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がん幹細胞療法の世界市場:価格、用量、臨床試験の考察

Global Cancer Stem Cell Therapy Market, Price, Dosage & Clinical Trial Insight 2025

発行 KuicK Research 商品コード 897329
出版日 ページ情報 英文 170 Pages
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がん幹細胞療法の世界市場:価格、用量、臨床試験の考察 Global Cancer Stem Cell Therapy Market, Price, Dosage & Clinical Trial Insight 2025
出版日: 2019年07月01日 ページ情報: 英文 170 Pages
概要

当レポートでは、世界のがん幹細胞療法市場について調査分析し、幹細胞の役割・機序、幹細胞移植、骨髄移植市場の機会、臍帯血移植市場の機会、臨床パイプラインなどについて、体系的な情報を提供しています。

第1章 幹細胞療法のイントロダクション

  • 概要
  • 歴史的発展

第2章 幹細胞の分類

  • 胚性幹 (ES) 細胞
  • 体性幹細胞

第3章 幹細胞治療の必要性

第4章 幹細胞治療の利点

第5章 がん治療における幹細胞の役割

  • 自殺遺伝子療法としての幹細胞
  • 腫瘍溶解性ウイルスの媒体としての幹細胞
  • がん治療後の幹細胞
  • ナノ粒子キャリアとしての幹細胞

第6章 がん幹細胞標的薬の機序

  • 分子シグナル伝達経路の標的化
  • がん幹細胞マーカーの標的化
  • がん幹細胞のニッチ・休止状態の標的化
  • miRNA発現の標的化
  • がん幹細胞アポトーシスの誘導
  • がん幹細胞分化の誘導

第7章 がん治療における幹細胞移植

  • 幹細胞移植の作用機序
  • がん治療における幹細胞移植の種類

第8章 治療後のがん幹細胞標的薬

  • 皮膚がんにおける幹細胞治療
  • 白血病における幹細胞治療
  • 大腸がんにおけるがん幹細胞治療
  • 乳がんにおけるがん幹細胞治療
  • その他のがんにおける幹細胞治療

第9章 造血幹細胞移植市場

  • 骨髄移植市場とコスト分析
  • 臍帯血移植市場

第10章 世界のがん幹細胞の臨床パイプライン:企業別、適応別、相別

  • 研究
  • 前臨床
  • 第I相
  • 第I/II相
  • 第II相
  • 第III相

第11章 世界の幹細胞治療市場の分析

  • 現在の市場シナリオ
  • 臨床パイプライン

第12章 個別化幹細胞がん治療

第13章 個別化幹細胞がん治療:適応別

第14章 世界の幹細胞市場力学・課題・促進要因

第15章 世界のがん幹細胞療法市場の将来の見通し

第16章 競合情勢

  • Aelan Cell Technologies
  • Baylx
  • Benitec Biopharma
  • BlueRock Therapeutics
  • Calidi Biotherapeutics
  • Cellular Dynamics International
  • Center for iPS Cell Research and Application
  • Century Therapeutics
  • Khloris Biosciences
  • ReNeuron
目次

"Global Cancer Stem Cell Therapy Market, Price, Dosage & Clinical Trial Insight 2025" Report Highlights:

  • Role & Mechanism Of Stem Cells In Cancer Treatment
  • Stem Cell Transplantation In Cancer Treatment
  • Global Bone Marrow Transplant Market Opportunity : > US$ 15 Billion
  • Global Cord Blood Transplant Market Opportunity
  • Cancer Stem Cell Therapy Clinical Pipeline: 37 Therapies
  • Majority Stem Cells In Preclinical Phase: 18 Therapies
  • Cancer Stem Cell Therapy Clinical Pipeline by Country: More Than 30 In USA
  • Post Therapy Cancer Stem Cell Targeting Drugs

Cancer incidences are escalating as a result of which demand for better therapeutics is increasing across the globe. There are several products in cancer market which have sufficiently high pharmacological efficiency and offers severe competition to other therapeutics belonging to same indication. Several cancer therapeutics have been developed in past years but they tend to become less effective in long-term. This creates large unmet medical needs as patients are not treated well despite the presence of suitable therapeutics. Cancer stem cell therapeutics are expected to change this scenario as they act on the very basis of development of cancer cells.

Innovations in pharmaceutical industry seem to be the main driving force for the development of cancer stem cell therapies. Investigators have been able to identify different stem cell sources which offers them large base for developing new therapies. Their customizability and appropriate usage is expected to help them to discover new pharmacological properties that may have high commercialization potential. As a result, large numbers of cancer stem cell therapies are entering in clinical trials across the globe.

