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イオンチャネル検査受託サービスの動向

Outsourced Ion Channel Testing Trends 2016

発行 HTStec Ltd 商品コード 269952
出版日 ページ情報 英文 63 Pages
納期: 即日から翌営業日
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イオンチャネル検査受託サービスの動向 Outsourced Ion Channel Testing Trends 2016
出版日: 2016年07月14日 ページ情報: 英文 63 Pages
概要

当レポートでは、HTStecによるイオンチャネル検査受託サービス産業全般を対象とした世界規模WEBベースベンチマーク調査の結果から、将来に向けて活躍の期待を担う生命科学関連事業者のニーズと関心に応える最新の市場情報をまとめ、概略以下の構成でお届けします。

  • 調査方法
  • 組織と調査回答
  • 回答者の所属企業または団体
  • 回答者の居住地域
  • 回答者の担当業務
  • 一次スクリーニング法を用いてイオンチャネルを研究中の回答者数
  • 治療標的としてイオンチャネルを扱うプログラム数
  • イオンチャネル一次スクリーニングで人気の高いプラットフォーム技術(1)
  • イオンチャネル一次スクリーニングで人気の高いプラットフォーム技術(2)
  • 一次スクリーニング検査を外部機関に委託したことがある回答者
  • イオンチャネル一次スクリーニングを経験していない回答者がいる理由
  • イオンチャネル一次スクリーニング受託サービスへの関心度(1)
  • イオンチャネル一次スクリーニング受託サービスへの関心度(2)
  • 委託イオンチャネル一次スクリーニングで人気の高いプラットフォーム技術(1)
  • 委託イオンチャネル一次スクリーニングで人気の高いプラットフォーム技術(2)
  • 異なるイオンチャネルスクリーニングサービスへの関心度
  • イオンチャネル一次スクリーニングサービス利用に向かう価格帯
  • 調査所見サマリー(1)
  • 選択性プロファイリングを外部機関に委託したいと思うタイミング
  • イオンチャネル選択性プロファイリングで人気の高い分析方式選択方法
  • 選択性プロファイリングを検討する際にもっとも関心度の高いイオンチャネルパネル
  • 委託イオンチャネル選択性プロファイリングで人気の高いプラットフォーム技術(1)
  • 委託イオンチャネル選択性プロファイリングで人気の高いプラットフォーム技術(2)
  • 人気の高いベンダーのパッチクランプデータプラットフォーム
  • 選択性プロファイリング利用に対する回答者の関心度
  • 選択性プロファイリングを外部機関に委託したことがある回答者数
  • イオンチャネル選択性プロファイリング提供機関選択の動機
  • 選択性プロファイリング受託サービスに期待される仕事ぶり(1)
  • 選択性プロファイリング受託サービスに期待される仕事ぶり(2)
  • 委託イオンチャネル安全性試験の諸相(1)
  • 委託イオンチャネル安全性試験の諸相(2)
  • 安全性試験のために外部機関から調達された化合物の年間数量
  • イオンチャネル安全性試験を外部機関に委託したことがある回答者数
  • 調査所見サマリー(2)
  • イオンチャネル安全性試験提供機関選択の動機
  • 委託イオンチャネル試験の年間予算
  • 委託イオンチャネル試験の内訳
  • 委託イオンチャネル試験市場の試算(1)
  • 委託イオンチャネル試験市場の試算(2)
  • 委託イオンチャネル試験市場試算の内訳
  • 回答者が利用に向けてもっとも関心を寄せるサービス提供機関の形態
  • もっとも利用を求められるイオンチャネル試験提供機関のサービス
  • 人気の高いイオンチャネル試験受託サービス提供機関(表)
  • もっとも信頼度・利用度の高い無料イオンチャネル試験サービス提供機関(表)
  • 人気の高い委託イオンチャネル一次スクリーニング提供機関
  • 人気の高い委託イオンチャネル選択性プロファイリング提供機関
  • 人気の高い委託イオンチャネル安全性試験提供機関
  • もっとも信頼度の高い個別支払い型イオンチャネルサービス提供機関
  • もっとも利用度の高い個別支払い型イオンチャネルサービス提供機関
  • 安定トランスフェクトイオンチャネル細胞ラインを利用している回答者数
  • 回答者の研究施設で利用されている安定トランスフェクトイオンチャネル細胞ラインの供給源
  • 安定トランスフェクトイオンチャネル細胞ラインの購入計画
  • 今後数年にわたる安定トランスフェクトイオンチャネル細胞ラインの購入予算
  • 受託イオンチャネル試験サービスのアンメットニーズ
  • 調査所見サマリー(3)

