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市場調査レポート
商品コード
1292508
白血病治療薬の世界市場規模、シェア、産業動向分析レポート薬剤クラス別(標的療法・免疫療法、化学療法)、流通チャネル別、タイプ別、地域別展望・予測、2023~2029年Global Leukemia Therapeutics Market Size, Share & Industry Trends Analysis Report By Drug Class (Targeted Therapy & Immunotherapy and Chemotherapy), By Distribution Channel, By Type, By Regional Outlook and Forecast, 2023 - 2029 |
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白血病治療薬の世界市場規模、シェア、産業動向分析レポート薬剤クラス別(標的療法・免疫療法、化学療法)、流通チャネル別、タイプ別、地域別展望・予測、2023~2029年 |
出版日: 2023年05月31日
発行: KBV Research
ページ情報: 英文 236 Pages
納期: 即納可能
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白血病治療薬の市場規模は、2029年までに117億米ドルに達すると予測され、予測期間中のCAGRは6.0%の市場成長率で上昇すると予想されています。
KBV Cardinalマトリックスで提示された分析によると、Pfizer, Inc.が本市場における先駆者です。2020年6月、Pfizer, Inc.は、ヘッジホッグ経路阻害剤であるDAURISMOを、化学療法の一種である低用量シタラビンと組み合わせて、成人患者の新規診断の急性骨髄性白血病(AML)治療として承認を取得しました。この承認により、Pfizer, Inc.は、欧州全域の患者に新たな治療選択肢を提供することで、がんと共に生きる人々に貢献します。AbbVie, Inc.、Bristol Myers Squibb Company、Sanofi S.A.、Gilead Sciences, Inc.などの企業が、この市場における主要なイノベーターとして挙げられます。
市場成長要因
白血病治療のための革新的な治療法
様々なタイプの白血病の治療成績を向上させるために、様々な医薬品を組み合わせた独自の治療技術を開発するために、数多くの研究プロジェクトが実施されています。例えば、化学療法は標準的な治療法ですが、化学療法にシタラビンやアントラサイクリンという医薬品を組み合わせて、患者の治療成績を向上させる新しい戦略が用いられています。化学療法に抵抗がある人が多いため、企業はこの病気を治療するための免疫治療薬を開発しています。したがって、市場開拓は、白血病患者のための最先端の診断と治療法の開発によって、予想される期間中に促進されると予想されます。
医薬品開発をサポートするバイオインフォマティクスツールの開発
製薬会社は現在、新規治療薬の発見や、決定した標的の活性を変化させることができる見込みのある新規化合物の発見に力を注いでいます。また、前臨床試験や臨床試験は、時間がかかり、価格も高く、リスクの高いものです。そのため、医薬品開発プロセスを促進するために、効率的で最先端の薬効予測方法が必要とされています。標的の特定、リードの最適化、リードの検証は、統計的アルゴリズムのようなバイオインフォマティクス技術を使用することで達成することができます。これらのツールは、医薬品開発と創薬の双方をサポートします。現在の医薬品開発ソリューションを改善するためのバイオインフォマティクスツールの使用が増加した結果、市場は拡大すると予想されます。
市場の抑制要因
白血病治療薬の副作用と厳しい規制
市場の拡大は、治療に伴う副作用や好ましくない反応によって制約を受けると予測されます。例えば化学療法は、皮膚症状、脱毛、感染症、高血圧、疲労、その他類似の副作用を引き起こします。また、治療法が異なれば、副作用の内容も異なります。例えば、吐き気、肝臓の問題、髪の色落ち、下痢、嘔吐などの類似の副作用が、標的治療によってもたらされることがあります。さらに、放射線療法を含む他の治療方法のいくつかの副作用は、白血病治療薬の採用率を低下させる可能性があります。予測期間中は、これらの要因が市場の成長を抑制すると予想されます。
タイプ別展望
タイプ別に、市場は急性リンパ性白血病、急性骨髄性白血病、慢性リンパ性白血病、慢性骨髄性白血病、その他に分類されます。2022年の市場では、慢性リンパ性白血病のセグメントが最も高い収益シェアを占めています。慢性リンパ性白血病(CLL)は、骨髄のリンパ球から血液にゆっくりと広がるがんです。このセグメントの成長に影響を与える3つの主要な動向は、あまり活動的でない生活様式の採用の加速、慢性リンパ性白血病の発生率の増加、および高齢者人口の増加です。
薬物クラスの展望
薬剤クラス別では、化学療法と標的治療・免疫療法に分類されます。2022年の市場では、標的治療・免疫療法分野が最大の収益シェアを占めています。がん細胞の特定の異常を標的とする薬物療法が使用されます。標的薬物療法は、これらの異常を妨害することによって、がん細胞を殺すことができます。がんに対抗するための免疫療法では、患者の免疫系が使用されます。がん細胞は、免疫系細胞による検出を回避するためのタンパク質を作るため、病気と戦う体の免疫系ががんを攻撃しない場合があります。免疫療法は、そのような処置を妨害することで効果を発揮します。
販売チャネルの展望
流通チャネル別に見ると、病院薬局、ドラッグストア・小売薬局、オンラインプロバイダーに二分されます。オンラインプロバイダー部門は、2022年の市場においてかなりの収益シェアを獲得しました。これは、継続的なサービスや様々なソリューションが容易に利用できることに起因しています。また、eコマースの売上急増、物流サービスの向上、簡単な支払い方法なども、市場拡大の要因となっています。
