敗血症：疫学予測（～2033年）

敗血症は感染症に起因する生命を脅かす合併症であり、感染に対する身体の反応が自身の組織や臓器を損傷することで起こります。敗血症は多臓器不全や死亡を引き起こし、特に早期に気づき、速やかに治療しなければ死に至ります（Elfekyら、2017）（Ruddら、2020）。敗血症は誰でも発症する可能性がありますが、1歳未満の小児、高齢者、免疫系が弱っている人に多く見られる症状です（Elfekyら、2017）。どのような感染症（細菌、ウイルス、真菌）でも敗血症になる可能性がありますが、肺炎、腹部感染、腎臓感染、血流感染（菌血症）を患っている人は敗血症を発症しやすくなります。敗血症のもっとも一般的な病原体には、細菌（グラム陽性、グラム陰性）、真菌が含まれます（Quenotら、2013）。

敗血症と敗血症性ショックは生命を脅かす病態であり、死亡率が極めて高いです（Shankar-Hariら、2017）（Dupuisら、2020）。敗血症は、感染に対する宿主の反応異常によって引き起こされる生命を脅かす臓器機能不全と定義されます（Singerら、2016）（Shankar-Hariら、2017）。敗血症性ショックは、持続的な動脈性低血圧を特徴とする急性循環不全の状態であり、輸液による蘇生ではうまく救命できないものと定義されます（Singerら、2016）（Shankar-Hariら、2017）。敗血症と敗血症性ショックの診断には、臨床データ、検査データ、生理学的データ、微生物学的データの組み合わせが必要です（Singerら、2016）。

当レポートでは、主要8市場（米国、フランス、ドイツ、イタリア、スペイン、英国、日本、中国）における敗血症について調査分析し、敗血症および敗血症性ショックのリスク因子や、過去の疫学の動向に関する情報を提供しています。

目次

第1章 目次

第2章 GlobalDataについて

第3章 敗血症：エグゼクティブサマリー

• カタリスト
• 関連レポート
• 今後のレポート

第4章 疫学

• 疾患の背景
• 危険因子と併存疾患
• 世界の過去の動向
• 主要8市場の予測手法
• 敗血症と敗血症性ショックの疫学的予測（2023年～2033年）
  • 敗血症と診断された患者
  • 敗血症と診断された患者：年齢別
  • 敗血症と診断された患者：性別
  • 敗血症と診断された患者：病原体別
  • 敗血症と診断された患者における臓器機能障害
  • 敗血症による院内死亡例
  • 敗血症性ショックと診断された患者
  • 敗血症性ショックと診断された患者：年齢別
  • 敗血症性ショックと診断された患者：性別
  • 敗血症性ショックと診断された患者：病原体別
  • 敗血症性ショックと診断された患者における臓器機能障害
  • 敗血症性ショックによる院内死亡例
• 考察
  • 疫学的予測の考察
  • COVID-19の影響
  • 分析の限界
  • 分析の強み

第5章 付録

第6章 お問い合わせ

List of Tables

• Table 1: Summary of updated data types
• Table 2: Risk factors and comorbidities for sepsis

List of Figures

• Figure 1: 8MM, diagnosed incident cases of sepsis, both sexes, N, all ages, 2023 and 2033
• Figure 2: 8MM, diagnosed incident cases of septic shock, both sexes, N, all ages, 2023 and 2033
• Figure 3: 8MM, diagnosed incidence of sepsis, all ages, both sexes, cases per 100,000 population, 2013-33
• Figure 4: 8MM, diagnosed incidence of septic shock, all ages, both sexes, cases per 100,000 population, 2013-33
• Figure 5: 8MM, sources used and not used to forecast diagnosed incident cases of sepsis and septic shock
• Figure 6: 8MM, sources used to forecast the diagnosed incident cases of neonatal sepsis and septic shock
• Figure 7: 8MM, sources used to forecast the diagnosed incident cases of sepsis/septic shock by causative agents
• Figure 8: 8MM, sources used to forecast organ dysfunction in the diagnosed incident cases of sepsis
• Figure 9: 8MM, sources used to forecast organ dysfunction in the diagnosed incident cases of septic shock
• Figure 10: 8MM, sources used for sepsis/septic shock in-hospital mortality cases
• Figure 11: 8MM, diagnosed incident cases of sepsis, both sexes, all ages, N, 2023
• Figure 12: 8MM, age-specific diagnosed incident cases of sepsis, all ages, N, 2023
• Figure 13: 8MM, sex-specific diagnosed incident cases of sepsis, all ages, N, 2023
• Figure 14: 8MM, diagnosed incident cases of sepsis by causative agent, both sexes, all ages, N, 2023
• Figure 15: 8MM, organ dysfunction in diagnosed incident cases of sepsis, both sexes, all ages, N, 2023
• Figure 16: 8MM, sepsis in-hospital mortality cases, both sexes, all ages, N, 2023
• Figure 17: 8MM, diagnosed incident cases of septic shock, both sexes, all ages, N, 2023
• Figure 18: 8MM, age-specific diagnosed incident cases of septic shock, both sexes, N, 2023
• Figure 19: 8MM, sex-specific diagnosed incident cases of septic shock, all ages, N, 2023
• Figure 20: 8MM, diagnosed incident cases of septic shock by causative agent, both sexes, all ages, N, 2023
• Figure 21: 8MM, organ dysfunction in diagnosed incident cases of septic shock, both sexes, all ages, N, 2023
• Figure 22: 8MM, septic shock in-hospital mortality cases, both sexes, all ages, N, 2023

Sepsis is a life-threatening complication arising from an infection, which occurs when the body's response to the infection damages its own tissues and organs. Sepsis causes multiple organ failure and death, especially if it is not recognized early and treated promptly (Elfeky et al., 2017; Rudd et al., 2020). Anyone can develop sepsis, but the condition is more common in children younger than one year of age, older adults, and those with weakened immune systems (Elfeky et al., 2017). Although any type of infection (bacterial, viral, or fungal) can lead to sepsis, people suffering from pneumonia, abdominal infection, kidney infection, and bloodstream infection (bacteremia) are more likely to develop sepsis. The most common pathogens for sepsis include bacteria (Gram-positive, Gram-negative), and fungi (Quenot et al., 2013).

