市場調査レポート

次世代シークエンシング製品市場のためのライブラリ調製と標的濃縮

Library Preparation and Target Enrichment for Next Generation Sequencing Product Markets

発行 Kalorama Information 商品コード 327525
出版日 ページ情報 英文 120 Pages
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次世代シークエンシング製品市場のためのライブラリ調製と標的濃縮 Library Preparation and Target Enrichment for Next Generation Sequencing Product Markets
出版日: 2015年03月26日 ページ情報: 英文 120 Pages
概要

ライブラリ調製と標的濃縮技術は臨床で用いるシーケンサーの不可欠な要素であり、シーケンサー技術が安価になるにつれ、より多くの試験所や研究プロジェクトに採用されてきました。次世代シークエンシングシステムの能力によってライフサイエンスの研究者がより幅広い実験を行なえるようになっています。こうした実験の多用なニーズが、ライブラリ調製と標的濃縮製品の需要を広げています。

当レポートでは、ライブラリ調製と標的濃縮市場の規模と予測、市場シェアと競合動向、業界内の重要動向、訴訟と知的財産に関するレビュー、およびアナリストによる結論と提言などをまとめています。

第1章 エグゼクティブサマリー

第2章 動向

  • シークエンシング、標的濃縮、ライブラリ調製に関する動向
  • 小規模システムの急速な導入が応用を拡大
  • アレイベースの標的濃縮技術の減少
  • 破壊的技術の可能性があるにも関わらず安定
  • シーケンサーの売上は劇的に拡大を続けている
  • 遺伝性疾患および癌が臨床における導入を促進
  • 法規制動向が不透明だが何らか発展はつづけている

第3章 製品上市:2012〜2015年

第4章 ライブラリ調製と標的濃縮市場

  • 収益予測
  • ゲノムシークエンシングコスト
  • ライブラリ調製と標的濃縮市場
  • 成長牽引因子

第5章 市場シェアと競合分析

第6章 知的財産と訴訟

第7章 取引分析:2010年以降340件の連携、合併、パートナーシップ

第8章 企業プロファイル

  • Agilent Technologies
  • F. Hoffmann-La Roche AG
  • Fluidigm
  • Illumina
  • Pacific Biosciences
  • Qiagen
  • Thermo Fisher Scientific

第9章 課題と戦略的提言

  • 課題
  • リスク
  • 戦略的提言

図表

目次
Product Code: KLI5480440

Library Preparation and Target Enrichment technologies are a necessary part of the sequencer's use in clinical applications. As the sequencer technologies become cheaper, they have been increasingly moving into more labs and new types of research projects in a virtuous cycle. The capabilities of next-generation sequencer (NGS) systems, along with the growing availability of vast amounts of annotated sequence data, have permitted life science researchers to undertake a much wider range of experiments. The diverse needs of these experiments have resulted in a high demand for library preparation and target enrichment products.

This report, ‘Library Preparation and Target Enrichment for Next Generation Sequencing Product Markets’ contains valuable information on the current state of LP/TE for next generation sequencing including:

  • Market Size and Forecasts for Library Prep and Target Enrichment
  • Market Share and Competitive Analysis
  • Over 340 Deals, Collaborations and Partnerships Since 2010 involving LP/TE.
  • Library Preparation and Target Enrichment Products Launched Since 2012
  • Important Trends in the Industry
  • Litigation and Intellectual Property Review
  • Analyst's Conclusions and Recommendations

DNA and RNA sequencing are becoming more central components of life science research. In addition to their prices dropping, the technologies continue to rapidly improve and become more user-friendly. The applications of sequencing span a broad range of industries and specializations, but the focus has mostly been life science research-related. As the science becomes more established, various clinical applications have become proven, and there are certain areas such as cancer where there are expected to be rapidly growing benefits in the near future.

The NGS systems are capable of a wide range of applications, and labs have taken advantage of their flexibility. The same system is often used for five or ten distinct applications. The NGS systems also have specific constraints on the type of sample that can be loaded, with regard to fragment size, adapters, and the like. The protocols can sometimes require several steps. These factors have created a market for a large range of products catering to all of the different variations of these numerous applications.

