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ガンマ・デルタT細胞癌治療の世界市場、臨床試験予測(2028年)

Gamma Delta T Cell Cancer Therapy Market & Clinical Trials Forecast 2028

出版日: | 発行: KuicK Research | ページ情報: 英文 180 Pages | 納期: 即日から翌営業日

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ガンマ・デルタT細胞癌治療の世界市場、臨床試験予測(2028年)
出版日: 2022年04月01日
発行: KuicK Research
ページ情報: 英文 180 Pages
納期: 即日から翌営業日
  • 全表示
  • 概要
  • 目次
概要

世界のガンマ・デルタT細胞癌治療の市場規模は、2028年までに400万米ドルを超えると予測されています。癌罹患率の上昇とそれに伴う効果的な治療薬の入手不可能性が、今後数年間の市場成長を促進するものと思われます。また、新製品の発売、製薬企業による継続的な投資、政府の取り組み強化も市場の成長に寄与すると考えられます。

当レポートでは、世界のガンマ・デルタT細胞癌治療市場について調査し、市場の概要とともに、ガンマ・デルタT細胞癌治療の役割とアプローチ、研究開発中の薬剤動向、地域別動向、臨床試験動向、および市場に参入する企業の競合動向などを提供しています。

目次

第1章 ガンマ・デルタT細胞癌治療のイントロダクション

  • T細胞ベースの免疫療法の新たな役割
  • ガンマ・デルタT細胞癌治療の概要

第2章 ガンマ・デルタT細胞癌治療 対 従来の治療法

  • ガンマ・デルタT細胞癌治療 対 CART細胞癌治療
  • ガンマ・デルタT細胞癌治療 対 腫瘍浸潤リンパ球療法
  • ガンマ・デルタT細胞癌治療 対 免疫チェックポイント阻害剤
  • ガンマ・デルタT細胞癌治療 対 モノクローナル抗体
  • ガンマ・デルタT細胞癌治療 対 その他

第3章 癌におけるガンマ・デルタT細胞の役割

  • 癌の進行におけるガンマ・デルタT細胞
  • ガンマ・デルタT細胞の抗腫瘍活性

第4章 ガンマ・デルタT細胞癌治療に採用されたアプローチ

  • 二重特異性抗体としてのガンマ・デルタT細胞
  • CARガンマ・デルタT細胞

第5章 ガンマ・デルタT細胞癌治療:研究開発中の主な薬剤

第6章 世界のガンマ・デルタT細胞癌治療の臨床パイプラインの概要

  • 企業別
  • 国別
  • 適応別
  • 相別

第7章 世界のガンマ・デルタT細胞癌治療の臨床試験動向、企業別、適応別、臨床試験段階別

  • 研究
  • 前臨床
  • 臨床
  • 第I相
  • 第I/II相

第8章 白血病におけるガンマ・デルタT細胞癌治療

  • 白血病におけるガンマ・デルタT細胞の役割
  • 急性白血病における進行中の臨床研究
  • 慢性リンパ性白血病の臨床試験
  • 白血病におけるガンマ・デルタT細胞の将来の市場機会

第9章 肺癌におけるガンマ・デルタT細胞癌治療

  • 概要
  • 進行中の研究開発
  • 肺癌におけるガンマ・デルタT細胞癌治療の将来の市場機会

第10章 乳癌におけるガンマ・デルタT細胞

  • 概要
  • 乳癌における進行中の研究開発
  • 乳癌におけるガンマ・デルタT細胞癌治療の将来の市場機会

第11章 大腸癌におけるガンマ・デルタT細胞

  • 結腸直腸癌におけるガンマ・デルタT細胞の機能
  • 結腸直腸癌における進行中の臨床試験
  • 結腸直腸癌におけるガンマ・デルタT細胞癌治療の将来の市場の可能性

