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加齢黄斑変性症 (AMD)/他の網膜疾患の治療薬の世界市場 (2019~2029年):ウェット型/ドライ型AMD、糖尿病網膜症 (DR)、Lucentis、Eylea、Avastin、Visudyne

Global Macular Degeneration (AMD) and Other Retinal Diseases Drugs Industry and Market 2019-2029: Wet AMD, Dry AMD, Diabetic Retinopathy, Lucentis, Eylea, Avastin, Visudyne

発行 Visiongain Ltd 商品コード 290418
出版日 ページ情報 英文 170 Pages
納期: 即日から翌営業日
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本日の銀行送金レート: 1GBP=143.96円で換算しております。

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加齢黄斑変性症 (AMD)/他の網膜疾患の治療薬の世界市場 (2019~2029年):ウェット型/ドライ型AMD、糖尿病網膜症 (DR)、Lucentis、Eylea、Avastin、Visudyne Global Macular Degeneration (AMD) and Other Retinal Diseases Drugs Industry and Market 2019-2029: Wet AMD, Dry AMD, Diabetic Retinopathy, Lucentis, Eylea, Avastin, Visudyne
出版日: 2019年07月31日 ページ情報: 英文 170 Pages
概要

世界の網膜疾患治療薬の市場規模は、2018年に148億5000万米ドルに達する、と予測されています。また2028年にかけて、6.7%のCAGR (複合年間成長率) で成長を遂げる見通しです。

当レポートでは、加齢黄斑変性症 (AMD) をはじめとした網膜疾患のための薬剤市場について調査し、売上動向、技術動向、市場の機会とともに収益予測、部門別 (ウェット型AMD・ドライ型AMD・DR (糖尿病網膜症)) の詳細動向などをまとめて取り上げております。

第1章 分析概要

第2章 世界の加齢黄斑変性症 (AMD)/他の網膜疾患の市場

  • 網膜疾患とは
  • 網膜疾患の種類
  • AMD/他の網膜疾患の診断・治療方法
  • AMDの推定患者数
  • DR (糖尿病網膜症) の併発患者数
  • RVO (網膜静脈閉塞症) の推定患者数
  • 市場の急成長の見通し
  • Eyleaが最大の治療薬となる
  • Regeneronのプレゼンスの大きさ
  • 最も大きな疾病地域はどこか?

第3章 網膜疾患市場:分野別の分析

  • ウェット型AMD:現在も最大の収益源
  • ウェット型AMD:血管由来のプロセスにより、薬剤標的が明確化
  • ドライ型AMD:網膜色素上皮 (RPE) 細胞へのダメージを阻止/無効化するためのアンメットニーズ
  • DR (糖尿病網膜症) :糖尿病黄斑浮腫 (DME) をターゲットとした臨床的な関心が高まる
  • Lucentis:Eyleaの延長試験により、他の領域での可能性が明確化
  • 全分野の予測

第4章 AMD/他の網膜疾患の市場における認証済み製品

  • 現在の製品が今後も市場を独占するのか?
  • Lucentis:市場で第2位の治療薬
  • Eylea:首位に立っているか?
  • Avastin:正式な承認がないが、最もよく使われる製品
  • Visudyne (Valeant/Novartis): 調査対象期間中は売上が減少する見込み
  • その他の製品

第5章 ウェット型AMD向け治療薬のパイプライン製品

  • 主なパイプライン候補薬
  • Fovista (Ophthotech Corporation/Novartis):次の目玉となるか?
  • パイプライン上にある、その他の成長因子の標的
  • APL-2:AMD関連の地図状萎縮 (GA) 患者の治療法の進化
  • 新たな抗VEGFR剤や送達システムが必要となるのか?
  • 抗炎症アプローチを活性化させるための、新たな薬剤送達システム
  • ウェット型AMD治療薬の開発における、分析中の新たな標的
  • 再生医療アプローチ

第6章 ドライ型AMD市場のパイプライン製品

  • ドライ型AMDの市場で飛躍的成長を遂げるのは誰か?
  • MC-1101 (MacuCLEAR): 市場のリーダーとなるのか?
  • ACU-4429 (Acucela):治験第III相にある視覚サイクルモジュレーター
  • ドライ型AMDにおける補体阻害への大きな期待
  • コルチコステロイド:ドライ型AMDの病因における炎症の役割を標的とする
  • 神経防護作用:現代医療の至高の目標の一つ
  • 再生医療:ドライ型AMDは最大の疾病ターゲットの一つ
  • ドライ型AMDのその他の治療法

