表紙:先端巨大症市場 - 市場の洞察、疫学、市場予測:2032年
市場調査レポート
商品コード
1337642

先端巨大症市場 - 市場の洞察、疫学、市場予測:2032年

Acromegaly - Market Insight, Epidemiology And Market Forecast - 2032

出版日: | 発行: DelveInsight | ページ情報: 英文 147 Pages | 納期: 1~3営業日

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先端巨大症市場 - 市場の洞察、疫学、市場予測:2032年
出版日: 2023年08月01日
発行: DelveInsight
ページ情報: 英文 147 Pages
納期: 1~3営業日
  • 全表示
  • 概要
  • 図表
  • 目次
概要

先端巨大症は、成人が罹患するまれな緩徐進行性の後天性疾患です。下垂体から成長ホルモン(GH)が過剰に分泌されます。下垂体は頭蓋骨の底部近くにある小さな腺で、いくつかのホルモンを貯蔵し、身体の必要に応じて血流に放出します。これらのホルモンは、さまざまな身体機能を調節します。ほとんどの患者さんにおいて、先端巨大症は下垂体から発生する良性腫瘍(腺腫)の増殖によって引き起こされます。先端巨大症の症状には、手、腕、足、頭の骨の異常な肥大があります。顎および頭蓋骨の前面の骨の増大は、典型的に最も明らかな骨の変化です。

先端巨大症の一般的な徴候や症状は、手足の肥大です。例えば、以前は合っていた指輪がはめられなくなったり、靴のサイズが徐々に大きくなったりします。また、下あごや眉骨が突出し、鼻が大きくなり、唇が厚くなり、歯の間隔が広がるなど、顔の形が徐々に変化することもあります。先端巨大症はゆっくりと進行するため、初期の徴候が何年もはっきりしないこともあります。古い写真と新しい写真を見比べて初めて身体的変化に気づくこともあります。全体的に、先端巨大症の徴候や症状は人によって異なる傾向があり、手足の肥大、顔面骨、唇、鼻、舌などの顔面の肥大、ザラザラした脂性で厚くなった皮膚、過度の発汗、体臭などがあります。

先端巨大症は、体内の成長ホルモン(GH)の過剰レベルによって引き起こされるまれな疾患です。ほとんどの患者さんでは、GHの過剰値は下垂体の良性(非がん性)腫瘍(下垂体腺腫)によって引き起こされます。ほとんどの腺腫は、ソマトトロープ細胞(GHを正常に分泌する下垂体細胞)と呼ばれる下垂体細胞の過剰な増殖から形成されます。ほとんどの患者において、この疾患は散発性であり、遺伝性の遺伝子変異によるものではありません。

下垂体腺腫で現在使用されている最良のバイオマーカーはKi-67核標識指数です。Ki-67は細胞周期を通じて発現し、MIB-1モノクローナル抗体を用いて日常的に検出されます。このアッセイは有用であるが、完全な信頼性はないです。細胞周期の制御に関与する細胞性腫瘍抗原であるp53もまた、下垂体腺腫を同定する可能性のあるバイオマーカーとして使用されています。

2022年、米国で診断された先端巨大症の有病者総数は27,000例であり、2032年までに増加すると予測されます。欧州4ヶ国と英国は、2022年に21,000例の先端巨大症の診断有病者数を占め、2032年までに増加すると予測されます。日本では、2022年の先端巨大症の腫瘍起源別症例数は、下垂体腫瘍で9,100例、非下垂体腫瘍で480例であり、2032年までに増加すると予測されます。欧州4ヶ国と英国では、2022年の先端巨大症の腫瘍サイズ別症例数は、巨大腺腫が18,300例、微小腺腫が3,050例であり、2032年までに増加するとみられています。

2022年の先端巨大症の市場規模は、米国が主要7ヶ国諸国中最大で7億米ドルでした。欧州4ヶ国カ国のうち、2022年の先端巨大症の市場規模が最も大きいのはドイツで、9,000万米ドルです。欧州4ヶ国カ国の中で最も市場規模が小さいのはスペインで、2022年の市場規模は5,000万米ドルでした。英国における先端巨大症の市場規模は、2022年に1億1,000万米ドルであることがわかっています。

