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核酸医薬品市場レポート:2031年までの動向、予測、競合分析

Nucleic Acid Drug Market Report: Trends, Forecast and Competitive Analysis to 2031


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Lucintel
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英文 150 Pages
納期
3営業日
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核酸医薬品市場レポート:2031年までの動向、予測、競合分析
出版日: 2025年03月13日
発行: Lucintel
ページ情報: 英文 150 Pages
納期: 3営業日
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  • 概要
  • 目次
概要

世界の核酸医薬品市場の将来は、遺伝性疾患、がん、心血管疾患市場に機会があり、有望視されています。世界の核酸医薬品市場は、2025年から2031年にかけて13.7%のCAGRで成長すると予想されています。この市場の主な促進要因は、遺伝性疾患の有病率の増加、遺伝子レベルでの疾患治療に対する需要の増加、核酸医薬品の利点に対する意識の高まりです。

  • Lucintel社の予測では、タイプ別ではアンチセンス核酸医薬品が予測期間中に最も高い成長を遂げる見込みです。
  • 用途別では、遺伝性疾患が最も高い成長が見込まれています。
  • 地域別では、北米が予測期間中に最も高い成長が見込まれます。

核酸医薬市場の戦略的成長機会

企業の成長を達成するために、核酸医薬の展望は主要な充当とともにいくつかの戦略的成長機会を提供しています。これらの機会を模索し、利用することは、当該企業にとって競争力強化につながると思われます。

  • がん治療:mRNAと遺伝子編集技術の応用は、新薬を必要とする新規がん治療の創造に活用され、患者に良い結果をもたらします。
  • 希少遺伝子疾患:希少な遺伝性疾患は核酸療法によって標的とすることができます。欠陥のある遺伝子を直接保護したり修復したりする新規の遺伝子治療を考え出す能力は、巨大な市場の可能性を提示します。
  • 感染症ワクチン:パンデミック対応への取り組みと、他の感染症に対するmRNAワクチンの成功が、この種の製品開発の入り口となりました。このアプリケーションは、公衆衛生上のワクチン対応を改善し、ワクチン製造の好機をもたらしてくれます。
  • 遺伝子治療プラットフォーム:この分野は、遺伝子治療プラットフォームへの企業利害関係者の投資や探索に値する機会です。遺伝子治療を実施する能力は、この分野を有利なものにしている数多くの疾病治療法を変える可能性があります。
  • 個別化医療ソリューション:個別化医療に向けて業界が進歩するにつれ、核酸療法を開発する機会も訪れると思われます。この利点は、遺伝的に標的化された集団に実施することで、その後の戦略の効率を高めることです。

こうした戦略的成長分野は、核酸医薬品の市場がいかに大きいかを示すことができます。このような変化を受け入れ、革新性に集中する企業は、今後数年間の成功に備えることができると思われます。

核酸医薬品市場促進要因・課題

核酸医薬品市場は、社会文化的、技術的、経済的、規制的要因を含むいくつかの市場促進要因・課題の影響を受けています。利害関係者がこのような力学の中で操縦するためには、これらの要因を評価することも重要です。

核酸医薬品市場を牽引する要因は以下の通り:

  • 技術の進歩:mRNAや遺伝子編集などの新規核酸医薬の継続的な進化が市場の拡大を可能にしています。これらの技術は治療の臨床結果を改善し、医療従事者の取り込みを増加させます。
  • 遺伝性疾患の有病率の上昇:遺伝性疾患や慢性疾患の有病率の上昇は、必要な治療に対する需要を生み出しています。核酸医薬品は課題解決に非常に有効であるため、市場は拡大しています。
  • バイオテクノロジー分野への投資:バイオテクノロジー、特に核兵器開発に対する新興国市場の資金開拓がこの市場の成長をもたらしています。ベンチャーキャピタルと政府助成金は、市場を破壊するプロジェクトに資金を提供しています。
  • 規制支援ブルーマー:規制当局の理解を得ることで、核酸医薬品の開発に対して各規制当局がより友好的になり、より迅速な承認プロセスが提供されるようになりました。このようなサポートにより、新しい治療法の上市までの時間が短縮され、患者にとっても有益なものとなります。
  • 個別化医療への注力:個別化医療には、患者の遺伝子構成の違いを考慮した核酸治療が必要です。革新的なソリューションの必要性が、このアプローチを強調しています。

