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肺動脈性高血圧症 : パイプライン分析

Pulmonary Arterial Hypertension - Pipeline Review, H1 2017

発行 Global Markets Direct 商品コード 213126
出版日 ページ情報 英文 227 Pages
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肺動脈性高血圧症 : パイプライン分析 Pulmonary Arterial Hypertension - Pipeline Review, H1 2017
出版日: 2017年03月08日 ページ情報: 英文 227 Pages
概要

肺動脈性高血圧症とは、肺動脈(心臓から肺に、酸素吸入用の血液を送る動脈)内部の血圧が上昇するという疾患です。主な症状には、倦怠感やめまい、失神の発作、胸部の圧迫感・痛み、足首・脚部の腫れもの(浮腫)、息切れ(呼吸困難)などがあります。主な治療薬には抗凝結剤や利尿剤、血管拡張薬などがあります。

当レポートでは、世界各国での肺動脈高血圧症(PAH)治療用のパイプライン製品の開発状況について分析し、製品開発・上市の最新動向や、治験の各段階にある製品の一覧、主要企業のプロファイル、主な薬剤の概要、最新の業界動向などの情報をお届けします。

目次

イントロダクション

  • 分析範囲

肺動脈性高血圧症の概要

治療薬の開発

  • 肺動脈性高血圧症向けパイプライン製品:概要
  • 肺動脈性高血圧症向けパイプライン製品:比較分析

各企業で開発中の肺動脈性高血圧症治療薬

大学/研究機関で研究中の肺動脈性高血圧症治療薬

パイプライン製品の概略

  • 後期段階の製品
  • 治験段階の製品
  • 初期段階の製品
  • 開発段階が不明の製品

肺動脈性高血圧症治療薬:開発中の製品の一覧(企業別)

肺動脈性高血圧症治療薬:研究中の製品の一覧(大学/研究機関別)

肺動脈性高血圧症治療薬の開発に従事している企業

  • APT Therapeutics, Inc.
  • Arena Pharmaceuticals, Inc.
  • 旭化成ファーマ
  • Ascendis Pharma A/S
  • Bial - Portela & Ca, S.A.
  • Cardioxyl Pharmaceuticals, Inc.
  • Carolus Therapeutics, Inc.
  • Celsion Corporation
  • Corridor Pharmaceuticals Inc.
  • Cytokinetics, Inc.
  • Eli Lilly and Company
  • Gilead Sciences, Inc.
  • Insmed Incorporated
  • Lacer, S.A.
  • LTT Bio-Pharma Co., Ltd.
  • Mezzion Pharma Co. Ltd.
  • miRagen Therapeutics, Inc.
  • 日本新薬
  • Novartis AG
  • Peloton Therapeutics, Inc.
  • PharmaIN Corporation
  • PhaseBio Pharmaceuticals, Inc.
  • Pluristem Therapeutics Inc.
  • Proteo, Inc.
  • Pulmokine, Inc.
  • Reata Pharmaceuticals, Inc.
  • Respira Therapeutics, Inc.
  • Sagene Pharmaceuticals, Inc.
  • Silence Therapeutics Plc
  • Sinoxa Pharma GmbH
  • SteadyMed Therapeutics, Inc.
  • Suda Ltd
  • 東レ

