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世界の細胞療法市場・臨床パイプラインの見通し

Global Cell Therapy Market, Price, Product & Clinical Pipeline Outlook 2024

発行 KuicK Research 商品コード 302594
出版日 ページ情報 英文 1200 Pages
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世界の細胞療法市場・臨床パイプラインの見通し Global Cell Therapy Market, Price, Product & Clinical Pipeline Outlook 2024
出版日: 2018年04月26日 ページ情報: 英文 1200 Pages
概要

当レポートでは、世界の細胞療法市場について調査分析し、市場の概要、応用、機序、臨床パイプライン、上市製品、競合情勢などについて、体系的な情報を提供しています。

第1章 細胞療法の概要

第2章 細胞療法による治療の必要性

  • 幹細胞研究の台頭
  • 研究・治療用の幹細胞を使用するメリット

第3章 細胞療法における幹細胞の応用

  • 幹細胞能力で差別化
  • 幹細胞の由来

第4章 細胞療法の応用:治療領域別

  • 循環器疾患の細胞療法
  • 神経疾患の細胞療法
  • 炎症性疾患の細胞療法
  • 糖尿病の細胞療法
  • がんの細胞療法
  • がんの幹細胞療法

第5章 細胞療法の機序

  • 幹細胞療法の2大機序の原理
  • アルツハイマー病の作用機序

第6章 細胞療法の送達方法

  • 送達方法の概要
  • 直接
  • 間接

第7章 細胞療法による治療の機序

  • 同種幹細胞治療
  • 自己幹細胞治療

第8章 世界の細胞療法市場の概要

  • 現在の市場シナリオ
  • 細胞療法の世界市場の現在の動向
  • 世界の細胞療法の臨床パイプラインの概要

第9章 世界の細胞療法市場:地域別

  • 北米
  • 欧州
  • アジア
  • その他

第10章 世界の細胞療法市場力学

  • 好ましい市場パラメーター
  • 市場成長抑制要因

第11章 世界の細胞療法市場の将来見通し

第12章 世界の細胞療法の臨床パイプライン:企業別、適応別、相別

  • 段階不明
  • 研究
  • 前臨床
  • 臨床
  • 第0相
  • 第I相
  • 第I/II相
  • 第II相
  • 第II/III相
  • 第III相
  • 申請済み
  • 承認済み

第13章 上市済みの細胞療法の臨床分析:企業別、適応別

第14章 競合情勢

  • AlloCure
  • Arteriocyte Medical Systems
  • Athersys Inc.
  • Baxter Healthcare Corporation
  • Bone Therapeutics
  • Celgene Corporation
  • Cell Medica
  • Cellerant Therapeutics
  • FibrocellScinence
  • Forticell Bioscience
  • Genzyme Corporation
  • Green Cross Cell
  • Histogenics Corporation
  • InnovacellBiotechnologie AG
  • Intrexon Corporation
  • Intercytex
  • ISTO Technologies
  • Macrocure
  • Mesoblast
  • Molmed
  • Nuo Therapeutics Inc
  • OmniCyte
  • Opexa Therapeutics
  • Organogenesis
  • Pharmicell
  • TCA Cellular Therapy
  • Stem Cell Inc.
  • Teva Pharmaceuticals
  • Tigenix
  • Vericel Corporation

図表

目次

"Global Cell Therapy Market, Price, Product & Clinical Pipeline Outlook 2024" Report Highlights:

  • Market Analysis by Application in Various Therapeutic Areas
  • Comprehensive Insight On Clinical Pipeline: 664 Cell Therapies
  • Cell Therapy Market Opportunity More Than US$ 25 Billion by 2024
  • Marketed Cell Therapies: 21
  • Price & Product Insight By Region/Country
  • Cell Therapy Clinical Pipeline Overview
  • Collaborations & Acquisition in the Cell Therapy Segment
  • Regional Analysis of the Cell Therapy Market

Cell therapy is an integral part of immunotherapy that has shown excellent therapeutic ability in several clinical indications. In recent years, studies regarding the use of cells for their therapeutic ability have gained immense popularity in the scientific and healthcare research community. The segment currently flourishes with several techniques like CAR-T cell therapy, Stem cell therapy, and cord blood cell therapy with each of them gaining extreme popularity due to their wide application in several clinical indications such as cancer, cardiovascular disease and cancer.

