頚椎人工椎間板置換装置の世界市場-2023-2030

市場の概要

頚椎人工椎間板置換装置の市場規模は、予測期間（2022-2029年）に20.9%のCAGRで成長しています。

頸椎椎間板置換術（CTDR）装置は、椎間板変性症（DDD）に苦しむ患者を治療する装置です。頸部痛は、頸椎領域におけるDDDの発症の主な原因です。頸椎椎間板置換術は、DDDを治療するために行われ、変性した椎間板を手術で引き抜き、人工椎間板を椎骨に移植するものです。この手術は低侵襲手術であり、術後の回復が早く、入院期間も短く、再手術の割合も低くなっています。

市場力学

頚椎人工椎間板置換装置の世界市場は、頸椎症例の増加、技術の進歩、高齢者人口の急増、装置の品質向上のための研究開発活動の増加、医療費の高騰などによって、牽引されていると考えられます。

頸椎椎間板置換装置の利点の増加が市場成長の原動力

高齢者人口の増加と医療機器の技術的進歩が、予測期間中の市場成長を牽引します。2020年にSpine Journalに掲載された記事の通り、頸椎椎間板置換（CDR）は、退行性障害の治療のための運動温存手術法です。CDRの理論的根拠は、痛みを和らげながら頸部の可動性を維持し、それによって隣接セグメント疾患のリスクを軽減することです。複数のin vitroの研究により、運動温存用インプラントを使用した場合、隣接椎間板の椎間板内圧が減少することが報告されています。

さらに、現在の頚椎椎間板置換術（TDR）のデザインには、ポリエチレン、ステンレス鋼、チタン、コバルトクロム（CoCr）など、様々な生体材料が用いられています。これらの材料は、椎間板腔での関節運動を可能にするベアリングサーフェスとして利用されることが最も重要です。移植された材料の長期的な生物学的影響には、摩耗粉、宿主の炎症性免疫反応、インプラントの不具合をもたらす骨溶解が含まれます。

市場関係者は、頸椎椎間板置換装置を提供しています。例えば、メドトロニック社製のプレステージLP頚椎椎間板のような人工椎間板は、隣接する2つの頚椎の間に配置され、病気の頚椎椎間板を置き換えます。この人工椎間板は、隣接する2つの頚椎の間の距離を維持するように設計されています。プレステージLP頚椎椎間板2枚は、隣り合っている2つの病気の頚椎椎間板の代わりとなり、手術が必要です。

頸椎椎間板置換術に伴うリスクが市場成長の妨げとなる

しかし、頸椎椎間板は、重要な神経や血管の近くに挿入されます。医療従事者はこれらの神経や血管を慎重に探し、保護しますが、手術の際に神経や血管を傷つける可能性があります。血管は少し切っただけで出血し、死に至ることもあります。神経を傷つけると、長期的に運動（麻痺）や感覚が失われる可能性があります。

COVID-19の影響分析

COVID-19の登場は、世界の頚椎人工椎間板置換装置市場に大きな影響を与えました。2022年7月にWorld Neurosurgeryに掲載された記事によると、2020年第2四半期にElective surgeryが激減しました。パンデミック中に手術を受けた患者は合併症の負担が大きく、合併症と死亡率の合計が増加しました。選択的脊椎手術の中止の影響は、米国および世界中の患者と脊椎外科医の両方が感じていました。

外科医の観点からは、予測される症例のバックログが回復するのに16ヶ月もの時間がかかると推定されました。腰椎の選択的手術は、パンデミックの最初の2ヶ月で90%減少しました。脊椎外来予約の3分の2は遠隔医療で占められています。頸椎と腰椎の固定術の手術件数が一貫して増加していることを考えると、米国での選択的な脊椎手術のキャンセルによる経済的な影響も顕著に現れました。これらの手術は、米国で最も費用のかかる手術のひとつに数えられています。

目次

第1章 市場調査手法とスコープ

• 調査手法
• 調査目的および調査範囲

第2章 市場の定義と概要

第3章 エグゼクティブサマリー

第4章 市場力学

• 市場影響要因
  • 促進要因
    • 治療費の低減
    • 保険適用範囲の拡大
  • 抑制要因
    • 規制当局別認可の遅れ
  • ビジネスチャンス
  • 影響分析

第5章 産業分析

• ポーターのファイブフォース分析
• サプライチェーン分析
• 規制分析

第6章 COVID-19の分析

• COVID-19の市場分析
  • COVID-19以前の市場シナリオ
  • COVID-19の現在の市場シナリオ
  • COVID-19の後、または将来のシナリオ
• COVID-19の中での価格ダイナミクス
• 需要-供給スペクトラム
• パンデミック時の市場に関連する政府の取り組み
• メーカーの戦略的取り組み
• まとめ

