市場調査レポート
商品コード
1337645
産後うつ病 - 市場考察、疫学、市場予測(2032年)Postpartum Depression - Market Insights, Epidemiology, and Market Forecast-2032 |
● お客様のご希望に応じて、既存データの加工や未掲載情報(例:国別セグメント)の追加などの対応が可能です。 詳細はお問い合わせください。
産後うつ病 - 市場考察、疫学、市場予測(2032年) |
出版日: 2023年08月01日
発行: DelveInsight
ページ情報: 英文 133 Pages
納期: 1~3営業日
|
当レポートでは、産後うつ病(PPD)の主要7市場について調査分析し、市場規模と予測、現在の治療法と新薬の情報などを提供しています。
There are various key players currently leading the treatment landscape of postpartum depression, such as Sage Therapeutics. The details of the country and therapy-wise market size have been provided below.
The section dedicated to drugs in the postpartum depression report provides an in-depth evaluation of marketed therapies and the late-stage pipeline drugs (Phase III and Phase II) related to postpartum depression.
The drug chapters section provides valuable information on various aspects related to clinical trials of postpartum depression, including specific details, such as the pharmacological mechanisms of the drugs involved, designations, approval status, patent information, and a comprehensive analysis of the pros and cons associated with each drug. Furthermore, it presents the most recent news updates and press releases on drugs targeting postpartum depression.
ZULRESSO (brexanolone) is a neuroactive steroid gamma-aminobutyric acid (GABA), a receptor-positive modulator indicated for treating PPD in adults. Brexanolone is available to patients only through a Risk Evaluation and Mitigation Strategy (REMS) program and must be administered at a certified healthcare facility.
Emerging Therapies
Zuranolone (SAGE-217) is an investigational, oral, novel medicine in development for postpartum depression (PPD). It is given once daily, a 2-week therapy neuroactive steroid (NAS) GABAA receptor positive allosteric modulator (PAM) specifically designed to relieve several depression disorders, including PPD, major depressive disorder (MDD), and treatment-resistant depression.
Ganaxolone (CCD-1042) is a lead clinical-stage drug candidate that brings a GABAA receptor modulating mechanism and an extensive safety database with exhibited anti-epileptic (antiseizure), anxiolytic (anti-anxiety) and anti-depressive. It is being developed in three different dosage forms (IV, capsule, and liquid) to maximize therapeutic reach to adult and pediatric patients in acute and chronic care settings with severe PPD.
Note: Detailed assessment will be provided in the final report of postpartum depression…
Postpartum depression (PPD) is a serious but treatable medical illness that involves extreme sadness, emotional liability, indifference and/or anxiety, and changes in energy, sleep, and appetite and carries risks for the mother and the newborn child. PPD usually starts within the first month or any time within the first year after childbirth and can last from weeks to months.
Treatments include antidepressant medications and the new upcoming therapeutic strategies that work on the principle of GABAA receptor modulation. The medical management for PPD comprises several aspects, such as interventions for depression, anxiety disorders, alcohol and drug abuse, and psychological interventions for eating disorders. The treatment strategy also encompasses psychological and psychosocial treatments and non-pharmacologic treatments. Besides, the medical care of a PPD patient and his family is incomplete without providing a support system for their psychosocial well-being.
Antidepressants, such as Abilify (aripiprazole), Zoloft (sertraline hydrochloride), Spravato (esketamine), Prozac (fluoxetine capsules), Celexa (citalopram hydrobromide), Luvox CR (Fluvoxamine Maleate), and Paxil CR (paroxetine) form the mainstay in the treatment for PPD. They are being used as off-label drugs for the treatment of PPD. The current market consists of only one approved product ZULRESSO (brexanolone/SAGE-547), to treat patients with PPD. ZULRESSO, which is marketed by Sage Therapeutics, was approved by the US FDA in March 2019.
Psychotherapy, such as cognitive behavioral therapy, is recommended as first-line treatment for mild-to-moderate PPD due to rapid efficacy, lack of adverse effects on mother and infant, and no impact on breastfeeding. Pharmacotherapy, either individually or in combination with psychotherapy, is advised for moderate-to-severe PPD. Selective serotonin inhibitors, particularly sertraline, and citalopram, are recommended due to their minimal effects on breastfeeding.
