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CRISPR Cas9 の世界市場:治験・治療用途の展望

Global CRISPR Cas9 Market, Clinical Trials & Therapeutic Application Outlook 2024

発行 KuicK Research 商品コード 913552
出版日 ページ情報 英文 200 Pages
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CRISPR Cas9 の世界市場:治験・治療用途の展望 Global CRISPR Cas9 Market, Clinical Trials & Therapeutic Application Outlook 2024
出版日: 2019年10月09日 ページ情報: 英文 200 Pages
概要

当レポートでは、世界のCRISPR-Cas9市場について、治験および治療用途にフォーカスして調査しており、市場概要、治験動向、企業・適応所別による治験、地域市場のシナリオ、適応症別による治療用途、および治験に関わる主要企業のプロファイルなど、体系的な情報を提供しています。

第1章 CRISPR-Cas9:イントロダクション

第2章 作用機序

  • 単細胞微生物におけるCRISPRによる免疫防御
  • CRISPR技術

第3章 CRISPR-Cas9のデリバリー方法

  • 物理的手法によるCRISPR-Cas9コンポーネントのデリバリー
  • ウィルスベクターによるCRISPR-Cas9コンポーネントのデリバリー
  • 非ウィルスベクター (バイオマテリアル) によるCRISPR-Cas9コンポーネントのデリバリー

第4章 CRISPR-Cas9:様々な用途の存在

  • CRISPR-Cas9技術に伴うメリット
  • その他のゲノム編集ツールとCRISPR-Cas9の比較

第5章 世界のCRISPR-Cas9治験:国・適応症別

  • 研究
  • 前臨床
  • フェーズI
  • フェーズI/II
  • フェーズII

第6章 世界のCRISPR-Cas9市場:現況

  • 世界のCRISPR市場分析
  • 世界のCRISPR市場:地域シナリオ

第7章 遺伝的疾患の除去:CRISPR-Cas9による鎌状赤血球貧血の治療

第8章 ベータサラセミア治療の革命

第9章 癌治療にとっての可能性

第10章 CRISPR-Cas9:ハンチントン病治療の第一歩

第11章 CRISPR-Cas9:肥満のまん延を覆す技術 (2型糖尿病)

第12章 CRISPR-Cas9:コレステロール治療

第13章 CRISPR-Cas9:マラリア対策

第14章 CRISPR-Cas9:嚢胞性線維症を無くす

第15章 CRISPR-Cas9:B型肝炎の除去

第16章 HIV/AIDS 治療の永久治療

第17章 CRISPR-Cas9:アルツハイマー病にとっての希望

第18章 CRISPR-Cas9:デュシェンヌ型筋ジストロフィー (DMD) の矯正

第19章 CRISPR:免疫療法の範囲を拡大

第20章 CRISPR-Cas9:世界市場におけるダイナミクス

第21章 CRISPR-Cas9:世界市場の将来展望

第22章 競合情勢

  • Beam Therapeutics
  • Casebia Therapeutics
  • CRISPR Therapeutics
  • EdiGENE Corporation
  • Editas Medicine
  • Emendo Biotherapeutics
  • Intellia Therapeutics
  • Modalis Therapeutics
  • Neon Therapeutics
  • Refuge Biotechnologies
  • Sarepta Therapeutics
  • Vertex Pharmaceuticals
目次

"Global CRISPR Cas9 Market, Clinical Trials & Therapeutic Application Outlook 2024" Report Highlight:

  • Report Focuses On Human Clinical Trials & Human Therapeutic Application
  • Global CRISPR Cas9 Market Overview
  • Global CRISPR Cas9 Clinical Trials: More Than 40 Trials
  • Global CRISPR Cas9 Clinical Trials by Company & Indication
  • Global CRISPR Cas9 Market Regional Scenario
  • Global CRISPR Cas9 Therapy Application by Multiple Indications
  • Key Companies Profile Involved In Clinical Trials: 12 Companies

CRISPR technology is one of the most advanced technology falling under the category of gene editing. It stands out as a mature existing system that can be used to engineer the genes with the desired ones. CRISPR contains innovative capabilities making its potential benefits endless. Till now, the theoretical knowledge about CRISPR has gained much attention and now it's the time for us to apply it for the practical use.