Clinical pipeline of cancer stem cells therapies is quite strong due to which multiple number of products are expected to be launched in global market in coming years. Development of stem cell therapies for CNS and CVS disorders has already gained lots of attention by investigators. Large population base and rapidly escalating cancer incidences are main factors behind growth of such investigational therapies. Budding stem cell therapies like development of cure for diabetes are also gaining momentum in past years. Less number of competitors is expected to increase the profit margins and allow cancer stem cell therapy developers to occupy major market shares. More stem cell therapies having high pharmacological and commercialization potential has yet to be discovered.

Several pharmaceutical companies are trying to develop different type of products that could target and eliminated cancer stem cells from the body. New candidates are at different stages of clinical trials which are expected to produce positive results. They are at different stages of clinical trials and they are expected to take some time before entering in market. Different methods are being studied targeting different mechanism by which cancer stem cells survive in the body. Different signaling pathways have been identified that play an important role in development of cancer stem cells.

The global stem cell therapy market is expected to witness favorable growth in future driven by the exponential increase in the research and development activities along with launch of 2 or more commercial stem cell therapies over a period of next 5 - 8 years. The shifting thrust towards targeted approach for cancer treatment will also create favorable environment for the development of stem cell therapies and will drive the overall market to new horizon in coming years.

Table of Contents

1. Introduction To Stem Cell Therapy

  • 1.1. Overview
  • 1.2. Historical Development

2. Stem Cells Classification

  • 2.1. Embryonic Stem Cells
  • 2.2. Somatic Stem Cells
    • 2.2.1. Mesenchymal Stem Cells
    • 2.2.2. Neural Stem Cells
    • 2.2.3. Hematopoietic Stem Cells
    • 2.2.4. Endothelial Progenitor Cells (EPC)
    • 2.2.5. Cancer Stem Cells

3. Need Of Stem Cell Therapeutics

4. Advantages of Stem Cell Therapeutics

5. Role Of Stem Cells In Cancer Treatment

  • 5.1. Stem Cell As Suicide Gene Therapy
  • 5.2. Stem Cell As Vehicle for Oncolytic Viruses
  • 5.3. Stem Cells In Post Cancer Treatment
  • 5.4. Stem Cells As Nanoparticle Carriers

6. Mechanism Of Cancer Stem Cell Targeting Drug

  • 6.1. Targeting The Molecular Signaling Pathway
  • 6.2. Targeting Cancer Stem Cell Markers
  • 6.3. Targeting Cancer Stem Cell Niche & Quiescent State
  • 6.4. Targeting The miRNA Expression
  • 6.5. Inducing Cancer Stem Cell Apoptosis
  • 6.6. Induction Of Cancer Stem Cell Differentiation

7. Stem Cell Transplantation In Cancer Treatment

  • 7.1. Mechanism Of Action Of Stem Cell Transplantation
  • 7.2. Types Of Stem Cell Transplants In Cancer Treatment
    • 7.2.1. Autologous Stem Cell Transplantation
    • 7.2.2. Allogeneic Stem Cell Transplantation
    • 7.2.3. Syngeneic Stem Cell Transplantation

8. Post Therapy Cancer Stem Cell Targeting Drugs

  • 8.1. Stem Cell Therapeutics In Skin Cancer
    • 8.1.1. Erivedge
    • 8.1.2. Odomzo
  • 8.2. Stem Cell Therapeutics In Leukemia
    • 8.2.1. Daurismo
  • 8.3. Cancer Stem Cell Therapeutics In Colon Cancer
    • 8.3.1. Sulindac
  • 8.4. Cancer Stem Cell Therapeutics In Breast Cancer
  • 8.5. Stem Cell Therapeutics In Other Cancer
    • 8.5.1. Vorinostat
    • 8.5.2. Belinostat
    • 8.5.3. Romidepsine
    • 8.5.4. Panabiostat

9. Hematopoietic Stem Cell Transplant Market

  • 9.1. Bone Marrow Transplant Market & Cost Analysis
  • 9.2. Cord Blood Transplant Market

10. Global Cancer Stem Cell Clinical Pipeline By Company, Indication & Phase

  • 10.1. Research
  • 10.2. Preclinical
  • 10.3. Phase-I
  • 10.4. Phase-I/II
  • 10.5. Phase-II
  • 10.6. Phase-III

11. Global Stem Cell Therapeutics Market Analysis

  • 11.1. Current Market Scenario
  • 11.2. Clinical Pipeline

12. Personalized Stem Cell Cancer Therapy

  • 12.1. Overview
  • 12.2. Advantages of Personalized Stem Cell Cancer Therapy

13. Personalized Stem Cell Cancer Therapy by Indication

  • 13.1. Glioblastoma
    • 13.1.1. Lung Cancer
    • 13.1.2. Acute Myeloid Leukemia & Melanoma
    • 13.1.3. Ovarian & Breast Cancer
    • 13.1.4. Pancreatic Cancer

