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市場調査レポート
商品コード
1276413
リンパ腫治療薬の世界市場規模、シェア、産業動向分析レポート:治療タイプ別、疾患タイプ別、投与経路別(注射、経口)、流通チャネル別、地域別展望と予測、2023~2029年Global Lymphoma Therapeutics Market Size, Share & Industry Trends Analysis Report By Treatment Type, By Disease Type, By Route of Administration (Injectable, and Oral Route), By Distribution Channel, By Regional Outlook and Forecast, 2023 - 2029 |
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リンパ腫治療薬の世界市場規模、シェア、産業動向分析レポート:治療タイプ別、疾患タイプ別、投与経路別(注射、経口)、流通チャネル別、地域別展望と予測、2023~2029年 |
出版日: 2023年04月28日
発行: KBV Research
ページ情報: 英文 260 Pages
納期: 即納可能
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リンパ腫治療薬市場規模は、2029年には249億米ドルに達し、予測期間中にCAGR7.8%の市場成長率で上昇すると予測されています。
治療の選択は、リンパ腫の種類やステージだけでなく、患者の現在の健康状態や病歴などの追加的な基準によって決定されます。リンパ腫の治療は、リンパ腫患者を長期寛解状態に導くと同時に、生存の可能性を高めるという2つの目標に向かって行われます。
リンパ系のがんはリンパ腫と呼ばれ、リンパ腫は異常な悪性細胞の速い増殖を特徴とするがんの亜型です。一般的には、リンパ節、脾臓、胸腺、骨髄にあるリンパ球と呼ばれる白血球に影響を与えます。このため、免疫反応を起こす能力が低下します。その結果、リンパ節の腫れ、高熱、体重減少、息切れ、倦怠感などの症状が直接的な症状として現れます。
COVID-19の影響分析
パンデミックは、診断や治療の遅れ、臨床試験の中断により、リンパ腫治療薬市場にマイナスの影響を与えました。リンパ腫治療薬は、化学療法や免疫抑制療法が、がん治療の重要な側面である併存する感染症を悪化させる潜在的なリスクがあるため、医療専門家に課題を突きつけています。最近、抗CD20抗体による治療を受けたB細胞性非ホジキンリンパ腫(B-NHL)患者は、重度のCOVID-19疾患に罹患する可能性があります。
市場成長要因
治療選択肢の技術的進歩
リンパ腫治療薬では、TAAに着目したさまざまな治療開発が導入されています。がん免疫療法は、がん治療において重要な位置を占めるようになっています。がん免疫療法は、がん治療の重要な一部となっています。がん免疫療法は、意図しないオフターゲット効果を生じさせず、いくつかの臨床的な利点を有しています。このため、がん免疫療法に有効で副作用の少ないテーラーメイドの組み換えワクチンの開発が進められています。最近開発された免疫チェックポイント阻害剤(ICI)は、がん治療を変え、患者の生存率を向上させました。CTLA-4やPD-1のようなチェックポイントタンパク質に合わせたICIは、いくつかのがん種の治療薬として承認されています。これらの要因が、市場の成長を後押ししています。
リンパ腫の症例が増加し、治療薬への需要が高まる
2018年に世界で約50万件のNHLの新規症例が報告され、全がん診断の2.8%を占めました。NHLを発症する性別ごとの年齢標準化確率は、男性で6.7、女性で4.7であることが判明しました。これは、男性の生涯累積リスクが0.72%であるのに対し、女性は0.35%であることを示しています。さらに、人間開発指数の高い国、低い国、中程度の国では、男性は7.8/10万人、女性は5.6/10万人、2.9/10万人でした。したがって、リンパ腫、特に非ホジキンリンパ腫(NHL)の症例が増加していることから、多くのリンパ腫治療薬に対する需要が高まり、予測期間中の市場成長を後押しすると期待されます。
市場抑制要因
治療に伴う副作用
リンパ腫の治療には副作用がつきものです。消化器系の問題、「ケモブレイン」、かゆみ、痛み、乾燥肌、疲労、吐き気、嘔吐、脱毛、睡眠障害、末梢神経障害(神経損傷)、口腔粘膜炎(口内炎)などがその一例です。リンパ腫の治療後は、感染症のリスクが上昇する可能性があります。そのため、警告的な兆候や症状、必要に応じて医療チームと連絡を取る方法について認識しておくことが極めて重要です。がん治療により、特定の血球型の不足が生じることがあります。赤血球の減少、白血球の減少、血小板の減少などは、いずれも貧血の症状です。これらは、予測される期間において、リンパ腫治療薬市場の成長を妨げると予想されます。