肺動脈性高血圧症:治療薬の評価

  • 単剤治療薬の場合
  • 併用治療薬の場合
  • 標的別
  • 作用機序別
  • 投与方法別
  • 分子の種類別

薬剤のプロファイル

  • (allopurinol + apocynin)
    • 製品概要
    • 機能メカニズム
    • 研究開発(R&D)の進展状況
  • がん・肺動脈性高血圧症(PAH)向け抗体
  • 肺動脈性高血圧症向け抗体
  • APT-102
  • バルドキソロンメチル
  • beraprost sodium ER
  • beraprost sodium SR
  • BIA-51058
  • CT-2009
  • 肺動脈性高血圧症向けノッチ3受容体拮抗薬
  • ファスジル
  • GS-4997
  • メシル酸イマチニブ
  • INS-1009
  • LA-419
  • リスリド
  • MFC-001
  • MFC-002
  • 肺動脈性高血圧症向け Endothelin-1阻害用オリゴヌクレオチド
  • 肺動脈性高血圧症向けMicroRNA-145阻害用オリゴヌクレオチド
  • 肺動脈性高血圧症向けmiR-145阻害用オリゴヌクレオチド
  • PB-1046
  • PB-1120
  • 肺動脈性高血圧症向けウロテンシン-II受容体拮抗ペプチド
  • PGC-VIP
  • PK-10453
  • PK-10571
  • PLX-PAD
  • PT-2977
  • QCC-374
  • R-190
  • ralinepag
  • RT-234
  • セレギリン+PDE-5阻害剤
  • セレキシパグ
  • 肺動脈性高血圧症向け小分子
  • 血管機能不全・肺動脈性高血圧症・勃起障害向けアルギナーゼ阻害薬
  • 慢性閉塞性肺疾患(COPD)・ぜんそく・肺動脈性高血圧症向けミオシン阻害用小分子
  • 肺動脈性高血圧症向け可容性エポキシドヒドロラーゼ阻害薬
  • 肺動脈性高血圧症向けACE2活性化用小分子
  • 肺動脈性高血圧症向け5-HT1B作動小分子
  • SPI-054
  • SPI-183
  • SUD-004
  • タクロリムス
  • タダラフィル
  • tiprelestat
  • TPN-171
  • TR-422
  • トレプロスチニル
  • treprostinil diolamine
  • TXA-127
  • ウデナフィル

肺動脈性高血圧症治療薬:パイプライン製品の最新動向

肺動脈性高血圧症治療薬:開発が休止状態の製品

肺動脈性高血圧症治療薬:開発が中止された製品

肺動脈性高血圧症関連製品の開発のマイルストーン

  • 注目すべき最新動向・プレスリリース
  • ■付録

図表一覧

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次
Product Code: GMDHC9152IDB

Summary

Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Pulmonary Arterial Hypertension - Pipeline Review, H1 2017, provides an overview of the Pulmonary Arterial Hypertension (Cardiovascular) pipeline landscape.

Pulmonary arterial hypertension (PAH) is a type of high blood pressure that occurs in the right side of the heart and in the arteries that supply blood to the lungs. Symptoms include chest pain, fatigue, passing out suddenly, and swelling of the legs (edema). Risk factors include family history, age, obesity, obstructive sleep apnea and other diseases, including congenital heart disease, lung disease, liver disease and connective tissue disorders like scleroderma and lupus. Treatment includes sildenafil, prostanoids and calcium channel blockers.

Report Highlights

Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Pulmonary Arterial Hypertension - Pipeline Review, H1 2017, provides comprehensive information on the therapeutics under development for Pulmonary Arterial Hypertension (Cardiovascular), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

The Pulmonary Arterial Hypertension (Cardiovascular) pipeline guide also reviews of key players involved in therapeutic development for Pulmonary Arterial Hypertension and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical, Discovery and Unknown stages are 2, 7, 9, 11, 36, 3 and 1 respectively. Similarly, the Universities portfolio in Preclinical and Discovery stages comprises 3 and 2 molecules, respectively.