第7章 糖尿病性網膜症 (DR) 市場のパイプライン製品

  • Ozurdex/Posurdex (Allergan):一般的なDME患者のための認可
  • Lucentis (ルセンティス):DRのゲームチェンジャー?
  • 新たな抗VEGF剤の追加
  • DR向けに開発中のステロイド
  • DR向けに開発中のその他の製品

第8章 地域市場の分析

  • どの市場が、最も大きな成長可能性を手に入れるのか?
  • 米国:網膜疾患の主要市場
  • 日本:強力な潜在的市場
  • 欧州主要5ヶ国 (EU5):人口高齢化による市場促進
  • BRIC諸国:最大の市場成長促進要因

第9章 世界のAMD/他の網膜疾患の治療薬市場における主要企業

  • Novartis AG
    • 企業概要
    • 財務分析
    • 近年の動向
  • F. Hoffmann-La Roche, Ltd.
  • Bayer AG
  • Regeneron Pharmaceuticals
  • Valent Pharmaceuticals International, Inc.
  • Pfizer Inc.
  • Acucela, Inc.
  • IVERIC bio, Inc.
  • GlaxoSmithKline Pharmaceuticals Ltd.
  • Allergan PLC

第10章 産業・市場の定性分析

  • 強み:眼科市場で最もダイナミックな領域
  • 弱み:抗VEGFアプローチへの過剰依存
  • 機会:市場と研究開発 (R&D) との新たなシナジー効果
  • 脅威:ドライAMDやDRにとって、予防や管理や薬剤治療よりも優れているか?
  • 社会的要因:低い診断率、低い服薬コンプライアンス
  • 技術的要因:眼科関連のイノベーション
  • 経済的要因:適応外治療と医療費償還の問題
  • 政治的要因:人口構造と糖尿病の問題

第11章 結論

付録

図表

List of Tables

  • Table 2.1 Overall World AMD and Other Retinal Diseases Pharmaceutical Market Forecast: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 2.2 Overall World AMD and Other Retinal Diseases Pharmaceutical Market Forecast: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 2.3 Market Breakdown by Product: Revenue ($bn), Market Share (%), 2018
  • Table 3.1 Market Breakdown by Disease Segment: Revenue ($bn), Market Share (%), 2018
  • Table 3.2 Types of CNV in Wet AMD, Description: Approximate Proportion of Cases (%), 2018
  • Table 3.3 Global Wet AMD Segment: Revenue ($bn), AGR (%), CAGR (%), Market Share (%), 2018-2023
  • Table 3.4 Global Wet AMD Segment Forecast: Revenue ($bn), AGR (%), CAGR (%), Market Share (%), 2023-2029
  • Table 3.5 Global Dry AMD Segment Forecast: Revenue ($bn), AGR (%), CAGR (%), Market Share (%), 2018-2023
  • Table 3.6 Global Dry AMD Segment Forecast: Revenue ($bn), AGR (%), CAGR (%), Market Share (%), 2023-2029
  • Table 3.7 Global DR Segment Forecast: Revenue ($bn), AGR (%), CAGR (%), Market Share (%), 2018-2023
  • Table 3.8 Global DR Segment Forecast: Revenue ($bn), AGR (%), CAGR (%), Market Share (%), 2023-2029
  • Table 3.9 Global Retinal Diseases Market Forecasts by Segment: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 3.10 Global Retinal Diseases Market Forecasts by Segment: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 3.11 Global Retinal Diseases Market Forecasts by Segment: Revenue ($bn), Market Share (%) for 2018, 2023 and 2029
  • Table 4.1 Global Retinal Diseases Market Forecasts by Segment: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 4.2 Global Retinal Diseases Market Forecasts by Segment: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 4.3 Market Breakdown by Product: Revenue ($bn), Market Share (%), 2023
  • Table 4.4 Market Breakdown by Product: Revenue ($bn), Market Share (%), 2029
  • Table 4.5 Lucentis: Revenue ($bn), AGR (%), 2014 & 2017
  • Table 4.6 Lucentis, Eylea and Avastin: Comparison of Reported Characteristics
  • Table 4.7 Lucentis: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 4.8 Lucentis: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 4.9 Eylea: U.S. Revenue ($bn), AGR (%), 2017-2018
  • Table 4.10 Eylea Forecast: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 4.11 Eylea Forecast: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 4.12 Avastin: Revenue ($bn), AGR (%), 2016-2018
  • Table 4.13 Avastin Forecast: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 4.14 Avastin Forecast: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 4.15 Visudyne Forecast: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 4.16 Visudyne Forecast: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 4.17 Other Drugs Forecast: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 4.18 Other Drugs Forecast: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 5.1 Selected R&D Pipeline for wAMD, 2018
  • Table 6.1 Selected R&D Pipeline for Dry AMD, 2018
  • Table 7.1 Selected R&D Pipeline for DR, 2017
  • Table 8.1 Regional Breakdown: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 8.2 Regional Breakdown: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 8.3 US Forecast: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 8.4 US Forecast: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 8.5 Japan Forecast: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 8.6 Japan Forecast: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 8.7 EU5 Forecast: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 8.8 EU5 Forecast: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 8.9 BRIC Nations Forecast: Revenue ($bn), AGR (%), CAGR (%), 2018-2023
  • Table 8.10 BRIC Nations Forecast: Revenue ($bn), AGR (%), CAGR (%), 2023-2029
  • Table 9.1 Novartis AG: Overview 2018
  • Table 9.2 Novartis Revenue ($bn) 2016, 2017
  • Table 9.3 Roche: Overview 2018
  • Table 9.4 Roche Revenue ($bn) 2017, 2018
  • Table 9.5 Bayer: Overview 2018
  • Table 9.6 Bayer AG Revenue ($bn) 2017 and 2018
  • Table 9.7 Regeneron Pharmaceuticals: Overview 2017
  • Table 9.8 Regeneron Pharmaceuticals: Revenue ($bn) 2016 and 2017
  • Table 9.9: Valent Pharmaceuticals International Inc.: Overview 2018
  • Table 9.10 Valent Pharmaceuticals International Inc: Revenue ($bn) 2016 and 2017
  • Table 9.11: Pfizer Inc.: Overview 2018
  • Table 9.12 Pfizer Inc: Revenue ($bn) 2017, 2018
  • Table 9.13: Acucela Inc.: Overview 2018
  • Table 9.14: IVERIC bio, Inc.: Overview 2018
  • Table 9.15 IVERIC bio, Inc. ($bn) 2017, 2018
  • Table 9.16: GlaxoSmithKline Pharmaceuticals Ltd.: Overview 2018
  • Table 9.17 GlaxoSmithKline Pharmaceuticals Ltd ($bn) 2017, 2018
  • Table 9.18: Allergan PLC: Overview 2018
  • Table 9.19 Allergan PLC ($bn) 2017, 2018
  • Table 10.1 Strengths and Weaknesses in the AMD and Other Retinal Diseases Market, 2018
  • Table 10.2 Opportunities and Threats in the AMD and Other Retinal Diseases Market, 2018
  • Table 10.3 Social, Technological, Economic and Political Factors Influencing the AMD and Other Retinal Diseases Pharmaceutical Market (STEP Analysis)