当レポートでは、主要7ヶ国における先端巨大症市場について調査し、市場の概要とともに、疫学、患者動向、新たな治療法、2032年までの市場規模予測、および医療のアンメットニーズなどを提供しています。

目次

第1章 重要な洞察

第2章 レポートのイントロダクション

第3章 先端巨大症市場の概要

第4章 エグゼクティブサマリー

第5章 主要な出来事

第6章 疾患の背景と概要

  • イントロダクション
  • 先端巨大症の原因
  • 先端巨大症の危険因子
  • 先端巨大症の兆候と症状
  • 先端巨大症のバイオマーカー
  • 先端巨大症の臨床症状
  • 先端巨大症の遺伝的背景
  • 先端巨大症の病態生理学
  • 合併症
  • 診断とスクリーニング
  • 治療
  • 治療ガイドライン

第7章 調査手法

第8章 疫学と患者数

  • 主な調査結果
  • 仮定と根拠
  • 主要7ヶ国で診断された先端巨大症の蔓延症例の合計
  • 米国
  • 欧州4ヶ国と英国
  • 日本

第9章 患者動向

第10章 上市済み治療法

第11章 新しい治療法

第12章 先端巨大症:主要7ヶ国市場分析

  • 主な調査結果
  • 市場の見通し
  • 主要な市場予測の前提条件
  • コンジョイント分析
  • 主要7ヶ国における先端巨大症の総市場規模
  • 主要7ヶ国における先端巨大症の市場規模、治療法別
  • 米国の市場規模
  • 欧州4ヶ国と英国の市場規模
  • 日本市場規模

第13章 KOLのビュー

第14章 SWOT分析

第15章 アンメットニーズ

第16章 市場アクセスと償還

  • 米国
  • 欧州4ヶ国と英国
  • 日本

第17章 付録

第18章 DelveInsightのサービス内容

第19章 免責事項

第20章 DelveInsightについて

図表

List of Tables

  • Table 1: Summary of Acromegaly, Market, and Epidemiology (2019-2032)
  • Table 2: Key Events
  • Table 3: Total Diagnosed Prevalent Cases of Acromegaly in the 7MM (2019-2032)
  • Table 4: Total Diagnosed Prevalent Cases of Acromegaly in the United States (2019-2032)
  • Table 5: Tumor Origin-specific Cases of Acromegaly in the United States (2019-2032)
  • Table 6: Gender-specific Cases of Acromegaly in the United States (2019-2032)
  • Table 7: Tumor Size-specific Cases of Acromegaly in the United States (2019-2032)
  • Table 8: Total Diagnosed Prevalent Cases of Acromegaly in EU4 and the UK (2019-2032)
  • Table 9: Tumor Origin-specific Cases of Acromegaly in EU4 and the UK (2019-2032)
  • Table 10: Gender-specific Cases of Acromegaly in EU4 and the UK (2019-2032)
  • Table 11: Tumor Size-specific Cases of Acromegaly in EU4 and the UK (2019-2032)
  • Table 12: Total Diagnosed Prevalent Cases of Acromegaly in Japan (2019-2032)
  • Table 13: Tumor Origin-specific Cases of Acromegaly in Japan (2019-2032)
  • Table 14: Gender-specific Cases of Acromegaly in Japan (2019-2032)
  • Table 15: Tumor Size-specific Cases of Acromegaly in Japan (2019-2032)
  • Table 16: Comparison of Marketed Drugs
  • Table 17: Patent Information
  • Table 18: Comparison of Emerging Drugs Under Development
  • Table 19: Paltusotine (CRN 00808), Clinical Trial Description, 2023
  • Table 20: Efficacy Results of ACROBAT Edge
  • Table 21: Efficacy results of ACROBAT Evolve
  • Table 22: CAM2029 (octreotide subcutaneous depot), Clinical Trial Description, 2023
  • Table 23: Key Market Forecast Assumptions for Paltusotine
  • Table 24: Key Market Forecast Assumptions for CAM2029
  • Table 25: Total Market Size of Acromegaly in the 7MM, in USD million (2019-2032)
  • Table 26: Market Size of Acromegaly by Therapies in the 7MM, in USD million (2019-2032)
  • Table 27: Total Market Size of Acromegaly in the United States, in USD million (2019-2032)
  • Table 28: Market Size of Acromegaly by Therapies in the United States, in USD million (2019-2032)
  • Table 29: Total Market Size of Acromegaly in EU4 and the UK, in USD million (2019-2032)
  • Table 30: Market Size of Acromegaly by Therapies in EU4 and the UK, in USD million (2019-2032)
  • Table 31: Total Market Size of Acromegaly in Japan, in USD million (2019-2032)
  • Table 32: Market Size of Acromegaly by Therapies in Japan, in USD million (2019-2032)

