5.8.1. Fabry Disease Market, 2018 - 2030 (USD Million)
• 5.9. Other
  • 5.9.1. Other Market, 2018 - 2030 (USD Million)

Chapter 6. Enzyme Replacement Therapy Market: Route of Administration Business Analysis

• 6.1. Route of Administration Market Share, 2024 & 2030
• 6.2. Route of Administration Segment Dashboard
• 6.3. Market Size & Forecasts and Trend Analysis, by Route of Administration, 2018 to 2030 (USD Million)
• 6.4. Parenteral
  • 6.4.1. Parenteral Market, 2018 - 2030 (USD Million)
• 6.5. Oral
  • 6.5.1. Oral Market, 2018 - 2030 (USD Million)

Chapter 7. Enzyme Replacement Therapy Market: End Use Business Analysis

• 7.1. End Use Market Share, 2024 & 2030
• 7.2. End Use Segment Dashboard
• 7.3. Market Size & Forecasts and Trend Analysis, by End Use, 2018 to 2030 (USD Million)
• 7.4. Infusion Centers
  • 7.4.1. Infusion Centers Market, 2018 - 2030 (USD Million)
• 7.5. Hospitals
  • 7.5.1. Hospitals Market, 2018 - 2030 (USD Million)
• 7.6. Other
  • 7.6.1. Other Market, 2018 - 2030 (USD Million)

Chapter 8. Enzyme Replacement Therapy Market: Regional Estimates & Trend Analysis by Product, Therapeutic Condition, and End Use

• 8.1. Regional Market Share Analysis, 2024 & 2030
• 8.2. Regional Market Dashboard
• 8.3. Market Size, & Forecasts Trend Analysis, 2018 to 2030:
• 8.4. North America
  • 8.4.1. North America Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.4.2. U.S.
    • 8.4.2.1. Key Country Dynamic
    • 8.4.2.2. Regulatory Framework
    • 8.4.2.3. Competitive Insights
    • 8.4.2.4. U.S. Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.4.3. Canada
    • 8.4.3.1. Key Country Dynamic
    • 8.4.3.2. Regulatory Framework
    • 8.4.3.3. Competitive Insights
    • 8.4.3.4. Canada Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.4.4. Mexico
    • 8.4.4.1. Key Country Dynamic
    • 8.4.4.2. Regulatory Framework
    • 8.4.4.3. Competitive Insights
    • 8.4.4.4. Mexico Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
• 8.5. Europe
  • 8.5.1. Europe Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.5.2. UK
    • 8.5.2.1. Key Country Dynamic
    • 8.5.2.2. Regulatory Framework
    • 8.5.2.3. Competitive Insights
    • 8.5.2.4. UK Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.5.3. Germany
    • 8.5.3.1. Key Country Dynamic
    • 8.5.3.2. Regulatory Framework
    • 8.5.3.3. Competitive Insights
    • 8.5.3.4. Germany Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.5.4. France
    • 8.5.4.1. Key Country Dynamic
    • 8.5.4.2. Regulatory Framework
    • 8.5.4.3. Competitive Insights
    • 8.5.4.4. France Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.5.5. Italy
    • 8.5.5.1. Key Country Dynamic
    • 8.5.5.2. Regulatory Framework
    • 8.5.5.3. Competitive Insights
    • 8.5.5.4. Italy Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.5.6. Spain
    • 8.5.6.1. Key Country Dynamic
    • 8.5.6.2. Regulatory Framework
    • 8.5.6.3. Competitive Insights
    • 8.5.6.4. Spain Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.5.7. Norway
    • 8.5.7.1. Key Country Dynamic
    • 8.5.7.2. Regulatory Framework
    • 8.5.7.3. Competitive Insights
    • 8.5.7.4. Norway Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.5.8. Denmark
    • 8.5.8.1. Key Country Dynamic
    • 8.5.8.2. Regulatory Framework
    • 8.5.8.3. Competitive Insights
    • 8.5.8.4. Denmark Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.5.9. Sweden
    • 8.5.9.1. Key Country Dynamic
    • 8.5.9.2. Regulatory Framework
    • 8.5.9.3. Competitive Insights
    • 8.5.9.4. Sweden Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
• 8.6. Asia Pacific
  • 8.6.1. Asia Pacific Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.6.2. Japan
    • 8.6.2.1. Key Country Dynamic
    • 8.6.2.2. Regulatory Framework
    • 8.6.2.3. Competitive Insights
    • 8.6.2.4. Japan Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.6.3. China
    • 8.6.3.1. Key Country Dynamic
    • 8.6.3.2. Regulatory Framework
    • 8.6.3.3. Competitive Insights
    • 8.6.3.4. China Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.6.4. India
    • 8.6.4.1. Key Country Dynamic
    • 8.6.4.2. Regulatory Framework
    • 8.6.4.3. Competitive Insights
    • 8.6.4.4. India Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.6.5. South Korea
    • 8.6.5.1. Key Country Dynamic
    • 8.6.5.2. Regulatory Framework
    • 8.6.5.3. Competitive Insights
    • 8.6.5.4. South Korea Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.6.6. Australia
    • 8.6.6.1. Key Country Dynamic
    • 8.6.6.2. Regulatory Framework
    • 8.6.6.3. Competitive Insights
    • 8.6.6.4. Australia Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.6.7. Thailand
    • 8.6.7.1. Key Country Dynamic
    • 8.6.7.2. Regulatory Framework
    • 8.6.7.3. Competitive Insights
    • 8.6.7.4. Thailand Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
• 8.7. Latin America
  • 8.7.1. Latin America Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.7.2. Brazil
    • 8.7.2.1. Key Country Dynamic
    • 8.7.2.2. Regulatory Framework
    • 8.7.2.3. Competitive Insights
    • 8.7.2.4. Brazil Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.7.3. Argentina
    • 8.7.3.1. Key Country Dynamic
    • 8.7.3.2. Regulatory Framework
    • 8.7.3.3. Competitive Insights
    • 8.7.3.4. Argentina Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
• 8.8. MEA
  • 8.8.1. MEA Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.8.2. South Africa
    • 8.8.2.1. Key Country Dynamic
    • 8.8.2.2. Regulatory Framework
    • 8.8.2.3. Competitive Insights
    • 8.8.2.4. South Africa Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.8.3. Saudi Arabia
    • 8.8.3.1. Key Country Dynamic
    • 8.8.3.2. Regulatory Framework
    • 8.8.3.3. Competitive Insights
    • 8.8.3.4. Saudi Arabia Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.8.4. UAE
    • 8.8.4.1. Key Country Dynamic
    • 8.8.4.2. Regulatory Framework
    • 8.8.4.3. Competitive Insights
    • 8.8.4.4. UAE Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)
  • 8.8.5. Kuwait
    • 8.8.5.1. Key Country Dynamic
    • 8.8.5.2. Regulatory Framework
    • 8.8.5.3. Competitive Insights
    • 8.8.5.4. Kuwait Enzyme Replacement Therapy Market Estimates and Forecasts, 2018 - 2030 (USD Million)