List of Figures

  • Figure 2.1 Overall World AMD and Other Retinal Diseases Pharmaceutical Market Forecast: Revenue ($bn), 2018-2029
  • Figure 2.2 Market Breakdown by Product Revenue ($bn), Market Share (%), 2018
  • Figure 2.3 Market Breakdown by Company: Market Share (%), 2018
  • Figure 2.4 Leading Causes of Blindness Worldwide, Proportion of Total (%), 2018
  • Figure 2.5 Leading Causes of Visual Impairment (Inclusive of Blindness) Worldwide, Proportion of Total (%), 2018
  • Figure 3.1 Market Breakdown by Disease Segment: Revenues ($bn), 2018
  • Figure 3.2 Market Breakdown by Disease Segment: Market Share (%), 2023
  • Figure 3.3 Global Wet AMD Segment Forecast: Revenue ($bn), 2019-2029
  • Figure 3.4 Global Dry AMD Segment Forecast: Revenue ($bn), 2019-2029
  • Figure 3.5 DR Segment Forecast: Revenue ($bn), 2019-2029
  • Figure 3.6 Global Retinal Diseases Market Breakdown by Segment: Revenue ($bn), 2019-2029
  • Figure 3.7 Global Retinal Diseases Market Breakdown by Segment: Revenue ($bn), 2018, 2023 and 2029
  • Figure 3.8 Market Breakdown by Disease Segment: Market Share (%), 2023
  • Figure 3.9 Market Breakdown by Disease Segment: Market Share (%), 2029
  • Figure 4.1 Market Breakdown by Product: Revenue ($bn), Market Share (%), 2023
  • Figure 4.2 Market Breakdown by Product: Revenue ($bn), Market Share (%), 2029
  • Figure 4.3 Market Forecast by Product: Revenue ($bn), 2019-2029
  • Figure 4.4 Market Breakdown by Product: Revenue ($bn), 2018, 2023 and 2029
  • Figure 4.5 Lucentis: Revenues Forecast ($bn), 2019-2029
  • Figure 4.6 Drivers and Restraints for Lucentis, 2018
  • Figure 4.7 Eylea Forecast: Revenue ($bn), 2018-2029
  • Figure 4.8 Drivers and Restraints for Eylea, 2018
  • Figure 4.9 Avastin Forecast: Revenue ($bn), 2019-2029
  • Figure 4.10 Drivers and Restraints for Avastin, 2018
  • Figure 4.11 Visudyne Forecast: Revenues ($bn), 2019-2029
  • Figure 4.12 Other Drugs Forecast: Revenues ($bn), 2019-2029
  • Figure 8.1 Regional Breakdown: Revenue ($bn), 2019-2029
  • Figure 8.2 Regional Breakdown: Revenue ($bn), 2018, 2023 and 2029
  • Figure 8.3 Regional Market Share (%), 2018
  • Figure 8.4 Regional Market Share (%), 2023
  • Figure 8.5 Regional Market Share (%), 2029
  • Figure 8.6 US Market: Revenue ($bn), 2019-2029
  • Figure 8.7 Japan: Revenue ($bn), 2019-2029
  • Figure 8.8 EU5: Grouped Revenue ($bn), 2019-2029
  • Figure 8.9 EU5 Breakdown Forecasts: Revenue ($bn), 2019-2029
  • Figure 8.10 EU5 Breakdown: Market Share (%), 2018
  • Figure 8.11 EU5 Breakdown: Market Share (%), 2023
  • Figure 8.12 EU5 Breakdown: Market Share (%), 2029
  • Figure 8.13 BRIC Nations Forecast: Revenue ($bn), 2019-2029
  • Figure 8.14 BRIC Nations Forecasts: Revenue ($bn), 2019-2029
  • Figure 8.15 Market Share (%) within BRIC Group by Country, 2018
  • Figure 8.16 Market Share (%) within BRIC Group by Country, 2023
  • Figure 8.17 Market Share (%) within BRIC Group by Country, 2029

