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市場調査レポート
商品コード
1172692
PEG化タンパク質の世界市場規模、シェア、産業動向分析レポート:製品・サービス別、タイプ別、エンドユーザー別、用途別、地域別展望・予測、2022年~2028年Global PEGylated Proteins Market Size, Share & Industry Trends Analysis Report By Product & Services, By Type, By End-user, By Application, By Regional Outlook and Forecast, 2022 - 2028 |
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PEG化タンパク質の世界市場規模、シェア、産業動向分析レポート:製品・サービス別、タイプ別、エンドユーザー別、用途別、地域別展望・予測、2022年~2028年 |
出版日: 2022年11月30日
発行: KBV Research
ページ情報: 英文 278 Pages
納期: 即納可能
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PEG化タンパク質の世界市場規模は、2028年までに21億米ドルに達し、予測期間中に11.3%のCAGRで市場成長すると予測されています。
タンパク質の不活性必要基と組み合わせることで、無毒で親水性の高い高分子ポリマーの一種であるポリエチレングリコール(PEG)は、タンパク質医薬品の相対分子量を増加させ、帯電特性の表面に覆われている抗原決定基に対して何らかの変化を生じさせます。国内外において、PEG化技術をタンパク質医薬品に活用することに顕著な関心が持たれています。
市販されている様々なPEG化医薬品は、その治療上および商業上の有用性が完全に確立されています。タンパク質ベースの医薬品が非タンパク質ベースの医薬品よりも好まれるようになってきており、PEG化によってタンパク質の安定性と循環半減期が向上するため、予測期間を通じてPEG化タンパク質産業の拡大を促進すると予想されています。
業界成長の主な要因は、がん、腎臓病、関節リウマチのような慢性疾患の有病率が増加していることです。例えば、IARC(国際がん研究機関)の推計によると、2020年には世界で1,930万人の新規がん患者が発生し、1,030万人が死亡すると予想されています。
COVID-19の影響度分析
COVID-19のパンデミックは、この分野にとって有益でした。政府や大手企業は、COVID-19予防のための最先端の薬物候補の作成に投資を増やしました。新しいワクチン、診断薬、現行薬の再利用のための研究開発の増加は、投資の増加と密接に関連していました。例えば、インドの製薬会社であるザイダス・カディラは、2021年4月に、同社のPEG化インターフェロンα2b既存薬を軽症例のCOVID-19患者の治療に使用するための緊急使用承認(EUA)を取得しました。同薬は以前、B型肝炎の治療薬として承認されていましたが、インド全土での広範な検討と臨床試験を経て、COVID-19に再利用されることになりました。
市場の成長要因
PEG化タンパク質は、より頻繁に、さまざまな用途で使用されるようになってきています。
より安定した非免疫原性の医薬品の開発は、PEG化タンパク質プロセスの大きな改善によって可能となり、世界のPEG化タンパク質市場の成長を加速させると予測されています。がん患者の膨大な増加を考えると、このアプローチはがんの治療において強い適用性を持っています。世界保健機関(WHO)は、2018年に世界で960万人ががんで命を落としたと推定しています。PEG化された後、CCNファミリーのタンパク質は、血液がんの治療に採用することができます。
世界的に高まるがんの割合
死因の第2位であるがんは、全死亡者数のかなりの割合を占めています。富裕国は発展途上国に比べ、がん罹患率がかなり高いです。これらの発展途上国では、人口増加、高齢化、既知の危険因子の増加により、ますます顕著になることが予想されます。先進国では肺がんは男性のみのがん関連死の主要原因の一つであり、新興国では乳がんががん関連死の主要原因となっています。
市場抑制要因
単離・精製の課題
タンパク質のPEG化は複雑なプロセスであり、タンパク質の組成や使用目的に応じてさまざまな方法で実施されます。不活性なPEGストリングは、目的のタンパク質と共有結合または非共有結合で複合化されます。もう一つの重要なステップは、PEG化されたタンパク質の精製であり、これは主にクロマトグラフィーと静電相互作用または分子サイズによって達成されます。貧血、腎臓病、多発性硬化症、血友病、悪性腫瘍などの症状に対して、多くのPEG化薬剤が使用されています。
製品およびサービスの展望
製品・サービス別に見ると、市場は消耗品とサービスに分けられます。市場の実質的な収益シェアは、サービス部門が示しています。PEG化タンパク質のサービスには、直鎖型と分岐型の両方があり、さまざまな分子量のPEGを使用することができます。ペプチドやタンパク質は、化学的に不安定で血液循環が速く、免疫反応を引き起こす性質があるため、治療への利用には限界があります。
タイプ別の展望
市場はタイプ別に、コロニー刺激因子、インターフェロン、エリスロポエチン、遺伝子組換え第VII因子、その他に分類されます。エリスロポエチンは、市場の楽観的な成長ペースを示しています。エリスロポエチン製剤の拡大は、末期腎不全、がん、HIV、神経疾患などの慢性疾患の有病率の増加によって推進されています。エリスロポエチン(EPO)を模倣した薬剤は、がん、HIV、腎臓病患者における重度の貧血の治療に使用することが可能です。
アプリケーションの展望
アプリケーション別に見ると、市場はがん、自己免疫疾患、肝炎、多発性硬化症、血友病、消化器疾患、その他に分けられます。その他のセグメントについては、有望な成長率を示しています。タンパク質ドラッグデリバリーおよびその他の疾患は、その他のセクションに含まれます。PEG化タンパク質の市場は、慢性疾患の頻度上昇の結果として成長すると予想されます。PEG化タンパク質は、体内での物質の安定性を高めることにより、標準的な薬剤に比べて薬効を向上させることができます。
エンドユーザー向け展望
市場はエンドユーザーによって、製薬・バイオテクノロジー企業、受託研究機関、学術・研究機関に分けられます。業界で大きな収益シェアを占めているのは、研究開発受託機関(CRO)です。CROは現在、受託研究および医薬品の製造における外部からの支援に対する需要が高まっているため、より普及しています。さらに、手間のかからないプロセスとFDAの認可により、バイオテクノロジーや製薬業界は現在、CROにサポートを依頼しています。
地域別の展望
地域別に見ると、市場は北米、欧州、アジア太平洋、LAMEAに分類されます。2021年は、北米が市場をリードし、最大のシェアを占めました。この地域のヘルスケアインフラは、不調や疾病の発生、慢性疾患、現代治療に対する人口の意識の結果として成長してきました。生物製剤に基づく研究活動のための資金や助成金の増加は、改善されたインフラとより良い経済状況の存在によって促進されます。
List of Figures
The Global PEGylated Proteins Market size is expected to reach $2.1 billion by 2028, rising at a market growth of 11.3% CAGR during the forecast period.
PEGylation is covalently and non-covalently connecting polyethylene glycol polymer chains to molecules, such as treatments, medications, or vesicles. The industry is expected to expand significantly throughout the anticipated time period, mainly due to increased PEGylation demand, a rise in the occurrence of chronic diseases, and the availability of effective new therapeutic options.
