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腫瘍溶解性ウイルス免疫療法の世界市場:投与量、価格および臨床試験の見通し(2026年)

Global Oncolytic Virus Immunotherapy Market, Dosage, Price & Clinical Trials Outlook 2026

出版日: | 発行: KuicK Research | ページ情報: 英文 285 Pages | 納期: 即日から翌営業日

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腫瘍溶解性ウイルス免疫療法の世界市場:投与量、価格および臨床試験の見通し(2026年)
出版日: 2020年10月08日
発行: KuicK Research
ページ情報: 英文 285 Pages
納期: 即日から翌営業日
  • 全表示
  • 概要
  • 図表
  • 目次
概要

世界の腫瘍溶解性ウイルス免疫療法の市場規模は、7億ドルに達する見通しです。臨床試験中の治療法125件のうち、米国が50件を占めています。

がんに関連する有病率と死亡率の増加は、より信頼性の高い治療法の開発に関して、常に現代医学への課題であり続けています。過去数年間で、研究者によって開発された画期的で新しいがん治療の1つは、腫瘍溶解性ウイルス免疫療法です。

がん治療にウイルスを使用するという未定義のアプリケーションと、がんの微小環境に関するウイルスの試験管内の操作は、前臨床および臨床レベルで成功した結果をもたらし、同市場の強化と拡大につながると見込まれています。腫瘍溶解性ウイルス療法の成長に関連する市場は、研究開発部門の活動を増やすことに焦点を合わせています。

当レポートは、世界の腫瘍溶解性ウイルス免疫療法市場について調査しており、市場の見通し、成長および抑制要因、作用機序、ウイルスタイプ・がんのタイプ・臨床試験のフェーズ別の市場分析、競合情勢、主要企業のプロファイル等の情報を提供しています。

目次

第1章 腫瘍溶解性ウイルスのイントロダクション

  • 腫瘍溶解性ウイルス療法の概要
  • 創世記から生物遺伝学への道

第2章 悪性腫瘍におけるウイルス療法の入門

  • がんに対する腫瘍溶解性ウイルス
  • 腫瘍細胞を標的とするためのアプローチ
    • プロアポトーシスターゲティング
    • トランスレーショナルターゲティング
    • 転写ターゲティング
    • トランスダクショナルターゲティング

第3章 作用機序

  • がん細胞へのウイルスの侵入
  • 発がん性ウイルスがたどる有効性経路
  • 腫瘍特異性のメカニズム
    • 欠陥のある抗ウイルス反応
    • 腫瘍選択的摂取のための受容体ターゲティング
    • 腫瘍特異的プロモーターの標的
    • ウイルス遺伝子の削除
    • 腫瘍微小環境におけるウイルス粒子のタンパク質分解処理

第4章 腫瘍溶解性ウイルス免疫療法の概要

  • 抗腫瘍免疫反応の刺激
  • がんワクチンとしての腫瘍溶解性ウイルス

第5章 腫瘍溶解性ウイルスとして投じられたウイルスのタイプ

  • 腫瘍溶解性野生型ウイルス
    • レオウイルス(呼吸器腸内オーファンウイルス)
    • 水疱性口内炎ウイルス(VSV)
    • ニューカッスル病ウイルス(NDV)
    • 粘液腫
  • 遺伝子操作された腫瘍溶解性ウイルス
    • アデノウイルス
    • 単純ヘルペスウイルス
    • ワクシニアウイルス

第6章 がんに対する潜在的な腫瘍溶解性ウイルス免疫療法

  • 乳がん
  • 肺がん
  • 前立腺がん
  • 黒色腫
  • 脳腫瘍
  • 血液がん

第7章 市場概要

  • 腫瘍溶解性ウイルスアーケードに向けた序文
  • 承認された腫瘍溶解性ウイルスの市場的側面

第8章 臨床パイプラインの概要

  • フェーズ別
  • 企業別
  • 国別
  • 適応症別
  • 患者セグメント別

第9章 世界の腫瘍溶解性ウイルス免疫療法:可用性、投与量、価格分析

  • Imlygic(Talimogene laherparepvec)
  • Oncorine (H101)

