酵素補充療法の世界市場規模 - 酵素別、適応症別、投与経路別、エンドユーザー別、予測、2023年～2032年

世界の酵素補充療法の市場規模は、様々な遺伝性疾患に対する生物製剤と標準的治療法の広範な受け入れにより、2023年から2032年にかけて7%を超えるCAGRを示すと見られています。

酵素補充療法（ERT）を含む生物製剤は、ゴーシェ病やファブリー病などの遺伝性疾患に対する先進的な標的治療として脚光を浴びています。生物学的製剤の治療効果と特異性、それに伴う患者やヘルスケアプロバイダーの間での採用率の上昇も、市場の成長を後押しします。例えば、2023年11月、武田薬品のADZYNMAは、先天性血栓性血小板減少性紫斑病（cTTP）の治療薬として最初で唯一の遺伝子組換えADAMTS13酵素補充薬として、米国FDAから承認を取得しました。

酵素補充療法業界は、酵素タイプ、適応症、投与経路、エンドユーザー、地域に区分されます。

酵素タイプに関しては、イミグルセラーゼセグメントの市場価値は2023年から2032年にかけてCAGR 8.4％を達成すると予測されています。イミグルセラーゼは、ゴーシェ病治療のための効果的な酵素補充療法として登場しました。希少疾患に対する認識と診断の高まりと相まって、患者数は拡大しており、イミグルセラーゼベースのERTに対する需要が高まっています。さらに、バイオテクノロジーの進歩や継続的な研究が、このセグメントの成長に寄与しています。

エンドユーザー別では、輸液センター分野のERT産業は2032年までCAGR 7.5％を記録する見込みです。酵素欠乏症の有病率の上昇と酵素補充療法の受け入れ拡大が、輸液センターサービスの需要に大きく寄与しています。さらに、治療に便利で管理された環境を利用できることから、輸液センターに対する患者の嗜好が高まっていることも、同分野の成長を後押ししています。

地域別では、欧州の酵素補充療法市場規模は2032年までCAGR 6.8%を記録すると予測され、先進ヘルスケアインフラ、認知度の向上、酵素欠乏症の有病率の上昇などが背景にあります。さらに、欧州では製薬会社と研究機関の共同研究がERT技術の進歩に貢献しています。さらに、革新的な治療を通じて患者の転帰を改善しようとする姿勢が強まっていることも、この地域の産業展望を拡大すると思われます。例えば、2023年5月、欧州委員会はファブリー病に対するポリ（エチレングリコール）（PEG）イレート酵素であるペグニガルシダーゼ・アルファの販売承認を与えました。

目次

第1章 調査手法と調査範囲

第2章 エグゼクティブサマリー

第3章 酵素補充療法市場の洞察

• 業界情勢
• 業界への影響要因
  • 促進要因
    • 希少遺伝性疾患の増加
    • 効果的な治療オプションに対する需要の高まり
    • 希少遺伝性疾患に対する認識の高まり
    • バイオテクノロジーと遺伝子工学の進歩
  • 業界の潜在的リスク＆課題
    • 治療費の高騰
    • ERT製品の入手可能性の制限
• 成長可能性分析
• COVID-19影響分析
• 規制状況
• 技術情勢
• ポーター分析
• PESTEL分析

第4章 競合情勢

• イントロダクション
• 企業マトリックス分析
• 競合ポジショニング・マトリックス
• 戦略ダッシュボード

第5章 酵素補充療法市場の推計・主要動向予測：酵素タイプ別、2018年～2032年

• 主要動向：酵素タイプ別
• イミグルセラーゼ
• アガルシダーゼベータ
• タリグルセラーゼ
• ベラグルセラーゼ・アルファ
• ラロニダーゼ
• アルグルコシダーゼ・アルファ
• ガルスルファーゼ
• イドゥルスルファーゼ
• 膵酵素
• ペガデマーゼ
• その他の酵素タイプ