CRISPR is one such technology that has totally revolutionized the working process in the scientific field. It has been only few years since its discovery and CRISPR has started dominating the research labs all over the world. Inspite of being a newly discovered technology, CRISPR has come out with latest methodologies of treating diseases with genetic or lifestyle inherited diseases.

Making targeted changes to the genome of an individual which was a long-standing goal for the researchers, has now become a dream come like true situation. The development of CRISPR technology has helped the bio-medical researchers to put out any experiment in an efficient way. CRISPR is not the first tool to get discovered for performing gene editing but it has made its way all to the top of the list in gene editing technologies.

CRISPR technology comes with a lot of potential in it. It is the most advanced technology for treating deadly diseases that the mankind is suffering from. CRISPR is successful in showing positive results in curing diseases such as: Sickle cell anemia, cancer, hepatitis B and cholesterol. CRISPR is used for producing alterations in the somatic cell lines as well as the germline (reproductive cells). With this application of CRISPR, it is possible to correct the mutation residing inside the genome of a fetus.

Clinical trials about the CRISPR components help in achieving the efficacy of the technology. More than 30 CRISPR-Cas9 clinical trials are going on, with a participation of more than 1,000 patients. Among all the countries, US and China are the most active countries that are running the maximum number of trials. CRISPR has not only marked its presence in the pharma sector, it has also come across a long path in gaining respect in the agriculture field. There is constant innovation going on in the laboratories for attaining maximum benefits from the CRISPR components.

The increasing potential benefits received from CRISPR are creating an unimaginable effect on the market of CRISPR across the globe. The market of CRISPR is going through a giant progress, as the benefits from CRISPR are increasing day by day. The market of CRISPR has shown a tremendous jump over the last few years. Researchers are also exploring different ways of utilizing CRISPR in both diagnostic as well as therapeutic development.

The successful commercialization of such development is likely to drive the market's revenue growth. The market of CRISPR is also driven by the increasing number of cancer cases, autoimmune diseases in the world. Inspite of the increasing cancer cases around the globe, other major factors driving the growth of CRISPR are the leading manufacturers of the pharmaceutical industry, technological advancements and the presence of skilled researchers.

Table of Contents

1. Introduction to CRISPR-Cas9

  • 1.1 Overview
  • 1.2 History of CRISPR-Cas9 Technology

2. Mechanism of Action

  • 2.1 Immune Defense with CRISPR in Single Celled Microorganisms
  • 2.2 CRISPR Technology

3. Delivery Methods for CRISPR-Cas9

  • 3.1 Delivery of CRISPR-Cas9 components through Physical Methods
    • 3.1.1 Microinjection
    • 3.1.2 Electroporation
    • 3.1.3 Hydrodynamic Delivery
  • 3.2 Delivery of CRISPR-Cas9 Components through Viral Vectors
    • 3.2.1 Adeno-Associated Virus (AAV)
    • 3.2.2 Lentivirus & Adenovirus
  • 3.3 Delivery of CRISPR-Cas9 Components through Non-Viral Vectors (Biomaterials)
    • 3.3.1 Liposomes
    • 3.3.2 Gold Nanoparticles
    • 3.3.3 DNA Nanoclew

4. CRISPR-Cas9: A Home to a Variety of Applications

  • 4.1 Advantages Accompanying CRISPR-Cas9 Technology
  • 4.2 CRISPR-Cas9 Comparison with other Genome Editing Tools

5. Global CRISPR-Cas9 Clinical Trials by Company & Indication

  • 5.1 Research
  • 5.2 Preclinical
  • 5.3 Phase-I
  • 5.4 Phase-I/II
  • 5.5 Phase-II

6. Global CRISPR-Cas9 Market Current Overview

  • 6.1 Global CRISPR Market Analysis
  • 6.2 Global CRISPR Market Regional Scenario

7. Elimination of Genetic Disease: Sickle-Cell Anemia through CRISPR-Cas9

  • 7.1 Overview
  • 7.2 Sickle Cell Treatment with CRISPR
  • 7.3 Clinical Trial for Testing CRISPR against Sickle Cell Anemia