List of Figures

  • Figure 1: Understanding of Acromegaly
  • Figure 2: Comorbidities of Acromegaly
  • Figure 3: Signs and Symptoms of Acromegaly
  • Figure 4: Clinical Manifestations of Acromegaly
  • Figure 5: Genetic Background for Acromegaly
  • Figure 6: Pathophysiology of Acromegaly
  • Figure 7: Complications for Acromegaly
  • Figure 8: Diagnostic Algorithm for Acromegaly
  • Figure 9: Treatment Algorithm for Acromegaly
  • Figure 10: Total Diagnosed Prevalent Cases of Acromegaly in the 7MM (2019-2032)
  • Figure 11: Total Diagnosed Prevalent Cases of Acromegaly in the United States (2019-2032)
  • Figure 12: Tumor Origin-specific Cases of Acromegaly in the United States (2019-2032)
  • Figure 13: Gender-specific Cases of Acromegaly in the United States (2019-2032)
  • Figure 14: Tumor Size-specific Cases of Acromegaly in the United States (2019-2032)
  • Figure 15: Total Diagnosed Prevalent Cases of Acromegaly in EU4 and the UK (2019-2032)
  • Figure 16: Tumor Origin-specific Cases of Acromegaly in EU4 and the UK (2019-2032)
  • Figure 17: Gender-specific Cases of Acromegaly in EU4 and the UK (2019-2032)
  • Figure 18: Tumor Size-specific Cases of Acromegaly in EU4 and the UK (2019-2032)
  • Figure 19: Total Diagnosed Prevalent Cases of Acromegaly in Japan (2019-2032)
  • Figure 20: Tumor Origin-specific Cases of Acromegaly in Japan (2019-2032)
  • Figure 21: Gender-specific Cases of Acromegaly in Japan (2019-2032)
  • Figure 22: Tumor Size-specific Cases of Acromegaly in Japan (2019-2032)
  • Figure 23: Total Market Size of Acromegaly in the 7MM (2019-2032)
  • Figure 24: Market Size of Acromegaly by Therapies in the 7MM, in USD million (2019-2032)
  • Figure 25: Total Market Size of Acromegaly in the United States, in USD million (2019-2032)
  • Figure 26: Market Size of Acromegaly by Therapies in the United States, in USD million (2019-2032)
  • Figure 27: Total Market Size of Acromegaly in EU4 and the UK, in USD million (2019-2032)
  • Figure 28: Market Size of Acromegaly by Therapies in EU4 and the UK, in USD million (2019-2032)
  • Figure 29: Total Market Size of Acromegaly in Japan, in USD million (2019-2032)
  • Figure 30: Market Size of Acromegaly by Therapies in Japan, in USD million (2019-2032)
  • Figure 31: Unmet Needs
  • Figure 32: Health Technology Assessment
  • Figure 33: Reimbursement Process in Germany
  • Figure 34: Reimbursement Process in France
  • Figure 35: Reimbursement Process in Italy
  • Figure 36: Reimbursement Process in Spain
  • Figure 37: Reimbursement Process in the United Kingdom
  • Figure 38: Reimbursement Process in Japan
目次
Product Code: DIMI0018

DelveInsight's 'Acromegaly - Market Insights, Epidemiology, and Market Forecast - 2032' report delivers an in-depth understanding of Acromegaly historical and forecasted epidemiology as well as the Acromegaly market trends in the United States, EU4 (Germany, France, Italy, and Spain), the UK, and Japan.