The most popular and common technique of cell therapy aims at using healthy cells from a compatible donor (Allogeneic) or from the patient itself (Autogenic) and their modification to amplify their therapeutic ability. It involves complex steps like genetic screening of cell, modification of cell by genetic sequencing, their harvesting and reinfusion into the patient's body. Each of these steps plays a vital role in the therapeutic outcome, thus leading to the establishment of the cell therapy market.

Stem cell therapy is currently the dominant segment in the cell therapy market with maximum success rate reported globally. Their special ability to differentiate into any type of cell without losing their identity makes them the most promising therapeutic entities of the future. Researchers claim that stem cells are bound to revolutionize regenerative medicine with it being applied in the treatment of complex disease such as cardiovascular disease, neurodegenerative disease, inflammatory disease and cancer.

Moreover, researchers assume that modification of cell therapy techniques could result in potential cures for multiple sclerosis, diabetes, spinal cord injury, cancer, heart disease, Parkinson's disease, Alzheimer's disease, and immune system disorders. The role of cell therapy and stem cell research will also be most helpful in the therapeutic sectors of cloning and regenerative medicine

Cell therapy based products like Kymriah, Provenge and Yescarta have been well received in the market inspite of their hefty price tag; costing well over US$ 100,000 which clearly indicates the lucrative nature of the cell therapy market. Innovations in pharmaceutical and biotechnology research are the key driving parameters for the development of cell therapies. For instance, holoclar treatment for curing blindness, cartistem for cartilage cell regeneration and Epicel for burn wound replacement have shown excellent outcome in their initial clinical studies which could become the gold standard therapeutics of the future.

Investigators have been able to identify different stem cell sources which offers them large base for developing new therapies. Majority of the cell therapy techniques can be customized according to a patient's requirement thus making it a leading segment in personalized therapy. As a result, large numbers of stem cell therapies are entering in clinical trials across the globe. They are at different stages of development and likely to be introduced in global market in coming years. This will help the stem cell therapy developers to generate significant revenues in coming years.

Inspite of several challenges restraining the growth of the cell therapy market, experts claim the segment to be a burgeoning market of the future. This claim is supported by the fact that more than 150 companies globally have invested over US$ 1 Billion in the fairly new industry. Active participation of countries like Japan, South Korea, China and India has made it a progressive market of the future with widely untapped potential.

Kuick Research Report on the Global cell therapy market provides a detailed insight into the current scenario of the cell therapy market worldwide. Key data like pricing of cell therapy products, cost analysis of cell therapy procedures, adoption rate, current market trends and recent developments that might impact the cell therapy market are also highlighted in the report. Further, extensive analysis using data from primary and secondary source has been used for the effective forecast and future projections regarding the cell therapy market.

Table of Contents

1. Prologue to Cell Therapy

  • 1.1 An Overview to Cells & Their Therapeutic Ability
  • 1.2 Unique Features of Cellular Therapeutics
    • 1.2.1 Stem Cells - Key Agents of Cellular Based Therapeutics
    • 1.2.2 Key Advantages of Cell Therapy over Other Existing Therapeutics

2. Mechanism of Cell Therapy Treatment

  • 2.1 Principle of Cell Therapy
    • 2.1.1 Cell Therapy & the Immune Response
    • 2.1.2 Mechanism of Regenerative Cell Therapy
  • 2.2 Role of Surface Markers & Their Targeting
    • 2.2.1 Targeting the Signal Cascades
    • 2.2.2 Targeting the Microenvironment
  • 2.3 Allogeneic Stem Cell Therapy
  • 2.4 Autologous Stem Cell Therapy

