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市場調査レポート
商品コード
1184285
組換えタンパク質の世界市場規模、シェア、産業動向分析レポート:製品別、エンドユーザー別、用途別、地域別展望および予測、2022年~2028年Global Recombinant Proteins Market Size, Share & Industry Trends Analysis Report By Product, By End User, By Application, By Regional Outlook and Forecast, 2022 - 2028 |
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組換えタンパク質の世界市場規模、シェア、産業動向分析レポート:製品別、エンドユーザー別、用途別、地域別展望および予測、2022年~2028年 |
出版日: 2022年12月30日
発行: KBV Research
ページ情報: 英文 283 Pages
納期: 即納可能
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組換えタンパク質の世界市場規模は、予測期間中にCAGR10.8%で成長し、2028年には26億米ドルに達すると予測されます。
この事業の成長は、肉芽腫性疾患、血友病、硬化症などの慢性疾患の発生率の増加によって促進されると予測されます。さらに、組換えタンパク質製品の改良、生物製剤やバイオシミラーへの嗜好の高まり、その他の理由もすべて、業界の拡大に寄与しています。SARS-CoV2ウイルスの治療薬や診断ツールの発見競争は、COVID-19の流行で盛り上がりました。
Global Genesによると、世界には4億人以上の人々がまれな遺伝性疾患に苦しんでいます。この数字は、治療法、ヘルスケア環境の改善、健康問題に対する一般の人々の知識の向上が急務であることを示しています。医薬品を生み出すためには、最先端の研究と薬物標的メカニズムに関する知識が不可欠です。
コホートプログラムにより、いくつかの地域ではバイオバンクが構築され、研究者は治療努力に革命をもたらす高品質のサンプルにアクセスできるようになりました。これにより、様々な病気のバイオマーカーの特定がより重視されるようになるかもしれません。例として、FDAは2022年8月、希少な血液疾患である進行性全身性肥満細胞症に対処するため、Ayvakitを承認しました。
COVID-19影響度分析
COVID-19ワクチンは、迅速かつ大規模な開発が要求され、商業的な製造活動も継続していることから、生物製剤を用いた研究の取り組みに好ましい影響を与え、結果的に業界の拡大に寄与しました。COVID-19のパンデミックは、タンパク質市場の拡大に好ましい影響を与えました。SARS-CoV-2感染に対してより効果的で、センターで容易に入手できる、異なるアジュバントと抗原のサブユニットを組み合わせた組換えタンパク質ワクチンが開発されるかもしれない、とCOVID感染の拡大に照らして提案されました。
市場の成長要因
慢性疾患の増加によるオーダーメイド医療への注目の高まり
組換えタンパク質は、慢性疾患に対する数少ない治療法として認知されており、慢性疾患が増加傾向にあることから、組換えタンパク質治療に対する需要は大きいです。GLOBOCANによると、2020年にメキシコで新たに発生するがん患者は195,499人、がん関連死は90,222人と推定されています。ワクチン、組換えタンパク質、細胞・遺伝子治療など、いくつかのバイオテクノロジーは、治療の個別化に不可欠であるため、個別化医療の開発に組み込まれる必要があります。
生物製剤の研究開発の増加
組換えタンパク質の市場は、生物製剤の研究開発の増加により、需要が拡大すると予想されます。研究開発産業は、長い研究期間と規制の遅れにより、従来から多くの資金を必要としてきました。研究開発に対する消費は、世界の支出の中でかなりの割合を占めています。各国政府は、研究開発を国家の発展、国際競争力、公益のための重要な要因として認識しています。その結果、研究開発の資金と支出は着実に増加しています。
市場の抑制要因
遺伝子組換えタンパク質が安価になってきています。
リコンビナント・タンパク質は、研究室で培養された細胞を使って作られるため、高価格の一因となっています。また、製造コストの8割を占めるといわれる精製も大きな経費の一つです。価格侵食とは、特定の市場に多くのプレーヤーが参入し、独自性のない同一商品を販売し、創造性のないリーズナブルな価格の商品で市場を飽和させることであると定義されています。価格侵食とは、ある市場においてこれらの製品の価格が常に低下し、市場の拡大が鈍化することです。
製品の展望
製品別では、成長因子およびケモカイン、免疫反応タンパク質、構造タンパク質、膜タンパク質、キナーゼタンパク質、制御タンパク質、組み換え代謝酵素、接着分子および受容体、その他の組換えタンパク質に分類されます。2021年には、免疫反応タンパク質がかなりの売上シェアを占めると予想されます。体内の重要なタンパク質群にサイトカインがあります。これらの小さなタンパク質は、免疫システムのメッセンジャーとして機能します。免疫系の連絡網として機能し、脅威に対する反応として生み出されます。免疫系細胞は、互いに直接触れることで相互作用することもあるが、より頻繁にはサイトカインを分泌することで近くの細胞や遠くの細胞に作用することができます。