The Acromegaly market report provides current treatment practices, emerging drugs, market share of individual therapies, and the current and forecasted 7MM Acromegaly market size. The report also covers the Acromegaly procedure, SWOT analysis, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.

Geography Covered:

  • The United States
  • EU4 (Germany, France, Italy, Spain) and the UK
  • Japan

Study Period: 2019-2032

Acromegaly Understanding

Acromegaly Overview

Acromegaly is a rare, slowly progressive, acquired disorder that affects adults. The pituitary gland produces too much growth hormone (GH). The pituitary gland is a small gland located near the base of the skull that stores several hormones and releases them into the bloodstream as needed by the body. These hormones regulate many different bodily functions. In most patients, acromegaly is caused by the growth of a benign tumor (adenoma) arising from the pituitary gland. Symptoms of acromegaly include abnormal enlargement in the hands, arms, feet, legs, and head bones. Enlargement of the bones in the jaws and the front of the skull are typically the most apparent bony changes.

Signs and Symptoms of Acromegaly

Common signs and symptoms of acromegaly are enlarged hands and feet. For example, patients cannot put on rings that used to fit, and the shoe size has progressively increased. It may also cause gradual changes in the face shape, such as a protruding lower jaw and brow bone, an enlarged nose, thickened lips, and wider spacing between the teeth. Because acromegaly progresses slowly, early signs may not be obvious for years. Sometimes, people notice the physical changes only by comparing old photos with newer ones. Overall, acromegaly signs and symptoms tend to vary from one person to another and may include any of the following: enlarged hands and feet, enlarged facial features, including the facial bones, lips, nose, and tongue, coarse, oily, thickened skin, excessive sweating, and body odor.

Causes of Acromegaly

Acromegaly is a rare disorder caused by excess levels of growth hormone (GH) in the body. In most patients, excess levels of GH are caused by a benign (noncancerous) tumor in the pituitary gland (pituitary adenoma). Most adenomas form from the excessive growth of a pituitary cell called a somatotrope cell (the pituitary cell that normally secretes GH). In most patients, the disease is sporadic and not due to an inherited genetic mutation.

Biomarkers of Acromegaly

The best biomarker currently used in Pituitary Adenomas is the Ki-67 nuclear labeling index. It is expressed throughout the cell cycle and routinely detected using the MIB-1 monoclonal antibody. This assay is useful but not perfectly reliable. p53, a cellular tumor antigen involved in cell cycle regulation, has also been used as a possible biomarker for identifying pituitary adenomas.

Continued in the report…

Acromegaly Epidemiology

The epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Diagnosed Prevalent Cases of Acromegaly, Tumor Origin-specific Cases of Acromegaly, Gender-specific Cases of Acromegaly, Tumor Size-specific Cases of Acromegaly covering the United States, EU4 (Germany, France, Italy, Spain), UK and Japan from 2019 to 2032.

Key Findings

  • In 2022, the total diagnosed prevalent cases of Acromegaly in the United States were ~27,000 cases, which are anticipated to increase by 2032.
  • EU4 and the UK accounted for ~21,000 diagnosed prevalent cases of Acromegaly in 2022, which is anticipated to increase by 2032.
  • In Japan, tumor origin-specific cases of Acromegaly were ~9,100 and ~480 for pituitary and non-pituitary tumors, respectively, in 2022, which are likely to increase by 2032.
  • In EU4 and the UK, tumor size-specific cases of acromegaly were ~18,300 and ~3,050 for macroadenomas and microadenomas, respectively, in 2022, which are likely to increase by 2032.

Acromegaly Drug Chapters

Acromegaly Marketed Drugs

MYCAPSSA (octreotide acetate): Amryt Pharma/Chiasma

MYCAPSSA is a somatostatin analog indicated for long-term maintenance treatment in acromegaly patients who have responded to and tolerated treatment with octreotide or lanreotide. It reduces the production of GH by binding to receptors on specialized cells in the pituitary gland. Being administrated orally, these capsules can serve as an alternative to the current standard-of-care injection therapy available for people living with acromegaly today.