第12章 膵癌におけるガンマ・デルタT細胞

  • 概要
  • 膵臓癌における進行中の研究開発
  • 膵臓癌におけるガンマデルタ療法の将来の市場の可能性

第13章 その他の癌における現在の臨床研究

  • 神経芽細胞腫における進行中の臨床試験
  • 膠芽腫で進行中の臨床試験
  • 頭頸部癌における進行中の研究開発

第14章 ガンマ・デルタT細胞癌治療市場の概要

  • 現在の市場シナリオ
  • ガンマ・デルタT細胞治療市場の市場可能性

第15章 ガンマ・デルタT細胞癌治療市場の力学

  • ガンマ・デルタT細胞治療市場:好ましい指標
  • ガンマ・デルタT細胞治療市場:課題

第16章 ガンマ・デルタT細胞癌治療の将来の展望

第17章 競合情勢

  • Acepodia
  • Adaptate Therapeutics
  • Adicet
  • Cytomed Therapeutics
  • Gadeta
  • GammaDelta Therapeutics
  • IN8bio
  • Kiromic Biopharma
  • Lava Therapeutics
  • Takeda Pharmaceuticals
  • TC Biopharm
目次

"Gamma Delta T Cell Cancer Therapy Market & Clinical Trials Forecast 2028" Report Highlights:

  • Commercialization Market Potential After Market Launch: > USD 4 Billion
  • Insight on Key Drugs In Research & Development
  • Global Gamma Delta T Cell Cancer Therapy Clinical Trials Insight
  • Gamma Delta T Cell Cancer Therapy In clinical Trials: > 15 Therapies
  • Gamma Delta T Cell Cancer Therapy Market Opportunity By Cancer Type
  • Adopted Approaches for Gamma Delta T Cell Therapy

The introduction of T cell based immunotherapy has greatly revolutionized the paradigm of cancer treatment. The progress in clinical research and innovation has led to the identification of small subsets of T cells classified as gamma delta T cells. Gamma delta T cells are the minor subsets of T cells which constitutes only about 1% to 5% of T cell population. Their unique biology and conferred advantages over conventional T cells has enabled the researchers to utilize these novel cells as promising candidate for adoptive immunotherapy. Since its identification, scientists have harnessed the potential of gamma delta T cells in the management of several cancers.

The gamma delta T cell therapy represents one of the most promising T cell therapies in clinical development which can be suggested by the rapid research and development activities among the pharmaceutical companies. The major companies in the market are presenting promising preclinical and clinical data of gamma delta T cell therapies. For instance in 2022, In8bio provided an update on ongoing phase-I clinical trial of INB-200. The novel gamma delta T cell product has shown manageable safety profile and promising progression free survival and overall survival rate. The encouraging data from clinical trial suggests the promising future of gamma delta T cell therapy in the management of cancer.

Apart from cancer, researchers are also expanding the role of gamma delta T cell therapy in the management of other diseases such as HIV, COVID-19, and other viral infections. Recently, Enochian Biosciences announced that US FDA has accepted a pre-investigational new drug request for a cell therapy treatment which combines autologous natural killer and gamma delta T-cells. Furthermore, several preclinical studies also indicate an innate involvement of gamma delta T cells in viral infections. The coming years will witness translation of these investigations in clinical trials, which will further propel the growth of market.

The rising investment form the pharmaceutical giants have led to the development of strong clinical pipeline of gamma delta T cell therapy products. The key players operating in the market are Acopedia, Takeda Pharma, Lava Therapeutics, TC Biopharma, Cytomed Therapeutics, Gamma delta Therapeutics and Adapate Therapeutics. The major drugs in the clinical pipeline include INB-200, LAVA-051, ADI-001, TCB-007, ACE-1813, KB-PD1, and several others. Apart from this, several pharmaceutical giants have also entered into collaboration, mergers, or other alliances to maintain their position in the market. In January 2022, Takeda Pharmaceutical announced the exercise of its option to acquire Adapate Therapeutics. Through this acquisition, Takeda will obtain Adapate antibody based gamma delta T-cell engager platform including pre-clinical candidate and discovery pipeline programs.

US is currently dominating the global initiatives in development of gamma delta T cell therapy driven by large number of ongoing clinical trials, presence of key players in the region, and increasing initiatives from various stake holders in the industry . Apart from this, US FDA is also granting orphan drug designation to gamma T cell therapies which provides several financial and non-financial incentives to boost the drug development process. For instance in 2021, US FDA has granted orphan drug designation to two gamma delta T cell therapies including GDX012 for acute myeloid leukemia and LAVA-051 for chronic lymphocytic leukemia.

As per our report findings, the global gamma delta T-cell therapy market is expected to surpass US$ 4 Million by 2028. The rise in cancer rates and the subsequent unavailability of effectively curing drugs will propel the growth of the market for coming years. In addition, new product launches, continuous investment by pharmaceutical companies, and increasing government initiatives will also contribute in growth of market. The report provides comprehensive analysis on the ongoing clinical trials in gamma delta T cell therapy. By analyzing the market dynamics, the future market opportunity of gamma delta T cell therapy in various cancers is also forecasted.

