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代謝型グルタミン酸受容体5 (mGluR5/GRM5/GPRC1E/MGLUR5):パイプライン製品の分析

Metabotropic Glutamate Receptor 5 - Pipeline Review, H1 2020

発行 Global Markets Direct 商品コード 363126
出版日 ページ情報 英文 76 Pages
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本日の銀行送金レート: 1USD=106.59円で換算しております。
代謝型グルタミン酸受容体5 (mGluR5/GRM5/GPRC1E/MGLUR5):パイプライン製品の分析 Metabotropic Glutamate Receptor 5 - Pipeline Review, H1 2020
出版日: 2020年05月30日 ページ情報: 英文 76 Pages
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本レポートは最新情報反映のため適宜更新し、内容構成変更を行う場合があります。ご検討の際はお問い合わせください。
概要

当レポートでは、世界各国での代謝型グルタミン酸受容体5 (mGluR5/GRM5/GPRC1E/MGLUR5) 治療用のパイプライン製品の開発状況について分析し、製品開発・上市の最新動向や、治験の各段階にある製品の一覧、主要企業のプロファイル、主な薬剤の概要、最新の業界動向などの情報をお届けします。

目次

  • イントロダクション
    • 分析範囲
  • 代謝型グルタミン酸受容体5 (mGluR5/GRM5/GPRC1E/MGLUR5) の概要
  • 治療薬の開発
    • 治験の段階別
    • 治療領域別
    • 症状別
  • パイプライン製品の概略
    • 後期段階の製品
    • 初期段階の製品
  • 各企業で開発中の治療薬
  • 各大学/研究機関で開発中の治療薬
  • 治療薬の評価
    • 単剤治療薬/併用治療薬の場合
    • 作用機序別
    • 投与方法別
    • 分子の種類別
  • 治療薬の開発に従事している企業
    • Addex Therapeutics Ltd
    • Confluence Pharmaceuticals LLC
    • エーザイ
    • Eli Lilly and Company
    • Heptares Therapeutics Limited
    • Hua Medicine (Shanghai) Ltd.
    • Johnson & Johnson
    • Medgenics, Inc.
    • Merz Pharma GmbH & Co. KgaA
    • Novartis AG
    • 大日本住友製薬
  • 薬剤のプロファイル
    • アカンプロセートカルシウム
      • 製品概要
      • 作用機序
      • 研究開発 (R&D) の進展状況
    • alloswitch-1
    • ジプラグルラントのER (制御放出)
    • ジプラグルラントのIR (即時放出)
    • DSR-98776
    • fasoracetam
    • GET-73
    • HTL-14242
    • JNJ-46778212
    • LSN-2463359
    • LSN-2814617
    • mavoglurant
    • MRZ-8676
    • 認知症向け代謝型グルタミン酸受容体5 (mGlu5) 活性化用小分子
    • 疼痛向けmGlu5拮抗用小分子
    • 神経疾患向けmGluR・mGluR6拮抗用小分子
    • 中枢神経系 (CNS) 疾患向けmGluR5拮抗用小分子
    • 運動機能障害向けmGluR5拮抗用小分子
    • 統合失調症向けmGluR5標的小分子
    • VU-0092273
    • VU-0431316
    • VU-0463841
    • VU-0467558
  • 開発が休止状態の製品
  • 開発が中止された製品
  • 注目すべき最新動向・プレスリリース (全15件)
  • 付録

