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表紙：アポトーシスアッセイの世界市場-2023年～2030年
市場調査レポート
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1348005

アポトーシスアッセイの世界市場-2023年～2030年

Global Apoptosis Assays Market - 2023-2030
出版日: | 発行: DataM Intelligence | ページ情報: 英文 186 Pages | 納期: 約2営業日

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アポトーシスアッセイの世界市場-2023年～2030年
出版日: 2023年09月11日
発行: DataM Intelligence
ページ情報: 英文 186 Pages
納期: 約2営業日
ご注意事項 :
本レポートは最新情報反映のため適宜更新し、内容構成変更を行う場合があります。ご検討の際はお問い合わせください。
  • 全表示
  • 概要
  • 目次
概要

概要

アポトーシスアッセイは、カスパーゼ活性化、ホスファチジルセリン（PS）の細胞表面露出、DNA断片化など、プログラムされた細胞死に関連する細胞イベントを検出し、定量します。細胞アポトーシスは、アネキシンV、カスパーゼ、TUNEL DNA断片化アッセイを用いてプログラムされた細胞死を検出・評価します。

細胞ベースのアッセイは、アポトーシスのタイムラインにわたる特定の細胞死プロセスを検出します。アポトーシスアッセイキットと試薬は、細胞のライフサイクルの自然な一部であるプログラム細胞死の調査に利用できます。

市場力学

革新的なアポトーシスアッセイキットの増加が市場成長を牽引すると予想される

アポトーシスアッセイキットは、アポトーシス細胞、壊死細胞、健常細胞を同時にモニターするように設計されています。革新的なアポトーシスキットは高度な技術と技術的手順を提供し、調査時間を短縮します。このように、これらの要因がキットの需要を増加させ、市場成長を牽引しています。

例えば、2022年12月9日、TransGen社は、フローサイトメトリーまたは蛍光顕微鏡を用いた早期アポトーシス検出のための異なるプローブと色素を用いた4種類のアネキシンV検査キットを発表しました。これらのキットは操作が簡単で、高感度かつ特異的で、細胞の初期アポトーシスを検出するのに適しています。

さらに、2022年9月20日、ナノライブ社は、細胞の健全性、死、アポトーシス、ネクローシスをラベルフリーでプロファイリングするプッシュボタン式の自動化ソリューションであるLIVE細胞死アッセイを販売しました。機械学習（ML）アルゴリズムに基づき、細胞オブジェクトを完全にラベルフリーで生死を分類し、アポトーシス細胞と壊死細胞を区別します。

加えて、新規治療薬の増加や先進治療開発のためのがん研究数の増加が市場成長の促進要因として作用しています。

研究開発に必要な高額の投資が市場成長の妨げになると予想される

抗がん剤の開発コストの高さは、アッセイのコストに影響を与える可能性があります。新薬1種類あたりの平均研究開発費は100万米ドル未満から200万米ドル以上と推定されています。例えば、ジヌツキシマブは小児リスクの神経芽腫の固形化後療法に使用される薬剤で、開発コストは2億7,600万米ドルです。このように、薬剤の開発コストの高さは市場の成長に影響を与える可能性があります。

目次

第1章 調査手法と調査範囲

第2章 定義と概要

第3章 エグゼクティブサマリー

第4章 市場力学

  • 影響要因
    • 促進要因
      • 革新的なアポトーシスアッセイキットの増加
    • 抑制要因
      • 研究開発に必要な高額の投資
    • 機会
    • 影響分析

第5章 産業分析

  • ポーターのファイブフォース分析
  • サプライチェーン分析
  • 価格分析
  • 規制分析
  • ロシア・ウクライナ戦争の影響分析
  • DMIの見解

第6章 COVID-19分析

第7章 製品別

  • アッセイキット
    • DNA断片化アッセイ
    • アネキシンV・細胞透過性アッセイ
    • ミトコンドリアアッセイ
  • 試薬
  • マイクロプレート

第8章 検出技術別

  • フローサイトメトリー
  • 細胞イメージング・顕微鏡
  • 分光光度法
  • その他

第9章 用途別

  • 創薬・医薬品開発
  • 臨床・診断用途
  • 幹細胞研究
  • その他

第10章 エンドユーザー別

  • 病院・診断研究所
  • 製薬・バイオテクノロジー企業
  • 学術・研究機関
  • その他

第11章 地域別

  • 北米
    • 米国
    • カナダ
    • メキシコ
  • 欧州
    • ドイツ
    • 英国
    • フランス
    • イタリア
    • スペイン
    • その他欧州
  • 南米
    • ブラジル
    • アルゼンチン
    • その他南米
  • アジア太平洋
    • 中国
    • インド
    • 日本
    • オーストラリア
    • その他アジア太平洋
  • 中東・アフリカ