第10章 腫瘍溶解性ウイルス治療市場における調査の進歩と医学の進歩

  • がんワクチンとしての腫瘍溶解性ウイルス療法の開発
  • 高度な結果を得るための腫瘍溶解性ウイルス療法とT細胞療法のコラボレーション
  • 小児の悪性腫瘍細胞の死滅における腫瘍溶解性ウイルス療法の予備的有効性
  • City of Hopeの研究者による腫瘍溶解性ウイルス療法とCAR-T細胞療法の併用研究
  • TG4001およびTG6002HPV誘発がんに対する陽性の臨床結果、など

第11章 腫瘍溶解性ウイルス治療市場進展に向けた戦略的提携と協業

  • MustangBioおよびNationwide Children's Hospital:膠芽腫の腫瘍溶解性ウイルス治療のための協力
  • PfizerおよびWestern:新規腫瘍溶解治療のための協業の発表
  • Tessa Therapeutics&Vyriad:新しい腫瘍溶解性治療を後押し
  • Boehringer IngelheimおよびVira Therapeutics:がん患者のための次世代腫瘍溶解性ウイルス療法の開発、など

第12章 企業、適応症およびフェーズ別の世界の腫瘍溶解性ウイルス免疫療法の臨床試験

  • 調査
  • 前臨床
  • 臨床
  • フェーズI
  • フェーズI/II
  • フェーズII
  • フェーズII/III
  • フェーズIII

第13章 市販の腫瘍溶解性ウイルス免疫療法の臨床的洞察

  • IMLYGIC
  • Oncorine

第14章 市場力学

  • 市場の成長要因
  • 市場の抑制要因

第15章 市場の将来展望

第16章 競合情勢

  • BioVex Inc.
  • Cell Genesys
  • Crusade Laboratories
  • Genelux Corporation
  • Jennerex Biotherapeutics
  • Lokon Pharma
  • Merck
  • MultiVir
  • Oncolys BioPharma
  • Oncolytics Biotech
  • Oncos Therapeutics (Targovax)
  • PsiOxus Therapeutics
  • Shanghai Sunway Biotech
  • タカラバイオ株式会社
  • VCN Biosciences
  • ViroTarg
  • Vyriad
図表

List of Figures

  • Figure 1-1: Demonstration of Categorization of Oncolytic Viruses
  • Figure 1-2: Illustration of Major Events in Clinical Virotherapy
  • Figure 2-1: Potential Advantages of Oncolytic Viruses over Conventional Therapies
  • Figure 3-1: The Diagrammatic Representation of Entry of Virions into Cancerous cells
  • Figure 3-2: Route of Anti-tumoral Efficacy of Oncolytic Viruses
  • Figure 3-3: Mechanism of Tumor Destruction by Oncolytic Viruses
  • Figure 3-4: Categorization Followed by Oncolytic Viruses for Tumor Selectivity
  • Figure 4-1: Demonstration of Phases of Immune Responses Elicited by the Oncolytic Viruses
  • Figure 5-1: Categorization of Oncolytic Viruses over the Basis of their Behavior
  • Figure 5-2: Diagrammatic Representation of Oncolysis Shown by Reovirus
  • Figure 5-3: Mechanism of Oncolytic Behavior of Adenoviruses
  • Figure 6-1: Selectively Killing of Prostate Cancer Cells by Oncolytic M-Protein Strains of VSV
  • Figure 6-2: Proposed Treatment of Oncolytic Viruses for Hematological Malignancies
  • Figure 7-1: Global - Oncolytic Virus Immunotherapy Market Opportunity (US$ Million), 2020 -2026
  • Figure 8-1: Global Oncolytic Virus Pipeline by Phase (%), 2020 till 2026
  • Figure 8-2: Oncolytic Virus Pipeline by Phase (Numbers), 2020 till 2026
  • Figure 8-3: Global - Oncolytic Virus Immunotherapy Clinical Trials by Company (Numbers), 2020 till 2026
  • Figure 8-4: Global - Oncolytic Virus Immunotherapy Clinical Trials by Country (Numbers), 2020 till 2026
  • Figure 8-5: Global - Oncolytic Virus Immunotherapy Clinical Trials by Indication (Numbers), 2020 till 2026
  • Figure 8-6: Global - Oncolytic Virus Immunotherapy Clinical Trials by Patient Segment (Numbers), 2020 till 2026
  • Figure 9-1: Imlygic - US & European Patent Expiration Year
  • Figure 9-2: Imlygic - Price of 1 Million PUF/ml & 100 Million PUF/ml Injectable Suspension (US$), September'2020
  • Figure 9-3: Imlygic - Dose for Initial Treatment Cycle & Subsequent Treatment Cycle (Million PUF/ml), September'2020
  • Figure 9-4: Imlygic - Duration of Initial & Subsequent Treatment Cycle (weeks), September'2020
  • Figure 9-5: Imlygic - Average Price of Initial Treatment Cycle & Each Subsequent Treatment Cycle (US$), September'2020
  • Figure 9-6: Imlygic - Volume Administered by Size of Lesion (ml), September'2020
  • Figure 9-7: Oncorine: Cost of Single Dose & Single Treatment Course (US$), September'2020
  • Figure 9-8: Oncorine - Duration of Treatment Cycle by Type of Cancer (Days), September'2020
  • Figure 14-1: Major Drivers for the Oncolytic Virus Therapies
  • Figure 14-2: Major Challenges Faced by Oncolytic Viral Therapies
  • Figure 16-1: Lokon Pharma - Clinical Pipeline
  • Figure 16-2: MultiVir -Clinical Pipeline
  • Figure 16-3: Oncolys BipoPharma- Clinical Pipeline
  • Figure 16-4: Oncos Therapeutics- Clinical Pipeline
  • Figure 16-5: Vyriad- Clinical Pipeline
目次

