頭頸部扁平上皮癌（HNSCC）市場：規模と動向レポート：疫学とパイプライン分析、競合評価、アンメットニーズ、臨床試験戦略、予測（2021年～2031年）

当レポートでは、頭頸部扁平上皮癌（HNSCC）市場について調査し、疾患の概要と疫学、パイプライン製品動向、アンメットニーズと機会、市場の見通しなどを提供しています。

目次

第1章 序文

第2章 エグゼクティブサマリー

第3章 疾患の概要

第4章 上市済薬剤とパイプライン薬剤の概要

• 市販薬の概要
• パイプライン分析
• 標的分析と臨床ベンチマーク

第5章 市場の見通し

第6章 アンメットニーズ

第7章 承認可能性分析とフェーズ移行成功率分析

第8章 競争力の評価

• 治療クラス別の競合分析

第9章 将来の参入企業

第10章 付録

第11章 お問い合わせ

This report includes an assessment of the disease epidemiology and 10-year patient-based forecast (PBF) across the 8MM for marketed and pipeline therapies with established mechanisms of action and cell & gene therapies by class, including early to late clinical stage pipeline products, with a launch date assessment by market for Head and Neck Squamous Cell Carcinomas (HNSCC). In addition to PBF sales data for the 8MM, this report contains sales forecast extrapolations for an additional 7 geographical markets (7M), totaling 15 major markets (15MM). These sales forecast extrapolations leverage data on pharmaceutical sales and drug availability from GlobalData's World Markets Healthcare (WMH) and POLI Price Intelligence databases.

The report also analyzes the clinical and commercial landscapes of GBM, with pricing assumptions based on currently marketed products by class of cell & gene therapies, accompanied by a transparent forecast methodology.

Additionally, the report evaluates indication-specific unmet needs and competitive assessment, and identifies key future players in the cell therapy market.

Cell and gene therapy (CGT) is not an established therapy area in HNSCC, but there is an active clinical pipeline. Gene therapies dominate the HNSCC CGT pipeline with 10 agents in Phase II and 13 agents in Phase I. Autologous T-cell receptors (TCRs) follow close behind with 3 agents in Phase II and 7 agents in Phase I of development. However, CGTs only constitute a modest proportion of the overall HNSCC pipeline, reflecting the unproven efficacy of these modalities in this cancer type.

Cell and gene therapies are expected to capture a combined total of 8% of the HNSCC market by the end of the forecast period in 2031, reaching $262 million in 8MM sales (US, France, Germany, Italy, Spain, UK, Japan, and China).

Sales forecasts for the 7M (Australia, South Korea, Belgium, Denmark, Switzerland, Israel, and Canada) assessed in this analysis show the overall HNSCC market (cell therapies and established/traditional therapies) is expected to reach $163 million by 2031.

CGT agents show promise for partially meeting unmet needs in HNSCC and can provide the most value by producing more therapeutic options for patients with locally advanced HNSCC. CGTs are not expected to address the unmet need of identifying new druggable targets, with the top 5 targets in the HNSCC already being well-established targets.

Key Highlights

Forecast includes 8 countries

Forecast covers 2021-2031

Seven markets are extrapolated, obtaining a 15-market value for all GBM therapeutics

Scope

• This report includes disease epidemiology, a 10-year patient-based forecast for marketed and pipeline therapies with established mechanisms of action and cell & gene therapies by class, including early- to late clinical stage pipeline products with launch date assessment by 8MM market.

Reasons to Buy

• OBTAIN CELL & GENE THERAPY SALES FORECASTS ACROSS MULTIPLE REGIONS
• GAIN INSIGHT INTO PROMISING EARLY STAGE APPROACHES
• Our indication specific forecast models answer questions such as:
• What is the target patient pool for cell & gene therapies in each cancer indication?
• Which patient groups are more likely to receive these therapies?
• What does the cell & gene therapy clinical stage pipeline look like in each cancer indication
• What is the anticipated breakdown between autologous and allogeneic cell therapies?
• When will cell & gene therapies launch in eac h market?
• What is the total market value projected for the forecast end, in 2031?

Table of Contents

Table of Contents

1. Preface

• 1.1. Contents
• 1.2. Report Scope

2. Executive Summary

3. Disease Overview

• 3.1. HNSCC Etiology & Treatment Algorithm 1
• 3.2. Treatment Algorithm 2

4. Marketed & Pipeline Drugs Overview

• 4.1. Marketed Drugs Overview
• 4.2. Pipeline Analysis
• 4.3. Target Analysis and Clinical Benchmarks

5. Market Outlook

• 5.1. 10-Year Market Analysis with Drivers and Barriers
• 5.2. 10-Year Market Outlook - 15 Markets

6. Unmet Needs

7. Likelihood of Approval Analysis and Phase Transition Success Rate Analysis

8. Competitive Assessment

• 8.1. Competitive Analysis by Class of Therapy

9. Future Players

• 9.1. Future Players Based on Pipeline Strength

10. Appendix

• 10.1. Cell and Gene Therapies Forecast Methodology Overview
• 10.2. Pricing of Cell and Gene Therapies
• 10.3. Pipeline Launch Assumptions
• 10.4. Abbreviations
• 10.5. Methodology
• 10.6. About the Authors

11. Contact Us