TEPEZZAの市場規模、予測、市場考察（2032年）

薬剤のサマリー

インスリン様成長因子1受容体阻害薬（IGF-1R）であるテプロツムマブは、チャイニーズハムスター卵巣（CHO-DG44）細胞で産生される完全ヒトIgG1モノクローナル抗体で、分子量は約148KDです。

テプロツムマブの代謝は完全には明らかにされていませんが、タンパク質分解による代謝が予測されます。注射用TEPEZZAは、無菌、防腐剤フリー、白色か灰色の凍結乾燥粉末として供給され、静脈注射に使用されます。各単回投与バイアルには、500mgのテプロツムマブ、L-ヒスチジン（7.45mg）、L-ヒスチジン塩酸塩一水和物（31.8mg）、ポリソルベート20（1mg）とトレハロース二水和物（946mg）が含まれます。10mLの滅菌注射用水（USP）で再構成した後、最終濃度は47.6mg/mLで、pHは5.5です。

当レポートでは、主要7市場（米国・ドイツ・フランス・イタリア・スペイン・英国・日本）におけるバセドウ病眼症向けTEPEZZAについて調査分析し、作用機序、用法と用量、研究開発活動についての考察、収益の予測などを提供しています。

目次

第1章 レポートのイントロダクション

第2章 バセドウ病眼症におけるTEPEZZAの概要

• 製品の詳細
• 臨床開発
  • 臨床研究
  • 臨床試験情報
  • 安全性と有効性
• 規制のマイルストーン
• その他の開発活動
• 製品プロファイル

第3章 競合情勢（上市済みの治療法）

第4章 競合情勢（後期の新治療法）

第5章 TEPEZZA市場の評価

• バセドウ病眼症におけるTEPEZZAの市場見通し
• 主要7市場の分析
  • 主要7市場のバセドウ病眼症向けTEPEZZAの市場規模
• 市場の分析：国別
  • 米国のバセドウ病眼症向けTEPEZZAの市場規模
  • ドイツのバセドウ病眼症向けTEPEZZAの市場規模
  • 英国のバセドウ病眼症向けTEPEZZAの市場規模

第6章 SWOT分析

第7章 アナリストの見解

第8章 付録

第9章 DelveInsightのサービス内容

第10章 免責事項

第11章 DelveInsightについて

第12章 レポート購入オプション

List of Tables

• Table 1: TEPEZZA, Clinical Trial Description, 2023
• Table 2: TEPEZZA, General Description
• Table 3: Competitive Landscape (Marketed Therapies)
• Table 4: Competitive Landscape (Late-stage Emerging Therapies)
• Table 5: TEPEZZA Market Size in the 7MM, in USD million (2019-2032)
• Table 6: TEPEZZA Market Size in the US, in USD million (2019-2032)
• Table 7: TEPEZZA Market Size in Germany, in USD million (2019-2032)
• Table 8: TEPEZZA Market Size in France, in USD million (2019-2032)
• Table 9: TEPEZZA Market Size in Italy, in USD million (2019-2032)
• Table 10: TEPEZZA Market Size in Spain, in USD million (2019-2032)
• Table 11: TEPEZZA Market Size in the UK, in USD million (2019-2032)
• Table 12: TEPEZZA Market Size in Japan, in USD million (2019-2032)

List of Figures

• Figure 1: TEPEZZA Market Size in the 7MM, USD million (2019-2032)
• Figure 2: TEPEZZA Market Size in the United States, USD million (2019-2032)
• Figure 3: TEPEZZA Market Size in Germany, USD million (2019-2032)
• Figure 4: TEPEZZA Market Size in France, USD million (2019-2032)
• Figure 5: TEPEZZA Market Size in Italy, USD million (2019-2032)
• Figure 6: TEPEZZA Market Size in Spain, USD million (2019-2032)
• Figure 7: TEPEZZA Market Size in the United Kingdom, USD million (2019-2032)
• Figure 8: TEPEZZA Market Size in Japan, USD million (2019-2032)

"TEPEZZA Market Size, Forecast, and Market Insight - 2032" report provides comprehensive insights about TEPEZZA for Graves' Ophthalmopathy in the seven major markets. A detailed picture of the TEPEZZA for Graves' Ophthalmopathy in the 7MM, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan for the study period 2019 -2032 is provided in this report along with a detailed description of the TEPEZZA for Graves' Ophthalmopathy. The report provides insights about mechanism of action, dosage and administration, as well as research and development including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the TEPEZZA market forecast analysis for Graves' Ophthalmopathy in the 7MM, SWOT, analysts' views, comprehensive overview of market competitors, and brief about other emerging therapies in Graves' Ophthalmopathy.

Drug Summary:

Teprotumumab, an insulin-like growth factor-1 receptor inhibitor (IGF-1R), is a fully human IgG1 monoclonal antibody produced in Chinese hamster ovary (CHO-DG44) cells with a molecular weight of approximately 148 KD.

The metabolism of teprotumumab has not been fully characterized; however, it is expected to undergo metabolism via proteolysis. TEPEZZA for injection is supplied as a sterile, preservative-free, and white to off-white, lyophilized powder for IV infusions. Each single-dose vial contains 500 mg of teprotumumab, L-histidine (7.45 mg), L-histidine hydrochloride monohydrate (31.8 mg), polysorbate 20 (1 mg), and trehalose dihydrate (946 mg). After reconstitution with 10 mL of sterile water for injection, USP, the final concentration is 47.6 mg/mL with a pH of 5.5.