Product details in the report…

SIGNIFOR LAR (pasireotide): Recordati/Novartis Pharmaceuticals

Novartis Pharmaceuticals developed SIGNIFOR LAR (pasireotide) as an injectable suspension. It is a long-acting release form of pasireotide pamoate, as a powder to be suspended in the provided diluent immediately before intramuscular injection. SIGNIFOR LAR is a somatostatin analog that consists of pasireotide pamoate uniformly distributed within microspheres which are made of biodegradable copolymers of poly (D, L-lactide-co-glycolide) acids (PLGA), and it is available in a vial containing the sterile pasireotide pamoate.

Products detailed in the report…

Acromegaly Emerging Drugs

Paltusotine (CRN 00808): Crinetics Pharmaceuticals

Paltusotine (CRN 00808), developed by Crinetics Pharmaceuticals, is an oral, selective, nonpeptide, somatostatin receptor type 2 (SST2) agonist with potential growth hormone (GH) secretion-inhibiting and antineoplastic activities. It is designed to reduce excess GH secretion from benign pituitary tumors and normalize IGF-1 levels in patients with acromegaly.

Products detailed in the report…

CAM-2029 (octreotide subcutaneous depot): Camurus AB

CAM2029 is a ready-to-use, long-acting subcutaneous injection depot based on the active substance octreotide formulated with Camurus' proprietary Fluid Crystal injection depot technology. It is provided as a prefilled syringe, thus not requiring reconstitution or conditioning before administration. Due to the superior ease of handling and administration, CAM2029 can conveniently be administered by patients. It was developed for the treatment of acromegaly and neuroendocrine tumors. This drug offers the potential for enhanced treatment efficacy in patients for whom current treatments provide suboptimal treatment effects.

Products detailed in the report…

Acromegaly Market Outlook

Acromegaly can start at any time after puberty. However, it occurs more often in middle age, and people are not always aware of their condition. Changes to the body may take place slowly over many years. Although acromegaly is treatable in most people, as symptoms gradually develop, health problems can develop before the disorder is diagnosed and treated.

The current treatment options include surgery, medicines, and radiation therapy. The treatment goals are to control tumor size, return GH and IGF-I levels to normal, improve symptoms, and manage related health problems. Currently, three types (Somatostatin analogs, dopamine agonists, and growth hormone-receptor antagonists) of medicines are used to treat acromegaly. However, they do not provide a cure for the disease. The medicines may be used alone or in combination with each other. The third treatment option is radiation therapy (stereotactic and conventional), which uses high-energy x-rays or particle waves to kill tumor cells. This type of treatment may be recommended if surgery is impossible or fails to remove all tumor tissue, and medicines are not an option.

However, in the current scenario, the treatment method for acromegaly is focused on preventing the tumor compression of surrounding tissues by excising the diseases causing areas and on reducing GH and IGF-1 levels to normal. Although the primary treatment method for acromegaly is transsphenoidal surgery, not all patients are eligible for surgery. Patients diagnosed with microadenomas and those with macroadenomas not close to other key structures in the brain, such as the nerves supplying the eyes or nearby blood vessels, are recommended for surgery.

Continued in the report…..

Key Findings

  • In 2022, the United States had the largest Acromegaly market size of ~USD 700 million among the 7MM countries.
  • Among the EU4 countries, Germany had the largest market size for Acromegaly in 2022, i.e., ~USD 90 million.
  • The smallest market size among EU4 countries was estimated in Spain, with ~USD 50 million in 2022.
  • The market size of Acromegaly in the UK was found to be ~USD 110 million in 2022.

The United States Market Outlook

This section provides the total Acromegaly market size and market size by therapies in the United States.

EU4 and the UK Market Outlook

The total Acromegaly market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.

Japan Market Outlook

The total Acromegaly market size and market size by therapies in Japan are provided.

Acromegaly Drugs Uptake

This section focuses on the uptake rate of potential drugs recently launched in the Acromegaly market or expected to get launched in the market during the study period 2019-2032. The analysis covers the Acromegaly market uptake by drugs, patient uptake by therapies, and sales of each drug.

