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市場調査レポート
商品コード
1519761
臓器オンチップ市場レポート:提供、タイプ、用途、最終用途、地域別、2024年~2032年Organ-on-chip Market Report by Offering, Type, Application, End Use, and Region 2024-2032 |
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臓器オンチップ市場レポート:提供、タイプ、用途、最終用途、地域別、2024年~2032年 |
出版日: 2024年07月01日
発行: IMARC
ページ情報: 英文 139 Pages
納期: 2~3営業日
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臓器オンチップの世界市場規模は2023年に6,160万米ドルに達しました。今後、IMARC Groupは、市場は2032年までに5億4,180万米ドルに達し、2024年から2032年の間に26.5%の成長率(CAGR)を示すと予測しています。この市場を牽引しているのは、技術的進歩、共同作業、医学研究におけるより正確で人道的な代替手段を通じた動物実験の削減に対する規制および倫理的重点の高まりによって刺激された、医薬品研究開発の強化における重要な役割です。
主要市場促進要因:医薬品とバイオテクノロジーにおける、より正確で倫理的な調査方法の必要性により、臓器オンチップ市場は急速に拡大しています。
主な市場動向:3Dバイオプリンティングやマイクロ流体工学などの技術的進歩が臓器オンチップモデルに革命をもたらし、その精度と応用可能性を高めています。
地理的動向:北米は強固な研究インフラと積極的な規制政策に支えられて市場をリードしているが、欧州とアジア太平洋はバイオテクノロジーへの投資増加により急速に追い上げています。
競合情勢:臓器オンチップ業界の主な市場プレイヤーとしては、Allevi Inc.、Altis Biosystems、AxoSim、BiomimX S.r.l.、Elveflow、Emulate Inc.、InSphero、MIMETAS、Nortis Inc.、TARA Biosystems Inc.、TissUse GmbHなどが挙げられます。
課題と機会:技術的な複雑さと高コストが課題となる一方で、個別化医療へのシフトの進展と多臓器モデルへの拡大が重要な機会となります。
医薬品研究開発の強化
臓器オンチップ市場の可能性が大きく広がるのは、医薬品開発・発見を劇的に強化できるからです。これらの技術は、従来の2次元細胞培養や動物モデルと比較して、人間の臓器がどのように反応するかをより正確にシミュレーションできるため、薬剤の試験や開発にかかる時間を短縮するのに役立ちます。したがって、この技術革新は、創薬の期間、コスト、失敗率を減らすために不可欠な、比類のない予測精度を提供します。その結果、製薬会社は臓器オンチップ技術を研究開発プロセスに組み込んでギャップを縮め、個別化医療や精密医療の進歩、治療成功率の向上につなげようとしています。さらに、このシフトは、最終段階で失敗した医薬品のコストを部分的にカバーする、多くの迅速な医薬品承認の見通しを生み出しています。
技術革新と提携
絶え間ない技術の進歩は、臓器オンチップ産業を変革する大きな刺激のひとつです。複数の臓器システムの機能を同時に再現できるチップの製造は、より完全な分析ツールであり、前臨床試験の第一段階をカバーし、臨床試験をより人々に近いものにします。現在行われている発明には、マイクロ流体工学、多次元構造内の細胞の3Dプリンティング、臓器オンチップ・システムのより良い機能性と拡張性を可能にする自動イメージングなどがあります。さらに、バイオテクノロジー企業、研究機関、技術スペシャリストの連携は、学際的な研究のための戦略的環境を形成し、その結果、この分野の迅速な改善をもたらしています。このような協力関係は、技術的な問題を克服し、アプリケーションを向上させるだけでなく、毒物検査、疾患モデリング、精密医療といった様々な分野を促進するために不可欠です。例えば、臓器オンチップ(OOC)技術は、より正確な予測モデルを提供することで、従来のin vitro ADMEおよび毒性試験に革命をもたらし、年間15%の成長率が推定される医薬品開発を強化します。多臓器システムを組み込んだOOCプラットフォームは、薬物動態学的および薬力学的試験を強化し、薬剤分子の時間および用量依存性効果に関する洞察を提供します。臓器オンチップ市場の売上に基づくと、2025年までに2億2,000万米ドルの市場規模に達すると予測されるこれらの先端技術は、正確なフロー制御と迅速なサンプル処理によって従来の2次元培養を凌駕し、有効性試験や毒性評価に不可欠なものとなっています。
規制と倫理の変化
科学研究における動物の使用に関する倫理的問題や規制の強化は、さらに臓器オンチップ産業の成長を刺激しています。世界中の機関や部局が、動物モデルよりも適切なデータを提供するこれらの技術の価値を認識しつつあります。これが、USFDAの臓器オンチップ・プログラムのような試みによって推進されていることです。従って、この移行は、動物に優しい調査技術を求める国民や政府の高まりと一致しています。臓器オンチップ技術は、より高い規制基準を満たすだけでなく、より人間的で科学的に高度な研究技術へのパラダイムシフトを促進することができるため、倫理的にも正当化されます。このような倫理的観点は、研究開発で使用される臓器オンチップデバイスを広く承認する上で、ますます重要な役割を果たすようになってきています。