第6章 酵素補充療法市場の推計・予測：適応症別、2018年～2032年

• 主要動向：適応症別
• ゴーシェ病
• ファブリー病
• ポンペ病
• 形質細胞障害
• SCID
• ムコ多糖症（MPS）
  • MPS I-Hurler、Hurler Scheie、Scheie
  • MPS II-ハンター
  • MPS III-サンフィリッポ
  • その他のムコ多糖症
• その他の適応症

第7章 酵素補充療法市場の推計・予測：投与経路別、2018年～2032年

• 主要動向：投与経路別
• 非経口
• 経口

第8章 酵素補充療法市場推計・予測：エンドユーザー別、2018年～2032年

• 主要動向：エンドユーザー別
• 病院
• 輸液センター
• その他のエンドユーザー

第9章 酵素補充療法市場推計・予測：地域別、2018年～2032年

• 主要動向：地域別
• 北米
  • 米国
  • カナダ
• 欧州
  • ドイツ
  • 英国
  • フランス
  • スペイン
  • イタリア
  • その他の欧州
• アジア太平洋
  • 中国
  • 日本
  • インド
  • オーストラリア
  • 韓国
  • その他のアジア太平洋
• ラテンアメリカ
  • ブラジル
  • メキシコ
  • その他のラテンアメリカ
• 中東・アフリカ
  • 南アフリカ
  • サウジアラビア
  • その他の中東・アフリカ

第10章 企業プロファイル

• Sanofi
• Biomarin Pharmaceutical Inc.
• AbbVie Inc.
• Pfizer, Inc.
• Alexion Pharmaceuticals Inc.
• Allergan plc
• Horizon Pharma Public Limited Company
• Recordati Rare Diseases
• Protalix Biotherapeutics
• Amicus Therapeutics, Inc.