3. Stem Cells - Their Application & Contribution in the Establishment of Cell Therapy Market

  • 3.1 Origin of Stem Cells
    • 3.1.1 Embryonic Stem Cells
    • 3.1.2 Adult Stem Cells
    • 3.1.3 Induced Pluripotent Stem Cells (iPSCs)
  • 3.2 Exploring Stem Cell's Ability to Differentiate
    • 3.2.1 Totipotent Stem Cells
    • 3.2.2 Pluripotent Stem Cells
    • 3.2.3 Multipotent Stem Cells
    • 3.2.4 Unipotent Stem Cells

4. Cell Therapy Market Analysis by Application in Various Therapeutic Areas

  • 4.1 Cell Therapy for Cardiovascular Disease
    • 4.1.1 Myocardial Infarction
    • 4.1.2 Heart Failure
  • 4.2 Cell Therapy for Neurological Disorders
    • 4.2.1 Parkinson's Diseases
    • 4.2.2 Alzheimer's Diseases
    • 4.2.3 Huntington's Diseases
  • 4.3 Cell Therapy for Inflammatory Diseases
    • 4.3.1 Asthma
    • 4.3.2 Arthritis
    • 4.3 Cell Therapy for Diabetes
    • 4.3.3 Type 1 diabetes
    • 4.3.4 Type 2 diabetes
  • 4.4 Cell Therapy for Cancer
    • 4.4.1 Stem Cells & Their Therapeutic Role in Cancer
    • 4.4.2 Role of Surface Markers & Their Targeting
    • 4.4.3 Targeting the Signal Cascades
    • 4.4.4 Targeting the Microenvironment

5. Product & Price Analysis of Cell Therapy Approved in US

  • 5.1 Apligraf & Dermagraft
  • 5.2 Carticel
  • 5.3 ChondroCelect
  • 5.4 Epicel
  • 5.5 Holoclar
  • 5.6 Kymriah
  • 5.7 Provenge
  • 5.8 Yescarta

6. Product & Price Analysis of Cell Therapy Products Approved in Europe

  • 6.1 Spherox
  • 6.2 Strimvelis

7. Product & Price Analysis of Cell Therapy Approved in South Korea

  • 7.1 Cartistem
  • 7.2 Cupistem
  • 7.3 Hearticellgram

8. Product & Price Analysis of Cell Therapy Approved in Japan

  • 8.1 HeartSheet
  • 8.2 Temcell

9. Current Status of the Global Cell Therapy Market

  • 9.1 Overview of the Global Cell Therapy Market
  • 9.2 Industrial Insight into the Cell Therapy Market - Key Players & Their Contribution
  • 9.3 Cell Therapy Clinical Pipeline Overview
  • 9.4 Investments in the Cell Therapy Market

10. Global Cell Therapy Market Trends

  • 10.1 Cell Therapy Enhancing the Effect of Existing Therapeutic Methods
  • 10.2 Cell Therapy Market More Oriented Towards Immune Cells
  • 10.3 Involvement of Both Academia & Industries to Enhance Progress of Cell Therapy Studies
  • 10.4 Impact of Cell Therapy on the Drug Delivery Market
  • 10.4.1 Direct Delivery Methods
  • 10.4.2 Indirect Delivery Method

11. Collaborations & Acquisition in the Cell Therapy Segment

  • 11.1 Collaborations
  • 11.2 Acquisition

12. Regional Analysis of the Cell Therapy Market

  • 12.1 North America
  • 12.2 Europe
  • 12.3 Asia
    • 12.3.1 China
    • 12.3.2 Japan
    • 12.3.3 South Korea
    • 12.3.4 India
  • 12.4 Rest of the World
    • 12.4.1 Africa
    • 12.4.2 Middle East
    • 12.4.3 South America

13. Global Cell Therapy Market Dynamics

  • 13.1 Growth Promoting Parameters of the Cell Therapy Market
  • 13.2 Commercial Challenges of the Cell Therapy Market