アプリケーションの展望
アプリケーション別に見ると、創薬・市場開拓、バイオ医薬品生産、バイオテクノロジー研究、学術研究、診断、その他のアプリケーションに分類されます。バイオテクノロジー研究は、2021年に大きな収益シェアを占めています。組換えタンパク質は、生物の基本的かつ根本的な原理を照らし出すのに役立ちます。これらの分子は、特定の遺伝子がコードするタンパク質の位置を特定し、ピンポイントで特定するために使用することができ、また、他の遺伝子が細胞シグナル伝達、代謝、成長、複製、死、翻訳、転写、タンパク質修飾などのプロセスにどのように関与しているかについてより詳しく知ることができます。
エンドユーザーの展望
組換えタンパク質市場は、エンドユーザーに基づき、製薬・バイオ医薬品業界、バイオテクノロジー業界、学術研究機関、受託研究機関、その他のエンドユーザーに分類されます。受託研究機関は、2021年の市場収益のかなりの部分を占めると予想されます。研究開発業界では、学術機関と企業間のパートナーシップやコラボレーションに関する投資が増加しました。例えば、ファイザーの治療イノベーションセンター(CTI)は、ヘルスケアシステムにおける利害関係者間の交流の場として機能しています。
地域別の展望
地域別に見ると、遺伝子組換えタンパク質市場は北米、欧州、アジア太平洋、LAMEAに分類されます。2021年の組換えタンパク質の主要地域市場は、北米でした。慢性疾患や遺伝性疾患の高い有病率、研究開発のための資金の確保、製薬業界の研究開発に対する政府の取り組み、研究・学術分野におけるライフサイエンス技術の利用の拡大、大手製薬・バイオテクノロジー企業の大きな存在、創薬・研究開発における分析機器の応用などが、北米が世界市場で大きなシェアを占めている要因となっているようです。
List of Figures
The Global Recombinant Proteins Market size is expected to reach $2.6 billion by 2028, rising at a market growth of 10.8% CAGR during the forecast period.
Recombinant proteins have a huge future in the study and development of cancer therapies. Examples of recombinant proteins used in cancer therapy research include growth factors, immunological checkpoints, and cell damage & oxidative stress proteins (preclinical stage). The utilization of recombinant proteins including immunological checkpoint, antibodies, and growth factors, for targeted purposes has risen as a result of a greater knowledge of neoplastic signalling cascades and the proteins involved in them.
Researchers utilise these proteins frequently to study how cancer signalling pathways and functions. Research uses recombinant immune checkpoints that directly target programmed death-1 (PD-1) and programmed death ligand-1 and 2 (PD-L1), including PD-1/PD-L1 Inhibitor 1 and PD-1/PD-L1 Inhibitor 2. Aside from that, proteins like CD40 Ligand/TRAP, CD226, and Human CellExp CTLA4/CD152 are often employed in studies on cancer therapy.
Growth in the business is predicted to be fueled by the increased incidence of chronic disorders such granulomatous disease, haemophilia, and sclerosis. Additionally, improved recombinant protein products, the growing preference for biologics and biosimilars, and other reasons all contribute to the industry's expansion. The race to discover cures and diagnostic tools for the SARS-CoV2 virus was fuelled by the COVID-19 epidemic.