Pulmonary Arterial Hypertension (Cardiovascular) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

  • The pipeline guide provides a snapshot of the global therapeutic landscape of Pulmonary Arterial Hypertension (Cardiovascular).
  • The pipeline guide reviews pipeline therapeutics for Pulmonary Arterial Hypertension (Cardiovascular) by companies and universities/research institutes based on information derived from company and industry-specific sources.
  • The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
  • The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
  • The pipeline guide reviews key companies involved in Pulmonary Arterial Hypertension (Cardiovascular) therapeutics and enlists all their major and minor projects.
  • The pipeline guide evaluates Pulmonary Arterial Hypertension (Cardiovascular) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
  • The pipeline guide encapsulates all the dormant and discontinued pipeline projects.
  • The pipeline guide reviews latest news related to pipeline therapeutics for Pulmonary Arterial Hypertension (Cardiovascular)

Reasons to buy

  • Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
  • Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
  • Find and recognize significant and varied types of therapeutics under development for Pulmonary Arterial Hypertension (Cardiovascular).
  • Classify potential new clients or partners in the target demographic.
  • Develop tactical initiatives by understanding the focus areas of leading companies.
  • Plan mergers and acquisitions meritoriously by identifying key players and it's most promising pipeline therapeutics.
  • Formulate corrective measures for pipeline projects by understanding Pulmonary Arterial Hypertension (Cardiovascular) pipeline depth and focus of Indication therapeutics.
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
  • Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.