Data Tables

• TABLE 1 Product mapping
• TABLE 2 Market revenue, by enzyme type (2022)
• TABLE 3 Market revenue, by indication (2022)
• TABLE 4 Market revenue, by route of administration (2022)
• TABLE 5 Market revenue, by end-user (2022)
• TABLE 6 Market share, by region (2022)
• TABLE 7 Global enzyme replacement therapy market size, by region, 2018 - 2022 (USD Million)
• TABLE 8 Global enzyme replacement therapy market size, by region, 2018 - 2022 (USD Million)
• TABLE 9 Global enzyme replacement therapy market size, by enzyme type, 2018 - 2022 (USD Million)
• TABLE 10 Global enzyme replacement therapy market size, by enzyme type, 2018 - 2022 (USD Million)
• TABLE 11 Global enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 12 Global enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 13 Global enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 14 Global enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 15 Global enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 16 Global enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 17 Industry impact forces
• TABLE 18 Imiglucerase market size, 2018-2022 (USD Million)
• TABLE 19 Imiglucerase market size, 2023-2032 (USD Million)
• TABLE 20 Agalsidase beta market size, 2018-2022 (USD Million)
• TABLE 21 Agalsidase beta market size, 2023-2032 (USD Million)
• TABLE 22 Taliglucerase market size, 2018-2022 (USD Million)
• TABLE 23 Taliglucerase market size, 2023-2032 (USD Million)
• TABLE 24 Velaglucerase alfa market size, 2018-2022 (USD Million)
• TABLE 25 Velaglucerase alfa market size, 2023-2032 (USD Million)
• TABLE 26 Laronidase market size, 2018-2022 (USD Million)
• TABLE 27 Laronidase market size, 2023-2032 (USD Million)
• TABLE 28 Alglucosidase alfa market size, 2018-2022 (USD Million)
• TABLE 29 Alglucosidase alfa market size, 2023-2032 (USD Million)
• TABLE 30 Galsulfase market size, 2018-2022 (USD Million)
• TABLE 31 Galsulfase market size, 2023-2032 (USD Million)
• TABLE 32 Idursulfase market size, 2018-2022 (USD Million)
• TABLE 33 Idursulfase market size, 2023-2032 (USD Million)
• TABLE 34 Pancreatic enzymes market size, 2018-2022 (USD Million)
• TABLE 35 Pancreatic enzymes market size, 2023-2032 (USD Million)
• TABLE 36 Pegademase market size, 2018-2022 (USD Million)
• TABLE 37 Pegademase market size, 2023-2032 (USD Million)
• TABLE 38 Other enzyme types market size, 2018-2022 (USD Million)
• TABLE 39 Other enzyme types market size, 2023-2032 (USD Million)
• TABLE 40 Gaucher disease market size, 2018-2022 (USD Million)
• TABLE 41 Gaucher disease market size, 2023-2032 (USD Million)
• TABLE 42 Fabry disease market size, 2018-2022 (USD Million)
• TABLE 43 Fabry disease market size, 2023-2032 (USD Million)
• TABLE 44 Pompe disease market size, 2018-2022 (USD Million)
• TABLE 45 Pompe disease market size, 2023-2032 (USD Million)
• TABLE 46 SCID market size, 2018-2022 (USD Million)
• TABLE 47 SCID market size, 2023-2032 (USD Million)
• TABLE 48 Mucopolysaccharidosis (MPS) market size, 2018-2022 (USD Million)
• TABLE 49 Mucopolysaccharidosis (MPS) market size, 2023-2032 (USD Million)
• TABLE 50 MPS I - Hurler, Hurler Scheie and Scheie market size, 2018-2022 (USD Million)
• TABLE 51 MPS I - Hurler, Hurler Scheie and Scheie market size, 2023-2032 (USD Million)
• TABLE 52 MPS II - Hunter market size, 2018-2022 (USD Million)
• TABLE 53 MPS II - Hunter market size, 2023-2032 (USD Million)
• TABLE 54 MPS III - Sanfilippo market size, 2018-2022 (USD Million)
• TABLE 55 MPS III - Sanfilippo market size, 2023-2032 (USD Million)
• TABLE 56 Other mucopolysaccharidosis market size, 2018-2022 (USD Million)
• TABLE 57 Other mucopolysaccharidosis market size, 2023-2032 (USD Million)
• TABLE 58 Other indications market size, 2018-2022 (USD Million)
• TABLE 59 Other indications market size, 2023-2032 (USD Million)
• TABLE 60 Parenteral market size, 2018-2022 (USD Million)
• TABLE 61 Parenteral market size, 2023-2032 (USD Million)
• TABLE 62 Oral market size, 2018-2022 (USD Million)
• TABLE 63 Oral market size, 2023-2032 (USD Million)
• TABLE 64 Hospitals market size, 2018-2022 (USD Million)
• TABLE 65 Hospitals market size, 2023-2032 (USD Million)
• TABLE 66 Infusion centers market size, 2018-2022 (USD Million)
• TABLE 67 Infusion centers market size, 2023-2032 (USD Million)
• TABLE 68 Other end-users market size, 2018-2022 (USD Million)
• TABLE 69 Other end-users market size, 2023-2032 (USD Million)
• TABLE 70 North America enzyme replacement therapy Market size, by country, 2018-2022 (USD Million)
• TABLE 71 North America enzyme replacement therapy market size, by country, 2023-2032 (USD Million)
• TABLE 72 North America enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 73 North America enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 74 North America enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 75 North America enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 76 North America enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 77 North America enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 78 North America enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 79 North America enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 80 North America enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 81 North America enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 82 U.S. enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 83 U.S. enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 84 U.S. enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 85 U.S. enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 86 U.S. enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 87 U.S. enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 88 U.S. enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 89 U.S. enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 90 U.S. enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 91 U.S. enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 92 Canada enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 93 Canada enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 94 Canada enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 95 Canada enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 96 Canada enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 97 Canada enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 98 Canada enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 99 Canada enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 100 Canada enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 101 Canada enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 102 Europe enzyme replacement therapy market size, by country, 2018-2022 (USD Million)
• TABLE 103 Europe enzyme replacement therapy market size, by country, 2023-2032 (USD Million)
