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市場調査レポート
商品コード
1652665
妊娠高血圧腎症市場 - 市場の洞察、疫学、市場予測:2034年Preeclampsia - Market Insight, Epidemiology, and Market Forecast - 2034 |
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妊娠高血圧腎症市場 - 市場の洞察、疫学、市場予測:2034年 |
出版日: 2025年01月01日
発行: DelveInsight
ページ情報: 英文 124 Pages
納期: 2~10営業日
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妊娠高血圧腎症は、妊娠20週以降に新たに発症する高血圧と蛋白尿を特徴とする複雑な妊娠障害です。胎盤の機能不全に起因し、全身の内皮の活性化と炎症反応を引き起こし、母体の循環に影響を及ぼすと考えられています。妊娠高血圧腎症は、初産婦、家族歴のある女性、高血圧や糖尿病などの既往症のある女性に多くみられます。
妊娠高血圧腎症の診断は、血圧と尿蛋白を測定する定期的な出生前スクリーニングに基づいており、24時間採尿で140/90mmHg、蛋白尿300mgで確定されます。
2023年5月、Thermo Fisher Scientificは、PIGFとsFlt-1レベルを測定することにより妊娠高血圧腎症のリスクを評価する2つのアッセイのFDA認可を取得しました。BRAHMSのKRYPTORを用いれば30分で測定でき、入院中の妊婦が2週間以内に重症の妊娠高血圧腎症を発症するリスクを評価することができます。
妊娠高血圧腎症の鑑別診断には、抗リン脂質抗体症候群、血栓性微小血管症、ループス腎炎、てんかんまたは発作性疾患、慢性腎疾患、慢性肝疾患、妊娠高血圧症候群、慢性高血圧症などが含まれます。
主要7ヶ国における妊娠高血圧腎症の総診断罹患数は、2024年には334,000人となります。2024年、主要7ヶ国における妊娠高血圧腎症の総市場規模は8,000万米ドルであり、予測期間中に成長が見込まれます。主要7ヶ国では、米国が2024年に7,000万米ドルで最も高い市場収益を占めています。
現在、妊娠高血圧腎症の新興領域はそれほど活発ではなく、開発している企業はわずかで、しかも前臨床段階にあります。最近、Comanche biopharmaのCBP-4888が妊娠高血圧腎症に対するファスト・トラック指定(FTD)を受け、活発化しています。
当レポートでは、主要7ヶ国における妊娠高血圧腎症市場について調査し、市場の概要とともに、疫学、患者動向、新たな治療法、2034年までの市場規模予測、および医療のアンメットニーズなどを提供しています。
Report Summary
Market
A few key players are leading the treatment landscape of Preeclampsia, such as Comanche biopharma, and others. The details of the country-wise and therapy-wise market size have been provided below.
The section dedicated to drugs in the Preeclampsia report provides an in-depth evaluation of pipeline drugs related to Preeclampsia. The drug chapters section provides valuable information on various aspects related to clinical trials of Preeclampsia, such as the pharmacological mechanisms of the drugs involved, designations, approval status, patent information, and a comprehensive analysis of the pros and cons associated with each drug. Furthermore, it presents the most recent news updates and press releases on drugs targeting Preeclampsia.
Currently, there are no effective pharmacological treatments or preventive strategies for preeclampsia. Available therapies primarily focus on controlling hypertension, a secondary consequence of placental dysfunction, rather than addressing the underlying pathophysiology. The optimal management strategy hinges on gestational age and disease severity, balancing maternal safety with fetal viability. As delivery remains the only definitive cure, clinicians must carefully time interventions to minimize risks while ensuring fetal maturation.
Aspirin is the most widely used preventive measure, with evidence suggesting that early initiation before 16 weeks of gestation may mitigate the risk of preeclampsia. However, its efficacy is significantly diminished when started later, underscoring the importance of early risk stratification and intervention.