Table of Contents

  • Table of Contents
    • List of Tables
    • List of Figures
  • Introduction
    • Global Markets Direct Report Coverage
  • Pulmonary Arterial Hypertension - Overview
  • Pulmonary Arterial Hypertension - Therapeutics Development
    • Pipeline Overview
    • Pipeline by Companies
    • Pipeline by Universities/Institutes
    • Products under Development by Companies
    • Products under Development by Universities/Institutes
  • Pulmonary Arterial Hypertension - Therapeutics Assessment
    • Assessment by Target
    • Assessment by Mechanism of Action
    • Assessment by Route of Administration
    • Assessment by Molecule Type
  • Pulmonary Arterial Hypertension - Companies Involved in Therapeutics Development
    • Actelion Ltd
    • APT Therapeutics Inc
    • Arena Pharmaceuticals Inc
    • Ascendis Pharma A/S
    • Asklepion Pharmaceuticals LLC
    • AVEO Pharmaceuticals Inc
    • Bial - Portela & Ca SA
    • Camurus AB
    • Celsion Corp
    • Celtaxsys Inc
    • Chiesi Farmaceutici SpA
    • Eli Lilly and Company
    • F. Hoffmann-La Roche Ltd
    • Galectin Therapeutics Inc
    • HitGen LTD
    • Insmed Inc
    • INSYS Therapeutics Inc
    • INVENT Pharmaceuticals Inc
    • Johnson & Johnson
    • Kowa Company Ltd
    • Liquidia Technologies Inc
    • MannKind Corp
    • Mast Therapeutics Inc
    • Mezzion Pharma Co Ltd
    • miRagen Therapeutics Inc
    • Morphogen-IX Ltd
    • Nippon Kayaku Co Ltd
    • Nippon Shinyaku Co Ltd
    • Northern Therapeutics Inc
    • Novartis AG
    • Peloton Therapeutics Inc
    • PhaseBio Pharmaceuticals Inc
    • Pluristem Therapeutics Inc
    • Polyphor Ltd
    • Proteo Inc
    • Pulmokine Inc
    • Reata Pharmaceuticals Inc
    • Respira Therapeutics Inc
    • Reviva Pharmaceuticals Inc
    • Selten Pharma Inc
    • Serodus ASA
    • Silence Therapeutics Plc
    • SteadyMed Therapeutics Inc
    • Suda Ltd
    • Toray Industries Inc
    • United Therapeutics Corp
    • Vivus Inc
  • Pulmonary Arterial Hypertension - Drug Profiles
    • (macitentan + tadalafil) - Drug Profile
    • acebilustat - Drug Profile
    • Antibody to Inhibit TRAIL for Pulmonary Arterial Hypertension - Drug Profile
    • Antisense Oligonucleotide to Inhibit miR-145 for Pulmonary Arterial Hypertension - Drug Profile
    • APT-602 - Drug Profile
    • ascomycin - Drug Profile
    • AV-353 - Drug Profile
    • bardoxolone methyl - Drug Profile
    • beraprost sodium SR - Drug Profile
    • BIA-51058 - Drug Profile
    • BMP-10 - Drug Profile
    • BMP-9 - Drug Profile
    • Cell Therapy to Activate eNOS for Pulmonary Arterial Hypertension - Drug Profile
    • CTX-3397 - Drug Profile
    • Drugs to Inhibit Notch3 for Pulmonary Arterial Hypertension - Drug Profile
    • esuberaprost sodium MR + treprostinil - Drug Profile
    • GMA-301 - Drug Profile
    • GMCT-01 - Drug Profile
    • GRMD-02 - Drug Profile
    • INS-1009 - Drug Profile
    • INV-240 - Drug Profile
    • JNJ-26993135 - Drug Profile
    • KAR-5585 - Drug Profile
    • L-Citrulline - Drug Profile
    • macitentan - Drug Profile
    • MD-0701 - Drug Profile
    • MFC-1040 - Drug Profile
    • MFC-2040 - Drug Profile
    • NK-104 NP - Drug Profile
    • Oligonucleotide to Inhibit Endothelin-1 for Lung Cancer, Pulmonary Arterial Hypertension and Respiratory Disorders - Drug Profile
    • Oligonucleotide to Inhibit MicroRNA-145 for Pulmonary Arterial Hypertension - Drug Profile
    • PB-1046 - Drug Profile
    • PB-1120 - Drug Profile
    • PF-543 - Drug Profile
    • PK-10453 - Drug Profile
    • PK-10571 - Drug Profile
    • PLX-PAD - Drug Profile
    • POL-6014 - Drug Profile
    • PT-2977 - Drug Profile
    • QCC-374 - Drug Profile
    • R-190 - Drug Profile
    • ralinepag - Drug Profile
    • RP-5063 - Drug Profile
    • RT-234 - Drug Profile
    • selexipag - Drug Profile
    • SER-100 - Drug Profile
    • sildenafil citrate - Drug Profile
    • sirolimus - Drug Profile
    • sirolimus albumin-bound - Drug Profile
    • Small Molecule to Inhibit ROCK-2 for Cardiovascular, Ophthalmology and Oncology - Drug Profile
    • Small Molecules for Pulmonary Arterial Hypertension - Drug Profile
    • Small Molecules to Activate ACE2 for Pulmonary Arterial Hypertension - Drug Profile
    • Small Molecules to Antagonize 5-HT1B for Pulmonary Arterial Hypertension - Drug Profile
    • Small Molecules to Antagonize PDGFR for Pulmonary Arterial Hypertension - Drug Profile
    • Small Molecules to Inhibit Soluble Epoxide Hydrolase for Pulmonary Arterial Hypertension - Drug Profile
    • sodium nitrite - Drug Profile
    • SPI-054 - Drug Profile
    • SPI-183 - Drug Profile
    • SUD-004 - Drug Profile
    • Synthetic Peptide to Antagonize Urotensin-II Receptor for Pulmonary Arterial Hypertension - Drug Profile
    • tacrolimus - Drug Profile
    • tadalafil - Drug Profile
    • tiprelestat - Drug Profile
    • tocilizumab - Drug Profile
    • TPN-729 - Drug Profile
    • TR-422 - Drug Profile
    • treprostinil diolamine - Drug Profile
    • treprostinil diolamine - Drug Profile
    • treprostinil diolamine - Drug Profile
    • treprostinil diolamine - Drug Profile
    • treprostinil diolamine SR - Drug Profile
    • ubenimex - Drug Profile
    • udenafil - Drug Profile
    • VPD-380 - Drug Profile
  • Pulmonary Arterial Hypertension - Dormant Projects
  • Pulmonary Arterial Hypertension - Discontinued Products
  • Pulmonary Arterial Hypertension - Product Development Milestones
    • Featured News & Press Releases
  • Appendix
    • Methodology
    • Coverage
    • Secondary Research
    • Primary Research
    • Expert Panel Validation
    • Contact Us
    • Disclaimer