疾患タイプ別展望
疾患タイプに基づき、リンパ腫治療薬市場はホジキンリンパ腫と非ホジキンリンパ腫に区分されます。ホジキンリンパ腫セグメントは、2022年にリンパ腫治療薬市場で大きな収益シェアを獲得しました。この成長は、ホジキンリンパ腫の有病率の上昇、疾患に対する認識の高まり、高齢者患者や再発・難治性(R/R)HL患者の大きなアンメットニーズなどの理由に起因しています。中程度の攻撃性を持つがんであるホジキンリンパ腫は、すぐに全身に広がる可能性があります。にもかかわらず、最も治癒しやすいがんの一つでもあります。
治療タイプの展望
治療タイプ別に見ると、リンパ腫治療薬市場は、免疫療法、化学療法、標的療法、放射線療法に分けられます。2022年のリンパ腫治療薬市場では、免疫療法分野が最も高い収益シェアを占めています。免疫療法の成長は、免疫学の進歩、免疫療法への幅広いアクセス、世界の製品承認数の増加などに起因しています。免疫療法は、良好な結果をもたらす治療法であることが判明しています。
投与経路の展望
投与経路別に見ると、リンパ腫治療薬市場は経口と注射に分類されます。注射セグメントは、2022年のリンパ腫治療薬市場において最大の収益シェアを示しました。これは、注射剤が皮下投与され、持続時間が5~7分であるためです。この方法は、静脈内投与よりもかなり速いです。これらの製品は、びまん性大細胞型B細胞リンパ腫、濾胞性リンパ腫、慢性リンパ球性白血病と診断された患者への使用が承認されています。
販売チャネルの展望
リンパ腫治療薬市場は、流通チャネル別に、病院薬局、小売薬局、その他に分類されます。2022年のリンパ腫治療薬市場では、小売薬局のセグメントが大きな収益シェアを記録しました。これは、小売薬局が医薬品の調製と販売を行うだけでなく、医薬品の適切な使用に関する顧客のカウンセリングや、起こりうる薬物相互作用に関する情報の提供を担当するためです。また、一般的な健康上の懸念や上市薬に関しても、小売薬剤師からアドバイスを受けることができます。
地域別展望
地域別に見ると、リンパ腫治療薬市場は、北米、欧州、アジア太平洋、LAMEAで分析されています。北米地域は、2022年に最大の収益シェアを獲得し、リンパ腫治療薬市場をリードしました。これは、リンパ腫の有病率の増加、標的療法や免疫療法を含むリンパ腫治療薬の進歩、この地域の重要な市場プレイヤーによる新製品リリースの増加によるものです。さらに、重要なプレイヤーの存在、最先端の薬剤へのアクセス、確立されたヘルスケアシステム、充実した研究開発費などが、この地域の市場成長を加速させるでしょう。
市場参入企業がとる主な戦略は買収です。カーディナルマトリックスに掲載された分析によると、Pfizer, Inc.、Johnson &Johnson、F. Hoffmann-La Roche Ltd.がリンパ腫治療薬市場の先駆者です。Eli Lilly And Company、Gilead Sciences, Inc.、Bristol Myers Squibb Companyなどの企業は、リンパ腫治療薬市場における主要な革新的企業の一部です。
List of Figures
The Global Lymphoma Therapeutics Market size is expected to reach $24.9 billion by 2029, rising at a market growth of 7.8% CAGR during the forecast period.
The term "lymphoma therapeutics" refers to the numerous medical treatments and interventions that are intended to treat lymphoma, a form of cancer that impacts the lymphatic system, which is a component of the immune system of the body. Lymphoma is one of the most common types of cancer globally. The elimination of malignant cells, the prevention of the disease's progression, and an improvement in the patient's standard of life are the primary focuses of lymphoma treatment strategies.