"Global Oncolytic Virus Immunotherapy Market, Dosage, Price & Clinical Trials Outlook 2026" Report Highlights:

  • Global Oncolytic Virus Immunotherapy Market: US$ 700 Million Opportunity
  • Global Oncolytic Virus Immunotherapy Clinical Trials: >125 Therapies In Trials
  • USA Dominates Oncolytic Virus Immunotherapy Clinical Trials: >50 Therapies In Trials
  • Comprehensive Insight on Clinical & Non Clinical Issues Related to Global Oncolytic Virus Immunotherapy Market Development
  • Approved Oncolytic Virus Immunotherapy: 2
  • Global Research Progress & Medical Advancement Insight
  • Imlygic (Talimogene laherparepvec) & Oncorine: Dosage, Price & Patent insight

Increase in prevalence and mortality rate associated with cancer has always remained a challenge to the modern medicine with respect to the development of more reliable therapies. In the past few years, one of the greatest breakthrough novel cancer therapy that has been developed by the researchers is the oncolytic virus immunotherapy. The overall procedure of the therapy is based on the ability of the oncolytic virus to infect and further lyse the tumor cells by boosting the immune system of the patient. Some of the virus strains that have been tested and proved to be adding to the various applications of the therapy are canine distemper virus, adenovirus, vaccinia virus and reovirus in the preclinical and clinical studies.

The undefined applications of using virus for the cancer treatment and the in-vitro manipulation of the virus with respect to cancer micro environment are estimated to be providing successful clinical outcomes at preclinical and clinical level, thus leading to the enhancement and the expansion of the market. All the clinical trials associated with the therapy are boosted with the available drivers as all concerned drivers are estimated to bring forward numerous opportunities for the cancer patients. The market concerned with the growth of the oncolytic virus therapy is also focused on increasing the research and development sector activities. The market within no time is estimated to be recognized as an important asset for the cancer therapeutics as it carries the ability to change the stringent cancer treatment paradigm available for the patients. The current clinical platform is estimated to be developing a competitive landscape for the other cancer markets as it is getting fragmented at a high speed when compared with other cancer therapies status.

The blockbuster model held by the therapy is also believed to be driving the large shareholder value of the market in the present as well as in the upcoming years. The increase in the perception of highly expensive drugs available under cell and gene therapy are expected to be one of the most regulated drivers for the global expansion of the oncolytic therapy. As a result of strong clinical background and healthy research and development sector, oncolytic virus therapy is becoming more prominent in the cancer landscape. With the primary goal of revolutionizing the cancer therapeutics market, it is estimated that the therapy in a short period of time will be successful in re-defining the unstructured cancer paradigm for the patients with advanced cancers.