地域別の展望
地域別に見ると、市場は北米、欧州、アジア太平洋、LAMEAで分析されています。2022年、北米地域は最大の収益シェアで市場をリードしました。北米は現在、高いヘルスケア支出、白血病新薬の創製における多くの重要なプレーヤー、白血病患者の増加により、市場の主導的地位を占めています。診断クリニックや病院などの医療機関では、多くの医療機器が設置されています。製薬・バイオテクノロジー業界では、米国には世界をリードする多くの相手先ブランドメーカーが存在します。
List of Figures
The Global Leukemia Therapeutics Market size is expected to reach $11.7 billion by 2029, rising at a market growth of 6.0% CAGR during the forecast period.
Chronic lymphocytic leukemia (CLL) is the major contributor to the market because of the growing older population. Thus, it is expected to generate approximately $4,834.8 million revenue of the total market by 2029. One in six deaths, or 9.6 million, was attributed to cancer in 2018, making it the second largest cause of death worldwide. For example, in the US, CLL accounts for 25 to 30% of all cases of leukemia. The American Cancer Society predicted that in the year 2020, there would be roughly 21,040 new cases of CLL and about 4,060 fatalities. CLL/SLL is responsible for 191,000 cases and 61,000 deaths annually. Adults as young as 30 years old can develop CLL. However, people over the age of 70 are most likely to experience it. Children with CLL are incredibly uncommon. It is well known that the incidence rises quickly with age.
The major strategies followed by the market participants are partnerships as the key developmental strategy to keep pace with the changing demands of end users. For instance, In October, 2022, Gilead joined hands with MacroGenics to develop and commercialize advanced monoclonal antibody-based therapeutics for the treatment of cancer. Under this collaboration, both companies would develop MGD024, an investigational, bispecific antibody that binds CD3 and CD123 utilizing MacroGenics' DART® platform. Additionally, In October, 2022, Bristol Myers Squibb signed an agreement with Century Therapeutics to develop and supply up to 4 induced pluripotent stems cell-derived, engineered natural killer cell and T cell programs for hematologic malignancies and solid tumors.
Based on the Analysis presented in the KBV Cardinal matrix; Pfizer, Inc. is the forerunner in the Market. In June, 2020, Pfizer, Inc. received approval from DAURISMO, a Hedgehog pathway inhibitor, combined with low-dose cytarabine, a chemotherapy type, for the treatment of newly diagnosed acute myeloid leukemia (AML) in adult patients. Through this approval, Pfizer would serve people living with cancers by providing a new treatment option for certain patients across Europe. Companies such as AbbVie, Inc., Bristol Myers Squibb Company, Sanofi S.A. and Gilead Sciences, Inc. are some of the key innovators in Market.