PEGylated chemicals also have certain extra advantages that support the growth of the sector, such as improved proteolytic defense, a longer half-life, decreased toxicity, and reduced immunogenicity. Because of their great biological activity and excellent selectivity, protein medicines have emerged as significant modern pharmacological products.
In combination with protein inactive necessary groups, polyethylene glycol (PEG), a type of non-toxic, high hydrophilic macromolecule polymer, increases the relative molecular mass of the protein drugs, causing some changes to the antigenic determinant that is covered on the surface of the charged property. Both domestically and internationally, there has been noticeable interest in the utilization of PEGylated technology in protein medicines.
A wide range of PEGylated medications on the market has completely established both their therapeutic and commercial usefulness. The preference for protein-based pharmaceuticals over non-protein-based drugs is increasing, and PEGylation's enhancement of protein stability and circulation half-life is anticipated to drive the PEGylated Protein Industry's expansion throughout the projection period.
The key driver of the industry's growth is the increasing prevalence of chronic conditions like cancer, kidney illness, and rheumatoid arthritis. For instance, according to estimations from the IARC (International Agency for Research on Cancer), there will be 19.3 million new cases of cancer and 10.3 million cancer deaths globally in 2020.
COVID-19 Impact Analysis
The COVID-19 pandemic was beneficial to the sector. The government and major players increased their investments in the creation of cutting-edge medication candidates for COVID-19 prevention. Increased research and development for new vaccines, diagnostics, and the repurposing of current medicines were closely linked to an increase in investments. For instance, Zydus Cadila, an Indian pharmaceutical company, acquired an Emergency Use Approval (EUA) in April 2021 to use its PEGylated Interferon alpha 2b existing medication to treat COVID-19 patients with mild instances. The medicine had previously been approved to treat Hepatitis B, but after extensive study and clinical trials across India, it was repurposed for COVID-19.
Market Growth Factors
Pegylated proteins are being used more often and in a variety of applications.
The development of more stable and non-immunogenic medicines is made possible by major improvements in PEGylated protein processes, which are predicted to accelerate the growth of the worldwide PEGylated protein market. Given the huge increase in cancer patients, the approach has strong applicability in the treatment of cancer. World Health Organization (WHO) estimates that 9.6 million individuals worldwide lost their lives to cancer in 2018. After being PEGylated, the protein from the CCN family can be employed in the treatment of blood cancer.
The Rising Rate Of Cancer Worldwide
The second-leading cause of death, cancer, is responsible for a significant fraction of all fatalities. Wealthy countries have a substantially higher cancer rate than developing ones. It is anticipated that recognized risk factors will be increasingly prominent in these developing nations due to population growth, aging, and a rise in known risk factors. Lung cancer is among the major cause of cancer-related death in men only in industrialized countries, while breast cancer is the major cause of cancer deaths in developing countries.