Sepsis and septic shock are life-threatening conditions with an extremely high mortality rate (Shankar-Hari et al., 2017; Dupuis et al., 2020). Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection (Singer et al., 2016; Shankar-Hari et al., 2017). Septic shock is defined as a state of acute circulatory failure characterized by persistent arterial hypotension that cannot be successfully rescued by fluid resuscitation (Singer et al., 2016; Shankar-Hari et al., 2017). A constellation of clinical, laboratory, physiologic, and microbiologic data is needed for the diagnosis of sepsis and septic shock (Singer et al., 2016).

Scope

• This report provides an overview of the risk factors and the global and historical epidemiological trends for sepsis and septic shock in the eight major markets (8MM: US, France, Germany, Italy, Spain, UK, Japan, and China).
• Additionally, this report includes a 10-year epidemiological forecast of sepsis for men and women from 2023-33 for the following segmentations in all ages across the 8MM: diagnosed incident cases of sepsis segmented by sex and age (ages 0-28 days, 1 month-17 years, 18-64 years, and 65 years and older), diagnosed incident cases of sepsis by causative agent (Gram positive and Gram negative bacteria, fungi, and other organism), diagnosed incident cases of sepsis by organ dysfunction (acute kidney dysfunction, acute respiratory dysfunction, disseminated intravascular coagulopathy [DIC], hepatic dysfunction, and cardiovascular dysfunction), and in-hospital mortality of sepsis.
• This report also includes a 10-year epidemiological forecast of septic shock for men and women from 2023-33 for the following segmentations in all ages across the 8MM: diagnosed incident cases of septic shock segmented by sex and age (0-28 days, 1 month-17 years, 18-64 years, and 65 years and older), diagnosed incident cases of septic shock by causative agent, agent (gram positive and gram negative bacteria, fungi, and other organism) diagnosed incident cases of septic shock by organ dysfunction (acute kidney dysfunction, acute respiratory dysfunction, DIC, hepatic dysfunction, and cardiovascular dysfunction), and in-hospital mortality of septic shock.

Reasons to Buy

• Sepsis Epidemiology series will allow you to:
• Develop business strategies by understanding the trends shaping and driving the global sepsis markets.
• Quantify patient populations in the global sepsis markets to improve product design, pricing, and launch plans.
• Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for sepsis therapeutics in each of the markets covered.
• Understand magnitude of the sepsis population by age, sex, causative agent, and organ dysfunction.

Table of Contents

1. List of Contents

• 1.1. List of Tables
• 1.2. List of Figures

2. About GlobalData

3. Sepsis: Executive Summary

• 3.1. Catalyst
• 3.2. Related reports
• 3.3. Upcoming reports

4. Epidemiology

• 4.1. Disease background
• 4.2. Risk factors and comorbidities.
• 4.3. Global and historical trends
• 4.4. 8MM forecast methodology.
  • 4.4.1. Sources
  • 4.4.2. Forecast assumptions and methods.
  • 4.4.3. Forecast assumptions and methods: diagnosed incident cases of sepsis
  • 4.4.4. Forecast assumptions and methods: diagnosed incident cases of sepsis by causative agent.
  • 4.4.5. Forecast assumptions and methods: organ dysfunction in diagnosed incident cases of sepsis.
  • 4.4.6. Forecast assumptions and methods: sepsis in-hospital mortality cases.
  • 4.4.7. Forecast assumptions and methods: diagnosed incident cases of septic shock.
  • 4.4.8. Forecast assumptions and methods: diagnosed incident cases of septic shock by causative agent.
  • 4.4.9. Forecast assumption and methods: organ dysfunction in diagnosed incident cases of septic shock.
  • 4.4.10. Forecast assumption and methods: septic shock in-hospital mortality cases.
• 4.5. Epidemiological forecast for sepsis and septic shock (2023–33)
  • 4.5.1. Diagnosed incident cases of sepsis.
  • 4.5.2. Age-specific diagnosed incident cases of sepsis
  • 4.5.3. Sex-specific diagnosed incident cases of sepsis
  • 4.5.4. Diagnosed incident cases of sepsis by causative agent.
  • 4.5.5. Organ dysfunction in diagnosed incident cases of sepsis
  • 4.5.6. Sepsis in-hospital mortality cases
  • 4.5.7. Diagnosed incident cases of septic shock.
  • 4.5.8. Age-specific diagnosed incident cases of septic shock
  • 4.5.9. Sex-specific diagnosed incident cases of septic shock
  • 4.5.10. Diagnosed incident cases of septic shock by causative agent
  • 4.5.11. Organ dysfunction in diagnosed incident cases of septic shock
  • 4.5.12. Septic shock in-hospital mortality cases
• 4.6. Discussion
  • 4.6.1. Epidemiological forecast insight
  • 4.6.2. COVID-19 impact.
  • 4.6.3. Limitations of the analysis
  • 4.6.4. Strengths of the analysis

5. Appendix

• 5.1. Bibliography
• 5.2. About the Authors
  • 5.2.1. Epidemiologist
  • 5.2.2. Reviewers
  • 5.2.3. Vice President of Disease Intelligence and Epidemiology
  • 5.2.4. Global Head of Pharma Research, Analysis and Competitive Intelligence

6. Contact Us