14. Global Stem Cell Market Dynamics Challenges & Drivers

  • 14.1. Challenges of Cancer Stem Cell Therapeutics
  • 14.2. Global Cancer Stem Cell Therapeutics Market Drivers

15. Global Cancer Stem Cell Therapy Market Future Outlook

16. Competitive Landscape

  • 16.1. Aelan Cell Technologies
  • 16.2. Baylx
  • 16.3. Benitec Biopharma
  • 16.4. BlueRock Therapeutics
  • 16.5. Calidi Biotherapeutics
  • 16.6. Cellular Dynamics International
  • 16.7. Center for iPS Cell Research and Application
  • 16.8. Century Therapeutics
  • 16.9. Khloris Biosciences
  • 16.10. ReNeuron

List of Figures

  • Figure 1-1: Research History on Stem Cell
  • Figure 2-1: Types of Stem Cells
  • Figure 4-1: Advantages of Stem Cell Therapies
  • Figure 5-1: Stem Cell Mediated Suicide Gene Therapy System
  • Figure 6-1 Different Molecular Signaling Pathways of Stem Cells
  • Figure 6-2: Mechanism of Stem Cell Therapeutics via Targeting Surface Markers
  • Figure 6-3: Mechanism by Inducing Cancer Stem Cell Apoptosis
  • Figure 6-4: Mechanism by Inducing Differentiation of Cancer Stem Cell
  • Figure 7-1: Mechanism of Action of Cancer Stem Cell Transplantation
  • Figure 7-2: Types of Stem Cell Transplantation
  • Figure 8-1: Erivedge - Patent on Product Type
  • Figure 8-2: Erivedge - Patent on Anticancer Property
  • Figure 8-3: Erivedge- Price for 28 Capsule Supply & Price per Unit (US$), July'2019
  • Figure 8-4: Odomzo Patent on Product Type
  • Figure 8-5: Odomzo Patent for Anticancer Property
  • Figure 8-6: Odomzo- Price for 30 Capsule Supply & Price per Unit (US$), July'2019
  • Figure 8-7: Daurismo- Price for 30 Tablets of 25mg & 100 mg Oral Tablet (US$), July'2019
  • Figure 8-8: Daurismo: Price per Tablet of 25 mg & 100 Mg Tablet (US$), July'2019
  • Figure 8-9: Sulindac: Price for 100 Tablet Supply of 150 mg & 200 mg (US$), July'2019
  • Figure 8-10: Sulindac: Per Unit Cost of 150 mg & 200 mg Tablet (US$), July 2019
  • Figure 8-11: Zolinza - Patent Issued In Different Years
  • Figure 8-12: Zolinza- Price for 120 Capsule Supplies Of 100mg & Price per Unit (US$), July'2019
  • Figure 813: Beleodaq - Patent Issued & Expiration Year for First Patent
  • Figure 8-14: Beleodaq - Patent Issued & Expiration Year for Second Patent
  • Figure 8-15: Istodax: Patent Issued & Expiration Year
  • Figure 9-1: Cost of Different Bone Marrow Transplant (US$ Million), July'2019
  • Figure 9-2: Bone Marrow Transplant Market (US$ Billion), 2018 - 2025
  • Figure 9-3: Global - Autologous v/s Allogeneic Bone Marrow Transplant Market(%), 2019
  • Figure 9-4: Global - Cord Blood Transplant Market (US$ Million), 2018-2025
  • Figure 11-1: Global - Cancer Stem Cell Therapeutics Market Opportunity (US$ Billion), 2019 - 2025
  • Figure 11-2: Global - Cancer Stem Cell Therapy Clinical Pipeline (%), 2019 till 2025
  • Figure 11-3: Global - Cancer Stem Cell Therapy Clinical Pipeline (Number of Trials), 2019 till 2025
  • Figure 11-4: Global - Cancer Stem Cell Therapy Clinical Pipeline by Country (Number of Trials), 2019 till 2025
  • Figure 11-5: Global - Cancer Stem Cell Therapy Clinical Pipeline by Company (Number of Trials), 2019 till 2025
  • Figure 12-1: Steps of Personalised Stem Cell Cancer Therapy
  • Figure 14-1: Challenges of Cancer Stem Cell Therapeutics
  • Figure 14-2: Drivers of Cancer Stem Cell Therapeutics
  • Figure 16-1: Baylx - Clinical Pipeline
  • Figure 16-2: Benitec Bioparma - Clinical Pipeline
  • Figure 16-3: BlueRock Therapeutics - Clinical Pipeline
  • Figure 16-4: Calidi Biotherapeutics - Clinical Pipeline
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