Table of Contents

1. Introduction to Gamma Delta T Cell Therapy

  • 1.1. Emerging Role of T Cell Based Immunotherapies
  • 1.2. Overview to Gamma Delta T Cell Therapy

2. Gamma Delta T Cell Therapy Vs. Conventional Therapies

  • 2.1. Gamma Delta T Cell Therapy Vs. CAR T Cell Therapy
  • 2.2. Gamma Delta T Cell Therapy Vs. Tumor Infiltrating Lymphocyte Therapy
  • 2.3. Gamma Delta T Cell Therapy Vs. Immune Checkpoint Inhibitors
  • 2.4. Gamma Delta T Cell Therapy Vs. Monoclonal Antibodies
  • 2.5. Gamma Delta T Cell Therapy Vs. Others

3. Role of Gamma Delta T Cells in Cancer

  • 3.1. Gamma Delta T Cells in Cancer Progression
  • 3.2. Anti Tumor Activity of Gamma Delta T Cells

4. Adopted Approaches for Gamma Delta T Cell Therapy

  • 4.1. Gamma Delta T Cell as Bispecific Antibodies
  • 4.2. CAR Gamma Delta T Cells

5. Gamma Delta T Cell Therapy: Key Drugs In Research & Development

6. Global Gamma Delta T Cell Cancer Therapy Clinical Pipeline Overview

  • 6.1. By Company
  • 6.2. By Country
  • 6.3. By Indication
  • 6.4. By Phase

7. Global Gamma Delta T Cell Cancer Therapy Clinical Trials Insight by Company, indication & Clinical Phase

  • 7.1. Research
  • 7.2. Preclinical
  • 7.3. Clinical
  • 7.4. Phase-I
  • 7.5. Phase-I/II

8. Gamma Delta T Cell Therapy in Leukemia

  • 8.1. Role of Gamma Delta T Cells in Leukemia
  • 8.2. Ongoing Clinical Research in Acute Leukemia
  • 8.3. Clinical Trials in Chronic Lymphocytic Leukemia
  • 8.4. Future Market Opportunity of Gamma Delta T Cells in Leukemia

9. Gamma Delta T Cell Therapy in Lung Cancer

  • 9.1. Overview
  • 9.2. Ongoing Research & Development
  • 9.3. Future Market Opportunity of Gamma Delta T Cell Therapy in Lung Cancer

10. Gamma Delta T Cells in Breast Cancer

  • 10.1. Overview
  • 10.2. Ongoing Research & Development in Breast Cancer
  • 10.3. Future Market Opportunity of Gamma Delta T Cell Therapy in Breast Cancer

11. Gamma Delta T Cells in Colorectal Cancer

  • 11.1. Function of Gamma Delta T Cells in Colorectal Cancer
  • 11.2. Ongoing Clinical Trials in Colorectal Cancer
  • 11.3. Future Market Potential of Gamma Delta T Cell Therapy in Colorectal Cancer

12. Gamma Delta T Cells in Pancreatic Cancer

  • 12.1. Overview
  • 12.2. Ongoing Research & Development in Pancreatic Cancer
  • 12.3. Future Market Potential of Gamma Delta Therapy in Pancreatic Cancer

13. Current Clinical Research in Other Cancers

  • 13.1. Ongoing Clinical Trials in Neuroblastoma
  • 13.2. Ongoing Clinical Trials in Glioblastoma
  • 13.3. Ongoing Research & Development in Head & Neck Cancer

14. Gamma Delta T Cell Therapy Market Overview

  • 14.1. Current Market Scenario
  • 14.2. Market Potential of Gamma Delta T Cell Therapy Market

15. Gamma Delta T Cell Therapy Market Dynamics

  • 15.1. Gamma Delta T Cell Therapy Market: Favorable Parameters
  • 15.2. Gamma Delta T Cell Therapy Market: Challenges

16. Gamma Delta T Cell Therapy Future Prospects

17. Competitive Landscape

  • 17.1. Acepodia
  • 17.2. Adaptate Therapeutics
  • 17.3. Adicet
  • 17.4. Cytomed Therapeutics
  • 17.5. Gadeta
  • 17.6. GammaDelta Therapeutics
  • 17.7. IN8bio
  • 17.8. Kiromic Biopharma
  • 17.9. Lava Therapeutics
  • 17.10. Takeda Pharmaceuticals
  • 17.11. TC Biopharm