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次

Executive Summary

This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on outsourced ion channel testing carried out in July 2016.

The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update HTStec's previous outsourced ion channel testing trends report (published May 2013).

The questionnaire was compiled to meet the needs and interests of the outsourced ion channel testing provider community. Many questions were the same as those in the 2013 report.

The main objectives were to comprehensively document current use of and potential interest in outsourcing ion channel primary screening, selectivity profiling and safety liability testing. The survey also investigated access to stably transfected cell lines and future purchasing plans. The aim was to compile a reference document on outsourced ion channel testing, which could be compared directly relative to HTStec's previous 2013 report. Equal emphasis was given to soliciting opinion from Pharma, Biotech and Academic Research market segments globally.

The survey looked at the following aspects of outsourced ion channel testing, as practiced to date (2016) and in some cases as predicted for the future (2018): targeting of ion channels as therapeutic targets using primary screening; number of on-going programs with ion channels as a therapeutic target; preferred and alternative primary screening platform technology; current outsourcing of ion channel primary screening; why some respondents have not outsourced ion channel primary screening to date; current level of interest in outsourcing ion channel primary screening; primary screening platforms respondents would most like to access at a fee-for-service service provider; primary screening services respondents most envisage accessing and price points for those services; stage where respondents are most interested in outsourcing ion channel selectivity profiling; preferred selection of assays when deciding on ion channel selectivity profiling; ion channel panels of most interest when considering selectivity profiling; technology platforms respondents most want to access at a fee-for-service service provider for selectivity profiling; with respect to patch clamping data the preferred vendor's platform; current level of interest in outsourcing ion channel selectivity profiling; current outsourcing of ion channel selectivity profiling; what motivates selection of an ion channel selectivity profiling service provider; selectivity profiling services respondents most envisage accessing and price points for those services; aspects of ion channel safety liability testing that are outsourced; current level of interest in outsourcing safety liability testing; current outsourcing of ion channel safety liability testing; what motivates selection of an ion channel safety liability testing service provider; outsourcing budget for all ion channel testing done at fee-for-service labs and its breakdown into fee-for-service categories; type of service providers most interested in accessing for ion channel outsourcing; importance of different ion channel testing services provided; preferred fee-for-service providers of ion channel primary screening, ion channel selectivity profiling and ion channel safety liability testing; most trusted and most used ion channel services providers; respondents with access to stably transfected ion channel cell lines in house; source of cell lines used in house; plans to purchase any stably transfected cell lines over the next few years; budget allocation to purchase stably transfected cell lines; and any unmet needs in outsourced ion channel testing.

The survey questionnaire consisted of 32 mainly multi-choice questions. In addition, there were 6 questions related solely to survey demographics.

The survey collected 71 validated responses, of these 75% provided comprehensive input.

Survey responses were geographically split: 38% North America; 35% Europe; 11% Asia (excluding Japan and China); 10% Japan; 3% China and 3% Rest of World.

Survey respondents were drawn from persons or groups actively using or interested in using outsourced ion channel primary screening, selectivity profiling and safety liability testing.

Respondents came from 23 Large Pharma; 15 Biotech Company; 14 Medium-Small Pharma; 9 University; 3 Research Institute: 2 Government Lab; 2 Academic Screening Center; 2 Other; and 1 Hospital/Clinic/ Medical School.

