市場調査レポート
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プロテオミクスの世界市場-2023年~2030年Global Proteomics Market - 2023-2030 |
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プロテオミクスの世界市場-2023年~2030年 |
出版日: 2023年09月27日
発行: DataM Intelligence
ページ情報: 英文 195 Pages
納期: 約2営業日
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プロテオミクス市場の動向は、技術進歩や調査研究の増加に起因する研究の上昇を示しています。さらに、承認された機器の利用可能性の上昇、市場におけるがん患者数の増加、研究開発の増加によるプロテオミクスへの応用の高まりが、プロテオミクス市場規模を押し上げています。
この分野での進歩の高まりにより、北米からの治療需要が伸びています。Thermo Fisher Scientific Inc.、Danaher、Agilent Technologies, Inc.、Merck KGaAのような主要な競合企業が市場で活発に活動しているため、市場は今後成長すると思われます。
プロテオミクス技術は現在、分子医学、特にバイオマーカーの同定に広く応用されています。プロテオミクスは、体液中の世界なタンパク質プロファイリングを評価することで、重要な疾患特異的バイオマーカーを見つけることができます。健康なサンプルと疾患に罹患したサンプルのタンパク質発現プロファイルを対比することで、プロテオミクスの発現はバイオマーカーの同定を可能にします。バイオマーカーを見つける最も簡単な方法は2D-PAGEで、腫瘍組織や体液を含む健康なサンプルと病気のサンプルのタンパク質プロファイルを比較します。
疾患特異的バイオマーカーは、その情報から、予後バイオマーカー、診断バイオマーカー、治療予測バイオマーカーに分類されます。疾患関連バイオマーカーとして作用する可能性のあるタンパク質や、疾患の経過に関与する可能性のあるタンパク質は、プロテオミクスを使って見つけることができます。質量分析によって発見されたバイオマーカーは、バイオインフォマティクス解析によって処理され、他の集団で再現される必要があります。
残念なことに、プロテオミクス技術を利用して明らかになったバイオマーカーのうち、関心が高まり、治験の負担が重くなり、かなりのレベルの論文が発表されたにもかかわらず、最終的にバリデーションが行われ、臨床現場での使用がFDAによって認可されたものは僅かでした。同市場は、調査研究の活発化により、予測期間を通じて主導権を握ると予測されています。
長年の研究の結果、多くの大手メーカーや組織が、プロテオミクスでより多くの知識を得たり、いくつかの病気を治療したりするために、いくつかの製品を開発したり研究したりしており、これがプロテオミクス市場の拡大を促進しています。革新的な創薬のためにプロテオミクスを研究している研究者は、重要な利害関係者がパートナーシップや共同研究を通じてこの分野を成長・発展させているため、大きなチャンスに恵まれています。例えば、プロテオミクスのワークフローは、トランスレーショナルリサーチに加えて、シングルセル研究などのアプリケーションのために、スループット、完全性、品質の面で強化されています。
サーモフィッシャーサイエンティフィック社の2021年11月の発表によると、サーモフィッシャー社は最近、次世代プロテオミクスソリューションのイノベーターであるBiognosys社との共同マーケティング契約を更新しました。このような研究協力は、プロテオミクスの高度な研究を通じて、より良い治療を提供するのに役立つでしょう。
評価の複雑さ、サンプルの処理方法の一貫性のなさ、重大な偽陽性の可能性、低タンパク質存在量の計算を制限するサンプルのばらつき、解析ソフトウェアの独自性による利用不可能性、シグナルとノイズの間の閾値を決定することの難しさ、厳密な統計的適用の欠如、タンパク質の障害無視、シグナル抑制。
バイオマーカーにおけるプロテオミクスにも限界があり、特にがんにおいては、患者の不均一性がバイオマーカー同定の主な障害の1つであることに言及すべきです。血漿タンパク質の動的多様性が膨大であること、血漿中の重要なバイオマーカーの存在量が限られていること、あるいは患者のばらつきがあることなどが、血漿プロテオミクスを利用したバイオマーカー同定を困難にしています。プロテオミクス技術の発展にもかかわらず、現在の1つの方法では、血漿プロテオームから新しいバイオマーカーを見つける過程で、前述の困難を同時に克服することはまだできません。これらの要素は、市場の拡大を制限する可能性があります。
The proteomics market trends show rising research owing to the rising technological advancements and research studies. Furthermore, rising application for proteomics due to the rising availability of approved instruments and increase in the number of cancer cases in the market, and an increase in the research and development is driving up the proteomics market size.
The market is experiencing a growth in demand for treatment from North America as a result of the rising advancements in this field. With significant competitors like Thermo Fisher Scientific Inc., Danaher, Agilent Technologies, Inc., and Merck KGaA actively operating in the market, the market will grow in upcoming time.
Proteomics technology is currently widely applied in molecular medicine, particularly for the identification of biomarkers. Proteomics can find significant disease-specific biomarkers by evaluating a global protein profiling in bodily fluids. By contrasting the protein expression profiles of healthy samples with those affected by disease, expression of proteomics enables the identification of biomarkers. The simplest method for finding biomarkers is 2D-PAGE, in which the protein profiles of healthy and sick samples, including tumor tissues and bodily fluids, are compared.
