表紙:世界のアプタマー市場 - 成長、傾向、および予測(2022年 - 2027年)
市場調査レポート
商品コード
391436

世界のアプタマー市場 - 成長、傾向、および予測(2022年 - 2027年)

Aptamers Market - Growth, Trends , COVID-19 Impact , and Forecasts (2022 - 2027)

出版日: | 発行: Mordor Intelligence Pvt Ltd | ページ情報: 英文 112 Pages | 納期: 2~3営業日

価格
価格表記: USDを日本円(税抜)に換算
本日の銀行送金レート: 1USD=135.61円
世界のアプタマー市場 - 成長、傾向、および予測(2022年 - 2027年)
出版日: 2022年01月17日
発行: Mordor Intelligence Pvt Ltd
ページ情報: 英文 112 Pages
納期: 2~3営業日
● ご注意事項
本レポートは最新情報反映のため適宜更新し、内容構成変更を行う場合があります。ご検討の際はお問い合わせください。
  • 全表示
  • 概要
  • 目次
概要

世界のアプタマー市場は2019年から2024年の間に17.8%のCAGRで成長すると予測されています。アプタマー開発技術の進歩、研究開発費の増加、この市場への投資企業の増加等が、当市場の成長を支える重要な要因に挙げられます。

当レポートでは世界のアプタマー市場について調査しており、市場の機会および動向、成長および阻害要因、タイプ・用途・地域別の市場分析、競合情勢、主要企業のプロファイルなどの情報を提供しています。

目次

第1章 イントロダクション

  • 研究の成果
  • 調査の前提条件
  • 調査範囲

第2章 調査方法

第3章 エグゼクティブサマリー

第4章 市場力学

  • 市場概況
  • 市場成長要因
  • 市場阻害要因
  • ポーターのファイブフォース分析
    • 新規参入の脅威
    • バイヤー/消費者の交渉力
    • サプライヤーの交渉力
    • 代替製品の脅威
    • 業界内の競争

第5章 市場セグメント

  • タイプ別
    • 核酸
    • ペプチド
  • 用途別
    • 診断
    • 治療学
    • 研究開発
  • 地域別
    • 北米
    • 欧州
    • アジア太平洋地域
    • 中東およびアフリカ
    • 南米

第6章 競合情勢

  • 企業プロファイル
    • AM Biotechnologies, LLC
    • Aptagen, LLC
    • Aptamer Sciences, Inc.
    • Aptamer Group
    • Aptus Biotech S.L.
    • Base Pair Biotechnologies, Inc.
    • NOXXON Pharma
    • SomaLogic Inc.
    • TriLink BioTechnologies, Inc.
    • Vivonics, Inc.

第7章 市場機会および将来動向

目次
Product Code: 46393

The Aptamers Market is expected to register a CAGR of 18.5% over the forecast period.

Globally, COVID-19 is an intractable health challenge resulting in an aberrant rate of morbidity and mortality. The mode of entry for SARS-CoV-2 into host cells occurs through clathrin-mediated endocytosis. As part of the efforts to mitigate COVID-19 infections, rapid and accurate detection methods, as well as vaccine and drug designs with SARS-CoV-2 targeting capabilities are critically needed. According to a research study by Caleb Acquah et al., published in Cellular and Molecular Bioengineering Journal, January 2021, globally, there is an urgent need to develop safe innovative biomedical technologies to mitigate the direct impact of COVID-19 on public health. Moreover, research advances into aptameric systems bode well with the fact that they can be engineered for the development of effective and affordable diagnostics, therapeutics, and prophylactic vaccines for SARS-CoV-2 and other infectious pathogens. Furthermore, according to a research study by Vamkudoth Koteswara Rao et al., published in Frontiers in Nanotechnology Journal, February 2021, the study results found that aptamer-based detection is the most specific, inexpensive, and rapid detection of COVID-19 without laboratory tools. In addition, more than 900 SARS-nCoV-2 test kits are in pipeline and a few test kits are developed using Aptamer technology.

Some of the factors that are driving the market growth include high advantage of aptamers compared to antibodies, advancements in the field of aptamer development technologies and growing investment in the companies and research institutes.

Numerous advantages offered by these small molecules, in comparison to established antibodies, have also led to higher demand for these molecules across a diverse range of medical applications. They are chemically synthesized, which eliminates batch-to-batch variation and demands less time for development. Along with this, continuous advancement in technologies is expected to stimulate market growth. According to a research study by Geanina Stefan et al., published in Electrochimica Acta Journal April 2021, the study results found that aptamers have come into the spotlight as bio-mimetic molecular recognition elements in the field of biomedicine due to various applications in diagnostics, drug delivery, therapeutics, and pharmaceutical analysis. Aptamers are composed of nucleic acid strands (DNA or RNA) that can specifically interact in a three-dimensional tailored design with the target molecule.