The global organ-on-chip market size reached US$ 61.6 Million in 2023. Looking forward, IMARC Group expects the market to reach US$ 541.8 Million by 2032, exhibiting a growth rate (CAGR) of 26.5% during 2024-2032. The market is driven by its critical role in enhancing pharmaceutical R&D, stimulated by technological advancements, collaborative efforts, and increasing regulatory and ethical emphasis on reducing animal testing through more accurate and humane alternatives in medical research.
Major Market Drivers: The organ-on-chip market is expanding rapidly, driven by the need for more accurate and ethical research methods in pharmaceuticals and biotechnology.
Key Market Trends: Technological advancements such as 3D bioprinting and microfluidics are revolutionizing organ-on-chip models, increasing their accuracy and applicability.
Geographical Trends: North America leads the market, supported by robust research infrastructure and proactive regulatory policies; however, Europe and Asia-Pacific are quickly catching up due to rising investments in biotech.
Competitive Landscape: Some of the major market players in the organ-on-chip industry include Allevi Inc., Altis Biosystems, AxoSim, BiomimX S.r.l., Elveflow, Emulate Inc., InSphero, MIMETAS, Nortis Inc., TARA Biosystems Inc., TissUse GmbH., etc. among many others.
Challenges and Opportunities: While technological complexities and high costs pose challenges, the growing shift towards personalized medicine and the expansion into multi-organ models present significant organ-on-chip market opportunities.
Pharmaceutical Research and Development Enhancement
The organ-on-chip market potential is greatly increased because it can dramatically enhance drug development and discovery. These techniques provide a more precise simulation of how human organs respond compared to conventional 2D cell cultures, and animal models and hence they help to reduce the time taken in drug testing and development. This innovation, thus, offers unparalleled prediction accuracy, essential for decreasing the duration, cost, and failure rates during drug discovery. As a result, pharmaceutical organizations are starting to integrate organ-on-chip technologies into their R&D processes to narrow the gap, leading to the advancement of personalized and precise medicine and higher therapeutic success rates. Besides, this shift produces the prospect of many quick drug approvals which partly cover the cost of those that failed in the final stage.