Most survey respondents had a senior job role or position which was in descending order: 11 research scientists; 11 section/group leaders; 11 senior scientists/researchers; 8 directors; 7 principal investigators; 6 lab managers; 6 professors/assistant professors; 4 department heads; 4 others; 2 outsourcing managers; and 1 vice president.

Survey results were expressed as an average of all survey respondents. In addition, where appropriate the data was reanalyzed after sub-division into the following 5 survey groups: 1) Large Pharma; 2) Other Screening Labs; 3) Academic Research; 4) Europe; and 5) North America.

The majority of respondents were investigating/targeting ion channels as therapeutic targets using primary screening, with a median of <5 programs undertaken today (2016).

Where primary screening of ion channels was undertaken in house the preferred screening platform was fluorescence-based assays (e.g. FLIPR/Hamamatsu FDSS),

Only a minority of respondents have outsourced the primary screening of ion channels to date and most of this was done at Charles River. Some feedback on why some respondents have not yet outsourced ion channel primary screening was documented.

The current (2016) level of interest in outsourcing ion channel primary screening was moderate for small-scale (10-100 compounds screened) or medium-scale (100-1,000 compounds screened) primary campaigns. The median maximum price point for accessing this screening was $1-$2 per data point.

Of those respondents interested in outsourcing primary screening a median of <5 programs per year were outsourced today (2016). The preferred platform to be accessed was automated patch-clamp (APC).

Most respondents want to outsource selectivity profiling after hits-to-leads (lead optimization).

Selection by target was the preferred way of selecting assays for ion channel selectivity profiling.

A cardiac channel panel was most wanted for selectivity profiling.

The preferred platform for selectivity profiling to be accessed at service providers was APC.

The preferred vendor's platform for patch clamping data was Sophion QPatch HT.

The median use of outsourced selectivity profiling today (2016) was 100-250 data points per year.

A majority of respondents have outsourced selectivity profiling of ion channels to date and most of that was done at Charles River and Eurofins.

Data quality (e.g. GΩ versus MΩ seal data) was rated of greatest motivation in selecting an ion channel selectivity profiling provider.

The following scenarios were envisaged for outsourced selectivity profiling services; 1) assay selection by target; 2) median 6-10 channels per profile; 3) median 6-10 compounds per profile; and 4) median $2-$5 maximum price point per data point.

hERG ion channel assays were the aspect of ion channel safety liability testing respondents most want to outsource today (2016).

A median 6-10 compounds per year were outsourced for safety liability testing today (2016).

Only a minority of respondents have outsourced safety liability testing of ion channels to date and most of that was done at Charles River and Eurofins.

Cutting-edge gold standard assays was ranked what most motivates respondent's selection of an ion channel safety liability provider.

The median annual outsourcing budget allocated for all ion channel testing was $50K-$100K today (2016), with the biggest proportion of this budget spent on selectivity profiling.

A bottom-up model was developed around the respondent's outsourcing budgets to estimate the global market for outsourced ion channel testing. The total market was estimated to be around $55Millon in 2016. Details of the segmentation and breakdown into component services are given in the full report.

The majority of respondents were interested in accessing a speciality CRO for ion channel testing services.

Selectivity profiling was rated the offering an ion channel service provider must provide.

The preferred providers of ion channel primary screening were Charles River, Eurofins, Axxam and Evotec.

The preferred providers of ion channel selectivity profiling were Charles River, Eurofins and Evotec.

The preferred providers of ion channel safety liability testing were Charles River, Eurofins and ThermoFisher Scientific.

The most trusted fee-for-service provider of ion channel testing was Charles River.

The most used fee-for-service providers of ion channel testing were Eurofins and Charles River.

The majority of respondents have access to stably transfected ion channel cell lines in house.

The majority of respondents make stably transfected ion channel cell lines themselves (i.e. in house).

The median budget allocated to purchase stably transfected ion channel cell lines was $10K-$25K.

The full report provides the data, details of the breakdown of the responses for each question, its segmentation, CAGR and the estimates for the future (2018). It also highlights some interesting differences between the survey groups.

