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免疫測定自動化の動向

Immunoassay Automation Trends 2014

発行 HTStec Ltd 商品コード 311739
出版日 ページ情報 英文 56 Pages
納期: 即日から翌営業日
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免疫測定自動化の動向 Immunoassay Automation Trends 2014
出版日: 2014年09月01日 ページ情報: 英文 56 Pages
概要

当レポートでは、HTStecによる世界的なウェブ調査−免疫測定およびその自動化に関する調査結果から、回答者のプロファイル、現在の市場情勢、アプリケーション分野、コスト、好みのベンダー、サプライヤー決定の影響要因、および将来の見通しなどについて詳細に分析しています。

目次

  • エグゼクティブサマリー
  • 目次
  • 調査手法
  • 調査参加者の内訳
  • 回答者の所属企業/組織
  • 回答者の出身地域
  • 回答者の担当業務
  • 回答者の主な免疫測定技術用途
  • 回答者の免疫測定の主なアプリケーション領域
  • 免疫測定フォーマットにおける最大関心のターゲットクラス
  • 免疫測定によって分析される主なサンプルソース
  • 免疫測定で最も使用される酵素/検出用化学物質
  • 現在、免疫測定に適用される自動化のレベル
  • 既に実行された免疫測定自動化の資本コスト
  • 既に実行された免疫測定自動化の詳細
  • 将来達成したいと思っている免疫測定自動化の回答者
  • 調査結果のサマリー(1)
  • 最も求められる自動免疫測定のプラットフォームタイプ
  • 自動免疫測定ワークステーションの購入計画
  • 好きな免疫測定自動化ベンダー(1)
  • 好きな免疫測定自動化ベンダー(2)
  • 自動化ベンダー選定の影響因子
  • 自動免疫測定実行の最大資本コスト
  • 完全免疫測定(ハンズフリー)自動化市場推計
  • 完全免疫測定(ハンズフリー)自動化市場区分
  • 新興の自動免疫測定プラットフォームの認識
  • 自動免疫測定プラットフォーム導入の主な促進因子
  • 自動免疫測定プラットフォーム導入を妨げる主な障壁
  • 新しい免疫測定プラットフォームでアッセイバッファ&プロトコルを変更する意思
  • 年間平均で96ウェルの免疫測定プレートが実行
  • 達成した・達成したい最大の免疫測定スループット
  • 免疫測定サンプルを分析するフォーマット
  • 免疫測定向けの最終アッセイ量
  • 調査結果のサマリー(2)
  • 年間の各免疫測定発現数(セルフビルド)
  • 免疫測定向けシングルアッセイ(ウェル)あたりの平均コスト
  • 免疫測定キット価格
  • 免疫測定キット価格vs.キットのアプリケーション領域
  • 免疫測定消耗品の年間予算
  • 免疫測定消耗品の年間予算の内訳
  • 免疫測定消耗品市場推計
  • 免疫測定消耗品市場区分
  • 免疫測定消耗品市場推計のコンポーネント内訳
  • サプライヤーの免疫測定キット購入の影響因子
  • 購入した免疫測定キットの主なサプライヤー(1)〜(3)
  • 現在の免疫測定による最大の障壁(制限)
  • 現在の免疫測定自動化におけるアンメットニーズ
  • 調査結果のサマリー(3)
目次

This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on immunoassays and their automation carried out in August 2014.

The survey was initiated by HTStec as part of its tracking of life science marketplaces and to partially update HTStec's previous ELISA Trends report (dated June 2012).

The questionnaire was compiled to meet the needs, requirements and interests of the immunoassay vendor community.

The objective was to comprehensively document current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.

Equal emphasis was given to soliciting opinion from all organisations where immunoassays are currently being undertaken, with no geographic bias in the distribution of persons contacted.

The survey looked at the following aspects of immunoassays, as practiced today (2014) and in many cases as predicted for the future (2017): main use of immunoassay technology today; main application area of immunoassay research; target classes investigated by immunoassays; main sample sources analyzed; enzyme/detection chemistry most used; level of automation applied; capital cost of automated solutions implemented; brief details of automated solution implemented; level of automation respondents want to achieve; how respondents prefer to access immunoassay automation; plans to purchase an automated immunoassay workstation and preferred automation vendors; factors influencing a decision to select a vendor for immunoassay automation; maximum capital cost for an automated (hands free) immunoassay workstation; awareness of new emerging immunoassay platforms or alternatives technologies; main drivers for adopting a new automated immunoassay platform; barriers to change that would limit adoption of a new automated immunoassay platform; enthusiasm to change assay buffers and/or protocols to work with a new automated immunoassay platform; number of immunoassay plates typically run per year; maximum immunoassay throughput achieved and wanted; assay formats used for immunoassay analysis; final immunoassay (incubation) volume; number of different immunoassays developed (self-built) per year; average cost per single immunoassay (per well); price paid for immunoassay kits and application area pricing relates to; annual budget for immunoassay consumables and the breakdown of that budget into components; most important factors in the decision to purchase a particular vendor's immunoassay kit; main suppliers of immunoassay kits purchased; biggest hurdles (limitations) that still need to be addressed with immunoassays today; and any unmet needs that exist in immunoassay automation today.