Technological Innovations and Collaborations
Continuous technological advancements are one of the major stimuli that are transforming the organ-on-chip industry. The manufacturing of chips capable of replicating several organ systems' functionalities at the same time is a more complete analysis tool, covering the first stage of preclinical testing and bringing clinical trials closer to the population. The inventions being made include incorporating microfluidics, 3D printing of cells within multi-dimensional structures, and automated imaging which allows for better functionality and scalability of organ-on-chip systems. Furthermore, associations between biotech firms, research institutions, and technology specialists have formed a strategic environment for cross-disciplinary studies that, in turn, results in fast improvements in this field. These collaborations are vital to overcoming technical issues and improving applications, as well as promoting various sectors like toxic things testing, disease modeling, and precision medicine. For instance, Organ-on-chip (OOC) technology revolutionizes traditional in vitro ADME and toxicity tests by offering a more accurate predictive model, enhancing drug development with an estimated growth rate of 15% annually. Incorporating multi-organ systems, OOC platforms enhance pharmacokinetic and pharmacodynamic studies, providing insights into the time and dose-dependent effects of drug molecules. Based on organ-on chip market revenue, these advanced technology, projected to reach a market size of $220 million by 2025, outperforms conventional 2D cultures with its precise flow control and rapid sample processing, making it essential for efficacy studies and toxicity evaluations.
Regulatory and Ethical Shifts
Ethical issues and stricter regulations concerning the application of animals in scientific research are additionally stimulating the growth of the organ-on-chip industry. Agencies and departments all around the world are coming to recognize the value of these technologies in providing more relevant data than animal models. This is what is being promoted by endeavors such as the USFDA's Organ-on-Chip program. Therefore, this transition is consistent with the growing public and governmental push for animal-friendly investigation techniques. Organ-on-chip technologies, not only qualifying for higher regulatory standards, are also ethically warranted, since they can promote a paradigm shift towards more human and scientifically advanced research techniques. This ethical standpoint is getting an increasing role in wider approval for organ-on-chip devices to be used in research and development.
IMARC Group provides an analysis of the key trends in each segment of the market, along with forecasts at the global, regional, and country levels for 2024-2032. Our report has categorized the market based on offering, type, application, and end use.
Products
Services
The report has provided a detailed breakup and analysis of the market based on the offering. This includes products and services.
Liver
Heart
Lung
Kidney
Others
Lung holds the largest share of the industry
A detailed breakup and analysis of the market based on the type have also been provided in the report. This includes the liver, heart, lung, kidney, and others. According to the report, lung accounted for the largest market share.
According to the organ-on-chip market trend, the lung-on-chip is the most expanded due to its high application in respiratory studies and drug discovery. This technology is suitable for modeling the complex structure and function of the human lung to provide a dynamic platform for respiratory diseases, drug response evaluation, and inhaled substances toxicity assessment. Its role in the process of speeding up the development of personalized therapies for different lung diseases, such as asthma and chronic obstructive pulmonary disorder (COPD), is truly emphasized. Lung-on-chip model leads to a more reliable and ethical replacement of animal testing, hence the assurance of drug efficacy and safety to the authorities, which is a prerequisite for successful market entry. This shifts drug discovery and biotechnology to the leadership role in this area, continuing and increasing the organ-on-chip market share.
Physiological Model Development
Drug Discovery
Toxicology Research
Drug discovery represents the leading market segment
The report has provided a detailed breakup and analysis of the market based on the application. This includes physiological model development, drug discovery, and toxicology research. According to the report, drug discovery represented the largest segment.
As per the organ-on-chip market overview, drug discovery is the largest segment for all phases of drug development. This is because the segment has such a key transforming way of developing the processes of pharmaceutical products. Organ-on-chip systems can mimic human organs' responses under various conditions in a way that otherwise would be impossible, allowing scientists to do early screenings for a prospective drug. This ability of the computer successfully enables us to estimate how those drugs will be affected by the human tissues, which in turn creates a step in the right direction of the efficacy and safety test process. It therefore follows that the drug discovery time frame is greatly shortened, and the clinical trial costs and risk become lower. The broadening utilization of these technologies by a pharmaceutical company indicates a great opportunity in this area to make drug hunting faster but not only, less costly and in line with better regulatory requirements for safety and effectiveness.
Pharmaceutical and Biotechnology Companies
Academic and Research Institutes
Cosmetics Industry
Others
Pharmaceutical and biotechnology companies exhibit a clear dominance in the market
A detailed breakup and analysis of the market based on the end use have also been provided in the report. This includes pharmaceutical and biotechnology companies, academic and research institutes, cosmetics industry, and others. According to the report, pharmaceutical and biotechnology companies accounted for the largest market share.