第12章 競合情勢

  • 競合シナリオ
  • 市況/シェア分析
  • M&A分析

第13章 企業プロファイル

  • Thermo Fisher Scientific Inc.
    • 企業概要
    • 製品ポートフォリオと説明
    • 財務概要
    • 主な動向
  • Elabscience Biotechnology Inc.
  • Bio-Rad Laboratories
  • Merck KGaA
  • Molecular Devices, LLC.
  • Becton, Dickinson, and Company
  • Bio-Techne Corporation.
  • Promega Corporation.
  • BPS Bioscience Inc.
  • Agilent Technologies, Inc.

第14章 付録

目次
Product Code: CD2191

Overview

Apoptosis assay detects and quantifies the cellular events associated with programmed cell death, including caspase activation, cell surface exposure of phosphatidylserine (PS), and DNA fragmentation. Cellular apoptosis assays to detect programmed cell death using Annexin V, Caspase, and TUNEL DNA fragmentation assays.

Cell-based assays detect specific cell death processes across the apoptotic timeline. Apoptosis assay kits and reagents are available for investigations in programmed cell death, a natural part of the cell's life cycle.

Market Dynamics

Increase in the innovative apoptotic assay kits is expected to drive the market growth

Apoptosis Assay Kit is designed to monitor apoptotic, necrotic, and healthy cells simultaneously. Innovative apoptosis kits offer advanced technologies and technological procedures, which reduces the time in research studies. Thus, these factors increase the demand for the kits, which drives the market growth.

For instance, on December 9, 2022, TransGen introduced 4 Annexin V testing kits with different probes and dyes for early apoptosis detection using flow cytometry or fluorescence microscopy. These kits are easy to operate, highly sensitive and specific, and are suitable for detecting early apoptosis of the cells.

Additionally, on September 20, 2022, Nanolive marketed the LIVE Cell Death Assay, a push button, automated solution for profiling cell health, death, apoptosis, and necrosis, label-free. Based on a machine learning (ML) algorithm, it classifies cellular objects completely label-free as living or dead, distinguishing apoptotic and necrotic cells.

Additionally, the increase in novel therapeutics and the increase in the number of cancer research for developing advanced treatments act as driving factors of the market growth.

High investments required in research and development are expected to hamper the market growth

Higher costs of developing a cancer drug can impact the cost of the assays. It is estimated that the average R&D cost per new drug ranges from less than $1 Million to more than $2 Million per drug. For instance, Dinutuximab, a drug used for post-consolidation therapy for childhood-risk neuroblastoma, costs $276 million to develop. Thus, the high cost of developing a drug can affect the market growth.

Segment Analysis

The global apoptosis market is segmented based on product, detection technology, application, end-user, and region.

Flow cytometry holds the largest market share in the global apoptosis assays market

The flow cytometry segment holds a significant position in the apoptosis assay market share due to the efficiency of the technique over the other methods. It is one of the most popular and versatile applications for studying apoptosis. It offers the ability to study large numbers of cells individually rather than in a mixed population, examining simultaneously the expression of many proteins like cell-specific markers and indicators of apoptosis.

It has wide applications in the pharmaceutical industry because it provides a way to understand the drug's mechanism of action in the drug discovery process. To stratify a better target for patients, it is necessary to understand the mechanism of drug action, which flow cytometry does.

On June 3, 2022, BD launched an advanced flow cytometry system that sorts cells based on their inner workings. The new BD FACSDiscover S8 Cell Sorter features the breakthrough BD cell view image technology.

Additionally, it has a variety of applications in research and development. Flow Cytometry detects changes in the plasma and mitochondrial membranes, caspase activity, nuclear condensation, and fragmentation as possible indicators of apoptosis. Flow cytometry allows the study of all aspects of apoptosis, from induction via surface receptors, to late stages where DNA fragmentation occurs. Thus, the above factors allow the usage of a flow cytometer in apoptosis studies. Thus, flow cytometry holds a significant market share.

Geographical Penetration

North America is expected to hold a significant position in the global apoptosis assays market share

An increase in the development of anticancer drugs in the region is expected to hold the region in the dominant market share. Apoptosis assays elucidate the cell death-related events during tumor cell killing by anti-cancer drugs. Apoptosis assays are available for single and multi-time point analysis as well as real-time live-cell imaging. Many anticancer drugs are designed to kill cells by inducing apoptosis.