As part of its coverage of the report, several major competitors are profiled. Companies profiled in the report are:

  • Agilent Technologies
  • F. Hoffmann-La Roche AG
  • Fluidigm
  • Illumina
  • Pacific Biosciences
  • Qiagen
  • Thermo Fisher Scientific

Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

  • Introduction
  • Background
  • Trends
  • Market Growth in Library Preparation and Target Enrichment
  • Acceleration of Product Introductions
  • A Period of Rapid Adoption, But Lower Prices
  • Likelihood of Longer-Term Challenges
  • Rapid Growth Overall, But Intense Competition
  • Customers' Research Models Evolving
  • Scope and Methodology
  • Applications and Definitions
  • Applications
  • Experiments
  • Promising Opportunities
  • Gaps in Scientific Knowledge
  • High Priority Research Areas
  • DNA Fragmentation
  • DNA Size Selection
  • Target Enrichment

CHAPTER TWO: TRENDS

  • Trends Relating to Sequencing, Target Enrichment and Library Prep
  • Rapid Adoption of Smaller Systems Driving Applications
  • Decline in Array-Based Target Enrichment Techniques
  • Stability Despite Possibility of Disruptive Technologies
  • Sequencer Sales Continue Dramatic Growth
  • Inherited Diseases and Cancer Driving Clinical Adoption
  • Regulatory Situation Unclear But Evolving Somewhat

CHAPTER THREE: PRODUCT LAUNCHES 2012-2105

  • 2015 Product Introductions
  • BGI NGS System Launch
  • Illumina HiSeq X Five
  • 2014 Product Introductions
  • Fluidigm Porducts
  • Eznymatics Archer Fusion Plex
  • Illumina Launches New HiSeq X Ten Reagent Kits
  • Roche SeqCap RNA
  • Agilent Sure Select Focused Exome
  • Beckman Coulter NEBNext UltraDirectional RNA
  • Fluidigm Single-Cell Exome Sequencing Workflow
  • Clear Seq AML
  • Lexogen QuantSeq3
  • Agilent SureSelect Clinical Research Exome
  • NextFlex Cell Free DNA
  • Enzymatics Archer FusionPlex Sarcoma Panel
  • Multiplicom STARGARDT MASTR
  • Qiagen GeneRead DNAseq V2
  • Agilent SureSelectQXT
  • HTG Molecular Diagnostics EdgeSeq miRNA
  • NuGEN Ovation Custom Target Enrichment System
  • Illumina V4 Reagents Kits for HiSeq
  • Illumina VeriSeq
  • Kapa Biosystems Hyper Prep Kit
  • Lexogen QuantSeq 3 mRNA-seq Library Prep kit,
  • Life Technologies Ion Chef
  • NuGEN Insert Dependent Adaptor Cleavage
  • Qiagen QIAexpert
  • Guardant Health 360 Test
  • Integrated DNA Technologies Launches Panels
  • Kapa Biosystems Adds Amplification Primers
  • Zymor Research Launches PicoMethyl Seq Library Prep
  • and RRHP 5hmC Library Prep kits.
  • Bioo Scientific NextFlex Dual
  • Covaris TruXtrac High Throughput FFPE
  • Enzymatics Archer ALK/RET/ROS1
  • epMotion for TruSeq
  • Life Technologies HID-Ion AmpliSeq
  • Qiagen REPLI-g WTA
  • RainDance ThunderBolts Cancer Panel
  • Rubicon Genomics PicoPlex DNA Seq
  • Illumina Next Seq 500
  • 2013 Product Introductions
  • 2012 Product Introductions

CHAPTER FOUR: LIBRARY PREPARATION AND TARGET ENRICHMENT MARKET

  • Revenues Forecast
  • Cost of Sequencing a Genome
  • Library Preparation and Target Enrichment Market
  • Growth Drivers
  • Illumina Consumables Revenues as Bellwether

CHAPTER FIVE: MARKET SHARE AND COMPETITIVE ANALYSIS

  • Introduction
  • Sequencer System Battles Turn Somewhat Calm
  • Library Preparation and Target Enrichment Market Shares
  • Smaller Companies Experiencing Mixed Success