The spleen, the thymus gland, lymph nodes (also known as lymph glands), and bone marrow are all elements that make up the lymphatic system. Lymphoma has the potential to affect not only these areas, but many other organs located throughout the body as well. Lymphoma patients have access to various treatment options, including radiation therapy, chemotherapy, immunotherapy, targeted therapy, and stem cell transplantation, among others.
The choice of treatment is determined not only by the type and stage of lymphoma but also by additional criteria, such as the patient's current state of health and medical history. Lymphoma treatments work toward the dual goals of inducing individuals with lymphoma into a state of long-term remission while also improving their chances of survival.
Cancer of the lymphatic system is referred to as lymphoma, and lymphoma is a subtype of cancer characterized by the fast proliferation of aberrant malignant cells. It typically affects the white blood cells (WBCs), also known as lymphocytes, in the lymph nodes, spleen, thymus, and bone marrow. This has the effect of reducing the body's ability to mount an immune response. As a result, the patient experiences symptoms such as swelling in the lymph nodes, high fever, loss of weight, shortness of breath, and weariness as a direct effect of the condition.
COVID-19 Impact Analysis
The pandemic negatively impacted the lymphoma therapeutics market due to delayed diagnosis and treatment and disruptions to clinical trials. Lymphoma therapeutics pose a challenge for healthcare professionals due to the potential risk of chemotherapeutic and immunosuppressive treatment exacerbating comorbid COVID-19 infections, which are crucial aspect of cancer therapy. Patients with B-cell non-Hodgkin's lymphoma (B-NHL), who have recently undergone treatment with anti-CD20 antibodies, are susceptible to severe COVID-19 disease.
Market Growth Factors
Technological advancement in the treatment options
Various treatment developments have been introduced in lymphoma therapeutics by focusing on TAAs; cancer immunotherapy has become a crucial part of cancer treatment. It does not produce unintended off-target effects and has several clinical advantages. This encourages the creation of highly effective, low-side-effect tailored recombinant vaccines for cancer immunotherapy. Immune checkpoint inhibitors (ICIs), recently developed, have changed cancer treatment and increased patient survival. ICIs tailored to checkpoint proteins, like CTLA-4 or PD-1, have been approved to treat several cancer types. These factors are propelling market growth.
Increasing cases of Lymphoma, raising the demand for therapeutics
Around half a million new cases of NHL were reported globally in 2018, accounting for 2.8% of all cancer diagnoses. The gender-specific age-standardized probability of developing NHL was found to be 6.7 in men and 4.7 in women. This indicates that men have a cumulative lifetime risk of 0.72%, while women have a risk of 0.35%. Furthermore, men's incidence was 7.8/100,000, and women's was 5.6/100,000 and 2.9/100,000 in high and low/medium human development index nations, respectively. Hence, the growing cases of Lymphoma, especially non-Hodgins Lymphoma (NHL), are expected to increase the demand for numerous lymphoma therapeutics boosting the market growth in the projected period.
Market Restraining Factors
The associated side effects of treatments
The treatment for lymphoma is associated with side effects. Some of them are digestive issues, "Chemo brain," itchy, painful, and dry skin, fatigue, nausea, and vomiting, hair loss, sleep issues, peripheral neuropathy (nerve injury), and oral mucositis (sore mouth). The risk of infection may rise after the treatment of lymphoma. Therefore, it's crucial to be aware of the warning signs and symptoms and how to get in touch with the medical team if necessary. Lack of specific blood cell types can result from cancer treatment. Low red blood cells, low white blood cells, and low platelets are all symptoms of anemia. These are expected to hinder the lymphoma therapeutics market growth in the projected period.
Disease Type Outlook
Based on disease Type, the lymphoma therapeutics market is segmented into Hodgkin lymphoma and non-Hodgkin lymphoma. The Hodgkin lymphoma segment acquired a significant revenue share in the lymphoma therapeutics market in 2022. The growth is attributed due to the reasons such as the rising prevalence of Hodgkin lymphoma, increased awareness of the disease, and the significant unmet needs of elderly patients and patients with relapsed or refractory (R/R) HL. The moderately aggressive cancer Hodgkin lymphoma can quickly spread throughout the body. Despite this, it's also one of the cancer forms that is most easily cured.