• TABLE 104 Europe enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 105 Europe enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 106 Europe enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 107 Europe enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 108 Europe enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 109 Europe enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 110 Europe enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 111 Europe enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 112 Europe enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 113 Europe enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 114 Germany enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 115 Germany enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 116 Germany enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 117 Germany enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 118 Germany enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 119 Germany enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 120 Germany enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 121 Germany enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 122 Germany enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 123 Germany enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 124 UK enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 125 UK enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 126 UK enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 127 UK enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 128 UK enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 129 UK enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 130 UK enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 131 UK enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 132 UK enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 133 UK enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 134 France enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 135 France enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 136 France enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 137 France enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 138 France enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 139 France enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 140 France enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 141 France enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 142 France enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 143 France enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 144 Spain enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 145 Spain enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 146 Spain enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 147 Spain enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 148 Spain enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 149 Spain enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 150 Spain enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 151 Spain enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 152 Spain enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 153 Spain enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 154 Italy enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 155 Italy enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 156 Italy enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 157 Italy enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 158 Italy enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 159 Italy enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 160 Italy enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 161 Italy enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 162 Italy enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 163 Italy enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 164 Rest of Europe enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 165 Rest of Europe enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 166 Rest of Europe enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 167 Rest of Europe enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 168 Rest of Europe enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 169 Rest of Europe enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 170 Rest of Europe enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 171 Rest of Europe enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 172 Rest of Europe enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 173 Rest of Europe enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 174 Asia Pacific enzyme replacement therapy market size, by country, 2018-2022 (USD Million)
• TABLE 175 Asia Pacific enzyme replacement therapy market size, by country, 2023-2032 (USD Million)
• TABLE 176 Asia Pacific enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 177 Asia Pacific enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 178 Asia Pacific enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 179 Asia Pacific enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 180 Asia Pacific enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 181 Asia Pacific enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 182 Asia Pacific enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 183 Asia Pacific enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 184 Asia Pacific enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 185 Asia Pacific enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 186 Japan enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 187 Japan enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 188 Japan enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 189 Japan enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 190 Japan enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 191 Japan enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 192 Japan enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 193 Japan enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 194 Japan enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 195 Japan enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 196 China enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 197 China enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 198 China enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 199 China enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 200 China enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 201 China enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 202 China enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 203 China enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 204 China enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 205 China enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 206 India enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 207 India enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 208 India enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 209 India enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 210 India enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 211 India enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 212 India enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 213 India enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 214 India enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 215 India enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 216 Australia enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 217 Australia enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 218 Australia enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 219 Australia enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 220 Australia enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 221 Australia enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 222 Australia enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 223 Australia enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 224 Australia enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 225 Australia enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 226 South Korea enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 227 South Korea enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 228 South Korea enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 229 South Korea enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 230 South Korea enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 231 South Korea enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 232 South Korea enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 233 South Korea enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 234 South Korea enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 235 South Korea enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 236 Rest of Asia Pacific enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 237 Rest of Asia Pacific enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 238 Rest of Asia Pacific enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 239 Rest of Asia Pacific enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 240 Rest of Asia Pacific enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 241 Rest of Asia Pacific enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 242 Rest of Asia Pacific enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 243 Rest of Asia Pacific enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 244 Rest of Asia Pacific enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 245 Rest of Asia Pacific enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 246 Latin America enzyme replacement therapy market size, by country, 2018-2022 (USD Million)