The pharmaceutical and biotechnology companies account for the largest market share. This superiority is mainly caused by the increased usage of micro-organ models in the drug discovery and development phases of these industries. The organ-on-chip companies use technology to copy human body functions and its responses to a higher level than conventional methods which use animal experimenting and 2D cell cultures. Improved capacities to match human organ functions and interact in a laboratory setting provide better detection of drug efficacy and toxicity at an early stage of development. It not only improves the prospects of success in the clinical trials but also decreases the time and cost involved in the process of commercialization of a new drug. Being that pharmaceutical and biotechnology company are constantly in search of inventive ways that will accelerate the research and development process, the utilization of organ-on-chip technologies is anticipated to keep increasing, therefore making this segment the largest one in the market and creating a positive organ-on-chip market outlook.
North America
United States
Canada
Asia-Pacific
China
Japan
India
South Korea
Australia
Indonesia
Others
Europe
Germany
France
United Kingdom
Italy
Spain
Russia
Others
Latin America
Brazil
Mexico
Others
Middle East and Africa
North America leads the market, accounting for the largest organ-on-chip market share
The report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa. According to the report, North America represents the largest regional market for organ-on-chip.
According to the organ-on-chip market report, the largest segment here is North America. This superiority comes from a strong research infrastructure, good funding of the biotechnology and pharmaceutical industry, and the exemplary support given to innovative healthcare solutions by the government and the private sector North American confident leadership in the market is further fortified by the existence of leading universities and research institutions that always drive the frontiers of the medical fieldwork with the Increasing organ-on-chip demand in technologies. Other than that, the area fosters an already existing regulatory framework that provides high adoption opportunities of cutting-edge tools for drug development and personalized medicine which include organ-on-chip. The dominance of these economic entities is what pushes other players to innovate the development and deployment of such technologies contribute to the regional prominence in the global market. This active and advanced veterinary system provides organ-on-chip market growth models which makes these models in use in medical research and pharmaceutical testing.
Allevi Inc.
Altis Biosystems
AxoSim
BiomimX S.r.l.
Elveflow
Emulate Inc.
InSphero
MIMETAS
Nortis Inc.
TARA Biosystems Inc.
TissUse GmbH
(Please note that this is only a partial list of the key players, and the complete list is provided in the report.)
Major players in the organ-on-chip industry keep improving and broadening their technological arsenals by different means, including research and development, cooperation, and mergers and acquisitions. According to organ-on-chip recent developments businesses aim to develop more specific and versatile organ-on-chip models capable of simulating human physiology more precisely for drug testing and disease modeling. The pragmatic cooperation is responsible for the quick product commercialization of new technologies in addition to broadening the microfluidic systems' application scope in personalized medicine, safety pharmacology, and complex biological research, which consequently fortifies their market positions. According to the organ-on-chip market forecast, strategic collaborations with pharmaceutical companies, academic institutions, and technology providers are creating a positive outlook for the market.
On March 7, 2023, Allevi, a pioneer in 3D bioprinting, adopted this transformative technology for its ability to accurately mimic human biological systems in animal-free research. Its expanding applications in drug discovery, regenerative and translational medicine, and preclinical research highlight the significant potential of this platform.
On January 23, 2024, CN Bio and Altis Biosystems partnered to create an advanced human Gut/Liver in vitro model for improved ADME studies, leveraging their organ-specific expertise for more accurate predictions. This next-generation Organ-on-a-Chip solution is available early through CN Bio's Contract Research Services.
On October 24, 2023, AxoSim, Inc., a leader in biomimetic human drug discovery platforms for neurological diseases, has completed its acquisition of microBrain(TM) assets from Vyant Bio's StemoniX subsidiary. This move enhances AxoSim's capabilities in advancing neurological research.