核酸医薬品市場における課題は以下の通り:

  • 規制上のハードル:規制上の課題:支持は高まっているものの、核酸医薬品の規制当局による承認取得は依然として難題です。企業はコンプライアンスを満たすために多大な時間とリソースを投資しなければならず、製品開発プロセスを遅らせています。
  • 高い開発コスト:核酸医薬品の開発コストは高く、中小企業の競争力を制限しています。この分野での成功には、効果的な資金調達とコスト管理が不可欠です。
  • 一般大衆の認識と受容:核酸医薬品に対する懐疑的な見方や、潜在的なリスクが受容の妨げとなる可能性があります。一般の人々を教育し、誤解に対処することが、これらの治療法に対する信頼を築く鍵です。これらの促進要因・課題は核酸医薬品市場を形成し、成長動向と戦略的意思決定に影響を与えます。利害関係者は、これらの洞察を利用して機会を特定し、課題を軽減することができます。

これらの促進要因・課題は、同様に核酸医薬品市場の形と特徴を決定し、その成長動向と戦略的選択を左右します。様々な利害関係者がこのダイナミックな業界でどのように機会を得たり、課題を軽減したりできるのか、これらのダイナミクスを強調することは重要です。

目次

第1章 エグゼクティブサマリー

第2章 世界の核酸医薬品市場:市場力学

  • イントロダクション、背景、分類
  • サプライチェーン
  • 業界の促進要因と課題

第3章 2019年から2031年までの市場動向と予測分析

  • マクロ経済動向(2019~2024年)と予測(2025~2031年)
  • 世界の核酸医薬品市場の動向(2019~2024年)と予測(2025~2031年)
  • タイプ別:核酸医薬品の世界市場
    • アンチセンス核酸医薬品
    • siRNA医薬品
    • SaRNA医薬品
    • miRNA薬
    • MRNA医薬品
    • その他
  • 用途別:核酸医薬品の世界市場
    • 遺伝性疾患
    • がん
    • 心血管疾患
    • その他

第4章 2019年から2031年までの地域別市場動向と予測分析

  • 地域別:核酸医薬品市場
  • 北米の核酸医薬品市場
  • 欧州の核酸医薬品市場
  • アジア太平洋地域の核酸医薬品市場
  • その他地域核酸医薬品市場

第5章 競合分析

  • 製品ポートフォリオ分析
  • 運用統合
  • ポーターのファイブフォース分析

第6章 成長機会と戦略分析

  • 成長機会分析
    • タイプ別:世界の核酸医薬品市場における成長機会
    • 用途別:世界の核酸医薬品市場における成長機会
    • 地域別:世界の核酸医薬品市場における成長機会
  • 世界の核酸医薬品市場の新たな動向
  • 戦略分析
    • 新製品開発
    • 世界の核酸医薬品市場の生産能力拡大
    • 世界の核酸医薬品市場における合併、買収、合弁事業
    • 認証とライセンシング

第7章 主要企業の企業プロファイル

  • Sarepta Therapeutics
  • Ionis Pharmaceuticals
  • Alnylam
  • Mina Therapeutics
  • BioNTech
  • NeXstar Pharmaceuticals
  • Nippon Shinyaku
目次

The future of the global nucleic acid drug market looks promising with opportunities in the genetic disease, cancer, and cardiovascular disease markets. The global nucleic acid drug market is expected to grow with a CAGR of 13.7% from 2025 to 2031. The major drivers for this market are the growing prevalence of genetic disorders, increasing demand for treating diseases at the genetic level, and rising awareness about the benefits of nucleic acid drugs.

  • Lucintel forecasts that, within the type category, antisense nucleic acid drugs are expected to witness the highest growth over the forecast period.
  • Within the application category, genetic disease is expected to witness the highest growth.
  • In terms of regions, North America is expected to witness the highest growth over the forecast period.

Gain Valuable insights for your business decisions with our comprehensive 150+ page report.

Emerging Trends in the Nucleic Acid Drug Market

The nucleic acid drug market is undergoing dramatic changes with a particular an understanding emerging trends that show why there is a paradigm shift towards more creative and effective therapies. These trends are a product of technological progress, policy improvements, and more intra-industry partnerships.