According to the information they provide, disease-specific biomarkers can be classified as prognostic, diagnostic, and treatment-predictive biomarkers. Proteins that may act as disease-associated biomarkers or be implicated in the course of disease can be found using proteomics. After being discovered by mass spectrometry, biomarkers need to be processed using bioinformatics analysis and replicated in other populations.
Unfortunately, only a few of the biomarkers revealed utilizing proteomics technology were ultimately validated and authorized by the FDA for use in clinical settings despite the increased interest, heavy investigational burdens, and a substantial level of publications. The market is predicted to take the lead throughout the forecast period owing to high research studies.
As a result of years of study, a number of major manufacturers or organizations are now developing or studying several products for their usage in proteomics to gain more knowledge and treat several diseases, which is promoting the expansion of the proteomics market. Researchers looking into proteomics for innovative drug discovery have a big opportunity due to the growth and development of the field by important stakeholders through partnerships or collaborations. Proteomics workflows, for instance, have been enhanced in terms of throughput, completeness, and quality for applications like single-cell studies in addition to translational research.
According to a November 2021 announcement from Thermo Fisher Scientific Inc., Thermo Fisher recently renewed their collaborative marketing contract with Biognosys, an innovator of next-generation proteomics solutions, in order to provide laboratories executing high-throughput plasma studies with cutting-edge or streamlined kits, instruments, and software for developing precise and effective workflows at scale. Such research collaborations may help in providing better treatments via high study on proteomics.
The evaluation's complexity, the inconsistent way samples are processed, the potential for significant false positives, the sample's variability restricting the low protein abundance calculation, the analysis software's propriety making it unavailable, the difficulty in determining the threshold between signal and noise, the lack of rigorous statistical application, protein hindrance ignorance, and signal suppression.
Proteomics in biomarker also has its limitations and it should be mentioned that patient heterogeneity is one of the main obstacles to biomarker identification, particularly in cancer. The vast dynamic variety of plasma proteins, limited abundance of important biomarkers in plasma, or patient variability provide difficulties for biomarker identification utilizing plasma proteomics. Despite the development of proteomic techniques, the current one method cannot yet simultaneously overcome the aforementioned difficulties in the process of finding new biomarkers in the plasma proteome. These elements can limit the market's expansion.
The global proteomics market is segmented based instrumentation technology, application, services and software, end user and region.
The drug discovery category from application held the largest market share in 2022 and is expected to maintain its dominance over the forecast period due to a growth in proteomics worldwide. Proteomics research based on MS has increased its influence during the past several years across practically all scientific disciplines. Because finding new drugs is a costly and complex process, newer technologies like proteomics can help and speed up the discovery process. Each new medicine candidate's discovery is thought to cost $70 million.
Drug development involves multiple stages and is a multidisciplinary field that makes use of system biology, genetics, proteomics, and metabolomics. Proteomics is important in the target identification phase. Studies on proteomics are helpful for examining medication activity, toxicity, resistance, and efficacy. Proteomics-based methodologies are more favorable than genomics, despite the fact that genomics is particularly useful in the drug development process, for a number of reasons.
The transcriptome stage is the only one to which genomics can convey biological events, and gene expression profiles are not indicative of protein expression. Therefore, the majority of research focuses on proteomics studies that quantitatively assess proteins and associated post-translational modifications (PTMs).
North America Accounted for Approximately 37.5% of the Market Share in 2022, Owing to the Strong Presence of Major Players and Increasing Healthcare Infrastructure Investment
Due to the rising need for proteomics in healthcare, manufacturers in North America have chances of increasing their operations. There are many producers and suppliers in North America and owing to the quick economic growth of the region, industrial production has expanded, driving the demand for application for proteomics.
Increasing expenditure on healthcare and rising research studies, advancement of technologies for treatment of diseases, and increase in pharmaceutical and biotechnology business establishment across the region are also contributing to the growth of proteomics market share of this region.
It is also anticipated that the main healthcare organizations' and enterprises' collaborative research projects as well as new product development, which constantly seeks to improve available alternatives, will contribute to the expanding demand. Individuals are becoming more aware of various instrumentation technologies and application for proteomics that are being utilized for management purposes, leading to the expansion of the market in this region. The above-mentioned factors further proves the dominance of North America on a global scale.
The major global players in the proteomics market include Thermo Fisher Scientific Inc., Danaher, Agilent Technologies, Inc., Bio-Rad Laboratories, Inc., Bruker, Merck KGaA, Promega Corporation, Waters Corporation, PerkinElmer Inc. and Panacea Biotec among others.
Due to the low prevalence as well as absence of major market participants in this region, it is predicted that the Russia-Ukraine conflict will not have a significant effect on the worldwide proteomics market. The growth of the global proteomics market, however, is anticipated to be relatively unaffected by the import and export of raw materials over the forecast period.
The global proteomics market is going to see decent growth in upcoming years owing to rising usage of proteomics and novel instruments/product launches. Several researches are taking place worldwide for treatment of cancer. Numerous advances are taking place leading to the growth of market such as biomarkers. According to DMI the proteomics market will see a decent growth with several novel treatments in the market.
The global proteomics market report would provide approximately 53 tables, 54 figures and 195 Pages.
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