This helps in understanding the drugs with the most rapid uptake and reasons behind the maximal use of new drugs and allows the comparison of the drugs based on market share and size, which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Acromegaly Development Activities

The report provides insights into therapeutic candidates in Phase II and III stages. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers collaborations, acquisitions, mergers, licensing, and patent details for Acromegaly emerging therapies.

Reimbursement Scenario in Acromegaly

Approaching reimbursement proactively can positively impact both during the late stages of product development and well after product launch. In the report, we consider reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.

Competitive Intelligence Analysis

We perform competitive market Intelligence analysis of the Acromegaly market using various competitive intelligence tools, including SWOT analysis, market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Report:

  • The report covers a descriptive overview of Acromegaly, explaining its procedure, causes, clinical manifestations, and currently available therapies.
  • Comprehensive insight has been provided into Acromegaly epidemiology and treatment.
  • Additionally, an all-inclusive account of the current and emerging therapies for Acromegaly is provided, along with the assessment of new therapies, which will impact the current treatment landscape.
  • The report includes a detailed review of the historical and forecasted Acromegaly market, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends shaping and driving the 7MM Acromegaly market.

Report Highlights:

  • The pipeline with novel MOA and oral ROA, increasing prevalence, and effectiveness of drugs will positively drive the Acromegaly market.
  • Companies and academics are working to assess challenges and seek opportunities that could influence Acromegaly R&D. The therapies under development focus on novel approaches to treat/improve the disease condition using Acromegaly.
  • Major players are involved in developing therapies for Acromegaly. The launch of emerging therapies will significantly impact the Acromegaly market.
  • Our in-depth analysis of the pipeline assets across different stages of development (Phase III and Phase II), different emerging trends, and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.

Acromegaly Report Insights

  • Patient Population
  • Therapeutic Approaches
  • Acromegaly Pipeline Analysis
  • Acromegaly Market Size and Trends
  • Market Opportunities
  • Impact of Upcoming Therapies

Acromegaly Report Key Strengths

  • 10-Year Forecast
  • The US, EU4 and the UK, and Japan Coverage
  • Acromegaly Epidemiology Segmentation
  • Key Cross Competition
  • Highly Analyzed Market
  • Drugs Uptake

Acromegaly Report Assessment

  • Current Treatment Practices
  • Unmet Needs
  • Pipeline Product Profiles
  • Market Attractiveness
  • SWOT analysis
  • Key Questions

Market Insights:

  • What was the Acromegaly market share (%) distribution in 2019, and what would it look like in 2032?
  • What would be the Acromegaly total market size as well as market size by therapies across the 7MM during the forecast period (2023-2032)?
  • What are the key findings pertaining to the market across the 7MM Coverage, and which country will have the largest Acromegaly market size during the forecast period (2023-2032)?
  • At what CAGR the Acromegaly market is expected to grow at the 7MM Coverage level during the forecast period (2023-2032)?
  • What would be the Acromegaly market outlook across the 7MM Coverage during the forecast period (2023-2032)?
  • What would be the Acromegaly market growth till 2032, and what would be the resultant market size in 2032?
  • How would the market drivers, barriers, and future opportunities affect the market dynamics and subsequent analysis of the associated trends?

Epidemiology Insights:

  • What are the risk, burdens, and unmet needs of Acromegaly?
  • What is the historical Acromegaly patient pool in the United States, EU4 (Germany, France, Italy, Spain) and the UK, and Japan?
  • What would be the forecasted patient pool of Acromegaly at the 7MM Coverage level?
  • What will be the growth opportunities across the 7MM Coverage with respect to the patient population pertaining to Acromegaly?
  • Out of the above-mentioned countries, which country would have the highest cases of Acromegaly during the forecast period (2023-2032)?
  • At what CAGR are these cases expected to grow across the 7MM Coverage during the forecast period (2023-2032)?

Current Treatment Scenario, Marketed Drugs, and Emerging Therapies:

  • What are the current treatment practices in Acromegaly, along with the approved therapy?
  • What are the current treatment guidelines for Acromegaly?
  • What are the Acromegaly marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety, and efficacy, etc.?
  • How many companies are developing therapies for Acromegaly?
  • How many emerging therapies are in the mid-stage and late stages of development for Acromegaly?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, and licensing activities related to Acromegaly therapies?
  • What are the recent novel therapies, targets, mechanisms of action, and technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Acromegaly and their status?
  • What key designations have been granted for the emerging therapies for Acromegaly?