With over 400 million people worldwide suffer from uncommon genetic illnesses, according to Global Genes. This figure demonstrates the urgent need for therapies, an improvement in healthcare environments, and increased public knowledge of health issues. A critical instrument for the creation of medicines is the requirement for cutting-edge research and knowledge of drug targeting mechanisms.
Cohort programmes have helped several regions create biobanks that give researchers access to high-quality samples that will revolutionise treatment efforts. This may lead to a greater emphasis on the identification of biomarkers for various illnesses. As an illustration, the FDA approved Ayvakit in August 2022 to address advanced systemic mastocytosis, a rare blood disorder.
COVID-19 Impact Analysis
The requirement for the COVID-19 vaccine to be developed quickly and on a large scale, as well as its ongoing commercial manufacturing activities, had a favourable effect on the development of biologics-based research initiatives and ultimately helped the industry's expansion. The COVID-19 pandemic had a favourable effect on the expansion of the proteins market. Recombinant protein vaccines may be developed with a combination of subunits of different adjuvants and antigens that will be more effective against SARS-CoV-2 infections and be readily available in the centre, it was suggested in light of the growth in COVID infection.
Market Growth Factors
Growing Emphasis On Customised Medicine Due To An Increase In The Prevalence Of Chronic Diseases
Recombinant proteins are one of the few recognised treatments for such conditions, and as chronic illnesses are on the rise, there is a significant demand for recombinant protein therapies. According to GLOBOCAN, there were estimated 195,499 new cancer cases and 90,222 cancer-related deaths in Mexico in 2020. Several biotechnologies, including vaccines, recombinant proteins, and cell and gene therapies, must be incorporated into the development of personalised medicine since they are essential to the personalization of care.
Increasing Biologics Research And Development
The market for recombinant proteins is anticipated to expand in demand due to the increased research and development on biologics. The R&D industry has traditionally required a lot of capital because of lengthy study periods and regulatory delays. Consumption on R&D accounts for a considerable share of global spending. Governments acknowledge R&D as a crucial factor in a nation's development, global competitiveness, and public good. R&D funding and spending have risen steadily as a result.
Market Restraining Factors
Recombinant proteins are getting cheaper.
Recombinant Proteins are made in labs using cells that have been grown, which contributes to their expensive price. Purification of these medications, which can make up as much as 80% of the manufacturing costs, is one of the major expenses. Price erosion is defined as when many players enter a particular market and sell identical products without any uniqueness, saturating the market with less creative and reasonably priced goods. Price erosion is the constant drop in the price of these products in a given market, which slows down market expansion.
Product Outlook
Based on Product, the market for recombinant proteins is classified into growth factors and chemokines, immune response proteins, structural proteins, membrane proteins, kinase proteins, regulatory proteins, recombinant metabolic enzymes, adhesion molecules and receptors, and other recombinant proteins. Immune response proteins are expected to command a sizable sales share in 2021. A crucial group of proteins in the body are cytokines. These little proteins act as immune system messengers. They serve as the immune system's network of communication and are created in reaction to a threat. Immune system cells can sometimes interact by touching one another directly, but more frequently, they do so via secreting cytokines, which can operate on other cells nearby or far away.
Application Outlook
Based on application, the market Drug Discovery & Development, Biopharmaceutical Production, Biotechnology Research, Academic Research Studies, Diagnostics, and Other Applications. The biotechnology research command a significant revenue share in 2021. Recombinant proteins aid in illuminating an organism's basic and underlying principles. These molecules can be used to identify and pinpoint the location of the protein that a particular gene encodes, as well as to learn more about how other genes are involved in processes such as cell signalling, metabolism, growth, replication, and death, as well as translation, transcription, and protein modification.
End User Outlook
Based on End User, the Recombinant Proteins Market is divided in pharmaceutical and biopharmaceutical industry, biotechnology industry, academic research institutes, contract research organisations, and other end users. Contract Research Organizations are expected to account for a sizable portion of market revenue in 2021. The R&D industry saw increased investments in regards to partnerships and collaborations between academic institutions and businesses. For instance, the Center for Therapeutic Innovation (CTI) at Pfizer serves as a forum for interaction among stakeholders in the healthcare system.
