JAKAFIの新興薬剤に関する洞察と市場予測：2032年

JAKAFI（別名ルキソリチニブ）は経口のキナーゼ阻害薬です。造血や免疫機能に重要なサイトカインや成長因子のシグナル伝達を仲介するJAK1およびJAK2を阻害します。JAKシグナル伝達には、サイトカイン受容体へのSTAT（シグナル伝達物質および転写活性化因子）のリクルート、活性化、それに続くSTATの核への局在化が関与し、遺伝子発現の調節につながります。この薬剤は、成人における原発性骨髄線維症、真性多血症後骨髄線維症、必須血小板血症後骨髄線維症を含む中等度または高リスクの骨髄線維症、ヒドロキシ尿素の効果が不十分または不耐容の成人における真性多血症、12歳以上の成人および小児患者におけるステロイド不応性の急性移植片対宿主病の治療に適応があります。

現在、BOS患者へのルキソリチニブ投与に関する研究はまだ予備段階にあり、cGVHDによるBOSにおいてルキソリチニブがステロイドを温存する有効な薬剤であることを示したケースシリーズが2件発表されたのみです。しかし、ルキソリチニブの肺機能への影響、毒性プロファイル、奏効に影響する因子は完全には明らかにされていません。

今後数年間で、閉塞性細気管支炎症候群の市場シナリオは、世界中の広範な研究と医療支出の増加により変化します。各社は、病状を治療／改善するための新たなアプローチに焦点を当てた治療法を開発し、課題を評価し、JAKAFIの優位性に影響を与える可能性のある機会を模索しています。閉塞性細気管支炎症候群に対する他の新興製品は、JAKAFIに厳しい市場競争をもたらすと予想され、近い将来、後発の新興治療薬の発売が市場に大きな影響を与えるとみられています。

当レポートでは、主要7ヶ国におけるLNP023（Iptacopan）市場について調査し、市場の概要とともに、2029年～2032年の売上予測データ、競合情勢、および国別動向などを提供しています。

目次

第1章 レポートのイントロダクション

第2章 閉塞性細気管支炎症候群に対するJAKAFIの概要

• 製品の詳細
• 臨床開発
  • 臨床研究
  • 臨床試験情報
  • 安全性と有効性
• 製品概要

第3章 競合情勢（後期段階の新興治療法）

第4章 JAKAFI市場評価

• 閉塞性細気管支炎症候群に対するJAKAFIの市場展望
• 主要7ヶ国市場分析
  • 主要7ヶ国における閉塞性細気管支炎症候群に対するJAKAFIの市場規模
• 国別市場分析
  • 米国
  • ドイツ
  • 英国

第5章 SWOT分析

第6章 アナリストの見解

第7章 付録

第8章 DelveInsightのサービス内容

第9章 免責事項

第10章 DelveInsightについて

第11章 レポート購入オプション

List of Tables

• Table 1: JAKAFI, Clinical Trial Description, 2023
• Table 2: JAKAFI, General Description
• Table 3: Competitive Landscape (Emerging Therapies)
• Table 4: JAKAFI Market Size in the 7MM, in USD million (2019-2032)
• Table 5: JAKAFI Market Size in the US, in USD million (2019-2032)
• Table 6: JAKAFI Market Size in Germany, in USD million (2019-2032)
• Table 7: JAKAFI Market Size in France, in USD million (2019-2032)
• Table 8: JAKAFI Market Size in Italy, in USD million (2019-2032)
• Table 9: JAKAFI Market Size in Spain, in USD million (2019-2032)
• Table 10: JAKAFI Market Size in the UK, in USD million (2019-2032)
• Table 11: JAKAFI Market Size in Japan, in USD million (2019-2032)

List of Figures

• Figure 1: JAKAFI Market Size in the 7MM, USD million (2019-2032)
• Figure 2: JAKAFI Market Size in the United States, USD million (2019-2032)
• Figure 3: JAKAFI Market Size in Germany, USD million (2019-2032)
• Figure 4: JAKAFI Market Size in France, USD million (2019-2032)
• Figure 5: JAKAFI Market Size in Italy, USD million (2019-2032)
• Figure 6: JAKAFI Market Size in Spain, USD million (2019-2032)
• Figure 7: JAKAFI Market Size in the United Kingdom, USD million (2019-2032)
• Figure 8: JAKAFI Market Size in Japan, USD million (2019-2032)

“"JAKAFI Emerging Drug Insight and Market Forecast - 2032" report provides comprehensive insights about JAKAFI for Bronchiolitis Obliterans Syndrome (BOS) in the seven major markets. A detailed picture of the JAKAFI for bronchiolitis obliterans syndrome in the 7MM, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan for the study period 2019 -2032 is provided in this report along with a detailed description of the JAKAFI for bronchiolitis obliterans syndrome. The report provides insights about mechanism of action, dosage and administration, as well as research and development including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the JAKAFI market forecast analysis for bronchiolitis obliterans syndrome in the 7MM, SWOT, analysts' views, comprehensive overview of market competitors, and brief about other emerging therapies in bronchiolitis obliterans syndrome.