What is the 7MM Coverage historical and forecasted market of Acromegaly?

Reasons to buy:

  • The report will help develop business strategies by understanding trends shaping and driving Acromegaly.
  • To understand the future market competition in the Acromegaly market and an insightful review of the market.
  • Organize sales and marketing efforts by identifying the best opportunities for Acromegaly in the 7MM Coverage.
  • Identifying strong upcoming players in the market will help devise strategies that will help get ahead of competitors.
  • Organize sales and marketing efforts by identifying the best opportunities for the Acromegaly market.
  • To understand the future market competition in the Acromegaly market.

Table of Contents

1. Key Insights

2. Report Introduction

3. Acromegaly Market Overview at a Glance

  • 3.1. Market Share (%) Distribution of Acromegaly by Therapies in 2019
  • 3.2. Market Share (%) Distribution of Acromegaly by Therapies in 2032

4. Executive Summary of Acromegaly

5. Key events

6. Disease Background and Overview

  • 6.1. Introduction
  • 6.2. Causes for Acromegaly
  • 6.3. Risk Factors of Acromegaly
  • 6.4. Signs and Symptoms of Acromegaly
  • 6.5. Biomarkers of Acromegaly
  • 6.6. Clinical Manifestations of Acromegaly
    • 6.6.1. Osteoarticular Manifestations
    • 6.6.2. Cardiovascular Manifestations
    • 6.6.3. Respiratory Manifestations
    • 6.6.4. Endocrinological and Other Manifestations
    • 6.6.5. Gastrointestinal Manifestations
  • 6.7. Genetic Background for Acromegaly
    • 6.7.1. Familial Isolated Pituitary Adenoma
    • 6.7.2. AIP (Aryl Hydrocarbon Receptor Interacting Protein)
    • 6.7.3. Multiple Endocrine Neoplasia Types 1 and 4 (MEN1 and MEN4)
    • 6.7.4. Carney Complex
    • 6.7.5. McCune-Albright Syndrome
    • 6.7.6. GH excess in Neurofibromatosis Type 1
    • 6.7.7. Somatic Changes in Somatotropinomas
  • 6.8. Pathophysiology of Acromegaly
  • 6.9. Complications
    • 6.9.1. Bone Complications from Acromegaly
    • 6.9.2. Soft Tissue Complications from Acromegaly
    • 6.9.3. Pituitary Hormone Deficiencies
    • 6.9.4. Sleep Apnea
    • 6.9.5. Heart Problems
    • 6.9.6. Diabetes
    • 6.9.7. Colon Polyps
  • 6.10. Diagnosis and Screening
    • 6.10.1. Blood tests
    • 6.10.2. Imaging tests
    • 6.10.3. Differential Diagnosis
    • 6.10.4. Diagnostic Algorithm
  • 6.11. Treatment
    • 6.11.1. Surgical Therapy
    • 6.11.2. Medical Agents
    • 6.11.3. Radiotherapy
    • 6.11.4. Management of Acromegaly in Pregnancy
    • 6.11.5. Treatment Algorithm
  • 6.12. Treatment Guidelines
    • 6.12.1. Pituitary Society Acromegaly Management Guidelines
    • 6.12.2. Acromegaly Consensus Group Guidelines 2020
    • 6.12.3. An Endocrine Society Clinical Practice Guideline 2014
    • 6.12.4. American Association of Clinical Endocrinologists Medical Guidelines (AACE)