  • Growth of Interest in MRNA Therapies: A great deal of success, was achieved with covid-19 MRNA vaccines, therefore shifting interest in other areas of medicine, such as oncology and rare genetic diseases. The increase in research and investment in mRNA and its technology will enable the rapid creation of customized medications.
  • Progress in Gene Editing Technologies: The advent of technologies such as CRISPR and TALEN is changing the scope of nucleic acid drugs since they can edit any component of DNA. Such development will enable the development of precise treatment for genetic disorders leading to safety as well as therapeutic efficacy.
  • Regulatory Evolution: Different regulatory authorities around the globe are beginning to cope with the fast pace of growth of many nucleic acid drugs. In parallel, new policies and expedited regulatory pathways are being developed to advance the speedy transformation and marketing of new innovative drugs.
  • Collaborative Research Efforts: Cooperation among universities, biotech companies, and legacy pharmaceutical firms is productive to the creation of nucleic acid medicines. Collaboration is helpful in information dissemination, resource mobilization, and enhancing the speed of the clinical trial phase.
  • Focus on Personalized Medicine Policy: The strategy of personalized medicine is increasingly becoming relevant in the nucleic acid market. This focused therapy works well to minimize side effects and improves the therapeutic benefits, making it a step forward.

These trends are proving to be game changers in the nucleic acid drug market, giving rise to new modalities that are making patients' lives better. The stakeholders need to be agile in order to take the most out of these trends.

Recent Developments in the Nucleic Acid Drug Market

The nucleic acid drug market has been undergoing dramatic changes on account of technological developments and more funding. Other interesting advancements tend towards the development of more RNA-targeted drugs and gene therapy.

  • Increased Use of mRNA Therapeutics: The successful use of mRNA vaccines during the COVID-19 pandemic has created great interest in mRNA therapeutics. Now companies are investigating the use of mRNA technologies for cancer immunotherapy and treatment of other diseases like rare genetic disorders, thus broadening the scope of therapy.
  • Gene Editing Technologies: The current advancement in gene editing tools and technologies that include CRISPR has made it possible to formulate new strategies for targeted therapy. These improvements allow efficient alterations of genes and have the possibility to address genetic disorders while building a future in cancer treatment.
  • Strategy in Biotech Startup Investments: The venture capital investment activity in biotech startups, technology that develops nucleic acid drugs, has undergone a boost. Investments of these types make possible emerging technologies, which in particular speed up the processes of bringing new treatments to the market, developing the ecosystem of research and development.
  • Global Partnerships: Partnership projects between countries or institutions are more common in the field of nucleic acid drug development. These working groups enhance the sharing of resources and resources and consequently combustion the research leading to faster development of new therapies to treat diseases.
  • Regulatory Reforms: The level agencies are constantly making efforts in order to improve and fast-track the approval of nucleic acid drugs. This entails introducing changes and reforms in the design of such products as unusual therapy which enable the fast offering of such therapy to those patients who need it.

New changes have emerged mostly in the nucleic acid drug market that has accelerated growth through stimulating creativeness in the areas of therapies provision. Additionally, collaboration and supporting developments through regulation will be important for the further advancement of this industry.

Strategic Growth Opportunities for Nucleic Acid Drug Market

To achieve corporate growth, the nucleic acid drug outlook offers a few strategic growth opportunities along with major appropriations. Seeking and exploiting these opportunities seem competitive enhancing capability to the firms concerned.

  • Cancer Treatment: Nucleic acid drugs become another key factor for market expansion in oncology. m Applications of mRNA and gene editing technologies are utilized in the creation of novel cancer therapy, which areas require new medicines, and bring better results for patients.
  • Rare Genetic Disorders: Rare genetic disorders can be targeted through nucleic acid therapies. The ability to come up with novel gene therapy that directly protects or repairs defective genes presents a huge market potential.
  • Infectious Disease Vaccines: The pandemic response efforts, along with the success of mRNA vaccines for other infectious diseases, became a gateway for the creation of this type of product. This application can improve the public health vaccine response and also provide appetizing opportunities in vaccine manufacture.
  • Gene Therapy Platforms: This is an opportunity area worth exploring and making investments by company stakeholders in the gene therapy platforms. The capacity to administer gene therapies can change the numerous disease treatment practices making this area lucrative.
  • Personalized Medicine Solutions: As the industry advances towards personalized medicine, opportunities to develop nucleic acid therapies will also be presented. The benefits of this are enhancing the efficiency of subsequent strategies by implementing them on genetically targeted populations.