List of Figures

  • Figure 1-1: History of T cell Based Immunotherapy
  • Figure 1-2: Gamma Delta T cell Therapy
  • Figure 1-3: Stimulants of Gamma Delta T Cells
  • Figure 2-1: Limitation of CAR T Cell Therapy
  • Figure 2-2: Limitations of TIL
  • Figure 2-3: Limitations of Monoclonal Antibodies
  • Figure 2-4: Drawback of Chemotherapeutic Drugs
  • Figure 3-1: Pro-Tumor Role of Gamma Delta T Cells
  • Figure 3-2: Antigen Presentation Functions of Gamma Delta T-Cells
  • Figure 3-3: Anti-Tumor Activity of Gamma Delta T-Cells
  • Figure 4-1: Gamma Delta T Cell Bispecific Antibodies - Mechanism of Action
  • Figure 4-2: Functional Advantages of γδ T Cells for CAR T Cancer Therapy
  • Figure 4-3: CAR γδ T Cells - Mechanism of Action
  • Figure 5-1: ADI-001 - Initiation & Completion Year of Phase-I Clinical Trial
  • Figure 5-2: LAVA-051 - Initiation & Completion Year of Phase-I/II Clinical Trial
  • Figure 5-3: DRI Cell Therapy - Initiation & Completion Year of Phase-I Clinical Trial
  • Figure 5-4: Adoptive Cell Therapy - Initiation & Completion Year of Phase-I Clinical Trial
  • Figure 5-5: GDX012 - Initiation & Completion Year of Phase-I Clinical Trial
  • Figure 5-6: GDT002 - Initiation & Completion Year of Phase-I Clinical Trial
  • Figure 6-1: Global - Gamma Delta T Cell Cancer Therapy in Clinical Pipeline by Company, 2022 till 2028
  • Figure 6-2: Global - Gamma Delta T Cell Cancer Therapy in Clinical Pipeline by Country, 2022 till 2028
  • Figure 6-3: Global - Gamma Delta T Cell Cancer Therapy in Clinical Pipeline by Indication, 2022 till 2028
  • Figure 6-4: Global Gamma Delta T Cell Cancer Therapy in Clinical Pipeline by Phase, 2022 till 2028
  • Figure 8-1: Global - Leukemia Incidences & Mortality (Million), 2020 & 2040
  • Figure 8-2: Benefits of Gamma Delta T Cells in Leukemia
  • Figure 8-3: Mechanism of Action of Vγ9/CD123 Bispecific Antibody
  • Figure 8-4: Global - Estimated Leukemia Cancer Cases, 2021-2028
  • Figure 8-5: US - Estimated Leukemia Cancer Cases, 2021-2028
  • Figure 8-6: Europe - Estimated Leukemia Cancer Cases, 2021-2028
  • Figure 8-7: China - Estimated Leukemia Cancer Cases, 2021-2028
  • Figure 8-8: Japan - Estimated Leukemia Cancer Cases, 2021-2028
  • Figure 9-1: Global - Lung Cancer Incidences & Mortality (Million), 2020 & 2040
  • Figure 9-2: Role of Gamma Delta T Cells in Lung Cancer
  • Figure 9-3: Global - Estimated Lung Cancer Cases, 2021-2028
  • Figure 9-4: US - Estimated Lung Cancer Cases, 2021-2028
  • Figure 9-5: Europe - Estimated Lung Cancer Cases, 2021-2028
  • Figure 9-6: China - Estimated Lung Cancer Cases, 2021-2028
  • Figure 9-7: Japan - Estimated Lung Cancer Cases, 2021-2028
  • Figure 10-1: Global - Breast Cancer Incidences (Million), 2020 & 2040
  • Figure 10-2: Global - Breast Cancer Mortality (Million), 2020 & 2040
  • Figure 10-3: Global - Estimated Breast Cancer Cases, 2021-2028
  • Figure 10-4: US - Estimated Breast Cancer Cases, 2021-2028
  • Figure 10-5: Europe - Estimated Breast Cancer Cases, 2021-2028
  • Figure 10-6: China - Estimated Breast Cancer Cases, 2021-2028
  • Figure 10-7: Japan - Estimated Breast Cancer Cases, 2021-2028
  • Figure 11-1: Role of Gamma Delta T Cells in Colorectal Cancer
  • Figure 11-2: Mechanism Underlying B7-H3 Regulating γδ T Cells Killing Colon Cancer Cells
  • Figure 11-3: Global - Estimated Colorectal Cancer Cases, 2021-2028
  • Figure 11-4: US - Estimated Colorectal Cancer Cases, 2021-2028
  • Figure 11-5: Europe - Estimated Colorectal Cancer Cases, 2021-2028
  • Figure 11-6: China - Estimated Colorectal Cancer Cases, 2021-2028
  • Figure 11-7: Japan - Estimated Colorectal Cancer Cases, 2021-2028
  • Figure 12-1: Global - Pancreatic Cancer Incidences, 2020 & 2040
  • Figure 12-2: Global - Pancreatic Cancer Mortality, 2020 & 2040
  • Figure 12-3: Role of Gamma Delta T Cells in Pancreatic Cancer Progression
