"Global Cell Therapy Market, Therapy Price, Dosage & Clinical Trials Insight 2027" Report Highlights:
- Global Cell Therapy Market Opportunity: More Than USD 40 Billion By 2027
- Cell Therapy Clinical Trial Insight by Indication, Company and Country
- Global Cell Therapy Clinical Pipeline: 1000 Cell Therapies
- Globally Marketed Cell Therapies: 25 Cell Therapies
- Cell Therapy Trials For COVID-19: 10 Cell Therapies
- Global COVID-19 Cell Therapy Clinical Trials By Phase & Company
- COVID-19 Impact Analysis on Global market & Clinical Trials
- Price & Product Insight By Region/Country
Over a period of time, cell therapy has emerged as next growth frontier for the pharmaceutical companies involved the research and development of innovative therapies for the treatment of simple to complex medical anomalies. The increasing focus on new technologies and methodologies are leading to path breaking innovations which are playing an important role in the practice of medicine and cell therapy. The cell therapy approach to treatment and prevention is more advanced and targeted as compare to traditional therapies as the former works at basic level on human science that is cells. Cell therapy treatment is more advanced and custom in nature and thus giving the required thrust to advancement of personalized therapy.
"Global Cell Therapy Market Opportunity To Surpass US$ 40 Billion by 2027 Driven By Robust Clinical Pipeline & Increasing Sales Of Therapies Like Yescarta & Kymriah"
Cell therapy research and clinical advancement has accelerated strongly in the limited period of time. Once limited to bone marrow transplants, the cell therapy field is currently prepared to achieve critical advances in various distinctive clinical signs. The same scenario can be reflected in the fact that the number of clinical trials have increased more than 50% in last 2 years. At present (June'2020), more than 1000 cell therapies are in pipeline and 25 therapies are commercially available in the market. Most of the cell therapies are in preclinical stage and close to 450 therapies are in Phase I, Phase II & Phase III trials. Analysis of the pipeline shows that the majority of cell therapy products that are currently under development are targeted towards treatment of complex disease like cardiovascular disease, neural disease and cancer.
The commercial acceptability and success of cell therapies can also be reflected from robust sales of therapies like Yescarta (Gilead Sciences) & Kymriah (Novartis). During 2019, the sales of Yescarta surpassed US$ 450 Million as compared to US$ 264 Million in 2018, with annual growth of almost 72%. Similarly, Kymriah witnessed growth of 260% with total sales of more than US$ 270 Million in 2019 as compare to less than US$ 75 Million in 2018. Further, the rapid approval and orphan status of few therapeutics coming out of the cell therapy pipeline ensures it to be a lucrative segment. Several collaborations in the past few years has created an optimistic scenario when it comes to the future of cell therapy segment. The cell therapy industry is rapidly growing industry with the several new products that having been accepted for clinical use over the past few years. There are many challenges that need to be resolved wisely before the cell therapies are widely accepted, including the optimization of their manufacture.
With increasing number of clinical trials, robust sales values and widening clinical indication base, it is clear reflection of the fact that the cell therapy market will witness remarkable growth trajectory in coming years. The global cell therapy market opportunity is estimated to surpass US$ 40 Billion by 2027 driven by increasing technical and manufacturing capabilities coupled with the advancements that will drive the acceptability of cell therapy procedures among the various stakeholders of the pharmaceutical industry. The current scenario of COVID-19 may slowdown the clinical trials conductibility or the market growth trajectory but the same COVID-19 pandemic is going to offer new growth avenues to the industry in form of ongoing clinical trials for the treatment of COVID-19.