COMPANIES LISTED:

  • Abbott
  • Acucela Pharmaceuticals
  • Alcon
  • Alimera Sciences
  • Allegro Opthalmics
  • Allergan
  • Ampio Pharmaceuticals
  • Ampio Pharmaceuticals
  • Avalanche Biotechnologies
  • Bayer Healthcare
  • Bioeq GmbH
  • Biophytis
  • Biovail Corporation
  • Bristol-Myers Squibb
  • CalTech
  • Cell Cure Neurosciences Ltd
  • Centocor
  • Chengdu Kanghong
  • Chengdu Kanghong Biotech
  • Clearside Biomedical
  • CoMentis
  • Daiichi Sankyo
  • Diffusion Pharmaceuticals
  • Eli Lilly
  • ESBATech
  • Eye Gate Pharmaceuticals
  • ForSight Vision4
  • Gene Signal
  • Genentech
  • GlaxoSmithKline
  • Hemera Biosciences
  • iCo Therapeutics
  • Icon Bioscience
  • Iconic Therapeutics
  • Janssen Pharmaceuticals
  • Jiangsu T-mab BioPharma
  • Kala Pharmaceuticals
  • LPATH
  • Lpath, Inc.
  • MacuCLEAR
  • Mateon Therapeutics
  • Medical Need
  • Merck Sharp & Dohme
  • Mesoblast
  • Mitsubishi Tanabe Pharma
  • Molecular Partners
  • MorphoSys
  • Neuron Systems
  • Neurotech
  • Novartis
  • Novo Nordisk
  • Oakwood Laboratories
  • Ocata Therapeutics (Advanced Cell Technology)
  • OHR Pharmaceutical
  • Ophthotech Corporation
  • OpRegen (Biotime)
  • Opthea
  • Ora Bio
  • Othera Pharmaceuticals
  • Otsuka Pharmaceutical
  • Oxford BioMedica
  • Oxigene
  • PanOptica
  • Pfenex
  • Pfizer
  • pSivida
  • Quark
  • Regenerative Patch Technologies
  • Regeneron/Bayer
  • Regenxbio
  • ReVision Therapeutics
  • River Vision Development
  • Roche
  • RXi Pharmaceuticals
  • Sanofi
  • Santen Pharmaceutical
  • SARcode Bioscience
  • SciFluor Life Sciences
  • Senju Pharmaceutical
  • SGS Life Science Services
  • Stealth BioTherapeutics
  • StemCells
  • Stemedica Cell Technologies
  • SV Life Sciences
  • Third Rock Ventures
  • ThromboGenics
  • Tyrogenex
  • UCB
  • Valeant Pharmaceuticals
  • Vitreoretinal Technologies
  • Xcovery Vision

List of Organisations Mentioned in the Report:

  • Association for Research in Vision and Ophthalmology
  • Columbia University
  • Germany's Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG)
  • International Diabetes Federation
  • Italian Competition Authority (ICA)
  • Japanese Ministry of Health, Labour and Welfare
  • Macula and Retina Institute Glendale
  • NHS
  • NICE
  • Oregon Health and Science University
  • Retinal Research Institute
  • Riken Institute
  • UK's General Medical Council
  • University College London (UCL)
  • US National Eye Institute
  • World Health Organisation (WHO)
目次
Product Code: PHA0460

The global macular degeneration and other retinal diseases market is estimated at $14.85bn in 2018 and is expected to grow at a CAGR of 6.7% during the forecast period.