第7章 ディスクタイプ別

• メタルオンメタル
• メタルオンバイオポリマー

第8章 材料別

• コバルトクロム
• チタン
• ステンレス鋼

第9章 適応症別

• 橈骨神経障害
• 椎弓切除術
• 脊髄症
• その他

第10章 エンドユーザー別

• 病院
• 外来手術センター
• 整形外科・外傷センター

第11章 地域別

• 北米
  • 米国
  • カナダ
  • メキシコ
• 欧州
  • ドイツ
  • 英国
  • フランス
  • イタリア
  • スペイン
  • その他欧州
• 南米
  • ブラジル
  • アルゼンチン
  • その他の南米地域
• アジア太平洋地域
  • 中国
  • インド
  • 日本
  • オーストラリア
  • その他アジア太平洋地域
• 中東・アフリカ地域

第12章 競合情勢

• 主な展開と戦略
• 企業シェア分析
• タイプ別ベンチマーク

第13章 企業プロファイル

• Zimmer Biomet Holdings
  • 企業概要
  • 製品ポートフォリオと説明
  • 主なハイライト
  • 財務概要
• Medtronic Plc
• Depuy Synthes
• NuVasive Inc
• Centinel Spine, Inc.
• Ranier Technology Limited
• Stryker Corporation
• AxioMed LLC
• Orthofix International
• Globus Medical Inc.

第14章 頚椎人工椎間板置換装置の世界市場-DataM

Market Overview

Cervical Total Disc Replacement Device Market size was valued at US$ XX million in 2021 and is estimated to reach US$ XX million by 2029, growing at a CAGR of 20.9% during the forecast period (2022-2029).

Cervical Total Disc Replacement (CTDR) device treats patients suffering from Degenerative Disc Disorders (DDD). Neck pain is the major cause of the development of DDD in the cervical spine region. Cervical disc replacement surgery is performed to treat DDD, where the degenerated disc is withdrawn surgically, and an artificial disc is implanted in the vertebra. This is a Minimal Invasive Surgery and results in quick recovery post-surgery, short hospital stays, and a downward revision surgery rate.

Market Dynamics

The global cervical total disc replacement device market is driven by increasing cases of cervical DDD, technological advancements, surge in geriatric population, increasing research and development activities to inprove the quality of device and rising healthcare expanditure.

Increasing benefits of cervical disc replacement devices drive market growth

The growing geriatric population and technological advancements in medical devices drive the market in the forecast period. As per the article published in Spine Journal in 2020, cervical disc replacement (CDR) is a motion-preserving surgical procedure for treating degenerative disorders. The rationale of CDR is to maintain cervical mobility while relieving pain, thereby reducing the risk of adjacent segment disease. Multiple in vitro studies have reported reduced intradiscal pressures in the adjacent level discs when using motion-preserving implants.

Furthermore, current cervical total disc replacement (TDR) designs incorporate various biomaterials, including polyethylene, stainless steel, titanium, and cobalt-chrome (CoCr). These materials are most important in their utilization as bearing surfaces, allowing for articular motion at the disc space. Long-term biological effects of implanted materials include wearing debris, host inflammatory immune reactions, and osteolysis resulting in implant failure.

The market players are offering cervical disc replacement devices. For instance, an artificial disc, such as the Prestige LP cervical disc produced by Medtronic, is placed between two adjacent cervical vertebrae to replace a diseased cervical disc. It is designed to maintain the distance between two adjacent cervical vertebrae. Two Prestige LP cervical discs replace two diseased cervical discs that are next to each other and require surgery.

The risk associated with cervical total disc replacement surgery will hamper the growth of the market

However, the cervical disc is inserted near important nerves and blood vessels. Healthcare professionals carefully find and protect these nerves and blood vessels, but there is a chance of injury to nerves or blood vessels at the time of the surgery. A little cut to a blood vessel can produce hemorrhage or even death. Injury to a nerve can cause long-term loss of movement (paralysis) or feeling.

COVID-19 Impact Analysis

The appearance of COVID-19 considerably impacted the global cervical total disc replacement device market. As per the article published in World Neurosurgery in July 2022, Elective surgery declined drastically during the second quarter of 2020. Patients undergoing surgery during the pandemic had a higher comorbidity burden, increasing total complication and mortality rates. The ramifications of canceling elective spine surgery were felt by both patients and spine surgeons in the U.S. and worldwide.

From a surgeon's perspective, the projected backlog of cases was estimated to take as long as 16 months to recover. Elective lumbar spine procedures decreased by 90% in the first two months of the pandemic. Telemedicine comprises two-thirds of outpatient spine appointments. The economic effect of canceling elective sp U.S9 ine surgery was also noticeable, given that cervical and lumbar fusion procedural volumes are consistently rising. These procedures rank among some of the most costly surgeries in the United States.