Table of Contents
1. Overview of Cell Therapy
- 1.1. Introduction to Cell Therapy
- 1.2. History & Evolution of Cell Therapy
2. Cell Therapy Classification
- 2.1. Allogeneic Cell Therapy
- 2.2. Autologous Cell Therapy
- 2.3. Human Embryonic Stem Cell Therapy
- 2.4. Neural Stem Cell Therapy
- 2.5. Mesenchymal Stem Cell Therapy
- 2.6. Hematopoietic Stem Cell Transplantation
3. Mechanism of Therapeutic Action in Cell Therapy
4. Manufacturing of Cell Therapies
- 4.1. Models for Manufacturing Cell Therapies
- 4.2. Facilities for Good Manufacturing Practice
5. Advantages of Cell Therapy Over Conventional Therapy
- 5.1. Anti-Aging with Cell Therapy
- 5.2. Addressing Other Diseases with Cell Therapy
6. Emergence of Personalized Cell Therapy
- 6.1. Overview of Personalized Cell Therapy
- 6.2. Personalized Cell Therapy Using Epigenetic Tools
- 6.3. Personalized Cell Therapy through Mesenchymal Stem Cells
- 6.4. Treatment of Parkinson's Disease through IPSCs
- 6.5. Case Study: Personalized Cell Therapy for Pulpitis Using Autologous Dental Pulp Stem Cells & Leukocyte Platelet Rich Fibrin
7. Cell Therapy Application by Therapeutic Areas
- 7.1. Cardiovascular Disease
- 7.2. Neurological Disorders
- 7.3. Inflammatory Diseases
- 7.4. Diabetes
8. Application of Cell Therapy to Cancer Therapeutics
- 8.1. Stem Cells & Their Therapeutic Role in Cancer
- 8.2. Role of Surface Markers & Their Targeting
9. Cell Therapy Research Insights at University Level
- 9.1. Cell Therapy for Diabetes in Animal Model
- 9.2. Cell Therapy as a Renewable Treatment Source for Cancer
- 9.3. Advancing CAR T-Cell Therapy for Cancer Treatment
- 9.4. Improving Depth & Durability of Cancer Treatment by CAR T-Cell Therapy
- 9.5. NKTR-214 in Combination with Adoptive Cell Therapy Against Melanoma
- 9.6. Regenerative Medicine Advanced Therapy Designation Granted to CAR T-Cell Therapy by FDA
- 9.7. UCLA & CASIS Collaboration for Regenerative Medicine & Stem Cell Research
- 9.8. Dual Stem Cell Therapy for Cardiac Repair
- 9.9. T-Cell Therapy against Multiple Forms of Cancers
- 9.10. Stem Cell Therapy against Covid-19 Pandemic
- 9.11. AgeX Therapeutics & University of California Research Program for Huntington's Disease & Other Neurological Disorders
- 9.12. Avacta Group plc & Memorial Sloan Kettering Cancer Center Research Collaboration for CAR-T Cell-Based Immunotherapy.
- 9.13. Remodeled CAR-T Cell Therapy Undergoing Extensive Groundwork
- 9.14. Invariant Natural Killer Cell's Long-Lasting Immunity against Cancer Cells
- 9.15. Light Sensitive CAR-T Cells against Skin Tumor in Mice Resulted to be Effective
- 9.16. Scorpion Toxin to Guide CAR-T Cells for Brain Cancer
10. Strateging Alliances for Promoting Cell Therapy Research
- 10.1. GlaxoSmithKline's Deal with Immatics Cell Therapy Science to Advance Cell Therapy
- 10.2. Indapta Therapeutics & Lonza's New Partnership for Advancing Cancer Cell Therapy
- 10.3. Key Biologics & Blood Centers of America to Open Access for Cell Therapy
- 10.4. Gamida Regulatory Nods with Lonza for Cell Therapy Product Production
- 10.5. GlaxoSmithKline & Lyell Immunopharma to Develop Next Generation Cancer Cell Therapies
- 10.6. Harvard & MIT to Bolster Cell & Gene Therapy Medical Research