How this report will benefit you

Read on to discover how you can exploit the future business opportunities emerging in this sector.

In this brand new 176-page report you will receive 110 charts - all unavailable elsewhere.

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Report Scope

Global AMD and Other Retinal Diseases Market forecasts from 2019-2029

Revenue forecasts for Global AMD and Other Retinal Diseases Drugs Market by Disease Segment from 2019-2029:

  • Wet AMD
  • Dry AMD
  • Diabetic Retinopathy
  • Other Retinal Diseases

Revenue forecasts for Global AMD and Other Retinal Diseases Drugs Market by Product from 2019-2029:

  • Lucentis
  • Eylea
  • Avastin
  • Visudyne
  • Others

Revenue forecasts for the Global AMD and Other Retinal Diseases Drugs Market by Region from 2019-2029:

  • U.S.
  • Japan
  • China
  • Germany
  • France
  • UK
  • Italy
  • Spain
  • Brazil
  • Russia
  • India
  • Rest of the World

Discussion and profiles of the below selected leading companies:

  • Acucela, Inc.
  • Allergan Plc
  • Bayer AG
  • F. Hoffman-La Roche, Ltd.
  • GlaxoSmithKline Pharmaceuticals, Ltd.
  • IVERIC bio, Inc.
  • Novartis AG
  • Pfizer, Inc.
  • Regeneron Pharmaceuticals
  • Valent Pharmaceuticals International, Plc

Analysis of the Drivers, Restraints, Opportunities and Threats of the global AMD and other retinal diseases market

  • The report also includes a SWOT and STEP analysis of the global AMD and other retinal diseases market
  • Discussion on the pipeline for Wet AMD. Dry AMD and Diabetic Retinopathy

Key questions answered by this report:

  • How is the retinal diseases market evolving and what are the market prospects from 2018?
  • What forces stimulate and restrain that market?
  • What are the sales figures for retinal diseases?
  • How will revenues of retinal diseases segments grow over the forecast period, 2019 to 2029?
  • How will individual product sales develop to 2029?
  • Which R&D pipeline products are likely to dominate the market in the next ten years, and what are their sales potentials?
  • Which submarkets and national markets form the main drivers of the overall world market to 2029?
  • How will social, technological, economic and political forces influence regional markets and world-level submarkets?
  • How will market shares of top countries change by 2029 - with their revenues - and which regions will lead the market in 2029?
  • Who are the leading companies and what are their prospects over the forecasted period?

Visiongain's study is intended for anyone requiring commercial analyses for the macular degeneration (AMD) and other reginal diseases drugs market. You find data, trends and predictions.

Buy our report today Global Macular Degeneration (AMD) and Other Retinal Diseases Drugs Industry and Market 2019-2029: Wet AMD, Dry AMD, Diabetic Retinopathy, Lucentis, Eylea, Avastin, Visudyne.

Visiongain is a trading partner with the US Federal Government.

Table of Contents

1. Report Overview

  • 1.1 Overview of the World Market for Macular Degeneration and Other Retinal Diseases
  • 1.2 Why You Should Read This Report
  • 1.3 How This Report Delivers
  • 1.4 Main Questions Answered by This Analysis
  • 1.5 Who Is This Study For?
  • 1.6 Methods of Research and Analysis
  • 1.7 Frequently Asked Questions (FAQs)
  • 1.8 Some Associated Reports
  • 1.9 About Visiongain

2. World AMD and Other Disease Market, 2018

  • 2.1 What are Retinal Diseases?
  • 2.2 Types of Retinal Diseases
  • 2.3 Diagnostics and Treatments for AMD and Other Retinal Diseases
  • 2.4 Nearly 200 Million People with AMD?
  • 2.5 Over 100 Million with DR
  • 2.6 First RVO Estimates Suggest Patient Population of 16 Million
  • 2.7 Market to Grow Rapidly by 2029
  • 2.8 Eylea Became Leading Drug in the Market
  • 2.9 Regeneron the Leading Presence in the Market
  • 2.10 Which are the Most Significant Disease Areas for the Market?