Treatment Type Outlook
On the basis of treatment Type, the lymphoma therapeutics market is divided into immune therapy, chemotherapy, target therapy and radiation therapy. The immune therapy segment held the highest revenue share in the lymphoma therapeutics market in 2022. The growth of immune therapy can be attributed to the progress in immunology, the wider accessibility of immune therapies, and the increasing number of product approvals globally. Immunotherapy has been found to be a highly successful treatment option with positive outcomes.
Route of Administration Outlook
By route of administration, the lymphoma therapeutics market is classified into oral route and injectable. The injectable segment witnessed the largest revenue share in the lymphoma therapeutics market in 2022. This is because the injection is administered subcutaneously and has a duration of 5-7 minutes. This method is significantly faster than intravenous administration. These products have been approved for usage in patients diagnosed with diffuse large B-cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia.
Distribution Channel Outlook
Based on the distribution channel, the lymphoma therapeutics market is bifurcated into hospital pharmacies, retail pharmacies and others. The retail pharmacies segment recorded a significant revenue share in the lymphoma therapeutics market in 2022. This is because retail pharmacies are responsible for the preparation and distribution of medications, as well as the counseling of customers regarding the proper use of medications and the provision of information regarding probable drug interactions. Also, customers can get advice from retail pharmacists regarding general health concerns as well as over-the-counter medications.
Regional Outlook
Region-wise, the lymphoma therapeutics market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The North America region led the lymphoma therapeutics market by generating the maximum revenue share in 2022. This is due to an increase in lymphoma prevalence, advancements in lymphoma therapeutics, including targeted therapies and immunotherapies, and an increase in the number of new product releases by significant market players in this region. Additionally, the existence of important players, the accessibility of cutting-edge medications, the well-established healthcare system, and substantial R&D spending will surge the market growth in the region.
The major strategies followed by the market participants are Acquisitions. Based on the Analysis presented in the Cardinal matrix; Pfizer, Inc., Johnson & Johnson, and F. Hoffmann-La Roche Ltd. are the forerunners in the Lymphoma Therapeutics Market. Companies such as Eli Lilly And Company, Gilead Sciences, Inc., and Bristol Myers Squibb Company are some of the key innovators in Lymphoma Therapeutics Market.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include AstraZeneca PLC, Bayer AG, Bristol Myers Squibb Company, F. Hoffmann-La Roche Ltd., Johnson & Johnson, Gilead Sciences, Inc., Seagen, Inc., Teva Pharmaceutical Industries Ltd., Pfizer, Inc. and Eli Lilly And Company.
Recent Strategies Deployed in Lymphoma Therapeutics Market
Partnerships, Collaborations and Agreements:
Jun-2022: AstraZeneca came into collaboration with GRAIL, LLC, a healthcare company whose focus is to detect cancer early when it can be cured. The collaboration aimed to develop and commercialize companion diagnostic (CDx) assays for their utilization with AstraZeneca's therapies. The partnership first concentrates on creating complementary diagnostic tools to recognize people with high-risk, early-stage diseases. Over the following few years, it is anticipated that additional studies will be conducted across various indications. Patients enrolled in AstraZeneca's clinical trials will be tested using GRAIL's methylation platform.
Apr-2022: Teva Pharmaceuticals signed a partnership with Roche Pharma China for improving lymphoma treatments by integrating the respective strengths and resources for further expanding the availability of Treanda in China. Following the partnership, the latter company reinforced its hematology portfolio and expanded the panorama of lymphoma treatment. Moreover, the companies work together for promoting the standardization of lymphoma treatment in China.
Mergers and Acquisitions:
Jan-2023: AstraZeneca acquired Neogene Therapeutics, Inc., a clinical-stage biotechnology company. Neogene's experience in TCR-T discovery, development, and manufacturing would support AstraZeneca's vision to change patient outcomes as part of a shared mission to provide cell treatments to patients with solid tumors. With the help of this acquisition, the former company's internal oncology cell therapy team will have a rare opportunity to collaborate with world-renowned experts in T-cell receptor biology and cell therapy manufacturing, opening up new avenues for the treatment of cancer.
Aug-2022: AstraZeneca took over TeneoTwo, Inc. (TeneoTwo)i, with TNB-486, Phase I clinical-stage CD19/CD3 T-cell engager, which is currently under evaluation in relapsed and refractory B-cell non-Hodgkin lymphoma. With the acquisition of TNB-486, a potential novel treatment for B-cell hemotologic malignancies like diffuse large B-cell lymphoma and follicular lymphoma is being created. Building on the success of Calquence (acalabrutinib), TNB-486 broadens AstraZeneca's hematology portfolio, which includes several therapeutic modalities and routes to target a variety of blood cancers.