- 10.7. Takeda & MD Anderson to Accelerate the Development of NK Cell Therapy Platform
- 10.8. Multiple Cell Therapy Collaborations Initiated by Takeda Pharmaceuticals
- 10.9. Mesenchymal Stem Cell Program Launch By Celltex against Covid-19
- 10.10. Artisan Bio Announces Global Research & Takeda to Undergo Next-Generation Cell Therapy Products Development
- 10.11. Astellas & Universal Cells, Inc. Collaboration for Cell Therapy Product Development for Undisclosed Indication
- 10.12. Fate Therapeutics & Janssen to Undergo Worldwide Collaboration for iPSC-derived Cell-based Cancer Immunotherapies
- 10.13. Kite & Teneobio Collaboration for the Development of CAR-T Antibodies
- 10.14. Lonza to Undergo Series of Collaborations for the Development of Novel Cell Cancer Therapies
- 10.15. Other Latest Press Releases for Stem Cell Therapy Research & Development
- 10.15.1. RegenMed Development Organization & CollPlant Business Alliance
- 10.15.2. Institute of Integrative Biology & Anika Therapeutics Business Alliance
- 10.15.3. The US FDA & Cytobank Collaboration Agreement
11. Global Cell Therapy Clinical Pipeline Overview
- 11.1. By Phase
- 11.2. By Country/Region
- 11.3. By Company
- 11.4. By Indication
- 11.5. By Patient Segment
- 11.6. By Route Of Administration
12. Impact of COVID-19 On Cell Therapy Research Landscape
13. Global COVID-19 Cell Therapy Clinical Trials By Phase & Company
- 13.1. Research
- 13.2. Preclinical
- 13.3. Clinical
- 13.4. Phase-I
- 13.5. Phase-I/II
- 13.6. Phase-II
14. Global Cell Therapies Clinical Pipeline By Company, Indication & Phase
- 14.1. Unknown
- 14.2. Research
- 14.3. Preclinical
- 14.4. Clinical
- 14.5. Phase-0
- 14.6. Phase-I
- 14.7. Phase-I/II
- 14.8. Phase-II
- 14.9. Phase-II/III
- 14.10. Phase-III
- 14.11. Preregistration
- 14.12. Registered
15. Global Cell Therapy Market Outlook
- 15.1. Current Market Scenario
- 15.2. Cell Therapy Market by Cell Source
- 15.2.1. Induced Pluripotent Stem Cell (IPSCs)
- 15.2.2. Bone Marrow
- 15.2.3. Umbilical Cord Blood Derived Cells
16. US-Cell Therapy Dosage & Cost Analysis
- 16.1. Allocord
- 16.2. Laviv
- 16.3. Maci
- 16.4. Clevecord
- 16.5. Hemacord
- 16.6. Ducord
- 16.7. Provenge
- 16.8. HPC, Cord Blood (Clinimmune Labs, University of Colorado Cord Blood Bank)
- 16.9. HPC, Cord Blood (LifeSouth Community Blood Centers, Inc)
- 16.10. HPC, Cord Blood (Bloodworks)
- 16.11. HPC, Cord Blood (MD Anderson Cord Blood Bank)
- 16.12. Gintuit
- 16.13. Kymriah*
- 16.14. Yescarta*
- 16.15. Carticel
17. South Korea-Cell Therapy Dosage & Cost Analysis
- 17.1. Cartistem
- 17.2. Chondron
- 17.3. KeraHeal
- 17.4. Cellgram
- 17.5. Cure Skin Injection
18. Australia, Europe & Japan-Cell Therapy Dosage & Cost Analysis
- 18.1. Holoclar (Europe)
- 18.2. Yescarta (EU)
- 18.3. Kymriah (EU)
- 18.4. Temcell HS (Japan)
- 18.5. Chondrocytes-T-Ortho-ACI (Australia)
19. Global Cell Therapy Market Scenario
- 19.1. US
- 19.2. South Korea
- 19.3. Europe
- 19.4. Japan
- 19.5. China
- 19.6. Rest of the World
20. Global Cell Therapy Research Advancements
- 20.1. Drug Based Therapies Advancements in Chronic Lymphocytic Leukemia
- 20.2. Advances in Cytomegalovirus Infection Prevention & Treatment