Regional Outlook
Based on geography, the Recombinant Proteins Market is classified into North America, Europe, Asia Pacific, and LAMEA. The leading regional market for recombinant proteins in 2021 was North America. The high prevalence of chronic and genetic diseases, the availability of funding for R&D, government initiatives for R&D in the pharmaceutical industry, the growing use of life science techniques in research and academia, the significant presence of major pharmaceutical and biotechnology organizations, and the application of analytical instruments in drug discovery and development are all factors that contribute to North America holding a significant share of the global market.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Bio-Techne Corporation, Thermo Fisher Scientific, Inc., Merck Group, Bio-Rad Laboratories, Inc., Abcam plc, Genscript Biotech Corporation, Miltenyi Biotec B.V. & Co. KG, Proteintech Group, Inc., BPS Bioscience, Inc., and RayBiotech Life, Inc.
Strategies Deployed in Recombinant Proteins Market
Nov-2022: Abcam comes into agreement with NanoString Technologies, Inc., a leading provider of life science tools for discovery and translational research. Through this agreement, Abcam RabMAb™ recombinant antibodies would be produced as part of the first 64-plex protein panel for NanoString's CosMx™ Spatial Molecular Imager (SMI). Additionally, this agreement would open the full capability of spatial biology and help enhance care for people with cancer.
2022-Jul: Bio-Rad Laboratories launched EconoFit Columns, a low-pressure prepacked chromatography column pack. The EconoFit columns are created for resin screening, enabling customers that are designing protein purification workflows to choose the optimal chemistry for various targets. The products offer run-to-run uniformity to support preparative scale purifications and method advancement for the latest target proteins, as well as to improve existing workflows.
Feb-2022: Abcam came into agreement with Twist Bioscience Corporation, a synthetic biology company. Under this agreement, Abcam would use a proprietary Twist VHH phage library for antibody development, discovery, and commercialization for research and diagnostic application. Moreover, Twist Bioscience grants Abcam the right to perform research and development activities utilizing Twist single domain (VHH) synthetic antibody library.
Jan-2022: Thermo Fisher Scientific Inc. completed the acquisition PeproTech, Inc., a leading developer, and manufacturer of recombinant proteins. Through this acquisition, PeproTech's recombinant proteins suite aligns with Thermo Fisher's cell culture media products and would allow Thermo Fisher to offer customers significant advantages through an integrated offering.
2021-Nov: Abcam partnered with Nautilus Biotechnology, Inc., a development-stage life sciences company. Under this partnership, Both companies would focus on the combined advancement of affinity binding reagents used on the Nautilus proteomic analysis system and would broaden in the upcoming time to the large-scale manufacturing and supply of reagents for production.
Mar-2021: Bio-Techne Corporation released Cultrex™ UltiMatrix, a hydrogel extracellular matrix that is beneficial for cultivating pluripotent stem cells and organoids in terms of performance and consistency. The product develops Matriz hydrogels that support the growth use of pluripotent stem and organoid cells for drug research, commercialize medicine, and regenerative medicine.
Nov-2020: Merck signed an agreement with Donghao Lansheng (Group) Co., Ltd., a large modern service industry. This agreement would drive a new process that helps the custom clearing of research material for analytical use and biomedical innovation, through this Merck would be able to process shipments with the technical dossier and fewer application needs.
Nov-2019: Abcam plc announced a partnership with BrickBio, a Tiger Gene suite company and have specialization in site-specific protein modification. Through this partnership, Abcam would have full rights to the platform for the formation of novel conjugation-ready recombinant products for the research equipment market and to produce the platform over its recombinant antibody and protein offering for diagnostic use.
Apr-2019: Bio-Techne Corporation Collaborated with Elpiscience BioPharma, a clinical-stage biopharmaceutical company. Through this collaboration, both companies aimed to advance anti-cancer therapeutics and boost the development of the latest biologics to meet the medical requirements in Oncology.
Apr-2018: Proteintech Group acquired HumanZyme, a manufacturer of recombinant human proteins. Through this acquisition, the company would strengthen its place as a manufacturer of antibodies, ELISA kits, and proteins.
Market Segments covered in the Report:
By Product
By End User
By Application
By Geography
Companies Profiled
Unique Offerings from KBV Research