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市場調査レポート
商品コード
1374831
尋常性乾癬治療の世界市場-2023年~2030年Global Plaque Psoriasis Treatment Market - 2023-2030 |
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カスタマイズ可能
適宜更新あり
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尋常性乾癬治療の世界市場-2023年~2030年 |
出版日: 2023年11月01日
発行: DataM Intelligence
ページ情報: 英文 187 Pages
納期: 即日から翌営業日
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尋常性乾癬は、細胞の増殖が非常に速い、長期にわたる慢性の自己免疫性皮膚疾患です。尋常性乾癬の最も一般的なタイプで、皮膚にプラークと呼ばれる厚く鱗屑性の斑点が生じます。通常、新しい皮膚細胞は28~30日ごとに増殖します。しかし、尋常性乾癬の場合、新しい細胞は3~4日ごとに成長し、皮膚表面に移動します。古い細胞と入れ替わる新しい細胞の蓄積がプラークを生み出します。
さらに、尋常性乾癬は伝染性ではありません。尋常性乾癬には治療法はありませんが、個人差や症状の程度に応じて多くの治療法があります。外用療法としては、エモリエント剤、保湿剤、コルチコステロイド、角質溶解剤、コールタール、アントラリン、ビタミンD3アナログおよびカルシニューリン阻害剤の使用があります。外用薬を組み合わせて使用すると、薬剤を単独で使用した場合よりも効果的なことがあります。また、光線療法も治療に最もよく用いられています。
尋常性乾癬に対する革新的な薬剤の採用が増加していることが、予測期間を通じて市場を牽引すると予想されます。革新的な薬剤の開発は、アンメットニーズに対応し、より良い疾患管理をもたらすことを目的としています。近年、バイオシミラーは尋常性乾癬の治療において最も注目されています。バイオシミラーは幅広い利点を提供し、参照生物製剤よりも研究開発がはるかに少なくて済むからです。バイオシミラーは製造コストがはるかに安いです。
例えば、2023年1月6日、アルボテックとテバ・ファーマシューティカルズは、アルボテックが提案したステラーラ(ウステキヌマブ)のバイオシミラーであるAVT04の生物製剤承認申請が米国食品医薬品局(FDA)に受理されたことを明らかにしました。ステラーラ(一般名:ウステキヌマブ)は、光線療法または全身療法が適応となる6歳以上の中等症から重症の尋常性乾癬患者を適応症としています。
さらに、FDA承認のような多くの規制当局の承認は、薬剤の安全性に対する患者の信頼を高めることにより、革新的な薬剤の採用を増加させます。例えば、2022年9月9日、ブリストル・マイヤーズスクイブ社は、米国食品医薬品局(FDA)より、全身療法または光線療法の候補である中等度から重度の尋常性乾癬の成人患者に対する治療薬として、ファースト・イン・クラスの経口選択的アロステリックチロシンキナーゼ2(TYK2)阻害薬であるSotyktu(deucravacitinib)が承認されたと発表しました。
また、免疫皮膚科学とリウマチ学のリーダーであるノバルティスは、2021年6月1日、全身療法または光線療法が適応となる6歳以上の小児患者における中等度から重度の尋常性乾癬の治療薬として、コセンティクス(一般名:セクキヌマブ)の米国食品医薬品局(FDA)の承認を取得しました。今回の承認は、米国において小児患者を対象とした初めての承認となります。
さらに、尋常性乾癬の有病率の増加、規制当局による承認の増加、先進治療の臨床試験の増加、認知度の向上と早期発見、新規薬剤や治療法の開発における技術進歩が、予測期間中に市場を牽引すると予想される要因となっています。
コルチコステロイド外用薬やその他の薬剤の大量投与に伴う合併症や副作用、光線療法にかかる高額な費用、より優れた正確な治療法の欠如などの要因が、市場の阻害要因になると予想されます。
Plaque psoriasis also known as psoriasis vulgaris is a long-lasting and chronic autoimmune skin disease that causes cells to reproduce very quickly. It's the most common type of psoriasis that causes thick, scaly patches called plaques on the skin. Typically, new skin cells grow every 28 to 30 days. But in the case of plaque psoriasis, new cells grow and move to the skin's surface every three to four days. The buildup of new cells replacing old cells creates plaques.
Moreover, plaque psoriasis isn't contagious. There is no cure for plaque psoriasis, but many treatment options are available, depending on the individual and the severity of symptoms. Topical therapy includes the use of emollients and moisturizers, corticosteroids, keratolytics, coal tar, anthralin, vitamin D3 analogs and calcineurin inhibitors. A combination of topical agents is sometimes more effective than when the drugs are used alone. Phototherapy is also most commonly used in the treatment.
The increasing adoption of innovative medications for plaque psoriasis is expected to drive the market over the forecast period. The development of innovative medications aims to address unmet needs and results in better disease management. In recent years, biosimilars are most focused in the treatment of plaque psoriasis, because biosimilars offers a wide range of benefits and require much less research and development than their reference biologics. Biosimilars are much cheaper to produce.