List of Tables

  • Number of Products under Development for Pulmonary Arterial Hypertension, H1 2017
  • Number of Products under Development by Companies, H1 2017
  • Number of Products under Development by Companies, H1 2017 (Contd..1), H1 2017
  • Number of Products under Development by Companies, H1 2017 (Contd..2), H1 2017
  • Number of Products under Development by Universities/Institutes, H1 2017
  • Products under Development by Companies, H1 2017
  • Products under Development by Companies, H1 2017 (Contd..1), H1 2017
  • Products under Development by Companies, H1 2017 (Contd..2), H1 2017
  • Products under Development by Companies, H1 2017 (Contd..3), H1 2017
  • Products under Development by Universities/Institutes, H1 2017
  • Number of Products by Stage and Target, H1 2017
  • Number of Products by Stage and Target, H1 2017 (Contd..1), H1 2017
  • Number of Products by Stage and Mechanism of Action, H1 2017
  • Number of Products by Stage and Mechanism of Action, H1 2017 (Contd..1), H1 2017
  • Number of Products by Stage and Route of Administration, H1 2017
  • Number of Products by Stage and Molecule Type, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Actelion Ltd, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by APT Therapeutics Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Arena Pharmaceuticals Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Ascendis Pharma A/S, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Asklepion Pharmaceuticals LLC, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by AVEO Pharmaceuticals Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Bial - Portela & Ca SA, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Camurus AB, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Celsion Corp, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Celtaxsys Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Chiesi Farmaceutici SpA, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Eli Lilly and Company, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by F. Hoffmann-La Roche Ltd, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Galectin Therapeutics Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by HitGen LTD, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Insmed Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by INSYS Therapeutics Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by INVENT Pharmaceuticals Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Johnson & Johnson, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Kowa Company Ltd, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Liquidia Technologies Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by MannKind Corp, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Mast Therapeutics Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Mezzion Pharma Co Ltd, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by miRagen Therapeutics Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Morphogen-IX Ltd, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Nippon Kayaku Co Ltd, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Nippon Shinyaku Co Ltd, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Northern Therapeutics Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Novartis AG, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Peloton Therapeutics Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by PhaseBio Pharmaceuticals Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Pluristem Therapeutics Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Polyphor Ltd, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Proteo Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Pulmokine Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Reata Pharmaceuticals Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Respira Therapeutics Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Reviva Pharmaceuticals Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Selten Pharma Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Serodus ASA, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Silence Therapeutics Plc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by SteadyMed Therapeutics Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Suda Ltd, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Toray Industries Inc, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by United Therapeutics Corp, H1 2017
  • Pulmonary Arterial Hypertension - Pipeline by Vivus Inc, H1 2017
  • Pulmonary Arterial Hypertension - Dormant Projects, H1 2017
  • Pulmonary Arterial Hypertension - Dormant Projects, H1 2017 (Contd..1), H1 2017
  • Pulmonary Arterial Hypertension - Discontinued Products, H1 2017

List of Figures

  • Number of Products under Development for Pulmonary Arterial Hypertension, H1 2017
  • Number of Products under Development by Companies, H1 2017
  • Number of Products under Development by Universities/Institutes, H1 2017
  • Number of Products by Top 10 Targets, H1 2017
  • Number of Products by Stage and Top 10 Targets, H1 2017
  • Number of Products by Top 10 Mechanism of Actions, H1 2017
  • Number of Products by Stage and Top 10 Mechanism of Actions, H1 2017
  • Number of Products by Routes of Administration, H1 2017
  • Number of Products by Stage and Routes of Administration, H1 2017
  • Number of Products by Top 10 Molecule Types, H1 2017
  • Number of Products by Stage and Top 10 Molecule Types, H1 2017
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