Market Growth Factors
Innovative therapies for leukemia treatments
Numerous research projects are being carried out to create distinct therapeutic techniques that combine diverse medicines to boost patient outcomes for various leukemia types. For example, although chemotherapy is the standard of care, a new strategy is being used that combines chemotherapy with the medicines cytarabine and anthracyclines to enhance patient outcomes. Because many people resist several chemotherapy medications, businesses are creating immune treatments to treat this illness. Therefore, market growth is anticipated to be boosted by the development of such cutting-edge diagnostics and therapies for leukemia patients during the anticipated period.
Developing bioinformatics tool to support drug development
Pharmaceutical companies are currently concentrating their efforts on finding novel therapeutic agents and prospective new compounds that can alter the activity of the determined target. Additionally, preclinical, and clinical studies are a drawn-out, frequently pricey, and risky procedure. To boost the drug development process, an efficient and cutting-edge method of predicting drug efficacy is therefore required. Target identification, lead optimization, and lead validation can all be accomplished with the use of bioinformatic technologies like statistical algorithms. These tools support both drug development and drug discovery. The market is anticipated to expand as a result of the increasing use of a bioinformatics tool for improving current drug development solutions.
Market Restraining Factors
Side Effects of leukemia therapeutics and strict regulations
The expansion of the market is projected to be constrained by the side effects and unfavorable responses associated with the treatments. Chemotherapy, for example, causes side effects, including skin conditions, hair loss, infections, high blood pressure, fatigue, and other similar side effects. Different therapies also have different adverse reactions. For example, similar side events, like nausea, liver issues, hair color loss, diarrhea, and vomiting, can be brought on by targeted therapy. Additionally, some side effects of other treatment modalities, including radiotherapy, may reduce the rate at which leukemia therapeutic agents are adopted. During the forecast period, these factors are expected to restrain market growth.
Type Outlook
Based on type, the market is segmented into acute lymphocytic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia, chronic myeloid leukemia, and others. In 2022, the chronic lymphocytic leukemia segment held the highest revenue share in the market. Chronic lymphocytic leukemia (CLL) is a cancer that spreads slowly from lymphocytes in the bone marrow to the blood. The three main trends influencing the segment's growth are the accelerated adoption of a less active way of life, an increasing incidence of chronic lymphocytic leukemia, and the growing elderly population.
Drug Class Outlook
By drug class, the market is fragmented into chemotherapy, and targeted therapy & immunotherapy. The targeted therapy & immunotherapy segment witnessed the largest revenue share in the market in 2022. Drug therapies that target specific abnormalities in cancer cells are used. Targeted medication therapies can kill cancer cells by obstructing these aberrations. The patient's immune system is used in immunotherapy to combat cancer. Cancer cells create proteins that assist them evade detection by immune system cells, thus the body's immune system that fights disease may not attack the cancer. Immunotherapy works by obstructing that procedure.
Distribution Channel Outlook
On the basis of distribution channel, the market is bifurcated into hospital pharmacies, drug store & retail pharmacies and online providers. The online providers segment acquired a substantial revenue share in the market in 2022. This is due to ongoing services and various solutions being readily available. In addition, the market's expansion is also fueled by a surge in e-commerce sales, better logistical services, and simple payment options.
Regional Outlook
Region wise, the market is analyzed across North America, Europe, Asia Pacific and LAMEA. In 2022, the North America region led the market with the maximum revenue share. North America now holds a leading position in the market due to high healthcare spending, many significant players in creating new leukemia medicines, and an increasing number of leukemia patients. Diagnostic clinics, hospitals, and other medical institutions have a lot of medical equipment installed. In the pharmaceutical & biotechnology industries, the United States is home to many original equipment manufacturers that lead the world.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Gilead Sciences, Inc., Bristol Myers Squibb Company, Sanofi S.A., AbbVie, Inc., Teva Pharmaceuticals Industries Ltd., Lupin Limited, Amgen, Inc., Takeda Pharmaceutical Company Limited, Pfizer, Inc. and Novartis AG.