The main questionnaire consisted of 28 multi-choice questions and 1 open-ended question. addition, there were 6 questions related solely to survey demographics.

The survey collected 86 validated responses, of these 87% provided comprehensive input.

Responses were geographically split: 51% North America; 36% Europe; 6% Asia (excluding China Japan); 4% Rest of World; 1% Japan; and 1% China.

Survey respondents were end-users of immunoassays and met the following criteria: 1) were currently undertaking immunoassays; & 2) made or influenced purchasing decisions for immunoassay kits, related consumables, instrumentation or automation.

Respondents came from 38 University/Research Institute/Not-for-Profit Facilities; 13 Biotech Companies; 11 Pharma; 8 Other; 5 Hospitals/Clinics; 4 Diagnostics Companies; 3 Contract Research Organisations; 2 Government/Military/Defence Facilities; and 2 Food Safety Companies.

Most survey respondents had a senior job role or position which was in descending order: 15 lab/ research managers; 14 research scientists; 11 principal investigators; 11 professors/assistant professors; 7 section/group leaders; 7 senior scientists/research associates; 6 directors; 3 presidents; 3 post-doctoral associates/fellows; 2 vice presidents; 2 others; and 1 graduate student.

Survey results were expressed as an average of all survey respondents. In addition, where appropriate the data was fully reanalyzed after sub-division into the following 5 survey groups based on their main use of immunoassay technology: 1) Basic Research; 2) Applied Research; 3) Non-Clinical Analysis/Testing; 4) Clinical Analysis/Testing; 5) QC/Manufacturing/Bioprocessing.

The main application areas of respondents immunoassay research was biomarkers and immunology.

The target class respondents were most interested in being setup and run in immunoassay format was inflammation markers.

The main sample source analyzed by immunoassays was cultured cells.

The enzyme/detection chemistry most used today was horseradish peroxidase-colorimetric.

Only 14% of respondents had applied full automation to their immunoassays to date.

The median capital cost of immunoassay automation already implemented to date was $40K-$60K.

The level of automation implemented is tabulated versus the capital cost paid for that automation.

Brief details of the immunoassay automation solutions respondents have already implemented were listed.

Most respondents want to achieve in the future full workflow (walkaway) immunoassay automation on an open generic platform.

The median interest in acquiring a fully automated immunoassay workstation over the coming years was possible (26-50% probability), with Bio-Rad and Tecan currently the most preferred automation vendors.

Precision was rated the greatest impact on a decision to select an immunoassay automation vendor.

The median maximum price respondents would pay for an automated system that could run their immunoassay requirements hands free was $60K.

Of a list of new emerging automated immunoassays platforms or alternative technologies respondents were most aware of Luminex microparticle-based flow tests; PerkinElmer AlphaLISA; qPCR-based alternative tests; and MesoScale Discovery ECL multiarray technology.

Facilitates improved performance/greater sensitivity/better uniformity was ranked the main motivator/driver for adopting a new improved or automated immunoassay platform.

The requirement to invest in new capital equipment was rated the most important barrier to change that would limit the adoption of a new improved or automated immunoassay platform.

The majority of respondents were amenable to changing assay buffers and/or protocols to work with a new immunoassay platform with potential to significantly improve performance.

The median number of 96-well immunoassay plates run per year was 100.

The median maximum immunoassay throughput achieved was five 96-well plates per 8h day.

The majority of immunoassay samples were analyzed in or from a 96-well microplate format today.

The median final assay volume for immunoassays assays today was 50μL to 100μL.

67% of respondents reported that they develop (self-build) immunoassays.

A median of 3 new immunoassays were developed per year.

The median cost per single immunoassay (well) today was $1-$2.50.

$300-$400 was the median average price paid per immunoassay kit of 96-wells.