Being not only restricted to clinical benefits, the therapy is moving forward to provide better post-treatment lives to the cancer patients. The therapy in the clinical studies have been able to put forward the value of the patients in terms of clinical outcomes as well as patient-related outcome measures, thus causing a wider acceptance to the therapy in the cancer therapeutics market. Some of the primary aim associated with the current clinical pipeline of the therapy involves limited cost expansion and increased success rate. Prominent factors like these are estimated to enhance access of the patient population to effective oncolytic virus therapy.

The future view of the oncolytic virus therapy is estimated to be enabling such innovative mechanisms that would be responsible for providing tremendous amount of opportunities to the cancer patients. Different gene-editing technologies, advancement in genomics and many others will map the therapy among the best-cancer regimens ever discovered. The leverage provided to the therapy in terms of opportunities depicts the possibility of the therapy to get recognized as a real cure to the cancer patients and eventually a dominating market. With the advent of the therapy for the cancer platform, there has been a significant transformation in the current cancer therapeutics market. In financial services, the market is estimated to perform with accuracy and speed in the future years.

As per " Global Oncolytic Virus Immunotherapy Market, Dosage, Price & Clinical Trials Outlook 2026" report findings, it is estimated that the total inflation of the market with respect to clinical platform, wider acceptance in a short period of time will drive the market in the upcoming years. Gradual increase in the interest of the researchers towards oncolytic virus therapy will develop the market which will eventually bring complete revolution in terms of applications to the cancer patients. The future market insight for the therapy is analyzed to provide unlimited number of trends and opportunities, leading to aggregation of all the cancer related bio-pharmaceutical companies and research centers towards the further development and commercialization of the therapy.

Table of Contents

1. Introduction to Oncolytic Virus

  • 1.1 Outline of Oncolytic Virotherapy
  • 1.2 Trail from Genesis to Biogenetics

2. Primer of Virotherapy in Malignancies

  • 2.1 Oncolytic Viruses towards Cancer
  • 2.2 Approaches for Targeting Tumor Cells
    • 2.2.1 Pro Apoptotic Targeting
    • 2.2.2 Translational Targeting
    • 2.2.3 Transcriptional Targeting
    • 2.2.4 Transductional Targeting

3. Viral Oncolysis Mechanism of Action

  • 3.1 Viral Entry into Cancerous Cells
  • 3.2 Efficacy Routes Followed by Oncogenic Viruses
  • 3.3 Mechanism of Tumor Specificity
    • 3.3.1 Defective Anti-Viral Responses
    • 3.3.2 Receptor Targeting for Tumor Selective Intake
    • 3.3.3 Targeting to Tumor Specific Promoters
    • 3.3.4 Viral Gene Deletions
    • 3.3.5 Proteolytic Processing of Virus Particles in Tumor Microenvironment

4. Oncolytic Viruses Immunotherapy Overview

  • 4.1 Stimulation of Antitumor Immune Responses
  • 4.2 Oncolytic Viruses as Cancer Vaccines

5. Varieties of Viruses Casted as Oncolytic Viruses

  • 5.1 Oncolytic Wild Type Viruses
    • 5.1.1 Reovirus (Respiratory Enteric Orphan Virus)
    • 5.1.2 Vesicular Stomatitis Virus (VSV)
    • 5.1.3 Newcastle Disease Virus (NDV)
    • 5.1.4 Myxoma
  • 5.2 Genetically Engineered Oncolytic Viruses
    • 5.2.1 Adenoviruses
    • 5.2.2 Herpes Simplex Virus
    • 5.2.3 Vaccinia Virus

6. Potential Oncolytic Virus Immunotherapy for Cancers

  • 6.1 Breast Cancer
  • 6.2 Lung Cancer
  • 6.3 Prostate Cancer
  • 6.4 Melanoma
  • 6.5 Brain Tumor
  • 6.6 Blood Cancer

7. Global Oncolytic Virus Immunotherapy Therapy Market Overview

  • 7.1 Preface towards Oncolytic Virus Arcade
  • 7.2 Market Aspects of Approved Oncolytic Viruses

8. Oncolytic Virus Immunotherapy Clinical Pipeline Overview

  • 8.1 By Phase
  • 8.2 By Company
  • 8.3 By Country
  • 8.4 By Indication
  • 8.5 By Patient Segment