3. Retinal Disease Market Subsectors, 2018

  • 3.1 Wet AMD Still the Main Source of Revenue in the Market
  • 3.2 Wet AMD: Angiogenic Processes Offer Well-Defined Drug Targets
    • 3.2.1 Revenue Forecasting for Wet AMD segment, 2019-2029
  • 3.3 Dry AMD: Unmet Need to Arrest or Reverse Damage to RPE
    • 3.3.1 Dry AMD Segment to Emerge in the Forecast Period
  • 3.4 DR: Coming into Clinical Focus, with DME the Main Target
    • 3.4.1 Segment to Grow in Importance as Diabetes Epidemic Continues
  • 3.5 Lucentis and Eylea Label Extensions Highlight Possibilities in Other Disease Areas
  • 3.6 Projections of all Segments, 2019-2029

4. Approved Products in the AMD and Other Retinal Diseases Market, 2019-2029

  • 4.1 Will the Current Products Dominate the Market through 2029?
  • 4.2 Lucentis: Second Leading Drug in the Market
    • 4.2.1 Positive Revenue Growth Shown in Past: 2014-2017
    • 4.2.2 Shadow of Avastin Still Hangs Over Lucentis
    • 4.2.3 Lucentis/Avastin Matters
    • 4.2.4 Eylea: The Bigger Threat to Lucentis?
    • 4.2.5 Extending the Label, Widening the Battleground: Lucentis Moves into DME and Beyond
    • 4.2.6 Improving Cost and Compliance for Lucentis
    • 4.2.7 Lucentis Revenue Forecast 2019-2029
    • 4.2.8 Will Loss of Physician Goodwill Harm Lucentis' Growth?
  • 4.3 Eylea: Holds the Throne?
    • 4.3.1 Increasing Revenue Growth in Past: Outside the US Sale Amplified
    • 4.3.2 VIEW 1 and VIEW 2: Is Eylea Superior or Just Non-Inferior to Lucentis?
    • 4.3.3 First Wave of Eylea's Expansion Finally Beginning to Break?
    • 4.3.4 Eylea into DME and Other New Indications
    • 4.3.5 Eylea Revenue Forecast 2019-2029
    • 4.3.6 How Far Can Eylea's Momentum Carry It?
  • 4.4 Avastin: No Formal wAMD Approval but Still the Most-Used Product
    • 4.4.1 Past Revenue illustrates Increasing Use of Avastin for wetAMD
    • 4.4.2 Judicial Review Averted in the UK by Price Adjustment
    • 4.4.3 Multiple Attempts to Block Off-Label Avastin Since 2007
    • 4.4.4 Roche and Novartis Challenge CATT's Headline Conclusions
    • 4.4.5 Will Eylea/Zaltrap Affect Avastin's Place in the Market?
    • 4.4.6 Avastin Revenue Forecast, 2019-2029
  • 4.4.7 Will Anything Dislodge Avastin from its Central Position?
  • 4.5 Visudyne (Valeant/Novartis): Declining Sales throughout the Forecast Period
    • 4.5.1 Visudyne Revenue Forecast, 2019-2029
  • 4.6 Other Drugs for Macular Degeneration and Other Retinal Diseases
    • 4.6.1 Other Drugs Revenue Forecast, 2019-2029