• TABLE 247 Latin America enzyme replacement therapy market size, by country, 2023-2032 (USD Million)
• TABLE 248 Latin America enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 249 Latin America enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 250 Latin America enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 251 Latin America enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 252 Latin America enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 253 Latin America enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 254 Latin America enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 255 Latin America enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 256 Latin America enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 257 Latin America enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 258 Brazil enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 259 Brazil enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 260 Brazil enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 261 Brazil enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 262 Brazil enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 263 Brazil enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 264 Brazil enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 265 Brazil enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 266 Brazil enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 267 Brazil enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 268 Mexico enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 269 Mexico enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 270 Mexico enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 271 Mexico enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 272 Mexico enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 273 Mexico enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 274 Mexico enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 275 Mexico enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 276 Mexico enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 277 Mexico enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 278 Rest of Latin America enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 279 Rest of Latin America enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 280 Rest of Latin America enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 281 Rest of Latin America enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 282 Rest of Latin America enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 283 Rest of Latin America enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 284 Rest of Latin America enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 285 Rest of Latin America enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 286 Rest of Latin America enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 287 Rest of Latin America enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 288 Middle East & Africa enzyme replacement therapy market size, by country, 2018-2022 (USD Million)
• TABLE 289 Middle East & Africa enzyme replacement therapy market size, by country, 2023-2032 (USD Million)
• TABLE 290 Middle East & Africa enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 291 Middle East & Africa enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 292 Middle East & Africa enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 293 Middle East & Africa enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 294 Middle East & Africa enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 295 Middle East & Africa enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 296 Middle East & Africa enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 297 Middle East & Africa enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 298 Middle East & Africa enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 299 Middle East & Africa enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 300 South Africa enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 301 South Africa enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 302 South Africa enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 303 South Africa enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 304 South Africa enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 305 South Africa enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 306 South Africa enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 307 South Africa enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 308 South Africa enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 309 South Africa enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 310 Saudi Arabia enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 311 Saudi Arabia enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 312 Saudi Arabia enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 313 Saudi Arabia enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 314 Saudi Arabia enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 315 Saudi Arabia enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 316 Saudi Arabia enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 317 Saudi Arabia enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 318 Saudi Arabia enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 319 Saudi Arabia enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)
• TABLE 320 Rest of Middle East & Africa enzyme replacement therapy market size, by enzyme type, 2018-2022 (USD Million)
• TABLE 321 Rest of Middle East & Africa enzyme replacement therapy market size, by enzyme type, 2023-2032 (USD Million)
• TABLE 322 Rest of Middle East & Africa enzyme replacement therapy market size, by indication, 2018-2022 (USD Million)
• TABLE 323 Rest of Middle East & Africa enzyme replacement therapy market size, by indication, 2023-2032 (USD Million)
• TABLE 324 Rest of Middle East & Africa enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2018-2022 (USD Million)
• TABLE 325 Rest of Middle East & Africa enzyme replacement therapy market size, by mucopolysaccharidosis (MPS), 2023-2032 (USD Million)
• TABLE 326 Rest of Middle East & Africa enzyme replacement therapy market size, by route of administration, 2018-2022 (USD Million)
• TABLE 327 Rest of Middle East & Africa enzyme replacement therapy market size, by route of administration, 2023-2032 (USD Million)
• TABLE 328 Rest of Middle East & Africa enzyme replacement therapy market size, by end-user, 2018-2022 (USD Million)
• TABLE 329 Rest of Middle East & Africa enzyme replacement therapy market size, by end-user, 2023-2032 (USD Million)