9. Global Oncolytic Virus Immunotherapy - Availability, Dosage & Price Analysis

  • 9.1 Imlygic (Talimogene laherparepvec)
  • 9.2 Oncorine (H101)

10. Research Progress & Medical Advancement in Oncolytic Virus Therapy Market

  • 10.1 Oncolytic Virus Therapy Development as a Cancer Vaccine
  • 10.2 Oncolytic Virus Therapy Collaboration with T-Cell Therapy for Advanced Results
  • 10.3 Preliminary Effectiveness of Oncolytic Virus Therapy in Killing Malignant Tumor Cells in Children
  • 10.4 Combined Study of Oncolytic Virus Therapy and CAR-T Cell Therapy by City of Hope Researchers
  • 10.5 TG4001 & TG6002 Positive Clinical Results against HPV-Induced Cancers
  • 10.6 Pelareorep-Anti-PD-1 Combination for the Treatment of Locally Advanced or Metastatic Triple-Negative Breast Cancer
  • 10.7 Adenovirus E3 Region to Substantially Improve Oncolytic Efficacy & Potency
  • 10.8 University of Helsinki Novel Solution for Advancing Oncolytic Virus Therapy
  • 10.9 Valo Therapeutics Technology Acquisition for Advancing Oncolytic Therapy
  • 10.10 Mayo Clinic to Expand Oncolytic Virus Therapy against Multiple Myeloma

11. Strategic Partnership & Collaborations to Advance the Oncolytic Virus Therapy Market

  • 11.1 Mustang Bio & Nationwide Children's Hospital to Undergo Collaboration for Oncolytic Virus Therapy for Glioblastoma
  • 11.2 Pfizer & Western Oncolytics Collaboration Announcement for Novel Oncolytic Treatment
  • 11.3 Tessa Therapeutics & Vyriad to Synergistically Boost the Novel Oncolytic Treatment
  • 11.4 Boehringer Ingelheim & Vira Therapeutics to Develop Next Generation Oncolytic Virus Therapy for the Cancer Patients
  • 11.5 Regeneron & Vyriad Therapeutics Collaboration for Unravelling Oncoytic Virus Therapy for Cancer Treatment
  • 11.6 DNAtrix & Valo Therapeutics Collaboration for Evaluating Peptide Based Oncolytic Therapy for the Cancer Patients
  • 11.7 Pfizer & Ignite Immunotherapy to Collaboration for Developing Next-Generation Oncolytic Virus Therapy
  • 11.8 AbbVie & Turnstone Biologics to Collaborate for Next-Generation Oncolytic Viral Immunotherapies
  • 11.9 ABL Europe & SillaJen to Expand Oncolytic Virus Therapy Market
  • 11.10 PsiOxus & BMS Ink Collaboration for the Development of Transgenic Oncolytic Therapy

12. Global Oncolytic Virus Immunotherapy Clinical Trials By Company, Indication & Phase

  • 12.1 Research
  • 12.2 Preclinical
  • 12.3 Clinical
  • 12.4 Phase-I
  • 12.5 Phase-I/II
  • 12.6 Phase-II
  • 12.7 Phase-II/III
  • 12.8 Phase-III

13. Marketed Oncolytic Virus Immunotherapy Clinical Insight

  • 13.1 IMLYGIC
  • 13.2 Oncorine

14. Global Oncolytic Virus Immunotherapy Market Dynamics

  • 14.1 Market Drivers
  • 14.2 Growth Inhibitors

15. Global Oncolytic Virus Immunotherapy Market Future Outlook

16. Competitive Landscape

  • 16.1 BioVex Inc.
  • 16.2 Cell Genesys
  • 16.3 Crusade Laboratories
  • 16.4 Genelux Corporation
  • 16.5 Jennerex Biotherapeutics
  • 16.6 Lokon Pharma
  • 16.7 Merck
  • 16.8 MultiVir
  • 16.9 Oncolys BioPharma
  • 16.10 Oncolytics Biotech
  • 16.11 Oncos Therapeutics (Targovax)
  • 16.12 PsiOxus Therapeutics
  • 16.13 Shanghai Sunway Biotech
  • 16.14 Takara Bio
  • 16.15 VCN Biosciences
  • 16.16 ViroTarg
  • 16.17 Vyriad
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