5. Pipeline for Wet AMD Segment

  • 5.1 The Leading Pipeline Candidates
  • 5.2 Fovista (Ophthotech Corporation/Novartis): The Next Big Thing?
    • 5.2.1 Three Phase III Trials to Confirm Fovista's Outstanding Phase II Results
    • 5.2.2 Ophthotech Goes Public to Fund Phase III Effort
    • 5.2.3 Ophthotech Partners with Novartis for Fovista
    • 5.2.4 Improving Angiogenesis Inhibition by Blocking Pericyte Recruitment
    • 5.2.5 The Move towards Combination Therapies
  • 5.3 Other Growth Factor Targets in the Pipeline
    • 5.3.1 Squalamine (OHR Pharmaceutical): Combination Targeting in a Single Eyedrop
    • 5.3.2 Allergan and Molecular Partners: Preclinical DARPin Hits VEGF and PDGF
    • 5.3.3 NT-506 (Neurotech Pharmaceutical): Sustained-Release VEGF/PDGF Options
  • 5.4 APL-2: Evaluation for the treatment of patients with Geographic Atrophy (GA) related to AMD
    • 5.4.1 A Chinese Competitor: Where Will Conbercept Fit In?
    • 5.4.2 Binding Affinity Comparable to Eylea
  • 5.5 Do We Need New Anti-VEGFR Agents or Delivery Systems?
    • 5.5.1 Abicipar Pegol (Allergan): Novel Protein with Extended Half-Life
    • 5.5.2 Brolucizumab (Alcon): Single-Chain Monoclonal Antibody Fragment
    • 5.5.3 NT-503 (Neurotech): New Delivery Platform for Anti-VEGF Agent
    • 5.5.4 Pan-90806 (PanOptica): Anti-VEGF Eyedrop in Preclinical Development
    • 5.5.5 Iontophoretic Delivery: EyeGate Pharmaceuticals Leading the Way
  • 5.6 Novel Delivery Systems to Rejuvenate Anti-Inflammatory Approaches
    • 5.6.1 Verisome System and IBI-30089 (Icon Bioscience)
    • 5.6.2 CPC-551 (Colby Pharmaceutical): An Alternative Anti-Inflammatory Approach?
  • 5.7 Other Targets Under Investigation in wAMD Drug Development
    • 5.7.1 Are Kinase Inhibitors Still a Going Concern in wAMD?
    • 5.7.2 Pazopanib (GlaxoSmithKline) and TG100801 (Sanofi): Two Eyedrop Kinase Inhibitors Drop Out of the Running
    • 5.7.3 X-82 Pill (Tyrogenex): Dual Kinase Inhibitor
    • 5.7.4 Factor C5: A More Promising Target Addressed by Zimura (Ophthotech) and LFG316 (Novartis)
    • 5.7.5 Integrins: Another Blockable Component of the Neovascularisation Cascade?
    • 5.7.6 Luminate (Allegro Ophthalmics): Novel Anti-Integrin Oligopeptide
    • 5.7.7 Novel Anti-Angiogenic Treatments in Development: Ora Bio's ORA102 and CoMentis' ATG003
    • 5.7.8 Zybrestat (Oxigene): New Mechanism of Action Offers Way to Disrupt Neovascularisation
    • 5.7.9 Synthetic Biologies: Oligonucleotides and SiRNAs for wAMD
  • 5.8 Regenerative Medicine Approaches
    • 5.8.1 Allogeneic Stem Cells (Mesoblast): Potential Synergistic Treatment for Use alongside Lucentis
    • 5.8.2 AVA-101 and AVA-201(Avalanche Biotechnologies): Ocular BioFactory for wAMD
    • 5.8.3 RetinoStat (Oxford BioMedica): LentiVector Technology to Deliver Anti-Angiogenic Genes

6. Pipeline for Dry AMD Segment

  • 6.1 Who Will Achieve the Big Breakthrough in Dry AMD?
  • 6.2 MC-1101 (MacuCLEAR): Leading the Pack?
    • 6.2.1 Increasing Choroidal Blood Flow with Repurposed Product
    • 6.2.2 Novel Endpoints in Phase III Study
    • 6.2.3 Can MacuCLEAR Make It?
  • 6.3 ACU-4429 (Acucela): Visual Cycle Modulator in Phase III
    • 6.3.1 Study Result Declared in May 2016
    • 6.3.2 Other Visual Cycle Modulators
  • 6.4 High Hopes for Complement Inhibition in Dry AMD
    • 6.4.1 Lampalizumab (Roche): The Big News of ARVO 2013
    • 6.4.2 MAHALO Study Indicates GA Progression Slowed by Lampalizumab
  • 6.5 Corticosteroids: Targeting Inflammation's Role in Dry AMD Pathogenesis
    • 6.5.1 Iluvien (Alimera Sciences): Study terminated
    • 6.5.2 AGN208397 (Allergan): New Potent Steroid Expected to Undergo Trials in Dry AMD
  • 6.6 Neuroprotection: One of Modern Medicine's Holy Grails
    • 6.6.1 Tandospirone (Alcon): Not effective in GA
    • 6.6.2 Renexsus (Neurotech): Possibly Promising Data in Dry AMD Studies
    • 6.6.3 Novadur (Allergan): Possible Efficacy with Longer Duration of Action
    • 6.6.4 VAR10200 (Varinel): A Preclinical Candidate to Watch
  • 6.7 Regenerative Medicine: Dry AMD One of the Biggest Disease Targets
    • 6.7.1 MA09-hRPE Cellular Therapy (Ocata Therapeutics): Signs of Efficacy in Landmark ESC Human Trial
    • 6.7.2 HuCNS-SC (StemCells): Leading Company in Neural Stem Cell Space
    • 6.7.3 Stemedyne-RPE (Stemedica Cell Technologies): Low-Oxygen Cells for Dry AMD Repair
    • 6.7.4 OpRegen (Biotime): Stem Cell leader with Dry AMD Interests
    • 6.7.5 First iPSC Trial in Japan in Dry AMD Patients
    • 6.7.6 Gene Therapies Less Prominent Than Stem Cells in Dry AMD
  • 6.8 Other Treatments for Dry AMD