Drug Summary:

JAKAFI (also known as Ruxolitinib) is an oral kinase inhibitor. It inhibits JAK1 and JAK2, which mediate the signaling of several cytokines and growth factors important for hematopoiesis and immune function. JAK signaling involves the recruitment of STATs (signal transducers and activators of transcription) to cytokine receptors, activation, and subsequent localization of STATs to the nucleus leading to modulation of gene expression. The drug is indicated for the treatment of intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis in adults; polycythemia vera in adults who have had an inadequate response to or are intolerant of hydroxyurea; and steroid-refractory acute graft-versus-host disease in adult and pediatric patients 12 years and older (Incyte Corporation, 2020).

Currently, studies on ruxolitinib administration in patients with BOS are still in the preliminary stage, with only two published case series, which indicated ruxolitinib is an effective steroid-sparing agent in BOS due to cGVHD. However, the effect of ruxolitinib on pulmonary function, its toxicity profile, and the factors affecting its response have not been fully determined.

Scope of the Report:

The report provides insights into:

• A comprehensive product overview including the JAKAFI description, mechanism of action, dosage and administration, research and development activities in bronchiolitis obliterans syndrome.
• Elaborated details on JAKAFI regulatory milestones and other development activities have been provided in this report.
• The report also highlights the JAKAFI research and development activities in bronchiolitis obliterans syndrome across the United States, Europe and Japan.
• The report also covers the patents information with expiry timeline around JAKAFI.
• The report contains forecasted sales of JAKAFI for bronchiolitis obliterans syndrome till 2032.
• Comprehensive coverage of the late-stage emerging therapies for bronchiolitis obliterans syndrome.
• The report also features the SWOT analysis with analyst views for JAKAFI in bronchiolitis obliterans syndrome.

Methodology:

The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by DelveInsight's team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.

JAKAFI Analytical Perspective by DelveInsight

In-depth JAKAFI Market Assessment

This report provides a detailed market assessment of JAKAFI for bronchiolitis obliterans syndrome in the seven major markets, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. This segment of the report provides forecasted sales data from 2029 to 2032.

JAKAFI Clinical Assessment

The report provides the clinical trials information of JAKAFI for bronchiolitis obliterans syndrome covering trial interventions, trial conditions, trial status, start and completion dates.

Report Highlights:

• In the coming years, the market scenario for bronchiolitis obliterans syndrome is set to change due to the extensive research and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
• The companies are developing therapies that focus on novel approaches to treat/improve the disease condition, assess challenges, and seek opportunities that could influence JAKAFI dominance.
• Other emerging products for bronchiolitis obliterans syndrome are expected to give tough market competition to JAKAFI and launch of late-stage emerging therapies in the near future will significantly impact the market.
• A detailed description of regulatory milestones, and developmental activities, provide the current development scenario of JAKAFI in bronchiolitis obliterans syndrome.
• Our in-depth analysis of the forecasted sales data of JAKAFI from 2029 to 2032 will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the JAKAFI in bronchiolitis obliterans syndrome.

Key Questions:

• What is the product type, route of administration and mechanism of action of JAKAFI?
• What is the clinical trial status of the study related to JAKAFI in bronchiolitis obliterans syndrome and study completion date?
• What are the key collaborations, mergers and acquisitions, licensing and other activities related to the JAKAFI development?
• What are the key designations that have been granted to JAKAFI for bronchiolitis obliterans syndrome?
• What is the forecasted market scenario of JAKAFI for bronchiolitis obliterans syndrome?
• What are the forecasted sales of JAKAFI in the seven major countries, including the United States, Europe (Germany, France, Italy, Spain, and the United Kingdom), and Japan?
• What are the other emerging products available and how are these giving competition to JAKAFI for bronchiolitis obliterans syndrome?
• Which are the late-stage emerging therapies under development for the treatment of bronchiolitis obliterans syndrome?

Table of Contents

1. Report Introduction

2. JAKAFI Overview in Bronchiolitis Obliterans Syndrome

• 2.1. Product Detail
• 2.2. Clinical Development
  • 2.2.1. Clinical studies
  • 2.2.2. Clinical trials information
  • 2.2.3. Safety and efficacy
• 2.3. Product Profile

3. Competitive Landscape (Late-stage Emerging Therapies)

4. JAKAFI Market Assessment

• 4.1. Market Outlook of JAKAFI in Bronchiolitis Obliterans Syndrome
• 4.2. 7MM Analysis
  • 4.2.1. Market Size of JAKAFI in the 7MM for Bronchiolitis Obliterans Syndrome
• 4.3. Country-wise Market Analysis
  • 4.3.1. Market Size of JAKAFI in the United States for Bronchiolitis Obliterans Syndrome
  • 4.3.2. Market Size of JAKAFI in Germany for Bronchiolitis Obliterans Syndrome
  • 4.3.3. Market Size of JAKAFI in France for Bronchiolitis Obliterans Syndrome
  • 4.3.4. Market Size of JAKAFI in Italy for Bronchiolitis Obliterans Syndrome
  • 4.3.5. Market Size of JAKAFI in Spain for Bronchiolitis Obliterans Syndrome
  • 4.3.6. Market Size of JAKAFI in the United Kingdom for Bronchiolitis Obliterans Syndrome
  • 4.3.7. Market Size of JAKAFI in Japan for Bronchiolitis Obliterans Syndrome

5. SWOT Analysis

6. Analysts' Views

7. Appendix

• 7.1. Bibliography
• 7.2. Report Methodology

8. DelveInsight Capabilities

9. Disclaimer

10. About DelveInsight

11. Report Purchase Options