Market Restraining Factors
Isolation And Purification Challenges
Protein PEGylation is a complicated process that can be carried out in different ways, depending on the protein's makeup and the intended use. Inert PEG strings are covalently or non-covalently complexed with proteins of interest. Another crucial step is the purification of the PEGylated protein, which is mostly accomplished through chromatography and electrostatic interactions or molecular sizes. For conditions such as anemia, kidney illness, multiple sclerosis, hemophilia, and malignancies, a number of PEGylated medications are in use.
Product and Services Outlook
Based on the Product and Services, the market is divided into Consumables and Services. The market's substantial revenue share is displayed by the services sector. PEGylated Proteins services are available in both linear and branching formats and can be used with PEGs of various molecular weights. Peptides and proteins frequently have limitations on their capacity to be used therapeutically due to their chemical instability, quick blood circulation, and propensity to trigger an immune response.
Type Outlook
Based on the type, the market is divided into Colony-stimulating factors, Interferons, Erythropoietin, Recombinant factor VII, and Others. Erythropoietin is demonstrating the market's optimistic growth pace. The expansion of erythropoietin drugs is being driven by an increase in the prevalence of chronic diseases such as end-stage renal diseases, cancer, HIV, and neurological disorders. Drugs that mimic erythropoietin (EPO) can be used to treat severe anemia in people with cancer, HIV, and renal disease.
Application Outlook
Based on Application, the market is divided into Cancer, Autoimmune diseases, Hepatitis, Multiple sclerosis, Hemophilia, Gastrointestinal disorders, and Others. The market is showing a promising growth rate for the other segments. Protein drug delivery and other disorders are included in the others section. The market for PEGylated Proteins is anticipated to grow as a result of the rising frequency of chronic disorders. PEGylated proteins improve a drug's action relative to a standard drug by increasing the stability of the substance in the body.
End-User Outlook
Based on the end-user, the market is divided into Pharmaceutical and biotechnology businesses, Contract research organizations, and Academic & research institutes. The significant revenue share in the industry was accounted for by Contract Research Organizations (CROs). CROs are currently more prevalent as a result of the rising demand for outside help with contract research and the creation of pharmaceuticals. Additionally, due to the hassle-free process and FDA clearance, the biotechnology and pharmaceutical industries now rely on CROs for support.
Regional Outlook
Based on geography, the market is categorized into North America, Europe, Asia Pacific, and LAMEA. In 2021, North America led the market and held the largest share. The region's healthcare infrastructure has grown as a result of the incidence of ailments and diseases, chronic conditions, and population awareness of modern therapies. The increase in funding and grants for biologics-based research activities is facilitated by the presence of improved infrastructure and better economic conditions.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Merck Millipore (Merck KGaA), Thermo Fisher Scientific, Inc., NOF Corporation, JenKem Technology Co. Ltd., Creative PEGworks, Celares GmbH, Quanta BioDesign, Ltd., Biomatrik, Inc., Iris Biotech GmbH, and Laysan Bio, Inc.
Strategies Deployed in PEGylated Proteins Market
Nov-2022: Thermo Fisher Scientific completed the acquisition of The Binding Site Group, a UK-based specialist protein company providing diagnostic products and instruments to clinicians and laboratories globally. This acquisition broadened Thermo's existing specialty diagnostics portfolio.
Aug-2022: Merck Group, the parent organization of Merck Millipore took over the Chemical division of Mecaro, a company focused on manufacturing heater blocks and chemical precursors for semiconductors. This acquisition enhances Merck's portfolio of semiconductor solutions.
Apr-2022: Thermo Fisher Scientific launched GMP-manufactured Gibco CTS TrueCut Cas9 protein. The product enhances Thermo's existing genome editing solutions and provides support to scientists developing personalized CAR T-cell therapeutics.
Mar-2022: Thermo Fisher took over Max Analytical, a chemical instrumentation company providing FTIR-based gas analytical solutions. The acquisition broadened Thermo's FTIR instrument, software, and service offerings.
Jan-2022: Thermo Fisher Scientific announced the acquisition of PeproTech, a provider of bioscience reagents. The acquisition complemented Thermo's bioscience business and enabled them to deliver better services to its pharma and biotech customers.
Dec-2021: Thermo Fisher acquired PPD, a pharmaceutical firm offering clinical research and laboratory services. The addition of PPD's clinical research services enables Thermo to advance its work in launching life-changing therapies to market.
Oct-2021: Thermo Fisher Scientific collaborated with 3M Health Car for maximizing process scalability and efficiency in commercial therapeutic manufacturing. The collaboration integrates Thermo's HyPerforma Single-Use Bioreactor Systems and 3M's Harvest RC providing premium solutions to advance manufacturing capacity to produce therapeutics.
Jan-2021: Thermo Fisher completed the acquisition of Mesa Biotech, a healthcare test and data company providing the molecular diagnostic test. This acquisition complemented Thermo's existing test services and helped Thermo cater to the increasing demand for COVID-related testing.
Market Segments covered in the Report:
By Product & Services
By Type
By End-user
By Application
By Geography
Companies Profiled
Unique Offerings from KBV Research