7. Pipeline for Diabetic Retinopathy Segment

  • 7.1 Ozurdex/Posurdex (Allergan): Approved for General DME Patient Population
  • 7.2 Lucentis: The Game Changer for DR?
  • 7.3 New Anti-VEGF Additions
    • 7.3.1 Is Eylea Better than Lucentis and Avastin for DME?
  • 7.4 Steroids in Development for DR
    • 7.4.1 Iluvien (Alimera/pSivida): New Option in European Markets
    • 7.4.2 A New Hope? Optina (Ampio Pharmaceuticals)
    • 7.4.3 Betamethasone Microsphere (Santen): Late-Stage Steroid Candidate
    • 7.4.4 Cortiject (Santen): Prodrug Candidate
    • 7.4.5 IBI-20089 (Icon Bioscience): Sustained-Release Formulation of Triamcinolone Acetonide
  • 7.5 Other Products in Development for DR
    • 7.5.1 Angiotensin Receptor Blockers/Angiotensin-Converting Enzyme Inhibitors: Some Off-Label Validation
    • 7.5.2 Vitreosolve (Innovations in Sight): Will a Phase III Trial Be Initiated?
    • 7.5.3 TriLipix (Abbott): No New Development for Promising Drug
    • 7.5.4 iCo-007 Intravitreal Injection (iCo Therapeutics): Phase 2 Enrolment Completed June 2013

8. Regional Market Breakdown, 2019-2029

  • 8.1 Which Markets Hold the Most Revenue Growth Potential?
  • 8.2 The US: Leading Market for Retinal Diseases
  • 8.3 Japan: Strong Market Potential
  • 8.4 EU5: Ageing Populations to Drive Market Growth
  • 8.5 BRIC Nations: The Biggest Growth Driver for the Market

9. Leading Companies in Global AMD and Other Retinal Diseases Market, 2018

  • 9.1 Novartis AG
    • 9.1.1 Company Overview
    • 9.1.2 Financials
    • 9.1.3 Key News
  • 9.2 F. Hoffmann-La Roche, Ltd.
    • 9.2.1 Company Overview
    • 9.2.2 Financials
    • 9.2.3 Key News
  • 9.3 Bayer AG
    • 9.3.1 Company Overview
    • 9.3.2 Financials
    • 9.3.3 Key News
  • 9.4 Regeneron Pharmaceuticals
    • 9.4.1 Company Overview
    • 9.4.2 Financials
    • 9.4.3 Key News
  • 9.5 Valent Pharmaceuticals International, Inc.
    • 9.5.1 Company Overview
    • 9.5.2 Financials
    • 9.5.3 Key News
  • 9.6 Pfizer Inc.
    • 9.6.1 Company Overview
    • 9.6.2 Financials
    • 9.6.3 Key News
  • 9.7 Acucela, Inc.
    • 9.7.1 Company Overview
    • 9.7.2 Key News
  • 9.8 IVERIC bio, Inc.
    • 9.8.1 Company Overview
    • 9.8.2 Financials
    • 9.8.3 Key News
  • 9.9 GlaxoSmithKline Pharmaceuticals Ltd.
    • 9.9.1 Company Overview
    • 9.9.2 Financials
  • 9.10 Allergan PLC
    • 9.10.1 Company Overview
    • 9.10.2 Financials

10. Qualitative Industry and Market Analysis

  • 10.1 Strengths: The Most Dynamic Area of the Ophthalmics Market
  • 10.2 Weaknesses: Heavily Dependent on Anti-VEGF Approach
  • 10.3 Opportunities: New Markets and R&D Synergies
  • 10.4 Threats: Prevention and Management Better Than Drug Treatment for Dry AMD and DR?
  • 10.5 Social: Low Diagnosis, Low Compliance
  • 10.6 Technological: Innovation for the Eye
  • 10.7 Economic: Off-Label Treatment and Reimbursement Issues
  • 10.8 Political: The Demography and Diabetes Challenges

11. Conclusions

  • 11.1 The Age of Lucentis: Nearing Its Conclusion?
  • 11.2 Lucentis vs. Eylea vs. Avastin: The Three-Way Anti-VEGF Market
  • 11.3 Indications Outside Wet AMD to Gain in Importance
  • 11.4 Dry AMD Market Has Huge Potential
  • 11.5 Fovista Most Prominent Among the Pipeline Candidates
  • 11.6 Retinal Diseases to Continue to Be the Leading Area of Ophthalmics

Appendices

  • Associated Visiongain Reports
  • Visiongain Report Sales Order Form
  • About Visiongain
  • Visiongain Report Evaluation Form
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