The increase in the number of cancer cases is influencing the development and launches of new drugs, thus increasing the region's market share. For instance, according to the American Cancer Society, it is estimated that 1.9 million new cancer cases have been diagnosed and 609,360 cancer deaths in the United States in 2022. Thus, increasing the development of drugs for the treatment of cancer.

An increase in the development and approvals of anticancer drugs increases apoptosis studies to evaluate the mechanism of the drug. For instance, on September 2, 2022, the FDA approved durvalumab in combination with gemcitabine and cisplatin for adult patients with locally advanced or metastatic biliary tract cancer. Thus, the number of anticancer drug approvals is expected to hold the region in the dominant position in the apoptosis assays market

COVID-19 Impact Analysis

COVID-19 has impacted the growth of the apoptosis assays market. The shift of focus to research and developing novel products for treating COVID-19 has created a negative impact on the apoptosis assays market growth. The delay in approvals of the kits has also affected the market growth. The delay in drug discovery has also impacted the apoptosis assays market.

Market Segmentation

By Product

  • Assay Kits
    • Caspase assays
    • DNA Fragmentation Assays
    • Annexin V and Cell Permeability Assays
  • Mitochondrial Assays
    • Reagents
    • Microplates

By Detection Technology

  • Flow Cytometry
  • Cell Imaging and Microscopy
  • Spectrophotometry
  • Others

By Application

  • Drug Discovery and Development
  • Clinical and Diagnostic Applications
  • Stem Cell Research
  • Others

By End-User

  • Hospital & Diagnostic Laboratories
  • Pharmaceutical & Biotechnology Companies
  • Academic & Research Institutes
  • Others

By Region

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Rest of Europe
  • South America
    • Brazil
    • Argentina
    • Rest of South America
  • Asia-Pacific
    • China
    • India
    • Japan
    • Australia
    • Rest of Asia-Pacific
  • Middle East and Africa

Competitive Landscape

The global apoptosis assays market is fragmented, with the presence of many local and international players. Thermo Fisher Scientific Inc., Elabscience Biotechnology Inc., Bio-Rad Laboratories, Merck KGaA, Molecular Devices, LLC., Becton, Dickinson, and Company, Bio-Techne Corporation., Promega Corporation., BPS Bioscience Inc., and Agilent Technologies, Inc. are the leading companies with a significant market share.

Why Purchase the Report?

  • To visualize the global apoptosis assays market segmentation based on product, detection technology, application, end-user, and region, as well as understand key commercial assets and players.
  • Identify commercial opportunities by analyzing trends and co-development.
  • Excel data sheet with numerous data points of apoptosis assays market-level with all segments.
  • PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
  • Product mapping available as excel consisting of key products of all the major players.

The global apoptosis assays market report would provide approximately 59 tables, 70 figures, and 186 Pages.

Target Audience 2023

  • Manufacturers/ Buyers
  • Industry Investors/Investment Bankers
  • Research Professionals
  • Emerging Companies

Table of Contents

1. Methodology and Scope

  • 1.1. Research Methodology
  • 1.2. Research Objective and Scope of the Report

2. Definition and Overview

3. Executive Summary

  • 3.1. Snippet by Product
  • 3.2. Snippet by Detection Technology
  • 3.3. Snippet by Application
  • 3.4. Snippet by End-User
  • 3.5. Snippet by Region

4. Dynamics

  • 4.1. Impacting Factors
    • 4.1.1. Drivers
      • 4.1.1.1. Increase in the innovative apoptotic assay kits
    • 4.1.2. Restraints
      • 4.1.2.1. High investments required in research and developments
    • 4.1.3. Opportunity
    • 4.1.4. Impact Analysis

5. Industry Analysis

  • 5.1. Porter's Five Force Analysis
  • 5.2. Supply Chain Analysis
  • 5.3. Pricing Analysis
  • 5.4. Regulatory Analysis
  • 5.5. Russia-Ukraine War Impact Analysis
  • 5.6. DMI Opinion

6. COVID-19 Analysis

  • 6.1. Analysis of COVID-19
    • 6.1.1. Scenario Before COVID
    • 6.1.2. Scenario During COVID
    • 6.1.3. Scenario Post COVID
  • 6.2. Pricing Dynamics Amid COVID-19
  • 6.3. Demand-Supply Spectrum
  • 6.4. Government Initiatives Related to the Market During Pandemic
  • 6.5. Manufacturers Strategic Initiatives
  • 6.6. Conclusion

