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光音響イメージング (PAI):技術・システム・市場・動向

Photoacoustic Imaging: Technology, Systems, and Market Trends

発行 TEMATYS - Exploration of Photonics Markets 商品コード 447073
出版日 ページ情報 英文 280 Pages
納期: 即日から翌営業日
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光音響イメージング (PAI):技術・システム・市場・動向 Photoacoustic Imaging: Technology, Systems, and Market Trends
出版日: 2017年03月01日 ページ情報: 英文 280 Pages

2016年における医療・バイオ医療向け光音響イメージング (PAI) の市場は、用途が前臨床および解析部門に限られたことから、3500万ドルの規模にとどまりました。今後は2017年の臨床製品の承認見込みを受け、2018年以降大幅な成長が期待されており、2022年には約2億4000万ドルの規模に成長すると予測されています。

当レポートでは、世界の医療・バイオ医療分野における光音響イメージング (PAI) の市場を調査し、PAIコンポーネントの概要、システム技術の概要、コンポーネント・用途別の市場予測、医療用PAIの特徴と参入要件、市場成長への推進因子と課題、アンメットニーズ、製品のロードマップなどをまとめています。

第1章 エグゼクティブサマリー

第2章 イントロダクション

第3章 PAI:強力なイメージングモダリティ

  • 経緯
  • 動作原理
  • デバイスタイプ
  • ラベルフリー
  • スケーラブル (断層撮影・顕微鏡・内視鏡)
  • 解剖学・機能性・分子・キネティクス・モニタリング
  • 他のモダリティとの比較
  • マルチモダリティ
  • 総論

第4章 PAI技術の概要

  • プロセスチェーン
  • 光源
  • 音響波検出
  • 全光学的検出
  • 信号処理
  • 画像再構成

第5章 市場・動向

  • イントロダクション
  • 市場区分
  • コンポーネントとR&D
  • 前臨床
  • 解析
  • 臨床
  • 特許環境
  • 世界市場のアクセシビリティ
  • 臨床市場のアクセシビリティ
  • 技術の工場
  • 法規制上のコンプライアンス
  • 臨床上のアンメットニーズ
  • 医師による受け入れ
  • 総論
  • 市場
  • 課題
  • 成長推進因子
  • ロードマップ

From Research Labs to Clinical Products


Since the first images obtained in 2000, Photoacoustic Imaging has raised more and more interest for biomedical and medical applications. First applications were found in Research and Development. A lot of Proofs of Concept for in vitro and in vivo diagnostics and monitoring have been established.

Currently, PAI is spreading to biomedical and medical markets. The 3 main segments are: Pre-clinical (drug efficiency monitoring on small animal), Analytics (microscopy, flow cytometry for in vitro diagnosis), Clinical (early stage diagnosis).

In 2016, the total PAI biomedical and medical market was worth $ 35M, due to the Pre-clinical and Analytics segments only. It is forecasted to reach around $ 240M in 2022. A sharp increase is expected starting from 2018, due to the release of clinical products that are to be approved in 2017, like the « Imagio » system from Seno Medical Instruments, US (already CE marked, pending FDA approval). Within 4 to 5 years, the clinical market is expected to become the largest segment of the PAI biomedical and medical market, ahead of Pre-clinical applications. The main applications that will benefit from PAI clinical products are cancer diagnostic, cardiovascular diseases, dermatology, brain imaging, therapy monitoring and drug developments.

In the report, each segment of the PAI market (R&D, Pre-clinical, Analytics and Clinical) is analyzed in detail. Market forecasts and perspectives up to 2022 are provided. Main players are listed and detailed.



In healthcare and life science, there is a huge demand for high resolution imaging at high penetration depth, in real time and at an affordable price. With an appropriate combination of optical and acoustical means, added to data processing and specific algorithms, Photoacoustic Imaging offers several advantages over other biomedical and medical imaging modalities:

  • Safe and non-invasive: it is therefore adapted for repeated use on in vivo tissues, and is suited for treatment monitoring contrary to X-rays.
  • Label-free: avoids the issue of approved labels in in vivo imaging.
  • Speckle free: contrary to OCT and ultrasonography. It provides higher quality images.
  • Scalable: PAI allows to image biological objects from organelles and cells to tissues or organs, while keeping the same high depth vs.

resolution ratio. -High penetration depth : up to several cm, allowing to image in 3D whole organs or whole body parts (like breast) -Provides various types of information: anatomical, functional, molecular and kinetic information.

In view of all those assets, one can wonder whether PAI could replace other techniques like X-rays for various major imagery applications like breast cancer detection and screening.

The report provides an overview of optical and acoustic technologies forming a PAI system, as well as the trends in data processing and image reconstruction algorithms. It describes in details the main features of PAI, that makes it a powerful technique for clinical applications.