The market players are adopting various strategies such as product launches, developments. collaborations, partnerships, and expansions to increase market share. For instance, in August 2020, Aptamer Sciences Inc., in co-operation with POSTECH, discovered a number of aptamers that specifically bind to the COVID-19 spike protein using ViroSELEX technology, a unique aptamer discovery technology, and applied for a material patent. However, many aptamers have failed to meet the requisite safety and efficacy standards in clinical studies. Thus, companies had to terminate their clinical investigation during late-stage clinical studies. This factor is likely to affect the growth of this market negatively. In addition, other factors, such as unfavorable pharmacokinetic properties of aptamers and low awareness level and incomplete regulatory policies, may hamper the overall market growth.

Key Market Trends

Diagnostics Segment is Expected to Witness a Healthy Growth Rate Over the Forecast Period

Appropriate diagnosis is the most crucial factor for the treatment of diseases, especially viral diseases. Over the past few years, aptamer technology has observed a significant rise in its demand and usage all across the world. It has been used in a wide range of diagnostic as well as therapeutic applications, and several strategies are currently being explored, in a definitive or conclusive way, using aptamers against virus proteins.

The outbreak of COVID-19 and lack of specific treatment and gold-standard diagnostic system for diagnosis has made the situation more complicated. Efforts have led to the production of several diagnostic kits that are associated with limitations such as accuracy and inadequate sensitivity. Aptamers are considered as multipotent biological probes that could be promising candidates to design sensitive and specific biosensors. Moreover, few studies have introduced specific aptamer types of coronavirus, that may help to select the best approach to obtain specific aptamers for the SARS-CoV-2 virus. For instance, according to a research study by Raheleh Torabi et al., published in Molecular and Cellular Probes Journal, October 2020, the study results found that helicase enzyme has an important role in viral replication and proliferation. Therefore, it could be considered as a potent target to develop the coronavirus therapeutic aptamers. N protein could be also a potent target to detect and inhibit COVID-19 due to its crucial role in the synthesis of viral RNA and SARS detection. By applying aptamers as sensitive diagnostic elements, it will be able to fabricate rapid, sensitive, low-cost, and user-friendly diagnostic tools of small volume clinical samples.

In addition, according to a research study by Sapna Devi et al., published in Saudi Journal of Biological Sciences May 2021, Aptamer (oligonucleotide or short peptides) that can specifically bind to target molecules have increasingly become popular in developing biosensors for sensitive detection of analytes, pathogens (bacteria, virus, fungus, prions), drug residues, toxins, and cancerous cells. Thus, aptamers were found to be successful in in-vivo application in disease diagnosis. From a diagnostic point of view, aptamers are presently being designed as a bio-recognition element in a variety of diagnostic systems to detect viral proteins, either in the blood (serum or plasma) or the infected cells.

The market players are adopting various strategies such as product launches, developments. collaborations, partnerships, and expansions to increase market share. For instance, in September 2020, Aptamer Group and Cytiva entered into a new collaboration agreement to produce a rapid test for the COVID-19 infection. In addition, in June 2020, in South Korea, Aptamer Sciences Inc., launched a non-small cell lung cancer risk test which is the world's first diagnostic kit to apply aptamer technology, and it is expected to help increase the rate of an early lung cancer diagnosis with convenience and high accuracy. Hence, the above-mentioned factors are expected to drive the segment growth over the forecast period.

North America Dominates the Market and Expected to do Same in the Forecast Period

The North American region dominates the aptamers market due to rapid technological advancements and high investment and funding to support the development of aptamers. The United States has been the hub of all major R and D activities related to aptamers. The first aptamer therapeutic product ''Macugen'' was approved in 2004 by the US FDA (United States Food and Drugs Administration).

Aptamers, explicitly synthesized for the nucleocapsid protein of SARS-CoV-2, are deployed and provide a rapid result. No refrigeration or preparation of the sample is required. The nanosensor-based assay will be able to detect COVID-19 in both symptomatic and asymptomatic cases accurately and distinguish the novel coronavirus from influenza and other common respiratory pathogens. According to a Canadian research study by Jiuxing Li et al., published in Nucleic Acids Research Journal, June 2021, the study results found that aptamers maintained full binding activity with the S1 protein spiked into 50% human saliva, which could support home-testing or rapid testing in congregate settings. Based on this finding, developed a simple colorimetric sandwich assay using the MSA1 aptamer as an molecular recognition elements (MRE) and showed that it was capable of detecting pseudotyped lentivirus in 50% saliva with a limit of detection of 400 fM. The study has confirmed the potential of the aptamers as diagnostic tools for COVID-19 detection in an easily accessed patient sample.