These strategic growth areas can show how big the market is for nucleic tool drugs. Firms that embrace these changes and concentrate on innovativeness will be prepared for success in the coming years.

Nucleic Acid Drug Market Driver and Challenges

The nucleic acid drug market is influenced by several drivers and challenges which include sociocultural, technological, economic, and regulatory factors. It is also important to appreciate these factors in order for stakeholders to maneuver in such dynamics.

The factors responsible for driving the nucleic acid drug market include:

  • Technological Advancements: Continued evolution of novel nucleic acid drugs such as mRNA and gene editing makes expansion of the market possible. These technologies improve the clinical outcomes of the therapies which increase the uptake of healthcare providers.
  • Rising Prevalence of Genetic Disorders: The rising prevalence of genetic disorders and chronic diseases is creating a demand for necessary therapies. Nucleic acid drugs are very effective in solving challenges, hence growing the market.
  • Investment in Biotech Sector: Increasing funds in biotechnology, particularly for its nuclear arms development is leading to growth in this market. Venture capital and government grants are funding the projects that are going to be disruptive in the market.
  • Regulatory Support Blumer: Availing understanding, each of such regulatory agencies has become more friendly to nucleic acid Drug development and provides quicker approval processes. This support decreases the time new therapies take to go to market and that is beneficial to the patients.
  • Focus on Personalized Medicine: Personalized medicine requires nucleic acid therapies that take in account the differences in the genetic composition of patients. The need for innovative solutions stresses this approach.

Challenges in the nucleic acid drug market are:

  • Regulatory Hurdles: Despite increasing support, navigating regulatory approval for nucleic acid drugs remains a challenge. Companies must invest significant time and resources to meet compliance, slowing the product development process.
  • High Development Costs: The cost of developing nucleic acid drugs is high, limiting the ability of smaller firms to compete. Effective funding and cost management are critical to success in this field.
  • Public Perception and Acceptance: Public skepticism about nucleic acid medicines and the potential risks involved may hinder acceptance. Educating the public and addressing misconceptions is key to building confidence in these therapies. These drivers and challenges shape the nucleic acid drug market, influencing growth trends and strategic decisions. Stakeholders can use these insights to identify opportunities and mitigate challenges.

These drivers and challenges equally determine the shape and characteristics of nucleic acids drugs market and dictate its growth trends, as well as strategic choices. It is important to emphasize these dynamics because of how various stakeholders can gain opportunities and/or mitigate challenges in this dynamic industry.

List of Nucleic Acid Drug Companies

Companies in the market compete on the basis of product quality offered. Major players in this market focus on expanding their manufacturing facilities, R&D investments, infrastructural development, and leverage integration opportunities across the value chain. Through these strategies nucleic acid drug companies cater increasing demand, ensure competitive effectiveness, develop innovative products & technologies, reduce production costs, and expand their customer base. Some of the nucleic acid drug companies profiled in this report include-

  • Sarepta Therapeutics
  • Ionis Pharmaceuticals
  • Alnylam
  • Mina Therapeutics
  • BioNTech
  • NeXstar Pharmaceuticals
  • Nippon Shinyaku

Nucleic Acid Drug by Segment

The study includes a forecast for the global nucleic acid drug market by type, application, and region.

Nucleic Acid Drug Market by Type [Analysis by Value from 2019 to 2031]:

  • Antisense Nucleic Acid Drugs
  • SiRNA Drugs
  • SaRNA Drugs
  • MiRNA Drugs
  • MRNA Drugs
  • Others

Nucleic Acid Drug Market by Application [Analysis by Value from 2019 to 2031]:

  • Genetic Disease
  • Cancer
  • Cardiovascular Diseases
  • Others

Nucleic Acid Drug Market by Region [Analysis by Value from 2019 to 2031]:

  • North America
  • Europe
  • Asia Pacific
  • The Rest of the World

Country Wise Outlook for the Nucleic Acid Drug Market

The expansion of the nucleic acid drug market is moving quickly, and it is particularly boosted due to the new entries in RNA therapies as well as gene editing technologies. Thanks to continuous advancements in understanding the many genetic diseases, there is increasing demand for specific therapies that have caused a lot of investment and research activity worldwide. Countries like the U.S., China, Germany, India, and Japan are some of the countries that are making strides in these potentials, each in a different manner with its level of enhancement of the nucleic acid drug arena.