Preeclampsia Disease Understanding and Treatment
Preeclampsia Overview
Hypertensive disorders of pregnancy constitute a leading cause of maternal and perinatal mortality worldwide. Preeclampsia, with or without severe features, is a disorder of pregnancy associated with new-onset hypertension, usually with accompanying proteinuria, which occurs most often after 20 weeks of gestation and frequently near term. This disease represents a spectrum of hypertensive disease in pregnancy, beginning with gestational hypertension and progressing to develop severe features, ultimately leading to its more severe manifestations, such as eclampsia and HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome. Early diagnosis and prompt management are essential to preventing both maternal and neonatal complications through symptomatic management and delivery planning.
Preeclampsia Diagnosis
Preeclampsia is diagnosed based on the presence of hypertension (systolic BP = 140 mmHg or diastolic BP = 90 mmHg) after 20 weeks of gestation, along with proteinuria (= 300 mg/24 hours or a protein-to-creatinine ratio = 0.3). In the absence of proteinuria, it can still be diagnosed if there are signs of organ dysfunction, such as renal impairment (creatinine > 1.1 mg/dL), elevated liver enzymes, neurological symptoms (e.g., headache, visual disturbances), or thrombocytopenia. Severe preeclampsia is characterized by significantly elevated BP (= 160/110 mmHg), marked proteinuria, or complications like pulmonary edema and organ damage.
Preeclampsia Treatment
To manage high blood pressure, medications like labetalol, nifedipine, or methyldopa may be prescribed. Labetalol is specifically licensed for pregnant women, while the others are used off-label when the benefits outweigh the risks. In severe cases, anticonvulsant medicine may be given to prevent or treat fits. Delivery is typically recommended around the 37th to 38th week, either through induced labor or cesarean section, to minimize complications. If the condition worsens before 37 weeks, earlier delivery may be necessary. Premature birth may pose additional risks for the baby. After delivery, preeclampsia generally improves, but complications can develop in the days following birth. Blood pressure will continue to be monitored, and additional medication may be prescribed if necessary. The baby may require monitoring in a neonatal intensive care unit if born prematurely. Postpartum, the patient will have follow-up appointments to check blood pressure and assess whether ongoing treatment is needed.
The Preeclampsia epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Total Incidence Cases, Total Diagnosed Incidence Cases, Age-specific Cases, Sub-type specific Cases, Severity specific Cases, Treated Cases of Preeclampsia in the United States, EU4 countries (Germany, France, Italy, and Spain) and the United Kingdom, and Japan from 2020 to 2034.
KOL Views
To stay abreast of the latest trends in the market, we conduct primary research by seeking the opinions of Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) who work in the relevant field. This helps us fill any gaps in data and validate our secondary research.
We have reached out to industry experts to gather insights on various aspects of Preeclampsia, including the evolving treatment landscape, patients' reliance on conventional therapies, their acceptance of therapy switching, drug uptake, and challenges related to accessibility. The experts we contacted included medical/scientific writers, professors, and researchers from prestigious universities in the US, Europe, the UK, and Japan.
Our team of analysts at Delveinsight connected with more than 10 KOLs across the 7MM. We contacted institutions such as the National Institute of Child Health and Human Development, St. Joseph's Health Care, University of Milan, Nagoya City University, etc., among others. By obtaining the opinions of these experts, we gained a better understanding of the current and emerging treatment patterns in the Preeclampsia market, which will assist our clients in analyzing the overall epidemiology and market scenario.
Qualitative Analysis
We perform Qualitative and Market Intelligence analysis using various approaches, such as SWOT analysis and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.
Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, designation, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Market Access and Reimbursement
Because newly authorized drugs are often expensive, some patients escape receiving proper treatment or use off-label, less expensive prescriptions. Reimbursement plays a critical role in how innovative treatments can enter the market. The cost of the medicine, compared to the benefit it provides to patients who are being treated, sometimes determines whether or not it will be reimbursed. Regulatory status, target population size, the setting of treatment, unmet needs, the number of incremental benefit claims, and prices can all affect market access and reimbursement possibilities.
The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.