7. Methodology

8. Epidemiology and Patient Population

  • 8.1. Key Findings
  • 8.2. Assumptions and Rationale
  • 8.3. Total Diagnosed Prevalent Cases of Acromegaly in the 7MM
  • 8.4. The United States
    • 8.4.1. Total Diagnosed Prevalent Cases of Acromegaly in the United States
    • 8.4.2. Tumor Origin-specific Cases of Acromegaly in the United States
    • 8.4.3. Gender-specific Cases of Acromegaly in the United States
    • 8.4.4. Tumor Size-specific Cases of Acromegaly in the United States
  • 8.5. EU4 and the UK
    • 8.5.1. Total Diagnosed Prevalent Cases of Acromegaly in EU4 and the UK
    • 8.5.2. Tumor Origin-specific Cases of Acromegaly in EU4 and the UK
    • 8.5.3. Gender-specific Cases of Acromegaly in EU4 and the UK
    • 8.5.4. Tumor Size-specific Cases of Acromegaly in EU4 and the UK
  • 8.6. Japan
    • 8.6.1. Total Diagnosed Prevalent Cases of Acromegaly in Japan
    • 8.6.2. Tumor Origin-specific Cases of Acromegaly in Japan
    • 8.6.3. Gender-specific Cases of Acromegaly in Japan
    • 8.6.4. Tumor Size-specific Cases of Acromegaly in Japan

9. Patient Journey

10. Marketed Therapies

  • 10.1. Key Cross
  • 10.2. MYCAPSSA (octreotide acetate): Amryt Pharma/Chiasma
    • 10.2.1. Product Description
    • 10.2.2. Regulatory Milestones
    • 10.2.3. Other Developmental Activities
    • 10.2.4. Safety and Efficacy
  • 10.3. SIGNIFOR LAR (pasireotide): Recordati/Novartis Pharmaceuticals
    • 10.3.1. Product Description
    • 10.3.2. Regulatory Milestones
    • 10.3.3. Other Developmental Activities
    • 10.3.4. Safety and Efficacy
  • 10.4. BYNFEZIA PEN (octreotide acetate): Sun Pharma
    • 10.4.1. Product Description
    • 10.4.2. Regulatory Milestones
    • 10.4.3. Other Developmental Activities

11. Emerging Therapies

  • 11.1. Key Cross
  • 11.2. Paltusotine (CRN 00808): Crinetics Pharmaceuticals
    • 11.2.1. Product Description
    • 11.2.2. Other Developmental Activities
    • 11.2.3. Clinical Developmental Activities
    • 11.2.4. Safety and Efficacy
  • 11.3. CAM2029 (octreotide subcutaneous depot): Camurus AB
    • 11.3.1. Product Description
    • 11.3.2. Other Developmental Activities
    • 11.3.3. Clinical Developmental Activities
    • 11.3.4. Safety and Efficacy

12. Acromegaly: Seven Major Market Analysis

  • 12.1. Key Findings
  • 12.2. Market Outlook
  • 12.3. Key Market Forecast Assumptions
  • 12.4. Conjoint Analysis
  • 12.5. Total Market Size of Acromegaly in the 7MM
  • 12.6. Market Size of Acromegaly by Therapies in the 7MM
  • 12.7. The United States Market Size
    • 12.7.1. Total Market Size of Acromegaly in the United States
    • 12.7.2. Market Size of Acromegaly by Therapies in the United States
  • 12.8. EU4 and the UK Market Size
    • 12.8.1. Total Market Size of Acromegaly in EU4 and the UK
    • 12.8.2. Market Size of Acromegaly by Therapies in EU4 and the UK
  • 12.9. Japan Market Size
    • 12.9.1. Total Market Size of Acromegaly in Japan
    • 12.9.2. Market Size of Acromegaly by Therapies in Japan

13. KOL Views

14. SWOT Analysis

15. Unmet Needs

16. Market Access and Reimbursement

  • 16.1. The United States
    • 16.1.1. Centers for Medicare & Medicaid Services (CMS)
  • 16.2. EU4 and the UK
    • 16.2.1. Germany
    • 16.2.2. France
    • 16.2.3. Italy
    • 16.2.4. Spain
    • 16.2.5. United Kingdom
  • 16.3. Japan
    • 16.3.1. MHLW
  • 16.4. MYCAPSSA (octreotide acetate)
  • 16.5. SIGNIFOR LAR (pasireotide)
  • 16.6. Somatuline
  • 16.7. Somavert (pegvisomant)

17. Appendix

  • 17.1. Bibliography
  • 17.2. Report Methodology

18. DelveInsight Capabilities

19. Disclaimer

20. About DelveInsight