PAI provides various types of information useful for biomedical and medical applications



Four implementations of PAI are possible, making it a tool that easily adapts to the clinical need : handheld PAI devices (HPAT) have been developed for point-of-care applications like dermatology or oncology diagnosis at the doctor's office.

Endoscopes integrating PAI have been demonstrated for cardio-vascular imaging inside arteries. Photoacoustic Computed Tomography (PACT) allows 3D imaging of organs. PAI can also be implemented in a microscope (PAM) for in vitro or ex vivo diagnosis.

PAI is thus expected to be adopted in various clinical applications. However, the access to the clinical market is long and complex.

One of the challenges is the acceptation of PAI by clinicians. To overcome this challenge, first clinical devices expected to be adopted are systems combining Ultra-sounds and PAI. Indeed, Ultrasonography (US) is a well-known and well-established technique. However, it provides only structural information. PAI brings functional information to US imaging. Moreover, the entry of PAI into clinical applications is going to be boosted by the growing number of companies - startups and large firms like Fujifilm or Canon - that are investing in this technology.

In the report, we point out the remaining challenges for clinical adoption of PAI, the issues to overcome to get a large imaging market share and a roadmap of the forthcoming clinical product.

The four types of PAI systems allow to meet several clinical applications



  • Provide an overview of Photoacoustic Imaging components and systems on the market and under development,
  • Define and analyze the different market segments of the PAI market,
  • Identify PAI main industrial and R&D players worldwide,
  • Provide a market forecast until 2022 for each application segment,
  • Underline main challenges to be addressed both on technology side and application side in short, mid and long-term.


Acoustic Medsystems, Acousys Biodevices, Actuated Medical, Advanced Optowave, Alpinion Medical, Analogic Ultrasound, Baltek, Bikero, BK Medical, Cephasonics, Canon, Cobolt, Continuum, Crystalaser, CTS, Echofos, Echolase, Edgewave, Elforlight , Ekspla, Endra Life Science, Esaote, Fairway Medical Technologies, Fujifilm, G.E. Healthcare, Hitachi Aloka, Hitachi Medical, Hologic, IB Lasers, Illumisonics, Imasonic, Innolas, Innolume, IPG, Japan Probes, Jenoptics, Kolo, Kibero, Laser Export Co, LDX Optronics, Ligth Age, Litron, Lotis TII, Microscopic Photo Acoustics, Multiwave, Omicron, Opotek, OptoSonics, Panametrics, PA Imaging, Philips Research N.A., Koninklijke Philips N.V., Photonics Industries, Photosound, PolarOnyx, Precision Acoustic, Prexion, Prosonic, Quantel, Quanta system, S-Sharp, Samsung Medison, Schimadzu, Seno Medical Instruments, Siemens Healthcare, Sirah, Sonaxis, Sonic, Sonotec, Spectra Physics, Supersonic Imagine, Symphotics TII, Teem Photonics, Tomowave Laboratories, Ultrasonix, Verasonics, Vermon, Vibronix, VisualSonics, Xarion Laser Acoustics, Zonare


  • PAI components Overview: light sources, acoustic transducers, data processing and algorithms
  • PAI systems technologies Overview: tomography, microscopy, handheld systems and endoscopy
  • Markets Forecast and Trends for Components and R&D, Pre-clinical, Analytics and Clinical segments
  • Key features of PAI for medical applications
  • Requirements for market accessibility
  • Market drivers and remaining challenges
  • Products roadmap
  • Patents Landscape

Table of Contents

1.Executive Summary


  • Context of the Study
  • Study Goals and Objectives
  • Information Sources and Methodology
  • Glossary
  • List of Companies

3.PAI : a powerful imaging modality

  • Historical
  • Principles of operation
  • Devices types
  • Label free
  • Scalable (Tomography, microscopy, endoscopy)
  • Anatomical, Functional, Molecular, Kinetic & Monitoring
  • Comparison with other modalities
  • Multimodalities
  • Conclusions

4.PAI technologies overview

  • Process chain
  • Light sources
  • Acoustic waves detections
  • All Optical detections
  • Signal processing
  • Image reconstruction

5.Markets and Trends

  • Introduction
  • Market segmentations
  • Components and R&D
  • Pre-clinical
  • Analytics
  • Clinical
  • Patents landscape
  • Global market 6. Market Accessibility
  • Clinical market accessibility
  • Technical improvement
  • Regulatory compliance
  • Unmet clinical needs
  • Clinicians acceptation
  • Funding 7. Conclusions
  • 4 markets
  • Remaining challenges
  • Drivers
  • Road map 8. About us
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