Recent Strategies Deployed in Leukemia Therapeutics Market
Partnerships, Collaborations and Agreements:
Dec-2022: Sanofi signed an agreement with Innate Pharma SA, a clinical-stage oncology-focused biotech company, for natural killer cell therapeutics in oncology. Under this agreement, Sanofi would develop, manufacture, and commercialize products resulting from the research collaboration.
Dec-2022: Gilead collaborated with ImmunoGen, Inc., a pioneer in broadening the field of antibody-drug conjugates (ADCs) for the treatment of cancer. This collaboration aims to evaluate the safety and anti-leukemia activity of pivekimab sunirine in combination with magrolimab, a potential, first-in-class, investigational CD47 inhibitor.
Oct-2022: Gilead joined hands with MacroGenics, a biopharmaceutical company engaged in the development and commercialization of advanced monoclonal antibody-based therapeutics for the treatment of cancer. Under this collaboration, both companies would develop MGD024, an investigational, bispecific antibody that binds CD3 and CD123 utilizing MacroGenics' DART® platform.
Oct-2022: Bristol Myers Squibb signed an agreement with Century Therapeutics, a biotechnology company. This agreement aims to develop and supply up to 4 induced pluripotent stems cell-derived, engineered natural killer cell and T cell programs for hematologic malignancies and solid tumors.
Mar-2022: Novartis came into an agreement with Carisma Therapeutics, a biopharmaceutical pioneer in macrophage-based therapeutics. Under this agreement, companies would aim to manufacture the HER 2 targeted CAR-M cell therapy, that is tested in initial trials for the treatment of solid tumors.
Mergers & Acquisitions:
Feb-2023: Kite, a Gilead Company, acquired Tmunity Therapeutics, a clinical-stage, biotech company specializing in next-generation CAR T-therapies and technologies. This acquisition aligns with Kite's available in-house cell therapy research capabilities by adding additional licensing agreements, pipeline assets, and platform capabilities.
Aug-2022: Bristol Myers Squibb acquired Turning Point Therapeutics, Inc., a clinical-stage precision oncology company. Following this acquisition, Bristol Myers Squibb strengthened its oncology franchise through Turning Point's precision oncology franchise.
Nov-2021: Pfizer, Inc. took over Trillium Therapeutics, a clinical-stage immuno-oncology company engaged in the development of advanced therapies for the treatment of cancer. This acquisition improves Pfizer's Oncology offerings with the addition of next-generation, investigational immuno-therapeutics for haematological malignancies.
Apr-2021: Sanofi acquired Kiadis, a clinical-stage company developing cell-based immunotherapy products. Following this acquisition, the Kiadis 'off-the-shelf' K-NK cell technology platform would have wide applications compared to solid and liquid tumors.
Product Launches and Product Expansions:
Mar-2022: Teva Pharmaceuticals, a U.S.-based affiliate of Teva Pharmaceutical Industries Ltd., introduced Revlimid, the generic version of lenalidomide capsules. This launch offers patients with another key treatment option for highly challenging conditions.
Approvals & Trials:
Oct-2021: Novartis got FDA approval for Scemblix, a provider of the much-required new option for patients with chronic myeloid leukemia. The Scemblix serves patients who suffer from inadequate or intolerance response after no less than two earlier tyrosine kinase inhibitor (TKI) treatments.
Sep-2021: Takeda Pharmaceutical Company Limited received FDA approval for EXKIVITY, an Oral Therapy specifically developed for patients with EGFR Exon20 Insertion+ NSCLC. The approval unveiled an effective treatment option for patients with EGFR Exon20 insertion+ NSCLC, fulfilling an urgent requirement for difficult-to-treat cancer.
Jun-2021: Bristol Myers Squibb received European Commission approval for Onureg, a maintenance therapy in adult patients with acute myeloid leukemia. Onureg is the only, once-daily frontline oral maintenance therapy in the European Union for patients with a wide range of acute myeloid leukemia (AML) subtypes.
Market Segments covered in the Report:
By Drug Class
By Distribution Channel
By Type
By Geography
Companies Profiled
Unique Offerings from KBV Research