miRNAの進歩：技術評価

RNAを用いた治療・診断に関する研究の加速とヒトゲノム解読技術の進歩により、生物学的経路におけるmiRNAの役割がより深く理解され、治療・診断の両分野での可能性が高まっています。miRNA診断薬の臨床検証が成功したことで、miRNA診断薬メーカーにはいくつかの機会が生まれました。miRNAが循環型バイオマーカーとして機能することで、体液からの診断が可能になります。甲状腺癌、乳癌、卵巣癌などの疾患の特定におけるmiRNAバイオマーカーの可能性が模索されています。miRNA診断薬はさらに成長し、ポイントオブケア診断薬として有望視されています。

当レポートでは、miRNA治療薬および診断薬の開発に焦点を当てます。miRNA研究への関心を高める要因や、miRNA治療薬・診断薬の商業化に影響を与える要因も明らかにしながら、miRNA技術企業にとっての新たな機会についても考察し、業界関係者や利害関係者の投資見通しをまとめています。

目次

戦略的インペラティブ

• 成長がますます困難になるのはなぜか、戦略的インペラティブ8（TM）：miRNA技術成長促進要因
• 戦略的インペラティブ
• miRNA業界に対する上位3つの戦略的インペラティブの影響
• 成長の機会が成長パイプラインエンジンを加速させる

成長機会分析

• 分析範囲
• セグメンテーション
• 成長促進要因
• 成長抑制要因

miRNA治療薬情勢の評価：イントロダクション

miRNA治療薬情勢の評価：用途

miRNA治療情勢の評価：デリバリーと安定性

miRNA診断情勢の評価：イントロダクション

miRNA診断情勢の評価：用途

miRNAの治療と診断の評価：資金調達情勢

成長機会

• 成長機会1：オフターゲット効果と毒性を低減するための標的送達システムの改善
• 成長機会2：疾患全体で循環するバイオマーカーを検出するためのPOC診断法の開発
• 成長機会3：プレシジョンメディシンのコンパニオン診断

付録

次のステップ

Developments in miRNA sequencing and analysis are driving future growth potential in therapeutics and diagnostics

Accelerated research around RNA-based therapeutics and diagnostics, accompanied by technology advancements in sequencing the human genome, has resulted in a better understanding of the role of miRNA in biological pathways, enhancing its potential in both therapeutics and diagnostics. The successful clinical validation of miRNA diagnostic tests has created several opportunities for miRNA diagnostic companies. The role of miRNAs as circulating biomarkers makes it possible to perform diagnostics from body fluids. The potential of miRNA biomarkers in identifying diseases like thyroid cancer, breast cancer, and ovarian cancer is being explored. miRNA diagnostics is expected to grow further and become prominent in point-of-care diagnostics. The development of miRNA therapeutics has had its challenges with respect to stability and delivery issues. However, newer approaches in the development of antagomiRs (miRNA inhibiting drugs) and agomiRs (miRNA replacement therapy) have shown promising results. miRNA companies have witnessed a highly competitive ecosystem and have been acquired by several larger pharma and diagnostics companies upon their entry into the clinical trial stage.

This study focuses on the developments in miRNA therapeutics and diagnostics. It identifies the factors driving interest in miRNA research as well as those affecting the commercialization of miRNA therapeutics and diagnostics. The report also discusses the emerging opportunities for miRNA technology companies and highlights investment prospects for industry participants and stakeholders.

Table of Contents

Strategic Imperatives

• Why Is It Increasingly Difficult to Grow?The Strategic Imperative 8™: Factors Creating Pressure on miRNA Technology Growth
• The Strategic Imperative 8™
• The Impact of the Top 3 Strategic Imperatives on the Micro Ribonucleic Acid (miRNA) Industry
• Growth Opportunities Fuel the Growth Pipeline Engine™
• Research Methodology

Growth Opportunity Analysis

• Scope of Analysis
• Segmentation
• Growth Drivers
• Growth Restraints

Assessment of miRNA Therapeutics Landscape: Introduction

• Emerging Trends in miRNA Therapeutics and Diagnostics
• Increasing Research in miRNA Therapeutics and Diagnostics
• miRNA Drugs Experiencing Rapid Strides in Clinical Development
• Enablers Accelerating miRNA Research and Commercial Development
• Introduction to miRNA Therapeutics
• miRNA Therapeutics to Address Complex Diseases
• Evolving Approaches in Developing Antagomirs and miRNA Mimics
• Structural Modifications to Increase miRNA Stability

Assessment of miRNA Therapeutics Landscape: Application

• Application of miRNAs in Diseases
• Oncology
• Respiratory Diseases
• Neurology
• Cardiovascular Diseases
• Other Diseases
• Other Diseases
• miRNA Therapeutics in Development by Companies
• Increasing miRNA Research Activities in Academia

Assessment of miRNA Therapeutics Landscape: Delivery and Stability

• Challenges in miRNA Therapeutics
• Important miRNA Therapeutics Delivery Systems
• Comparison of miRNA Delivery Systems
• Developing Newer Delivery Systems
• Future Prospects of miRNA Therapeutics

Assessment of miRNA Diagnostics Landscape: Introduction

• Introduction to miRNA Diagnostics
• Benefits of miRNA Diagnostics
• Opportunities for Using miRNA in Diagnostics
• Emerging Developments in miRNA Diagnostics

Assessment of miRNA Diagnostics Landscape: Application

• Oncology
• Neurological Diseases
• Cardiovascular and Other Diseases

Assessment of miRNA Therapeutics & Diagnostics: Funding Landscape

• M&A miRNA Therapeutics
• M&A miRNA Diagnostics
• Funding Landscape of miRNA companies
• miRNA-Important Takeaways
• miRNA-Important Takeaways

Growth Opportunity Universe

• Growth Opportunity 1: Improved Targeted Delivery Systems to Reduce Off-target Effects and Toxicity
• Growth Opportunity 1: Improved Targeted Delivery Systems to Reduce Off-target Effects and Toxicity (continued)
• Growth Opportunity 2:Development of POC Diagnostics to Detect Circulating Biomarkers Across Diseases
• Growth Opportunity 2: Development of POC Diagnostics to Detect Circulating Biomarkers Across Diseases (continued)
• Growth Opportunity 3: Companion Diagnostics for Precision Medicine
• Growth Opportunity 3: Companion Diagnostics for Precision Medicine (continued)

Appendix

• Technology Readiness Levels (TRL): Explanation
• Funding Landscape for miRNA Therapeutics
• Funding Landscape for miRNA Therapeutics (continued)
• Funding Landscape for miRNA Diagnostics

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