$400-$500 was the median maximum price respondents would want to pay for an immunoassay kit of 96-wells.

The cost paid per immunoassay kit was tabulated with the application area of the kits priced.

The median annual immunoassay consumables budget per lab per year today was $25K-$50K.

The greatest proportion of the immunoassay consumables budget was spent on immunoassay kits (single analyte assays), followed by antibodies and then immunoassays kits (multiplexed assays).

A bottom-up model was developed around the respondent's annual budget for immunoassay consumables to estimate the global market, which in 2014 was around $900M. Nearly 50% of this market was allocated to immunoassays kits (both single and multiplexed analytes). The market was segmented by immunoassay activity focus and geography, with CAGR estimates for 2017 made.

Specificity (i.e. cross-reactivity & interference with related analytes) was rated as the factor of greatest importance in a decision to purchase a supplier's immunoassay kit.

The main (most used) supplier of immunoassay kits purchased by respondents was R&D Systems.

Improving detection capability in complex samples was ranked the biggest hurdle (limitation) with immunoassays today.

Feedback on some unmet needs that exist in immunoassay automation today were listed.

The full report provides the data, details of the breakdown of the responses for each question, its segmentation and some estimates for the future (2017). It also highlights some interesting differences between the survey groups.

PLEASE NOTE: this market report covers all types of immunoassays, it includes conventional ELISAs, immunoassays that are linked to some non-enzymatic reporters or are homogenous (no-wash) (e.g. PerkinElmer AlphaLISA) and those microparticle-based methods (e.g. Luminex, BioScale, Gyros) that remove samples from microplates for analysis and utilize flow-based detection.

Table of Contents

  • Executive Summary
  • Table of Contents
  • Survey Methodology
  • Breakdown Of Survey Participants
  • Respondent's Company Or Organisational Origin
  • Respondent's Geographic Origin.
  • Respondent's Job Role
  • Respondent's Main Use Of Immunoassay Technology
  • Main Application Area For Respondent's Immunoassay Research
  • Target Classes of Greatest Interest In An Immunoassay Format
  • Main Sample Sources Analyzed By Immunoassays
  • Enzyme/Detection Chemistries Most Used In Immunoassays
  • Level Of Automation Applied To Immunoassays Today
  • Capital Cost Of Immunoassay Automation Already Implemented
  • Details Of Immunoassay Automation Already Implemented
  • Immunoassay Automation Respondents Want To Achieve In The Future
  • Summary of Survey Findings (1)
  • Most Wanted Type Of Automated Immunoassay Platform
  • Plans To Purchase An Automated Immunoassay Workstation
  • Preferred Immunoassay Automation Vendors (1)
  • Preferred Immunoassay Automation Vendors (2)
  • Factors That Impact The Selection Of An Automation Vendor
  • Maximum Capital Cost For Implementing Automated Immunoassays
  • Full Immunoassay (Hands Free) Automation Market Estimate
  • Full Immunoassay (Hands Free) Automation Market Segmentation
  • Awareness Of New Emerging Automated Immunoassay Platforms
  • Main Drivers For Adopting An Automated Immunoassay Platform
  • Barriers Limiting Adoption Of An Automated Immunoassay Platform
  • Willingness To Change Assay Buffer & Protocols On A New Immunoassay Platform
  • Number of 96-Well Immunoassay Plates Typically Run Per Year
  • Maximum Immunoassay Throughput Achieved and Wanted
  • Format In Which Immunoassay Samples Are Analyzed
  • Final Assay Volume For Immunoassays
  • Summary of Survey Findings (2)
  • Number of Different Immunoassays Developed (Self-Built) Per Year
  • Average Cost Per Single Assay (Well) for Immunoassays
  • Immunoassay Kit Pricing
  • Immunoassay Kit Pricing Versus Application Area of Kits
  • Annual Immunoassay Consumables Budget
  • Breakdown Of Annual Immunoassay Consumables Budget
  • Immunoassay Consumables Market Estimate
  • Immunoassay Consumables Market Segmentation
  • Component Breakdown of Immunoassay Consumables Market Estimate
  • Factors Influencing The Purchase Of A Supplier's Immunoassay Kit
  • Main Suppliers Of Immunoassay Kits Purchased (1)
  • Main Suppliers Of Immunoassay Kits Purchased (2)
  • Main Suppliers Of Immunoassay Kits Purchased (3)
  • Biggest Hurdles (Limitations) With Immunoassays Today
  • Unmet Needs In Immunoassay Automation Today
  • Summary of Survey Findings (3)
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