Aug-2022: Bristol Myers Squibb completed the acquisition of Turning Point Therapeutics, a pharmaceutical company engaged in the discovery and development of precision medicine for cancer and other diseases. The acquisition added a product line of investigational medicines designed for targeting the most common mutations related to oncogenesis, to Bristol Myers' portfolio.
Nov-2021: Pfizer acquired Trillium Therapeutics, a clinical-stage immuno-oncology company that develops innovative therapies for cancer treatment. The acquisition added a biologics portfolio that enhanced the patient's innate immune system ability to detect and destroy cancer cells.
Product Launches and Expansions:
Mar-2023: Teva Pharmaceuticals together with NATCO Pharma Limited, announced the additional strengths for the generic version of Revlimid®1 (lenalidomide capsules), in 2.5 mg, and 20 mg strengths, in the United States. Teva's lenalidomide capsules can be utilized for the treatment of multiple myeloma when combined with dexamethasone, specific myelodysplastic syndromes, and mantle cell lymphoma after receiving specific prior treatment.
Trials and Approvals:
Mar-2023: AstraZeneca received approval from National Medical Products Administration (NMPA) in China for Calquence (acalabrutinib), a next-generation, selective Bruton's tyrosine kinase (BTK) inhibitor. This inhibitor is indicated for the treatment of mantale cell lymphoma in adult patients who have already obtained the therapy at least once.
Jan-2023: Eli Lilly and Company announced that U.S. FDA approved Jaypirca™ (pirtobrutinib), the First and Only Non-Covalent (Reversible) BTK Inhibitor. The inhibitor would be used for the treatment of Relapsed or Refractory Mantle Cell Lymphoma After At least Two Lines of Systemic Therapy, Including a BTK Inhibitor, among adult patients.
Nov-2022: Seagen announced that U.S. FDA approved ADCETRIS® (brentuximab vedotin), the new indication for children with untreated high-risk Hodgkin lymphoma. It is suitable for the treatment of pediatric patients 2 years and above.
Aug-2022: AstraZeneca got the approval from US Food and Drug Administration (FDA) for its new tablet formulation of Calquence (acalabrutinib). This tablet formulation provides enhanced flexibility to patients and physicians when making treatment plans for chronic lymphocytic leukemia and mantle cell lymphoma.
Jun-2022: Bristol Myers Squibb got approval from U.S. FDA for CAR T Cell Therapy Breyanzi® for Relapsed or Refractory Large B-cell Lymphoma after a Prior Therapy once. This therapy is indicated for the treatment of follicular lymphoma grade 3B, primary mediastinal large B-cell lymphoma, large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma (DLBCL) not otherwise specified (including DLBCL arising from indolent lymphoma), and high-grade B-cell lymphoma, among adult patients.
Apr-2022: Kite, a Gilead Company, got approval from U.S. Food and Drug Administration (FDA) for Yescarta® (axicabtagene ciloleucel) CAR T-cell therapy. The therapy is beneficial for adult patients with large B-cell lymphoma that is refractory to first-line chemoimmunotherapy or that relapses within 12 months of first-line chemoimmunotherapy.
Feb-2021: Bristol Myers received U.S. Food and Drug Administration approval for Breyanzi (lisocabtagene maraleucel), a cell-based gene therapy. The therapy is indicated for the treatment of adult patients suffering from large B-cell lymphoma. This therapy is suitable for patients who have not responded to, or who have relapsed after, at least two other types of systemic treatment.
Jan-2021: Pfizer got U.S. Food and Drug Administration (FDA) approval for the supplemental New Drug Application (sNDA) for XALKORI® (crizotinib). This drug would be utilized for the treatment of pediatric patients 1 year and older and young adults with refractory or relapsed, systemic anaplastic large cell lymphoma (ALCL) that is anaplastic lymphoma kinase (ALK)-positive.
Market Segments covered in the Report:
By Treatment Type
By Disease Type
By Route of Administration
By Distribution Channel
By Geography
Companies Profiled
Unique Offerings from KBV Research