• Dosage and administration

The recommended dose of TEPEZZA is an IV infusion of 10 mg/kg for the initial dose, followed by an IV infusion of 20 mg/kg every 3 weeks for seven additional infusions.

• Mechanism of action

Teprotumumab's mechanism of action in patients with Graves' Ophthalmopathy has not been fully characterized. It binds to IGF-1R and blocks its activation and signaling.

Scope of the Report:

The report provides insights into:

• A comprehensive product overview including the TEPEZZA description, mechanism of action, dosage and administration, research and development activities in Graves' Ophthalmopathy.
• Elaborated details on TEPEZZA regulatory milestones and other development activities have been provided in this report.
• The report also highlights the TEPEZZA research and development activities in Graves' Ophthalmopathy across the United States, Europe and Japan.
• The report also covers the patents information with expiry timeline around TEPEZZA.
• The report contains forecasted sales of TEPEZZA for Graves' Ophthalmopathy till 2032.
• Comprehensive coverage of the late-stage emerging therapies for Graves' Ophthalmopathy.
• The report also features the SWOT analysis with analyst views for TEPEZZA in Graves' Ophthalmopathy.

Methodology:

The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by DelveInsight's team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.

TEPEZZA Analytical Perspective by DelveInsight

• In-depth TEPEZZA Market Assessment

This report provides a detailed market assessment of TEPEZZA for Graves' Ophthalmopathy in the seven major markets, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. This segment of the report provides forecasted sales data from 2024 to 2032.

• TEPEZZA Clinical Assessment

The report provides the clinical trials information of TEPEZZA for Graves' Ophthalmopathy covering trial interventions, trial conditions, trial status, start and completion dates.

Report Highlights:

• In the coming years, the market scenario for Graves' Ophthalmopathy is set to change due to the extensive research and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
• The companies are developing therapies that focus on novel approaches to treat/improve the disease condition, assess challenges, and seek opportunities that could influence TEPEZZA dominance.
• Other emerging products for Graves' Ophthalmopathy are expected to give tough market competition to TEPEZZA and launch of late-stage emerging therapies in the near future will significantly impact the market.
• A detailed description of regulatory milestones, and developmental activities, provide the current development scenario of TEPEZZA in Graves' Ophthalmopathy.
• Our in-depth analysis of the forecasted sales data of TEPEZZA from 2024 to 2032 will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the TEPEZZA in Graves' Ophthalmopathy.

Key Questions:

• What is the product type, route of administration and mechanism of action of TEPEZZA?
• What is the clinical trial status of the study related to TEPEZZA in Graves' Ophthalmopathy and study completion date?
• What are the key collaborations, mergers and acquisitions, licensing and other activities related to the TEPEZZA development?
• What are the key designations that have been granted to TEPEZZA for Graves' Ophthalmopathy?
• What is the forecasted market scenario of TEPEZZA for Graves' Ophthalmopathy?
• What are the forecasted sales of TEPEZZA in the seven major countries, including the United States, Europe (Germany, France, Italy, Spain, and the United Kingdom), and Japan?
• What are the other emerging products available and how are these giving competition to TEPEZZA for Graves' Ophthalmopathy?
• Which are the late-stage emerging therapies under development for the treatment of Graves' Ophthalmopathy?

Table of Contents

1. Report Introduction

2. TEPEZZA Overview in Graves' Ophthalmopathy

• 2.1. Product Detail
• 2.2. Clinical Development
  • 2.2.1. Clinical studies
  • 2.2.2. Clinical trials information
  • 2.2.3. Safety and efficacy
• 2.3. Regulatory Milestones
• 2.4. Other Developmental Activities
• 2.5. Product Profile

3. Competitive Landscape (Marketed Therapies)

4. Competitive Landscape (Late-stage Emerging Therapies)

5. TEPEZZA Market Assessment

• 5.1. Market Outlook of TEPEZZA in Graves' Ophthalmopathy
• 5.2. 7MM Analysis
  • 5.2.1. Market Size of TEPEZZA in the 7MM for Graves' Ophthalmopathy
• 5.3. Country-wise Market Analysis
  • 5.3.1. Market Size of TEPEZZA in the United States for Graves' Ophthalmopathy
  • 5.3.2. Market Size of TEPEZZA in Germany for Graves' Ophthalmopathy
  • 5.3.3. Market Size of TEPEZZA in France for Graves' Ophthalmopathy
  • 5.3.4. Market Size of TEPEZZA in Italy for Graves' Ophthalmopathy
  • 5.3.5. Market Size of TEPEZZA in Spain for Graves' Ophthalmopathy
  • 5.3.6. Market Size of TEPEZZA in the United Kingdom for Graves' Ophthalmopathy
  • 5.3.7. Market Size of TEPEZZA in Japan for Graves' Ophthalmopathy

6. SWOT Analysis

7. Analysts' Views

8. Appendix

• 8.1. Bibliography
• 8.2. Report Methodology

9. DelveInsight Capabilities

10. Disclaimer

11. About DelveInsight

12. Report Purchase Options