Tyrosine Protein Kinase CSK - Pipeline Review, H1 2020
発行: Global Markets Direct
ページ情報: 英文 96 Pages
According to the recently published report 'Tyrosine Protein Kinase CSK - Pipeline Review, H1 2020'; Tyrosine Protein Kinase CSK (C Src Kinase or Protein Tyrosine Kinase CYL or CSK or EC 220.127.116.11) pipeline Target constitutes close to 12 molecules. Out of which approximately 6 molecules are developed by companies and remaining by the universities/institutes.
Tyrosine Protein Kinase CSK (C Src Kinase or Protein Tyrosine Kinase CYL or CSK or EC 18.104.22.168) - Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. It plays an important role in the regulation of cell growth, differentiation, migration and immune response. It phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs). To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. It suppresses signaling by various surface receptors including T-cell receptor (TCR) and B-cell receptor (BCR).
The report 'Tyrosine Protein Kinase CSK - Pipeline Review, H1 2020' outlays comprehensive information on the Tyrosine Protein Kinase CSK (C Src Kinase or Protein Tyrosine Kinase CYL or CSK or EC 22.214.171.124) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Tyrosine Protein Kinase CSK (C Src Kinase or Protein Tyrosine Kinase CYL or CSK or EC 126.96.36.199) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Pre-Registration, Phase III, Phase II and Phase I stages are 2, 1, 2 and 1 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 5 and 1 molecules, respectively. Report covers products from therapy areas Oncology, Cardiovascular, Central Nervous System, Dermatology, Gastrointestinal, Hematological Disorders, Immunology, Infectious Disease, Respiratory and Toxicology which include indications Breast Cancer, Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Bile Duct Cancer (Cholangiocarcinoma), Chronic Myelocytic Leukemia (CML, Chronic Myeloid Leukemia), High-Grade Glioma, Metastatic Breast Cancer, Non-Small Cell Lung Cancer, Peripheral T-Cell Lymphomas (PTCL), Recurrent Glioblastoma Multiforme (GBM), Solid Tumor, Triple-Negative Breast Cancer (TNBC), Actinic (Solar) Keratosis, Adenocarcinoma Of The Gastroesophageal Junction, Adenoid Cystic Carcinoma (ACC), Amyotrophic Lateral Sclerosis, Anaplastic Large Cell Lymphoma (ALCL), Angioimmunoblastic T-Cell Lymphoma (AITL)/Immunoblastic Lymphadenopathy, Angiosarcoma, Arrhythmias, Asthma, B-Cell Acute Lymphocytic Leukemia (B-Cell Acute Lymphoblastic Leukaemia), Blood Cancer, Cervical Cancer, Chronic Obstructive Pulmonary Disease (COPD), Colon Cancer, Colorectal Cancer, Epithelial Ovarian Cancer, Epstein-Barr Virus (HHV-4) Infections, Esophageal Squamous Cell Carcinoma (ESCC), Ewing Sarcoma, Fallopian Tube Cancer, Fibrosarcoma, Follicular Lymphoma, Gallbladder Cancer, Gastric Cancer, Gastroesophageal (GE) Junction Carcinomas, Gastrointestinal Tumor, Glioblastoma Multiforme (GBM), Gliosarcoma, Head And Neck Cancer Squamous Cell Carcinoma, Hematological Tumor, Hepatocellular Carcinoma, Hormone Refractory (Castration Resistant, Androgen-Independent) Prostate Cancer, Hypereosinophilic Syndrome, Leiomyosarcoma, Liposarcoma, Lung Adenocarcinoma, Lung Cancer, Lymphoma, Malignant Glioma, Mantle Cell Lymphoma, Marginal Zone B-cell Lymphoma, Melanoma, Metastatic Biliary Tract Cancer, Metastatic Colorectal Cancer, Metastatic Pancreatic Cancer, Mild Cognitive Impairment, Myelodysplastic Syndrome, Myelofibrosis, Myeloid Metaplasia, Myocardial Infarction, Nasopharyngeal Cancer, Natural Killer Cell Lymphomas, Oligodendroglioma, Ovarian Cancer, Peritoneal Cancer, Polycythemia Vera, Prostate Cancer, Psoriasis, Pulmonary Arterial Hypertension, Radiation Injury, Renal Cell Carcinoma, Rhabdomyosarcoma, Skin Cancer, Small-Cell Lung Cancer, Soft Tissue Sarcoma, Synovial Sarcoma, Systemic Mastocytosis, T-Cell Lymphomas, Thymoma (Thymic Epithelial Tumor), Thyroid Cancer, Transitional Cell Carcinoma (Urothelial Cell Carcinoma) and Waldenstrom Macroglobulinemia (Lymphoplasmacytic Lymphoma).
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.