For instance, on January 06, 2023, Alvotech and Teva Pharmaceuticals cleared that the U.S. Food and Drug Administration (FDA) has accepted for review a Biologics License Application for AVT04, Alvotech's proposed biosimilar to Stelara (ustekinumab). STELARA (ustekinumab) is indicated for the treatment of patients 6 years or older with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.
Moreover, many regulatory approvals such as FDA approvals increase the adoption of innovative medications by boosting the trust in patients about the safety of the medications. For instance, on September 09, 2022, Bristol Myers Squibb released that the U.S. Food and Drug Administration (FDA) approved Sotyktu(deucravacitinib), a first-in-class, oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor, for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
Additionally, on June 1, 2021, Novartis, a leader in immuno-dermatology and rheumatology, cleared the U.S. Food and Drug Administration (FDA) approval of Cosentyx (secukinumab) for the treatment of moderate to severe plaque psoriasis in pediatric patients six years and older who are candidates for systemic therapy or phototherapy. This is the first approval for Cosentyx in a pediatric population in the US.
Further, the increasing prevalence of plaque psoriasis, rising regulatory approvals, increasing clinical trials for advanced therapies, increasing awareness and early detection and technological advancements in the development of novel drugs and therapies are the factors expected to drive the market over the forecast period.
Factors such as complications and side effects associated with the high doses of topical corticosteroids and other drugs, the high cost of the treatment phototherapy and the lack of better and accurate treatment are expected to hamper the market.
The global plaque psoriasis treatment market is segmented based on disease type, treatment type, sales channel and region.
The topical medications segment is expected to hold the largest market share over the forecast period. Usually, there is no cure for plaque psoriasis, but topical medications are considered first-line therapeutics based on the severity and symptoms. Various types of topical medications such as anthralin, roflumilast (zoryve), corticosteroids, tapinarof (VTAMA), salicylic acid, coal tar, zinc pyrithione and topical emollients are most commonly used for the treatment.
For instance, on May 24, 2022, Dermavant Sciences, a biopharmaceutical company dedicated to developing and commercializing innovative therapeutics in immuno-dermatology, cleared the U.S. Food and Drug Administration (FDA) approval of VTAMA (tapinarof) cream, 1%, an aryl hydrocarbon receptor agonist, indicated for the topical treatment of plaque psoriasis in adults. This approval makes VTAMA cream the first and only FDA-approved steroid-free topical medication in its class.
Moreover, on July 29, 2022, Arcutis Biotherapeutics, Inc. cleared the U.S. Food and Drug Administration (FDA) approval of the New Drug Application for ZORYVE (roflumilast) cream 0.3% for the treatment of plaque psoriasis, including intertriginous areas, in patients 12 years of age or older. The first and only topical phosphodiesterase-4 (PDE4) inhibitor approved for the treatment of plaque psoriasis, ZORYVE provides rapid clearance of psoriasis plaques and reduces itch in all affected areas of the body.
Further, their wide availability, acceptability, and, ease of application helps to hold the largest market share. The topical medications manage skin symptoms and have anti-inflammatory effects on the skin to clear psoriasis plaques. They include a class of medication called a corticosteroid. Although they are effective and fast-acting for better patient outcomes. In addition, their wide adoption also increases the demand for topical medications.
North America region is expected to hold the largest market share over the forecast period owing to the strong presence of major players and increasing adoption of novel medications. North America especially in the United States has a strong presence of major players such as pharmaceutical companies, biotechnology companies and medical device companies. This presence of major players actively performs in research activities for the development of more advanced and effective therapeutics for the treatment of plaque psoriasis.
For instance, on December 20, 2021, Amgen released the U.S. Food and Drug Administration (FDA) approval of Otezla (apremilast) for the treatment of adult patients with plaque psoriasis who are candidates for phototherapy or systemic therapy. With this expanded indication, Otezla is now the first and only oral treatment approved in adult patients with plaque psoriasis across all severities, including mild, moderate and severe.
Furthermore, due to the increasing prevalence of the condition, there is an increasing adoption of novel medications in the region. For instance, according to the National Psoriasis Foundation/USA, more than 8 million people in the U.S. have psoriasis. About eight in 10 people with psoriasis have plaque psoriasis. The increasing prevalence is increasing the demand for the adoption of novel therapeutics for the early management of the condition and associated severity for the better patient outcomes.
The major global players in the plaque psoriasis treatment market include: Dermavant Sciences, Inc., Novartis AG, Pfizer Inc., Mylan N.V., Boehringer Ingelheim Pharmaceuticals, Inc., AstraZeneca PLC, Lupin Pharmaceuticals, Inc., Bristol-Myers Squibb Company, AbbVie Inc., Eli Lilly and Company and among others.
The COVID-19 pandemic significantly impacted the global plaque psoriasis treatment market. During the pandemic, many clinical trials were delayed or temporarily halted due to the redirected focus on the COVID-19 pandemic. This could have affected the development and approval timelines for new treatments or drugs in plaque psoriasis. The pandemic accelerated the adoption of telehealth services. Dermatologists and healthcare providers started offering virtual consultations, which could have influenced patients with plaque psoriasis to receive care and prescriptions. The pandemic also disrupted the supply chain of these treatment drugs globally.
The global plaque psoriasis treatment market report would provide approximately 61 tables, 59 figures, and 187 Pages.
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