CHAPTER SIX: INTELLECTUAL PROPERTY AND LITIGATION

  • Important Litigation and IP Developments
  • Sequenom and Other NIPT Companies Suing Each Other
  • Sequenom Shareholder Sues Over Price “Capping”
  • Class Action Shareholder Lawsuit Filed Against Pacific Biosciences
  • Helicos' Patent Infringement Suit Against PacBio, Life Technologies, and Illumina
  • Illumina's Two Lawsuits Against Complete Genomics for Infringement
  • Life Technologies and Illumina Dispute Over Amplification on Solid Surfaces
  • Life Technologies Files Infringement Suit Against Promega
  • Enzo Biochem Disputes CalTech Sequencing Patents
  • Azco Biotech Sues Qiagen and Intelligent Bio-Systems
  • Intelligent Bio-Systems (Qiagen) and Columbia University Sue Illumina for Infringement
  • LabCorp's Esoterix Sues Life Technologies
  • Genetic Technologies Sues Several Firms for Infringement of Haplotype
  • Determination Technique
  • Illumina Sues Life Technologies Over Ion Torrent Systems
  • Affymetrix Dismisses Suit Against Pacific Biosciences and Former Employees
  • Life Technologies Defeats VisiGen Stakeholders After Arbitration
  • Catalyst Assets Sues Life Technologies for Infringement
  • Patent Interference Between Life Technologies and Pacific Biosciences
  • LadaTech Sues Illumina Over DNA Amplification Patent
  • Illumina Files ‘841 Patent Infringement Suit Against Affymetrix
  • Affymetrix and Illumina Settle Case Over ‘243, ‘432, ‘531, ‘365, and ‘716
  • Applied Biosystems and Illumina Claims and Counter-claims Over Sequencingby-Ligation Both Unsuccessful
  • Fluidigm and Applied Biosystems Agree to End Case
  • Beckman Coulter and Applied Biosystems Settle Outstanding Legal Disputes
  • Cepheid and Idaho Technology Settle Dispute Over PCR Patents
  • Huang v. CalTech
  • Applied Biosystems and Amersham plc (GE Healthcare) Settle Sequencing
  • Patent Litigation
  • Early ABI (Life Technologies) Patents

CHAPTER SEVEN: DEALS ANALYSIS -340 COLLABORATIONS, MERGERS, PARTNERSHIPS SINCE 2010

  • List of Deals Involving NGS, LP and TE, Feb 2010 to Jan 2015

CHAPTER EIGHT: CORPORATE PROFILES

  • Agilent Technologies
  • F. Hoffmann-La Roche AG
  • Fluidigm
  • Illumina
  • Pacific Biosciences
  • Qiagen
  • Thermo Fisher Scientific

CHAPTER NINE: CHALLENGES AND STRATEGIC RECOMMENDATIONS

  • Challenges
  • Risks
  • Use of Services
  • Shortcomings and Pitfalls
  • Low Barriers
  • LDT
  • Prices
  • Restraints on Adoption
  • Strategic Recommendations
  • Partnership Strategy
  • Product Development Strategy
  • Preparation Needed
  • Role of Services
  • Role of Data
  • Global Market Strategy

LIST OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

  • Figure 1-1: Market Growth in Target Enrichment and Library Preparation, 2014 to 2019

CHAPTER THREE: PRODUCT LAUNCHES 2012-2015

  • Table 3-1: Products for Library Preparation and Target Enrichment

CHAPTER FOUR: LIBRARY PREPARATION AND TARGET ENRICHMENT MARKET

  • Figure 4-1: Cost of Sequencing a Genome
  • Table 4-1: Library Preparation and Target Enrichment Market
  • Figure 4-2: Library Preparation and Target Enrichment Revenues, 2014 and 2019
  • Table 4-2: Library Preparation and Target Enrichment Growth Rate
  • Figure 4-3: Library Preparation and Target Enrichment Growth Rate
  • Table 4-3: Revenues by Region, 2014
  • Figure 4-4: Revenues by Region, 2014
  • Table 4-4: Illumina Quarterly Consumables Revenues (2012-2014)
  • Figure 4-5: Illumina Quarterly Consumables Revenues (2012-2014)
  • Table 4-5: Illumina Annual Consumables Revenues for Sequencing and for Other Purposes (2012-2014)
  • Table 4-6: Illumina Consumables Growth Rates for Seqeuncing Consumables (2012-2014)
  • Figure 4-6: Illumina 2012 Sequencing Consumables Share
  • Figure 4-7: Illumina 2014 Sequencing Consumables Share

CHAPTER FIVE: COMPETITIVE ANALYSIS

  • Table 5-1: Library Preparation and Target Enrichment Market Shares
  • Figure 5-1: Library Preparation and Target Enrichment Market Shares

CHAPTER SEVEN: 340 DEALS

  • Table 7-1: List of Deals Involving NGS, LP and TE, Feb 2010 to Jan 2015
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