Charts & Figures

• FIG 1 GMI report coverage: Critical research elements
• FIG 2 Top-down approach
• FIG 3 Market estimation and forecast methodology
• FIG 4 Market forecasting methodology
• FIG 5 Breakdown of primary participants
• FIG 6 Enzyme replacement therapy market 360 degree synopsis, 2018 - 2032
• FIG 7 Growth potential analysis, by enzyme type
• FIG 8 Growth potential analysis, by indication
• FIG 9 Growth potential analysis, by route of administration
• FIG 10 Growth potential analysis, by end-user
• FIG 11 Porter's analysis
• FIG 12 PESTEL analysis
• FIG 13 Company matrix analysis, 2022
• FIG 14 Global company market share analysis, 2022
• FIG 15 Competitive positioning matrix, 2022
• FIG 16 Strategic dashboard, 2022

Enzyme Replacement Therapy Market size is set to exhibit over 7% CAGR from 2023 to 2032, driven by the broader acceptance of biologics and standard treatments for various genetic disorders.

Biologics, including enzyme replacement therapy (ERT) are gaining prominence as advanced and targeted treatments for genetic disorders, such as Gaucher disease and Fabry disease. The therapeutic efficacy and specificity of biologics and the subsequently rising adoption amongst patients and healthcare providers will also boost the market growth. For instance, in November 2023, Takeda's ADZYNMA received clearance from the U.S. FDA as the first and only recombinant ADAMTS13 enzyme replacement medication for the treatment of congenital thrombotic thrombocytopenic purpura (cTTP).

The enzyme replacement therapy industry is segmented into enzyme type, indication, route of administration, end-user, and region.

With respect to enzyme type, the market value from imiglucerase segment is anticipated to attain 8.4% CAGR from 2023-2032. Imiglucerase has emerged as an effective enzyme replacement therapy for the treatment of Gaucher disease. The expanding patient pool coupled with the rising awareness and diagnosis of rare diseases is amplifying the demand for Imiglucerase-based ERTs. Moreover, the rising advancements in biotechnology and continuous research will contribute to the segment growth.

Based on end-user, the ERT industry from the infusion centers segment is likely to record 7.5% CAGR through 2032. The rising prevalence of enzyme deficiency disorders coupled with the increasing acceptance of enzyme replacement therapies is adding significantly to the demand for infusion center services. Additionally, the increasing patient preference for infusion centers due to the availability of convenient and controlled environment for the treatment is likely to support the segment growth.

Regionally, the Europe enzyme replacement therapy market size is slated to observe 6.8% CAGR through 2032 driven advanced healthcare infrastructure, increasing awareness, and the rising prevalence of enzyme deficiency disorders. Moreover, collaborations between pharmaceutical companies and research institutions in Europe will contribute to increasing advancements in ERT technologies. Additionally, the growing commitment to improving patient outcomes through innovative therapies will augment the regional industry outlook. For instance, in May 2023, the European Commission granted marketing authorization for pegunigalsidase alfa, the Poly (ethylene glycol) (PEG) ylated enzyme for Fabry disease.

Table of Contents

Chapter 1 Methodology & Scope

• 1.1 Market definition
• 1.2 Base estimates & calculations
• 1.3 Forecast calculation
• 1.4 Covid-19 impact analysis at global level
• 1.5 Data validation
• 1.6 Data sources
  • 1.6.1 Primary
  • 1.6.2 Secondary
    • 1.6.2.1 Paid sources
    • 1.6.2.2 Public sources

Chapter 2 Executive Summary

• 2.1 Enzyme replacement therapy 360 degree synopsis, 2018 - 2032 (USD Million)
  • 2.1.1 Business trends
  • 2.1.2 Region trends
  • 2.1.3 Enzyme type trends
  • 2.1.4 Indication trends
  • 2.1.5 Route of Administration trends
  • 2.1.6 End-user trends

Chapter 3 Enzyme Replacement Therapy Market Insights

• 3.1 Industry landscape, 2018 - 2032 (USD Million)
• 3.2 Industry impact forces
  • 3.2.1 Growth drivers
    • 3.2.1.1 Increasing incidence of rare genetic disorders
    • 3.2.1.2 Rising demand for effective treatment options
    • 3.2.1.3 Growing awareness of rare genetic diseases
    • 3.2.1.4 Advancements in biotechnology and genetic engineering
  • 3.2.2 Industry pitfalls & challenges
    • 3.2.2.1 High cost of therapy
    • 3.2.2.2 Limited availability of ERT products
• 3.3 Growth potential analysis
  • 3.3.1 By enzyme type
  • 3.3.2 By indication
  • 3.3.3 By route of administration
  • 3.3.4 By end-user
  • 3.3.5 By region
• 3.4 COVID-19 impact analysis
• 3.5 Regulatory landscape
• 3.6 Technology landscape
• 3.7 Porter's analysis
• 3.8 PESTEL analysis