In the North America region, research and development happens to be the most active area of application of aptamers. A significant proportion of demand is seen in research applications, which is also responsible for generating revenues in the market. Furthermore, the growing acceptance of personalized medicine is also one of the major factors driving the growth of the market. Aptamers have evolved rapidly in the past ten years, and aptamers have targeted a range of molecules involved in tumor progression and metastasis, present at different sites. In March 2021, in United States, Eastern Virginia Medical School initiated a phase I clinical trial to determine whether a tenofovir (TFV) aptamer-based biosensor (aptasensor) can detect TFV in biological fluids from women randomized to different dosing regimens representing high and low adherence. The trial is expected to complete in January 2022. Hence, owing to above mentioned factors, the market is expected to grow over the forecast period in the region.

Competitive Landscape

The Aptamers Market is consolidated competitive. The companies are implementing certain strategic initiatives, such as mergers, new product launches, acquisitions, and partnerships, which help them in strengthening their market position. Some of the market players include Aptagen, LLC, Aptamer Sciences Inc., Base Pair Biotechnologies Inc., Aptamer Group, Aptus Biotech S.L., among others.

Additional Benefits:

  • The market estimate (ME) sheet in Excel format
  • 3 months of analyst support

TABLE OF CONTENTS

1 INTRODUCTION

  • 1.1 Study Assumptions and Market Definition
  • 1.2 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 High Advantage of Aptamers, Compared to Antibodies
    • 4.2.2 Advancements in the Field of Aptamer Development Technologies
    • 4.2.3 Growing Investment in the Companies and Research Institutes
  • 4.3 Market Restraints
    • 4.3.1 Unfavorable Pharmacokinetic Properties of Aptamers
    • 4.3.2 Low Awareness Level and Incomplete Regulatory Policies
  • 4.4 Porter's Five Force Analysis
    • 4.4.1 Threat of New Entrants
    • 4.4.2 Bargaining Power of Buyers/Consumers
    • 4.4.3 Bargaining Power of Suppliers
    • 4.4.4 Threat of Substitute Products
    • 4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION

  • 5.1 By Type
    • 5.1.1 Nucleic Acid
    • 5.1.2 Peptide
  • 5.2 By Application
    • 5.2.1 Diagnostics
    • 5.2.2 Therapeutics
    • 5.2.3 Research and Development
    • 5.2.4 Other Applications
  • 5.3 Geography
    • 5.3.1 North America
      • 5.3.1.1 United States
      • 5.3.1.2 Canada
      • 5.3.1.3 Mexico
    • 5.3.2 Europe
      • 5.3.2.1 Germany
      • 5.3.2.2 United Kingdom
      • 5.3.2.3 France
      • 5.3.2.4 Italy
      • 5.3.2.5 Spain
      • 5.3.2.6 Rest of Europe
    • 5.3.3 Asia-Pacific
      • 5.3.3.1 China
      • 5.3.3.2 Japan
      • 5.3.3.3 India
      • 5.3.3.4 Australia
      • 5.3.3.5 South Korea
      • 5.3.3.6 Rest of Asia-Pacific
    • 5.3.4 Middle East and Africa
      • 5.3.4.1 GCC
      • 5.3.4.2 South Africa
      • 5.3.4.3 Rest of Middle East and Africa
    • 5.3.5 South America
      • 5.3.5.1 Brazil
      • 5.3.5.2 Argentina
      • 5.3.5.3 Rest of South America

6 COMPETITIVE LANDSCAPE

  • 6.1 Company Profiles
    • 6.1.1 AM Biotechnologies LLC
    • 6.1.2 Aptagen LLC
    • 6.1.3 Aptamer Sciences Inc.
    • 6.1.4 Aptamer Group
    • 6.1.5 Aptus Biotech S.L.
    • 6.1.6 Base Pair Biotechnologies Inc.
    • 6.1.7 NOXXON Pharma
    • 6.1.8 SomaLogic Inc.
    • 6.1.9 Baush Health Companies Inc.
    • 6.1.10 Maravai Lifesciences (Trilink Biotechnologies)
    • 6.1.11 NeoVentures Biotechnology, Inc.
    • 6.1.12 Vivonics, Inc.

7 MARKET OPPORTUNITIES AND FUTURE TRENDS