Table of Contents

  • Survey Methodology
  • Organisation & Response To The Survey
  • Respondent's Company Or Organisational Origin
  • Respondent's Geographic Origin
  • Respondent's Job Role
  • Respondents Investigating Ion Channels Using Primary Screening
  • No. of Programs With Ion Channels As Therapeutic Targets
  • Preferred Platform Technologies For Ion Channel Primary Screening (1)
  • Preferred Platform Technologies For Ion Channel Primary Screening (2)
  • Respondents Who Have Outsourced Primary Screening
  • Why Some Respondents Have Not Yet Outsourced Ion Channel Primary Screening
  • Level Of Interest In Outsourcing Ion Channel Primary Screening (1)
  • Level Of Interest In Outsourcing Ion Channel Primary Screening (2)
  • Preferred Platform Technologies For Outsourced Ion Channel Primary Screening (1)
  • Preferred Platform Technologies For Outsourced Ion Channel Primary Screening (2)
  • Interest In Outsourcing Different Ion Channel Screening Services
  • Price Points For Accessing Ion Channel Primary Screening Services
  • Summary Of Survey Findings (1)
  • When Respondents Want To Outsource Selectivity Profiling
  • Preferred Way Of Selecting Assays For Ion Channel Selectivity Profiling
  • Ion Channel Panels Of Most Interest When Considering Selectivity Profiling
  • Preferred Platform Technologies For Outsourced Ion Channel Selectivity Profiling (1)
  • Preferred Platform Technologies For Outsourced Ion Channel Selectivity Profiling (2)
  • Preferred Vendor's Platform For Patch Clamping Data
  • Respondent's Level Of Use Of Selectivity Profiling
  • Respondents Who Have Outsourced Selectivity Profiling
  • What Motivates Selection Of An Ion Channel Selectivity Profiling Provider (1)
  • What Motivates Selection Of An Ion Channel Selectivity Profiling Provider (2)
  • Scenarios Envisaged For Outsourced Selectivity Profiling Services (1)
  • Scenarios Envisaged For Outsourced Selectivity Profiling Services (2)
  • Aspects Of Ion Channel Safety Liability Testing Outsourced (1)
  • Aspects Of Ion Channel Safety Liability Testing Outsourced (2)
  • No. Of Compounds Outsourced For Safety Liability Testing Per Year
  • Respondents Who Have Outsourced Ion Channel Safety Liability Testing
  • Summary Of Survey Findings (2)
  • What Motivates Selection Of An Ion Channel Safety Liability Provider (1)
  • What Motivates Selection Of An Ion Channel Safety Liability Provider (2)
  • Annual Budget For Outsourced Ion Channel Testing
  • Breakdown Of Outsourced Ion Channel Testing Budget
  • Outsourced Ion Channel Testing Market Estimate (1)
  • Outsourced Ion Channel Testing Market Estimate (2)
  • Breakdown Of Ion Channel Outsourcing Market Estimate
  • Type Of Service Provider Respondents Are Most Interested In Accessing
  • Importance Of An Ion Channel Provider Offering Various Services (1)
  • Importance Of An Ion Channel Provider Offering Various Services (2)
  • Preferred Providers Of Ion Channel Outsourced Services (Table)
  • Most Trusted & Most Used Fee-For-Service Providers Of Ion Channel Testing (Table)
  • Preferred Providers Of Outsourced Ion Channel Primary Screening
  • Preferred Providers Of Outsourced Ion Channel Selectivity Profiling
  • Preferred Providers Of Outsourced Ion Channel Safety Liability Testing
  • Most Trusted Fee-For-Service Providers Of Ion Channel Testing
  • Most Used Fee-For-Service Providers Of Ion Channel Testing
  • Respondents With Access To Stably Transfected Ion Channel Cell Lines
  • Source of Stably Transfected Cell Lines Used In Respondent's Lab
  • Plans To Purchase Stably Transfected Cell Lines
  • Budget To Purchase Stably Transfect Cells Over The Next Few Years
  • Unmet Needs In Outsourced Ion Channel Testing
  • Summary Of Survey Findings (3)
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