14. Future Prospectus & Scope of the Cell Therapy Market

15. Global Cell Therapy Clinical Pipeline by Company, Indication & Phase

  • 15.1 Unknown
  • 15.2 Research
  • 15.3 Preclinical
  • 15.4 Clinical
  • 15.5 Phase-0
  • 15.6 Phase-I
  • 15.7 Phase-I/II
  • 15.8 Phase-II
  • 15.9 Phase-II/III
  • 15.10 Phase-III
  • 15.11 Preregistration
  • 15.12 Registered

16. Marketed Cell Therapy Clinical Insight

  • 16.1 Immuncell-LC
  • 16.2 Adipocell (Anterogen)
  • 16.3 Provenge
  • 16.4 CureXcell
  • 16.5 Holoclar
  • 16.6 MACI
  • 16.7 Carticel
  • 16.8 MyoCell
  • 16.9 Laviv
  • 16.10 Prochymal
  • 16.11 Grafix
  • 16.12 Gintuit
  • 16.13 Autologous Mesenchymal Stem Cell Therapy - Pharmicell
  • 16.14 Cartistem
  • 16.15 CHONDRON
  • 16.16 BioCart
  • 16.17 NuCel
  • 16.18 Dendritic Cell-Activated Cytokine-Induced Killer Cells
  • 16.19 Chondrotransplant DISC
  • 16.20 Urocell
  • 16.21 CellSpray

17. Competitive Landscape

  • 17.1 AlloCure
  • 17.2 Arteriocyte Medical Systems
  • 17.3 Athersys Inc.
  • 17.4 Baxter Healthcare Corporation
  • 17.5 Bone Therapeutics
  • 17.6 Celgene Corporation
  • 17.7 Cell Medica
  • 17.8 Cellerant Therapeutics
  • 17.9 FibrocellScinence
  • 17.10 Forticell Bioscience
  • 17.11 Genzyme Corporation
  • 17.12 Green Cross Cell
  • 17.13 Histogenics Corporation
  • 17.14 InnovacellBiotechnologie AG
  • 17.15 Intrexon Corporation
  • 17.16 Intercytex
  • 17.17 ISTO Technologies
  • 17.18 Macrocure
  • 17.19 Mesoblast
  • 17.20 Molmed
  • 17.21 Nuo Therapeutics Inc
  • 17.22 OmniCyte
  • 17.23 Opexa Therapeutics
  • 17.24 Organogenesis
  • 17.25 Pharmicell
  • 17.26 TCA Cellular Therapy
  • 17.27 Stem Cell Inc.
  • 17.28 Teva Pharmaceuticals
  • 17.29 Tigenix
  • 17.30 Vericel Corporation