図表一覧

図表

List of Tables

  • Number of Products under Development by Stage of Development, H1 2020
  • Number of Products under Development by Therapy Areas, H1 2020
  • Number of Products under Development by Indications, H1 2020
  • Number of Products under Development by Indications, H1 2020 (Contd..1), H1 2020
  • Number of Products under Development by Companies, H1 2020
  • Products under Development by Companies, H1 2020
  • Products under Development by Companies, H1 2020 (Contd..1), H1 2020
  • Number of Products under Investigation by Universities/Institutes, H1 2020
  • Products under Investigation by Universities/Institutes, H1 2020
  • Number of Products by Stage and Mechanism of Actions, H1 2020
  • Number of Products by Stage and Route of Administration, H1 2020
  • Number of Products by Stage and Molecule Type, H1 2020
  • Pipeline by Addex Therapeutics Ltd, H1 2020
  • Pipeline by Bristol-Myers Squibb Co, H1 2020
  • Pipeline by Hua Medicine Shanghai Ltd, H1 2020
  • Pipeline by Laboratorio Farmaceutico CT Srl, H1 2020
  • Pipeline by Lactocore Inc, H1 2020
  • Pipeline by Novartis AG, H1 2020
  • Pipeline by Park Active Molecules, H1 2020
  • Pipeline by Richter Gedeon Nyrt, H1 2020
  • Pipeline by Sosei Heptares, H1 2020
  • Dormant Products, H1 2020
  • Dormant Products, H1 2020 (Contd..1), H1 2020
  • Dormant Products, H1 2020 (Contd..2), H1 2020
  • Discontinued Products, H1 2020
  • Discontinued Products, H1 2020 (Contd..1), H1 2020

List of Figures

  • Number of Products under Development by Stage of Development, H1 2020
  • Number of Products under Development by Therapy Areas, H1 2020
  • Number of Products under Development by Top 10 Indications, H1 2020
  • Number of Products by Mechanism of Actions, H1 2020
  • Number of Products by Stage and Mechanism of Actions, H1 2020
  • Number of Products by Stage and Route of Administration, H1 2020
  • Number of Products by Molecule Types, H1 2020
  • Number of Products by Stage and Molecule Types, H1 2020
目次
Product Code: GMDHC2430TDB

Summary:

According to the recently published report 'Metabotropic Glutamate Receptor 5 - Pipeline Review, H1 2020'; Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) pipeline Target constitutes close to 19 molecules. Out of which approximately 12 molecules are developed by companies and remaining by the universities/institutes.

Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Metabotropic glutamate receptor 5 (mGluR5) is a G protein-coupled receptor. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol calcium second messenger system and generates a calcium activated chloride current. mGluR5 plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.

The report 'Metabotropic Glutamate Receptor 5 - Pipeline Review, H1 2020' outlays comprehensive information on the Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.

It also reviews key players involved in Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase II, Phase I, Preclinical and Discovery stages are 3, 1, 7 and 1 respectively. Similarly, the universities portfolio in Preclinical stages comprises 7 molecules, respectively.

Report covers products from therapy areas Central Nervous System and Genetic Disorders which include indications Anxiety Disorders, Depression, Fragile X Syndrome, Alzheimer's Disease, Autism, Dyskinesia, Major Depressive Disorder, Schizophrenia, Alcohol Addiction, Cognitive Impairment, Cognitive Impairment Associated With Schizophrenia (CIAS), Dementia, Drug Addiction, Drug-Induced Dyskinesia, Movement Disorders, Neurology, Pain, Parkinson's Disease, Rett Syndrome, Spasmodic Torticollis (Cervical Dystonia) and Substance (Drug) Abuse.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope:

  • The report provides a snapshot of the global therapeutic landscape for Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5)
  • The report reviews Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics

Reasons to Buy:

  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5)
  • Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

  • Table of Contents
    • List of Tables
    • List of Figures
  • Introduction
    • Global Markets Direct Report Coverage
  • Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Overview
    • Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Therapeutics Development
    • Products under Development by Stage of Development
    • Products under Development by Therapy Area
    • Products under Development by Indication
    • Products under Development by Companies
    • Products under Development by Universities/Institutes
  • Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Therapeutics Assessment
    • Assessment by Mechanism of Action
    • Assessment by Route of Administration
    • Assessment by Molecule Type
  • Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Companies Involved in Therapeutics Development
    • Addex Therapeutics Ltd
    • Bristol-Myers Squibb Co
    • Hua Medicine Shanghai Ltd
    • Laboratorio Farmaceutico CT Srl
    • Lactocore Inc
    • Novartis AG
    • Park Active Molecules
    • Richter Gedeon Nyrt
    • Sosei Heptares
  • Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Drug Profiles
    • alloswitch-1 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • arbaclofen - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
  • Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Dormant Products
  • Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Discontinued Products
  • Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Product Development Milestones
    • Featured News & Press Releases
      • Appendix
      • Methodology
      • Coverage
      • Secondary Research
      • Primary Research
      • Expert Panel Validation
      • Contact Us
    • Disclaimer