7. By Product

  • 7.1. Introduction
    • 7.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
    • 7.1.2. Market Attractiveness Index, By Product
  • 7.2. Assay Kits *
    • 7.2.1. Introduction
    • 7.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
    • 7.2.3. DNA Fragmentation Assays
    • 7.2.4. Annexin V and Cell Permeability Assays
    • 7.2.5. Mitochondrial Assays
  • 7.3. Reagents
  • 7.4. Microplates

8. By Detection Technology

  • 8.1. Introduction
    • 8.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
    • 8.1.2. Market Attractiveness Index, By Application
  • 8.2. Flow Cytometry *
    • 8.2.1. Introduction
    • 8.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
  • 8.3. Cell Imaging and Microscopy
  • 8.4. Spectrophotometry
  • 8.5. Others

9. By Application

  • 9.1. Introduction
    • 9.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
    • 9.1.2. Market Attractiveness Index, By Application
  • 9.2. Drug Discovery and Development *
    • 9.2.1. Introduction
    • 9.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
  • 9.3. Clinical and Diagnostic Applications
  • 9.4. Stem Cell Research
  • 9.5. Others

10. By End-User

  • 10.1. Introduction
    • 10.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
    • 10.1.2. Market Attractiveness Index, By End-User
  • 10.2. Hospital & Diagnostic Laboratories *
    • 10.2.1. Introduction
    • 10.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
  • 10.3. Pharmaceutical & Biotechnology Companies
  • 10.4. Academic & Research Institutes
  • 10.5. Others

11. By Region

  • 11.1. Introduction
    • 11.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Region
    • 11.1.2. Market Attractiveness Index, By Region
  • 11.2. North America
    • 11.2.1. Introduction
    • 11.2.2. Key Region-Specific Dynamics
    • 11.2.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
    • 11.2.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Detection Technology
    • 11.2.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
    • 11.2.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
    • 11.2.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
      • 11.2.7.1. U.S.
      • 11.2.7.2. Canada
      • 11.2.7.3. Mexico
  • 11.3. Europe
    • 11.3.1. Introduction
    • 11.3.2. Key Region-Specific Dynamics
    • 11.3.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
    • 11.3.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Detection Technology
    • 11.3.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
    • 11.3.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
    • 11.3.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
      • 11.3.7.1. Germany
      • 11.3.7.2. UK
      • 11.3.7.3. France
      • 11.3.7.4. Italy
      • 11.3.7.5. Spain
      • 11.3.7.6. Rest of Europe
  • 11.4. South America
    • 11.4.1. Introduction
    • 11.4.2. Key Region-Specific Dynamics
    • 11.4.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
    • 11.4.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Detection Technology
    • 11.4.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
    • 11.4.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
    • 11.4.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
      • 11.4.7.1. Brazil
      • 11.4.7.2. Argentina
      • 11.4.7.3. Rest of South America
  • 11.5. Asia-Pacific
    • 11.5.1. Introduction
    • 11.5.2. Key Region-Specific Dynamics
    • 11.5.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
    • 11.5.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Detection Technology
    • 11.5.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
    • 11.5.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
    • 11.5.7. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
      • 11.5.7.1. China
      • 11.5.7.2. India
      • 11.5.7.3. Japan
      • 11.5.7.4. Australia
      • 11.5.7.5. Rest of Asia-Pacific
  • 11.6. Middle East and Africa
    • 11.6.1. Introduction
    • 11.6.2. Key Region-Specific Dynamics
    • 11.6.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
    • 11.6.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Detection Technology
    • 11.6.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
    • 11.6.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User

12. Competitive Landscape

  • 12.1. Competitive Scenario
  • 12.2. Market Positioning/Share Analysis
  • 12.3. Mergers and Acquisitions Analysis

13. Company Profiles

  • 13.1. Thermo Fisher Scientific Inc. *
    • 13.1.1. Company Overview
    • 13.1.2. Product Portfolio and Description
    • 13.1.3. Financial Overview
    • 13.1.4. Key Developments
  • 13.2. Elabscience Biotechnology Inc.
  • 13.3. Bio-Rad Laboratories
  • 13.4. Merck KGaA
  • 13.5. Molecular Devices, LLC.
  • 13.6. Becton, Dickinson, and Company
  • 13.7. Bio-Techne Corporation.
  • 13.8. Promega Corporation.
  • 13.9. BPS Bioscience Inc.
  • 13.10. Agilent Technologies, Inc.

LIST NOT EXHAUSTIVE

14. Appendix

  • 14.1. About Us and Services
  • 14.2. Contact Us