In addition to improving currently available treatments and increasing access to those treatments, novel therapeutics are needed that specifically target the underlying pathophysiology of the disorder. The patient burden will increase in the coming times, and approval of the emerging drug will expand the market. Therefore, the overall market size will increase, which could be a better investment therapy area.
Postpartum depression (PPD) is the most common non-psychotic complication of childbearing affecting approximately 10-15% of women. It can interfere with normal maternal-infant bonding and adversely affect acute and long-term child development. Women with a history of depression and other mental health conditions, various face a higher risk of PPD. The signs and symptoms of PPD include depressed mood, loss of interest, changes in sleep patterns, change in appetite, feelings of worthlessness, inability to concentrate, and suicidal ideation. Women may also experience anxiety. Patients having PPD may also have psychotic symptoms, which include delusions and hallucinations.
Postpartum depression is diagnosed when at least five depressive symptoms are present for at least 2 weeks. In the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), postpartum depression is considered when a patient has a major depressive episode along with the peripartum onset, and it is not mentioned as a separate disease. Screening for PPD can be done 2-6 months after childbirth. Women with postpartum depression should also be assessed for manic features. Several screening tools are available, and one of the most frequently used is the Edinburgh Postnatal Depression Scale (EPDS). The diagnosis of PPD should be strongly considered in women who score above 12 on the EPDS scale.
Further details related to country-based variations are provided in the report…
Postpartum depression can be treated with medication and counseling. Antidepressant medications, cognitive-behavioral therapy (CBT), and interpersonal therapy effectively treat PPD. Other treatments which may be useful include psychodynamic therapy, light therapy, exercise, and yoga. Other classes of medications are being prescribed for PPD as off-label therapies. One such class of medication is selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, sertraline, and others. Venlafaxine, a serotonin-norepinephrine reuptake inhibitor, has also been useful in treating PPD. As with treatment-refractory major depression in the general population, electroconvulsive therapy (ECT) is an option for depressed postpartum women who do not respond to antidepressant medication or who have severe or psychotic symptoms.
Further details related to treatment and management are provided in the report…
The postpartum depression epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by, Total Diagnosed Prevalent Cases of Maternal Postpartum Depression (PPD) Cases in the 7MM covering the United States, EU4 countries (Germany, France, Italy, Spain) and the United Kingdom, and Japan from 2019 to 2032.
In order to stay abreast of the latest trends in the market, we conduct primary research by seeking the opinions of Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) who work in the relevant field. This helps us fill any gaps in data and validate our secondary research.
We have reached out to industry experts to gather insights on various aspects of postpartum depression, including the evolving treatment landscape, patients' reliance on conventional therapies, their acceptance of therapy switching, drug uptake, and challenges related to accessibility. The experts included medical/scientific writers, professors, and researchers from prestigious universities in the US, Europe, the UK, and Japan.
Our team of analysts at Delveinsight connected with more than 15 KOLs across the 7 Major Markets (7MM). We contacted institutions such as the University of Nevada, University of Valencia, UConn Health Center, Strasbourg University, and others. By obtaining the opinions of these experts, we gained a better understanding of the current and emerging treatment patterns in the postpartum depression market, which will assist our clients in analyzing the overall epidemiology and market scenario.
We perform Qualitative and Market Intelligence analysis using various approaches, such as SWOT analysis and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.
Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, designation, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
In efficacy, the trial's primary and secondary outcome measures are evaluated; for instance, in trials for postpartum depression, one of the most important primary endpoints was depressive symptoms measured by the HAM-D total score. Based on these, the overall efficacy is evaluated.
Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Because newly authorized drugs are often expensive, some patients escape receiving proper treatment or use off-label, less expensive prescriptions. Reimbursement plays a critical role in how innovative treatments can enter the market. The cost of the medicine, compared to the benefit it provides to patients who are being treated, sometimes determines whether or not it will be reimbursed. Regulatory status, target population size, the setting of treatment, unmet needs, the number of incremental benefit claims, and prices can all affect market access and reimbursement possibilities.
The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.