Segment Analysis

The radiculopathy segment is expected to grow at the fastest CAGR during the forecast period (2022-2029)

The radiculopathy segment accounts for the largest market share. Cervical total disc replacement is a routinely used treatment for radiculopathy due to degenerative disease of the cervical spine. The procedure originated to avoid complications seen with the traditional anterior cervical discectomy and fusion.

Cervical radiculopathy is a frequently encountered neurologic condition most often caused by encroachment of a cervical nerve root. It typically presents with neck and arm pain and sometimes sensory loss or loss of motor function in the affected nerve root distribution. The most common cause of cervical radiculopathy is degenerative features, including reduced disc height, osteophyte formation, and disc herniation.

Anterior cervical discectomy and fusion, either as individual implant surgical therapy or with further plating, has been the standard criterion for cervical radiculopathy for decades, and more than 100,000 patients receive this treatment in the US annually. Surgical treatment for cervical radiculopathy is growing in most countries and is projected to rise by more than 10% in the next 20 years.

Geographical Analysis

North America region holds the largest market share of the global cervical total disc replacement device market

North America dominates the cervical total disc replacement device market and is expected to show a parallel trend over the forecast period. The market is driven in the North American region by the increasing geriatric population, active key players, and product launches.

The key players apply market strategies such as acquisition and product launches to expand the business. For instance, in February 2021, NuVasive acquired Simplify Medical, which develops the Simplify Cervical Artificial Disc for cervical total disc replacement (cTDR), valued at $150m. With the acquisition, NuVasive can address all key parts of the cervical spine by providing inclusive, procedurally integrated solutions across anterior cervical discectomy and fusion (ACDF), posterior cervical fusion (PCF), and cTDR procedures.

Also, in April 2021, NuVasive, Inc. announced that the NuVasive Simplify Cervical Artificial Disc (Simplify Disc) received approval from the U.S. Food and Drug Administration for two-level cervical total disc replacement (cTDR). In a two-level FDA Investigational Device Exemption study, the Simplify Disc demonstrated clinical superiority at 24 months compared to anterior cervical discectomy and fusion (ACDF).

Competitive Landscape

The cervical total disc replacement device market is a moderately competitive presence of local and global companies. Some of the key players contributing to the market's growth are Zimmer Biomet Holdings, Medtronic Plc, Depuy Synthes, NuVasive Inc, Centinel Spine, Inc., Ranier Technology Limited, Stryker Corporation, AxioMed LLC, Orthofix International, Globus Medical Inc., among others. The major players are adopting several growth strategies, such as product launches, acquisitions, and collaborations, contributing to the growth of the cervical total disc replacement device market globally.

For instance,

In August 2021, Orthofix Medical launched the M6-C artificial cervical disc compared to anterior cervical discectomy and fusion for the therapy of contiguous two-level symptomatic cervical radiculopathy in the United States.

Zimmer Biomet Holdings

Overview:

Zimmer Biomet is a medical device company founded in 1927 to produce aluminum splints. The headquartered is in Warsaw, Indiana. Zimmer Biomet delivers personalized strategy and tailored solutions so you can manage the pain.

Product Portfolio:

Mobi-C Cervical Disc: The Mobi-C Cervical Disc is developed for cervical disc replacement to repair segmental motion and disc height. The components of Mobi-C include superior and inferior cobalt chromium molybdenum alloy endplates coated with plasma-sprayed titanium and hydroxyapatite coating and a polyethylene mobile bearing insert.

The global cervical total disc replacement device market report would provide access to approximately 60+ market data tables, 60+ figures, and in the range of 200+ (approximate) pages.

Table of Contents

1. Market Methodology and Scope

• 1.1. Research Methodology
• 1.2. Research Objective and Scope of the Report

2. Market Definition and Overview

3. Executive Summary

4. Market Dynamics

• 4.1. Market Impacting Factors
  • 4.1.1. Drivers
    • 4.1.1.1. Lower cost of treatment
    • 4.1.1.2. Increase in the insurance coverage for the devices
  • 4.1.2. Restraints:
    • 4.1.2.1. Slow regulatory Approvals
  • 4.1.3. Opportunity
  • 4.1.4. Impact Analysis

5. Industry Analysis

• 5.1. Porter's Five Forces Analysis
• 5.2. Supply Chain Analysis
• 5.3. Regulatory Analysis

6. COVID-19 Analysis

• 6.1. Analysis of Covid-19 on the Market
  • 6.1.1. Before COVID-19 Market Scenario
  • 6.1.2. Present COVID-19 Market Scenario
  • 6.1.3. After COVID-19 or Future Scenario
• 6.2. Pricing Dynamics Amid Covid-19
• 6.3. Demand-Supply Spectrum
• 6.4. Government Initiatives Related to the Market During Pandemic
• 6.5. Manufacturer's Strategic Initiatives
• 6.6. Conclusion