  • United States: In the U.S., the nucleic acid drug market is booming with efficient focus on mRNA therapeutic drugs owing to the recent success of COVID-19 vaccination marketing. The leading biotech companies are actively working on mRNA-oriented drug pipelines for multiple disease applications including but not limited to cancers and inherited disorders. The FDA maintains an encouraging environment for the advancement of new technologies by assisting in the fast-tracking of new technology drugs to the market through an accelerated review. pharmaceutical industry collaborations with universities are becoming more accustomed and prevalent leading to better developments in CRISPR and other forms of gene editing technologies.
  • China: The market for nucleic acid drugs in China is advancing rapidly thanks to the government's keenness to enhance biotechnology research and development. The country has attracted tremendous investment in mRNA technology, where several local players are manufacturing vaccines and therapeutics. Efforts are being made to create a legal framework that allows for an easy and fast regulatory approval for nucleic acid drugs which in turn makes them available in the market quickly. Moreover, partnerships with foreign companies are stimulating know-how and technological development, making China a significant player in the nucleoside drugs market.
  • Germany: Germany has been labeled a strong biotechnology country with an emerging nucleic acid drug market. With the focus shifting towards RNA therapeutics and gene editing technologies, the state has several ongoing clinical trials for gene therapy medicine under development. There is a growing tendency in German enterprises to sign more research collaborations to expedite nucleic acid drug development. The attitude to new attachments is positive, and the approval process of new therapeutics is framed which creates further opportunities for Germany in this respect.
  • India: The nucleic acid drug market in India is gradually evolving, particularly in areas like mRNA technology and gene therapies. There are government efforts towards biotechnology research and some young companies work on nucleic acid drugs. There are increasing partnerships between Indian companies and foreign pharmaceutical corporations which help in technological and innovative development. However, such challenges are present as obtaining regulatory clearances and the shortage of specialists devoted to the nucleic acid drugs development sphere are on the way.
  • Japan: The nucleic acid drug market in Japan is defined by the high expenditure on genetic therapies along with a clear regulatory environment. The country is emerging into the creation of mRNA vaccines, developing gene modification techniques and leading pharmaceutical companies are researching them. In this light, the last few years saw a rise in academic-corporate collaborations aimed at supporting invention, while the Japanese government initiated reforms intended for the development of biotechnology. As new technologies develop and those barriers are cleared the market will grow by leaps and bounds in addressing the unmet medical needs in genetics diseases and oncology.

Features of the Global Nucleic Acid Drug Market

Market Size Estimates: Nucleic acid drug market size estimation in terms of value ($B).

Trend and Forecast Analysis: Market trends (2019 to 2024) and forecasts (2025 to 2031) by various segments and regions.

Segmentation Analysis: Nucleic acid drug market size by type, application, and region in terms of value ($B).

Regional Analysis: Nucleic acid drug market breakdown by North America, Europe, Asia Pacific, and Rest of the World.

Growth Opportunities: Analysis of growth opportunities in different types, applications, and regions for the nucleic acid drug market.

Strategic Analysis: This includes M&A, new product development, and competitive landscape of the nucleic acid drug market.

Analysis of competitive intensity of the industry based on Porter's Five Forces model.

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This report answers following 11 key questions:

  • Q.1. What are some of the most promising, high-growth opportunities for the nucleic acid drug market by type (antisense nucleic acid drugs, SiRNA drugs, SaRNA drugs, MiRNA drugs, MRNA drugs, and others), application (genetic disease, cancer, cardiovascular diseases, and others), and region (North America, Europe, Asia Pacific, and the Rest of the World)?
  • Q.2. Which segments will grow at a faster pace and why?
  • Q.3. Which region will grow at a faster pace and why?
  • Q.4. What are the key factors affecting market dynamics? What are the key challenges and business risks in this market?
  • Q.5. What are the business risks and competitive threats in this market?
  • Q.6. What are the emerging trends in this market and the reasons behind them?
  • Q.7. What are some of the changing demands of customers in the market?
  • Q.8. What are the new developments in the market? Which companies are leading these developments?
  • Q.9. Who are the major players in this market? What strategic initiatives are key players pursuing for business growth?
  • Q.10. What are some of the competing products in this market and how big of a threat do they pose for loss of market share by material or product substitution?
  • Q.11. What M&A activity has occurred in the last 5 years and what has its impact been on the industry?