Chapter 9. Competitive Landscape

• 9.1. Participant Overview
• 9.2. Company Market Position Analysis
• 9.3. Company Categorization
• 9.4. Strategy Mapping
• 9.5. Company Profiles/Listing
  • 9.5.1. Carl Zeiss Meditec, Inc.
    • 9.5.1.1. Overview
    • 9.5.1.2. Financial Performance
    • 9.5.1.3. Product Benchmarking
    • 9.5.1.4. Strategic Initiatives
  • 9.5.2. Shire Plc;
    • 9.5.2.1. Overview
    • 9.5.2.2. Financial Performance
    • 9.5.2.3. Product Benchmarking
    • 9.5.2.4. Strategic Initiatives
  • 9.5.3 Sanofi S.A.
    • 9.5.2.1. Overview
    • 9.5.2.2. Financial Performance
    • 9.5.2.3. Product Benchmarking
    • 9.5.2.4. Strategic Initiatives
  • 9.5.4. Biomarin Pharmaceutical Inc.
    • 9.5.4.1. Overview
    • 9.5.4.2. Financial Performance
    • 9.5.4.3. Product Benchmarking
    • 9.5.4.4. Strategic Initiatives
  • 9.5.5. AbbVie
    • 9.5.5.1. Overview
    • 9.5.5.2. Financial Performance
    • 9.5.5.3. Product Benchmarking
    • 9.5.5.4. Strategic Initiatives
  • 9.5.6. Alexion Pharmaceuticals Inc.
    • 9.5.6.1. Overview
    • 9.5.6.2. Financial Performance
    • 9.5.6.3. Product Benchmarking
    • 9.5.6.4. Strategic Initiatives
  • 9.5.7. Allergan plc
    • 9.5.7.1. Overview
    • 9.5.7.2. Financial Performance
    • 9.5.7.3. Product Benchmarking
    • 9.5.7.4. Strategic Initiatives
  • 9.5.8. Horizon Pharma Public Limited Company
    • 9.5.8.1. Overview
    • 9.5.8.2. Financial Performance
    • 9.5.8.3. Product Benchmarking
    • 9.5.8.4. Strategic Initiatives
  • 9.5.9. Actelion (Janssen)
    • 9.5.9.1. Overview
    • 9.5.9.2. Financial Performance
    • 9.5.9.3. Product Benchmarking
    • 9.5.9.4. Strategic Initiatives
  • 9.5.10. Recordati Rare Diseases
    • 9.5.10.1. Overview
    • 9.5.10.2. Financial Performance
    • 9.5.10.3. Product Benchmarking
    • 9.5.10.4. Strategic Initiatives
  • 9.5.11. Protalix Biotherapeutics
    • 9.5.11.1. Overview
    • 9.5.11.2. Financial Performance
    • 9.5.11.3. Product Benchmarking
    • 9.5.11.4. Strategic Initiatives
  • 9.5.12. Amicus Therapeutics, Inc.
    • 9.5.12.1. Overview
    • 9.5.12.2. Financial Performance
    • 9.5.12.3. Product Benchmarking
    • 9.5.12.4. Strategic Initiatives