Chapter 4 Competitive Landscape, 2022

• 4.1 Introduction
• 4.2 Company matrix analysis, 2022
• 4.3 Competitive positioning matrix, 2022
• 4.4 Strategic dashboard, 2022

Chapter 5 Enzyme Replacement Therapy Market Estimates and Forecast, By Enzyme Type, 2018-2032 (USD Million)

• 5.1 Key trends, by enzyme type
• 5.2 Imiglucerase
• 5.3 Agalsidase beta
• 5.4 Taliglucerase
• 5.5 Velaglucerase alfa
• 5.6 Laronidase
• 5.7 Alglucosidase alfa
• 5.8 Galsulfase
• 5.9 Idursulfase
• 5.10 Pancreatic enzymes
• 5.11 Pegademase
• 5.12 Other enzyme types

Chapter 6 Enzyme Replacement Therapy Market Estimates and Forecast, By Indication, 2018-2032 (USD Million)

• 6.1 Key trends, by indication
• 6.2 Gaucher disease
• 6.3 Fabry disease
• 6.4 Pompe disease
• 6.5 Plasma cell disorders
• 6.6 SCID
• 6.7 Mucopolysaccharidosis (MPS)
  • 6.7.1 MPS I - Hurler, Hurler Scheie and Scheie
  • 6.7.2 MPS II - Hunter
  • 6.7.3 MPS III - Sanfilippo
  • 6.7.4 Other mucopolysaccharidosis
• 6.8 Other indications

Chapter 7 Enzyme Replacement Therapy Market Estimates and Forecast, By Route of Administration, 2018-2032 (USD Million)

• 7.1 Key trends, by route of administration
• 7.2 Parenteral
• 7.3 Oral

Chapter 8 Enzyme Replacement Therapy Market Estimates and Forecast, By End-user, 2018-2032 (USD Million)

• 8.1 Key trends, by end-user
• 8.2 Hospitals
• 8.3 Infusion centers
• 8.4 Other end-users

Chapter 9 Enzyme Replacement Therapy Market Estimates and Forecast, By Region, 2018-2032 (USD Million)

• 9.1 Key trends, by region
• 9.2 North America
  • 9.2.1 U.S.
  • 9.2.2 Canada
• 9.3 Europe
  • 9.3.1 Germany
  • 9.3.2 UK
  • 9.3.3 France
  • 9.3.4 Spain
  • 9.3.5 Italy
  • 9.3.6 Rest of Europe
• 9.4 Asia Pacific
  • 9.4.1 China
  • 9.4.2 Japan
  • 9.4.3 India
  • 9.4.4 Australia
  • 9.4.5 South Korea
  • 9.4.6 Rest of Asia Pacific
• 9.5 Latin America
  • 9.5.1 Brazil
  • 9.5.2 Mexico
  • 9.5.3 Rest of Latin America
• 9.6 Middle East & Africa
  • 9.6.1 South Africa
  • 9.6.2 Saudi Arabia
  • 9.6.3 Rest of Middle East & Africa

Chapter 10 Company Profiles

• 10.1 Sanofi
• 10.2 Biomarin Pharmaceutical Inc.
• 10.3 AbbVie Inc.
• 10.4 Pfizer, Inc.
• 10.5 Alexion Pharmaceuticals Inc.
• 10.6 Allergan plc
• 10.7 Horizon Pharma Public Limited Company
• 10.8 Recordati Rare Diseases
• 10.9 Protalix Biotherapeutics
• 10.10 Amicus Therapeutics, Inc.