Table of Contents

1. Executive Summary

2. Global Nucleic Acid Drug Market : Market Dynamics

  • 2.1: Introduction, Background, and Classifications
  • 2.2: Supply Chain
  • 2.3: Industry Drivers and Challenges

3. Market Trends and Forecast Analysis from 2019 to 2031

  • 3.1. Macroeconomic Trends (2019-2024) and Forecast (2025-2031)
  • 3.2. Global Nucleic Acid Drug Market Trends (2019-2024) and Forecast (2025-2031)
  • 3.3: Global Nucleic Acid Drug Market by Type
    • 3.3.1: Antisense Nucleic Acid Drugs
    • 3.3.2: SiRNA Drugs
    • 3.3.3: SaRNA Drugs
    • 3.3.4: MiRNA Drugs
    • 3.3.5: MRNA Drugs
    • 3.3.6: Others
  • 3.4: Global Nucleic Acid Drug Market by Application
    • 3.4.1: Genetic Disease
    • 3.4.2: Cancer
    • 3.4.3: Cardiovascular Diseases
    • 3.4.4: Others

4. Market Trends and Forecast Analysis by Region from 2019 to 2031

  • 4.1: Global Nucleic Acid Drug Market by Region
  • 4.2: North American Nucleic Acid Drug Market
    • 4.2.1: North American Market by Type: Antisense Nucleic Acid Drugs, SiRNA Drugs, SaRNA Drugs, MiRNA Drugs, MRNA Drugs, and Others
    • 4.2.2: North American Market by Application: Genetic Disease, Cancer, Cardiovascular Diseases, and Others
  • 4.3: European Nucleic Acid Drug Market
    • 4.3.1: European Market by Type: Antisense Nucleic Acid Drugs, SiRNA Drugs, SaRNA Drugs, MiRNA Drugs, MRNA Drugs, and Others
    • 4.3.2: European Market by Application: Genetic Disease, Cancer, Cardiovascular Diseases, and Others
  • 4.4: APAC Nucleic Acid Drug Market
    • 4.4.1: APAC Market by Type: Antisense Nucleic Acid Drugs, SiRNA Drugs, SaRNA Drugs, MiRNA Drugs, MRNA Drugs, and Others
    • 4.4.2: APAC Market by Application: Genetic Disease, Cancer, Cardiovascular Diseases, and Others
  • 4.5: ROW Nucleic Acid Drug Market
    • 4.5.1: ROW Market by Type: Antisense Nucleic Acid Drugs, SiRNA Drugs, SaRNA Drugs, MiRNA Drugs, MRNA Drugs, and Others
    • 4.5.2: ROW Market by Application: Genetic Disease, Cancer, Cardiovascular Diseases, and Others

5. Competitor Analysis

  • 5.1: Product Portfolio Analysis
  • 5.2: Operational Integration
  • 5.3: Porter's Five Forces Analysis

6. Growth Opportunities and Strategic Analysis

  • 6.1: Growth Opportunity Analysis
    • 6.1.1: Growth Opportunities for the Global Nucleic Acid Drug Market by Type
    • 6.1.2: Growth Opportunities for the Global Nucleic Acid Drug Market by Application
    • 6.1.3: Growth Opportunities for the Global Nucleic Acid Drug Market by Region
  • 6.2: Emerging Trends in the Global Nucleic Acid Drug Market
  • 6.3: Strategic Analysis
    • 6.3.1: New Product Development
    • 6.3.2: Capacity Expansion of the Global Nucleic Acid Drug Market
    • 6.3.3: Mergers, Acquisitions, and Joint Ventures in the Global Nucleic Acid Drug Market
    • 6.3.4: Certification and Licensing

7. Company Profiles of Leading Players

  • 7.1: Sarepta Therapeutics
  • 7.2: Ionis Pharmaceuticals
  • 7.3: Alnylam
  • 7.4: Mina Therapeutics
  • 7.5: BioNTech
  • 7.6: NeXstar Pharmaceuticals
  • 7.7: Nippon Shinyaku