List of Figures

  • Figure 1-1: Basic Overview of Cell Therapy
  • Figure 1-2: Historical Insight into Cell Therapy
  • Figure 1-3: Key Goals of using Cell Therapy
  • Figure 2-1: Mechanism of Paracrine Signaling
  • Figure 2-2: Demonstration of the Endocrine Signaling
  • Figure 2-3: Illustration of the Autocrine Signaling
  • Figure 2-4: Paracrine Signaling in Heart Repair
  • Figure 2-5: Common Sources of Cells in Cell Therapy
  • Figure 2-6: Requirements of an Ideal Cell Donor in Cell Therapy
  • Figure 2-7: Steps in Allogeneic Stem Cell Therapy
  • Figure 2-8: Steps in Autologous Stem Cell Therapy
  • Figure 3-1: Application of Cell Therapy in Various Clinical Indications
  • Figure 3-2: Global - Cell Therapy Type by Donor Cell Source (%).2018
  • Figure 3-3: Global - Stem Cell v/s Non Stem Cell Therapy Studies (%), 2018
  • Figure 3-4: Type of Stem Cells on the Basis of Origin
  • Figure 3-5: Global - Cell Therapy Product Source (%), 2018
  • Figure 3-6: Type of Stem Cells & Their Ability to Differentiate
  • Figure 3-7: Global - Type of Immune Cells Used in Cell Therapy (%), 2018
  • Figure 4-1: Global - Mortality Caused by Non Communicable Disease (%), 2018
  • Figure 4-2: Cell Therapy - Clinical Trials by Indication (%), 2018
  • Figure 4-3: Cell Therapy for Cardiovascular Disease
  • Figure 4-4: Overview of Stem Cell Therapy in Cardiovascular Disease
  • Figure 4-5: Cell Therapy in Neurological Disorders
  • Figure 4-6: Cell Therapy in Treatment of Alzheimer's disease
  • Figure 4-7: Cell Therapy in Diabetes
  • Figure 5-1: Apligraf - Cost per Use (US$/Patient), 2018
  • Figure 5-2: Carticel - Price Analysis (US$/Patient), 2018
  • Figure 5-3: ChondroCelect - Price Analysis (US$/Patient), 2018
  • Figure 5-4: Epicel - Price Analysis per 1% Total Body Surface Area (US$/Patient), 2018
  • Figure 5-5: Kymriah - Therapy Price Analysis (US$/Year), 2018
  • Figure 5-6: Provenge - Price Analysis (US$/Year), 2018
  • Figure 5-7: Yescarta - Price Analysis (US$), 2018
  • Figure 6-1: Spherox - Price Analysis (US$/Patient), 2018
  • Figure 6-2: Strimvelis - Price Analysis (US$ & Euro), 2018
  • Figure 7-1: Cartistem - Price Analysis (US$/Dose), 2018
  • Figure 7-2: Hearticellgram - Price Analysis (US$/Patient), 2018
  • Figure 8-1: HeartSheet - Treatment Cost Analysis (US$/ Administration), 2018
  • Figure 8-2: Temcell - Price Analysis (US$/72 Million Cells), 2018
  • Figure 9-1: Global - Cell Therapy Clinical Pipeline by Phase (%), 2018 till 2024
  • Figure 9-2: Global - Cell Therapy Clinical Pipeline by Phase (Number), 2018 till 2024
  • Figure 9-3: Global - Cell Therapy Clinical Pipeline by Discontinued Trials(%),2018 till 2024
  • Figure 9-4: Global - Cell Therapy Clinical Pipeline by Discontinued Trials (Number), 2018 till 2024
  • Figure 10-1: Global - Preference of Cell Type in Cell Therapy (%), 2018
  • Figure 10-2: Cell Therapy - Funding in Industry & Academia (%), 2018
  • Figure 12-1: Cell Therapy - Trials Conducted by Region (%), 2018
  • Figure 12-2: Europe - Cell Therapy Clinical Trial Analysis by Region (%), 2018
  • Figure 12-3: Asia - Cell Therapy Clinical Trial by Region (%), 2018
  • Figure 12-4: Cell Therapy-Comparative Cost Analysis by Region (US$), 2018
  • Figure 12-5: Rest of the World - Cell Therapy Clinical Trial by Region (%), 2018
  • Figure 13-1: Global - Key Factors Driving the Cell Therapy Market
  • Figure 13-2: Global - Cell Therapy Market Challenges
  • Figure 14-1: Future Objectives of the Cell Therapy market
  • Figure 14-2: Global - Cell Therapy Market Opportunity (US$ Billion), 2018 -2024
  • Figure 14-3: Key Developments Impacting the Future Cell Therapy Market
  • Figure 17-1: Arteriocyte Medical Systems Clinical Pipeline
  • Figure 17-2: Bone Therapeutics Clinical Pipeline
  • Figure 17-3: Celgene Clinical Pipeline
  • Figure 17-4: Cellerant Therapeutics Clinical Pipeline
  • Figure 17-5: Fibrocell Science Clinical Pipeline
  • Figure 17-6: Genzyme Clinical Pipeline
  • Figure 17-7: Intrexon Clinical Pipeline
  • Figure 17-8: ISTO Clinical Pipeline
  • Figure 17-9: Mesoblast Clinical Pipeline
  • Figure 17-10: Molmed Clinical Pipeline
  • Figure 17-11: Pharmicell Clinical Pipeline
  • Figure 17-12: Tigenix Clinical Pipeline
  • Figure 17-13: Vericel Corporation Clinical Pipeline
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