- 20.3. Stem Cell Therapy for the Treatment of Parkinson's Disease
- 20.4. Stem Cell Therapy for the Treatment of Alzheimer's Disease
- 20.5. Treatment of Rheumatoid Arthritis via Stem Cell Therapy
- 20.6. Role of Stem Cell Therapy in Treating Infertility
- 20.7. Stem Cells for Eye Diseases
- 20.8. Cell Therapy for Stroke and Angina Pectoris
- 20.9. Stem Cell Therapy in Improving Wrinkles & Acne Scars
21. Treg Cells-The Next Step To Advance Cell Therapy
- 21.1. Introduction to Treg Cell
- 21.2. Isolation & Expansion of Treg Cell
- 21.3. Mechanism of Action
- 21.4. Clinical Trials of Treg Cell Therapy
- 21.4.1. Adoptive Cell Therapy of Treg cells to Prevent GvHD
- 21.4.2. Adoptive Cell Therapy of Polyclonal & Alloantigen-specific Treg cells to
- Prevent Solid Organ Transplant Rejection
- 21.5. Treg Cell Therapy for the Treatmet of Autoinflammatory & Autoimmune Diseases
- 21.5.1. Inflammatory Bowel Disease
- 21.5.2. Systemic Lupus Erythematosus
- 21.5.3. Autoimmune Hepatitis
- 21.5.4. Pemphigus Vulgaris
- 21.5.5. Allergy and Asthma
- 21.6. Future Prospects of Treg Cell Therapy
22. Global Cell Therapy Market Future Prospects
23. Marketed Cell Therapies Clinical Insight by Company & Indication
- 23.1. Tisagenlecleucel (Kymriah)
- 23.2. Axicabtagene Ciloleucel (Yescarta)
- 23.3. Allogeneic Cultured Keratinocytes And Fibroblasts (Gintuit)
- 23.4. Adipose Stem Cell Therapy (Adipocell (Anterogen), Cupistem & Queencell)
- 23.5. Tonogenchoncel-L (INVOSSA-K inj)
- 23.6. Mesenchymal Stem Cell Therapies (Stempeucel)
- 23.7. Remestemcel-L (Prochymal & TEMCELL HS Inj.)
- 23.8. Sipuleucel-T (Provenge)
- 23.9. Autologous Mesenchymal Stem Cell Therapy-Pharmicell
- 23.10. Autologous Cultured Chondrocytes (MACI)
- 23.11. Autologous Cultured Chondrocytes (Chondrotransplant DISC)
- 23.12. Autologous Corneal Epithelial Stem Cell Therapy (Holoclar)
- 23.13. Nalotimagene Carmaleucel (Zalmoxis)
- 23.14. Mesenchymal Stem Cell Therapy For Cartilage Repair (Cartistem)
- 23.15. Autologous Chondrocyte Implant-TETEC
- 23.16. Muscle-Derived Autologous Stem Cell Therapy (MyoCell)
- 23.17. Human Skin Replacement (CellSpray)
- 23.18. Leukocyte Cell Therapy (CureXcell)
- 23.19. Autologous Cultured Chondrocyte Implant (Carticel)
- 23.20. Azficel-T (Laviv)
- 23.21. Autologous Cultured Chondrocytes (CHONDRON)
- 23.22. Autologous Chondrocytes (BioCart)
- 23.23. Amniotic Cell Therapy (NuCel)
- 23.24. Dendritic Cell-Activated Cytokine-Induced Killer Cells-Shanghai Jia Fu Medical
- 23.25. Autologous Cultured Myoblasts And Fibroblasts (Urocell)
24. Competitive Landscape
- 24.1. Athersys Inc.
- 24.2. Baxter Healthcare Corporation
- 24.3. Bone Therapeutics
- 24.4. Celgene Corporation
- 24.5. Cell Medica
- 24.6. Cellerant Therapeutics
- 24.7. FibrocellScinence
- 24.8. Genzyme Corporation
- 24.9. Green Cross Cell
- 24.10. Histogenics Corporation
- 24.11. Intrexon Corporation
- 24.12. Intercytex
- 24.13. ISTO Biologics
- 24.14. Macrocure
- 24.15. Mesoblast
- 24.16. Molmed
- 24.17. Nuo Therapeutics Inc
- 24.18. OmniCyte
- 24.19. Opexa Therapeutics
- 24.20. Organogenesis
- 24.21. Pharmicell
- 24.22. TCA Cellular Therapy
- 24.23. Stem Cell Inc.
- 24.24. Teva Pharmaceuticals
- 24.25. Tigenix
- 24.26. Vericel Corporation