8. Revolutionizing the Treatment of Beta-Thalassemia

  • 8.1 Overview
  • 8.2 CRISPR Application in Treating Beta-Thalassemia
  • 8.3 CRISPR Clinical Trial for Beta-Thalassemia

9. Potential for Curing Cancer

  • 9.1 Overview
  • 9.2 CRISPR-Cas9 Fight for Cancer
  • 9.3 CRISPR Trial for Cancer Treatment Research

10. CRISPR-Cas9: A Step Closer to Treat Huntington's Disease

  • 10.1 Overview
  • 10.2 CRISPR-Cas9 Towards Huntington's Disease
  • 10.3 CRISPR Mediated Treatment of Huntington's Disease in Mouse Models

11. CRISPR-Cas9 Technique to Reverse Obesity Epidemic (Type 2 Diabetes)

  • 11.1 Overview
  • 11.2 CRISPR Treatment for Obesity
  • 11.3 Clinical Trials for Reducing Obesity Using CRISPR

12. CRISPR-Cas9 Treatment for Cholesterol

  • 12.1 Overview
  • 12.2 Expanding the Application of CRISPR for Cholesterol
  • 12.3 Lab Clinical Studies Reflecting the Positive Side of CRISPR

13. CRISPR-Cas9 Against Malaria

  • 13.1 Overview
  • 13.2 CRISPR-Cas9 Technology for Malaria Treatment
  • 13.3 Mosquitoes Carrying Parasites Eliminated using CRISPR-Cas9

14. CRISPR-Cas9 for Knocking Out Cystic Fibrosis

  • 14.1 Overview
  • 14.2 CRISPR-Cas9: A Versatile Tool for Deactivating CFTR
  • 14.3 Development & Research: CRISPR-Cas9

15. CRISPR-Cas9 for the Removal of Hepatitis B

  • 15.1 Overview
  • 15.2 CRISPR-Cas9 Rising against cccDNA
  • 15.3 Clinical Lab Studies Clears HBV cccDNA on Human Cell Lines

16. Permanent Cure for HIV/AIDS Treatment

  • 16.1 Overview
  • 16.2 CRISPR-Cas9 for Deleting CCR5 Gene
  • 16.3 Clinical Results Achieved Using CRISPR-Cas9 for HIV/AIDS
  • 16.4 Gene-Edited Babies: HIV resistant

17. CRISPR Hope for Alzheimer's Disease

  • 17.1 Overview
  • 17.2 CRISPR-Cas9 for Alzheimer's Disease
  • 17.3 Lab Clinical Studies for Eliminating Alzheimer's

18. CRISPR-Cas9 to Correct Duchenne Muscular Dystrophy (DMD)

  • 18.1 Overview
  • 18.2 CRISPR-Cas9 Technology Over-Powering DMD Gene
  • 18.3 CRISPR Success in Treating DMD in Mice Models

19. CRISPR Enhances the Reach of Immunotherapy

  • 19.1 CRISPR for Immunosuppressive Defects
  • 19.2 CRISPR Mediated Generation of CAR-T Cells

20. Global CRISPR-Cas9 Market Dynamics

  • 20.1 Market Drivers for CRISPR-Cas9 Therapy
  • 20.2 Challenges Overpowering CRISPR

21. Global CRISPR-Cas9 Market Future Outlook

22. Competitive Landscape

  • 22.1 Beam Therapeutics
  • 22.2 Casebia Therapeutics
  • 22.3 CRISPR Therapeutics
  • 22.4 EdiGENE Corporation
  • 22.5 Editas Medicine
  • 22.6 Emendo Biotherapeutics
  • 22.7 Intellia Therapeutics
  • 22.8 Modalis Therapeutics
  • 22.9 Neon Therapeutics
  • 22.10 Refuge Biotechnologies
  • 22.11 Sarepta Therapeutics
  • 22.12 Vertex Pharmaceuticals