  • Figure 12-4: Global - Estimated Pancreatic Cancer Cases, 2021-2028
  • Figure 12-5: US - Estimated Pancreatic Cancer Cases, 2021-2028
  • Figure 12-6: Europe - Estimated Pancreatic Cancer Cases, 2021-2028
  • Figure 12-7: China - Estimated Pancreatic Cancer Cases, 2021-2028
  • Figure 12-8: Japan - Estimated Pancreatic Cancer Cases, 2021-2028
  • Figure 14-1: Global - Cell Therapy Market (US$ Billion), 2020 - 2028
  • Figure 14-2: Global - Gamma Delta T Cell Therapy Market Opportunity by 1% of Total Cell Therapy Market (US$ Billion), 2022-2028
  • Figure 14-3: Global - Gamma Delta T Cell Therapy Market Opportunity by 2% of Total Cell Therapy Market (US$ Billion), 2022-2028
  • Figure 14-4: Global - Gamma Delta T Cell Therapy Market Opportunity by 3% of Total Cell Therapy Market (US$ Billion), 2022-2028
  • Figure 14-5: Global - Gamma Delta T Cell Therapy Market Opportunity by 4% of Total Cell Therapy Market (US$ Billion), 2022-2028
  • Figure 14-6: Global - Gamma Delta T Cell Therapy Market Opportunity by 5% of Total Cell Therapy Market (US$ Billion), 2022-2028
  • Figure 14-7: Global - Gamma Delta T Cell Therapy Market Opportunity by 6% of Total Cell Therapy Market (US$ Billion), 2022-2028
  • Figure 14-8: Global - Gamma Delta T Cell Therapy Market Opportunity by 7% of Total Cell Therapy Market (US$ Billion), 2022-2028
  • Figure 14-9: Global - Gamma Delta T Cell Therapy Market Opportunity by 8% of Total Cell Therapy Market (US$ Billion), 2022-2028
  • Figure 14-10: Global - Gamma Delta T Cell Therapy Market Opportunity by 9% of Total Cell Therapy Market (US$ Billion), 2022-2028
  • Figure 14-11: Global - Gamma Delta T Cell Therapy Market Opportunity by 10% of Total Cell Therapy Market (US$ Billion), 2022-2028
  • Figure 15-1: Global - Cancer Incidences & Mortality Rates (Billion), 2020 & 2040
  • Figure 15-2: Gamma Delta T Cells Favorable Market Parameters
  • Figure 15-3: Stages of Drug Development

List of Tables

  • Table 8-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2022-2028
  • Table 8-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2022-2028
  • Table 8-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2022-2028
  • Table 8-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2022-2028
  • Table 8-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2022-2028
  • Table 9-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2022-2028
  • Table 9-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2022-2028
  • Table 9-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2022-2028
  • Table 9-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2022-2028
  • Table 9-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2022-2028
  • Table 10-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2022-2028
  • Table 10-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2022-2028
  • Table 10-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2022-2028
  • Table 10-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2022-2028
  • Table 10-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2022-2028
  • Table 11-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2022-2028
  • Table 11-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2022-2028
  • Table 11-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2022-2028
  • Table 11-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2022-2028
  • Table 11-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2022-2028
  • Table 12-1: Global - Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2022-2028
  • Table 12-2: US - Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2022-2028
  • Table 12-3: Europe - Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2022-2028
  • Table 12-4: China - Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2022-2028
  • Table 12-5: Japan - Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2022-2028