7. By Disc Type

• 7.1. Introduction
  • 7.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Disc Type
  • 7.1.2. Market Attractiveness Index, By Disc Type
• 7.2. Metal on Metal*
  • 7.2.1. Introduction
  • 7.2.2. Market Size Analysis, US$ Million, 2020-2029 and Y-o-Y Growth Analysis (%), 2021-2029
• 7.3. Metal on Biopolymer

8. By Material

• 8.1. Introduction
  • 8.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Material
  • 8.1.2. Market Attractiveness Index, By Material
• 8.2. Cobalt-Chromium*
  • 8.2.1. Introduction
  • 8.2.2. Market Size Analysis, US$ Million, 2020-2029 and Y-o-Y Growth Analysis (%), 2021-2029
• 8.3. Titanium
• 8.4. Stainless Steel

9. By Indication

• 9.1. Introduction
  • 9.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Indication
  • 9.1.2. Market Attractiveness Index, By Indication
• 9.2. Radiculopathy*
  • 9.2.1. Introduction
  • 9.2.2. Market Size Analysis, US$ Million, 2020-2029 and Y-o-Y Growth Analysis (%), 2021-2029
• 9.3. Laminectomy
• 9.4. Myelopathy
• 9.5. Others

10. By End User

• 10.1. Introduction
  • 10.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
  • 10.1.2. Market Attractiveness Index, By End User
• 10.2. Hospitals*
  • 10.2.1. Introduction
  • 10.2.2. Market Size Analysis, US$ Million, 2020-2029 and Y-o-Y Growth Analysis (%), 2021-2029
• 10.3. Ambulatory Surgical Centers
• 10.4. Orthopedic and Trauma Centers

11. By Region

• 11.1. Introduction
  • 11.1.1. Market Size Analysis, US$ Million, 2020-2029 and Y-o-Y Growth Analysis (%), 2021-2029, By Region
  • 11.1.2. Market Attractiveness Index, By Region
• 11.2. North America
  • 11.2.1. Introduction
  • 11.2.2. Key Region-Specific Dynamics
  • 11.2.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Disc Type
  • 11.2.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Material
  • 11.2.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Indication
  • 11.2.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
  • 11.2.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
    • 11.2.7.1. U.S.
    • 11.2.7.2. Canada
    • 11.2.7.3. Mexico
• 11.3. Europe
  • 11.3.1. Introduction
  • 11.3.2. Key Region-Specific Dynamics
  • 11.3.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Disc Type
  • 11.3.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Material
  • 11.3.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Indication
  • 11.3.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
  • 11.3.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
    • 11.3.7.1. Germany
    • 11.3.7.2. U.K.
    • 11.3.7.3. France
    • 11.3.7.4. Italy
    • 11.3.7.5. Spain
    • 11.3.7.6. Rest of Europe
• 11.4. South America
  • 11.4.1. Introduction
  • 11.4.2. Key Region-Specific Dynamics
  • 11.4.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Disc Type
  • 11.4.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Material
  • 11.4.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Indication
  • 11.4.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
  • 11.4.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
    • 11.4.7.1. Brazil
    • 11.4.7.2. Argentina
    • 11.4.7.3. Rest of South America
• 11.5. Asia Pacific
  • 11.5.1. Introduction
  • 11.5.2. Key Region-Specific Dynamics
  • 11.5.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Disc Type
  • 11.5.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Material
  • 11.5.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Indication
  • 11.5.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User
  • 11.5.7. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
    • 11.5.7.1. China
    • 11.5.7.2. India
    • 11.5.7.3. Japan
    • 11.5.7.4. Australia
    • 11.5.7.5. Rest of Asia Pacific
• 11.6. Middle East and Africa
  • 11.6.1. Introduction
  • 11.6.2. Key Region-Specific Dynamics
  • 11.6.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Disc Type
  • 11.6.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Material
  • 11.6.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Indication
  • 11.6.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End User

12. Competitive Landscape

• 12.1. Key Developments and Strategies
• 12.2. Company Share Analysis
• 12.3. Type Benchmarking

13. Company Profiles

• 13.1. Zimmer Biomet Holdings*
  • 13.1.1. Company Overview
  • 13.1.2. Product Portfolio and Description
  • 13.1.3. Key Highlights
  • 13.1.4. Financial Overview
• 13.2. Medtronic Plc
• 13.3. Depuy Synthes
• 13.4. NuVasive Inc
• 13.5. Centinel Spine, Inc.
• 13.6. Ranier Technology Limited
• 13.7. Stryker Corporation
• 13.8. AxioMed LLC
• 13.9. Orthofix International
• 13.10. Globus Medical Inc.

LIST NOT EXHAUSTIVE

14. Global Cervical Total Disc Replacement Device Market - DataM

• 14.1. Appendix
• 14.2. About Us and Services
• 14.3. Contact Us