List of Figures

  • Figure 1-1: Key Events in the History of CRISPR-Cas9 System Development
  • Figure 2-1: CRISPR Immune Mechanism in Bacteria
  • Figure 2-2: CRISPR Technology Working in Cell Lines
  • Figure 3-1: Delivery Methods for CRISPR-Cas9
  • Figure 3-2: Delivery Pathways for CRISPR-Cas9 Components
  • Figure 3-3: Physical Mode of Delivery for CRISPR-Cas9 Components
  • Figure 3-4: Viral Mode of Delivery for CRISPR-Cas9 Components
  • Figure 3-5: Non-Viral Mode of Delivery for CRISPR-Cas9 Components
  • Figure 4-1: Advantages of CRISPR-Cas9 Technology
  • Figure 4-2: Comparison between Different Genome Editing Tools
  • Figure 5-1: Global - CRISPR-Cas9 Clinical Trials by Phase (%), 2019 till 2024
  • Figure 5-2: Global - CRISPR-Cas9 Clinical Trials by Phase (Number), 2019 till 2024
  • Figure 6-1: Global - CRISPR Investments (US$ Million), 2011 & 2016
  • Figure 6-2: Global - Research Papers Published, 2011 & 2016
  • Figure 6-3: Global - CRISPR Market Size (US$ Million), 2018 - 2024
  • Figure 7-1: Normal RBCs VS Sickle Shaped RBCs
  • Figure 7-2: Treatment of Sickle Cell Anemia through CRISPR-Cas9
  • Figure 7-3: Phases Involved in a Clinical Trial of a Drug
  • Figure 8-1: Mutated Gene leading to Beta-Thalassemia
  • Figure 8-2: CRISPR-Cas9 Therapy for Beta-Thalassemia
  • Figure 9-1: Difference between Normal Cells & Cancer Cells
  • Figure 9-2: CRISPR-Cas9 Treatment for Cancer
  • Figure 9-3: Ongoing Clinical Trials on CRISPR in Different Types of Cancer
  • Figure 10-1: Defective Genes Leading to Huntington's Disease
  • Figure 10-2: CRISPR-Cas9 Technique for Huntington's Disease
  • Figure 10-3: Experiment Conducted to Test CRISPR-Cas9 Effect on Transgenic R6/2 Mouse Model
  • Figure 11-1: Obesity Related Health Issues
  • Figure 11-2: Mutations Leading to Obesity
  • Figure 11-3: CRISPR-Cas9 Controlling Obesity
  • Figure 12-1: Cholesterol Pathways Present in the Body
  • Figure 12-2: Mutation Leading to Clogging of Arteries
  • Figure 12-3: CRISPR-Cas9 against Cholesterol
  • Figure 12-4: Experiment Conducted to Test CRISPR-Cas9 on Cholesterol Level
  • Figure 13-1: Malaria Transmission Cycle
  • Figure 13-2: CRISPR Cas9 Machinery against Malaria
  • Figure 13-3: Experiment Conducted to Test CRISPR against Plasmodium
  • Figure 14-1: CRISPR-Cas9 Correcting Cystic Fibrosis
  • Figure 14-2: Experiment Conducted on CF Patient to Evaluate CRISPR
  • Figure 15-1: HBV Virus Infecting Healthy Liver Cells
  • Figure 15-2: CRISPR Activity against Hepatitis B Virus
  • Figure 15-3: Experiment Showing Reduction in HBV Viral Proteins due to CRISPR
  • Figure 16-1: HIV Infection Leading to AIDS
  • Figure 16-2: CRISPR Knocking Out CCR5 Gene
  • Figure 17-1: APP Gene Mutation Leading to Alzheimer's Disease
  • Figure 17-2: CRISPR-Cas9 Machinery for Alzheimer's Disease
  • Figure 17-3: Strategies Adopted by Researchers to Treat Alzheimer's Through CRISPR
  • Figure 17-4: Experiment Conducted to Test CRISPR for Alzheimer's
  • Figure 18-1: DMD Gene Mutation Leading to Duchenne muscular Dystrophy
  • Figure 18-2: CRISPR-Cas9 Editing DMD Gene
  • Figure 18-3: Experiment Showing the Success of CRISPR in Treating DMD in Mice
  • Figure 19-1: Cancer Cells Escaping Immune
  • Figure 19-2: CRISPR Potential Activities
  • Figure 20-1: Key Drivers Leading to the Development of CRISPR
  • Figure 21-1: Future of CRISPR-Cas9 Gene Editing Technology
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