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セルベース無標識(LF)検出の動向

Cell-Based Label-Free Detection Trends 2014

発行 HTStec Ltd 商品コード 234296
出版日 ページ情報 英文 63 Pages
納期: 即日から翌営業日
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セルベース無標識(LF)検出の動向 Cell-Based Label-Free Detection Trends 2014
出版日: 2014年09月01日 ページ情報: 英文 63 Pages
概要

当レポートでは、HTStecによる世界的なウェブ調査−セルベースの無標識(LF)検出に関するベンチマーキング調査結果から、現在の市場情勢、アプリケーション分野および新製品/サービスへの関心および将来の見通しについて詳細に分析しています。

  • エグゼクティブサマリー
  • 目次
  • 回答者の所属組織と回答
  • 回答者の所属企業/組織
  • 回答者の出身地域
  • 回答者の担当業務
  • 回答者の主要研究分野
  • 回答者がセルベース分析に現在利用しているLFアプローチ
  • LF技術を利用して実施されている全セルベース分析の割合
  • 回答者のラボにおけるセルベースLF検知用機器
  • セルベース分析に利用され最も認知されているLF機器ブランド(1)
  • セルベース分析に利用され最も認知されているLF機器ブランド(2)
  • セルベースアッセイ向け各LEベンダーの現在の認知度(1)
  • セルベースアッセイ向け各LEベンダーの現在の認知度(2)
  • セルベースLF分析で調査されるターゲットクラス
  • セルベースLF分析で調査される疾病分野
  • 最も関心が高いセルベースLF分析のアプリケーション
  • 回答者が思うLFプロバイダー特有のメリットがあるアプリケーション
  • セルベースLF反応をモニタリングするのに最も有益な期間
  • セルベースLF検知の好まれるアプローチ(1)
  • セルベースLF検知の好まれるアプローチ(2)
  • 調査結果のサマリー(1)
  • セルベースLFプラットフォームの付加価値分野
  • セルベースLFプラットフォームが加える大きな価値
  • セルベースLFアッセイの典型的スループット
  • 今日のバイオセンサーフォーマットで実行されるセルベースLFアッセイの割合
  • セルベースLFアッセイにおけるコーテッドプレート要件(1)
  • セルベースLFアッセイにおけるコーテッドプレート要件(2)
  • セルベースアッセイに最も要求されるマイクロプレートコーティング
  • 自動セルベースLF検知装置を所有する回答者
  • セルベースLFアッセイ自動化のエクスペリエンス
  • セルベースLFアッセイ最大の利点
  • セルベースLFアッセイ最大の欠点
  • LFベース心臓毒性アッセイに最も必要とされる特徴&機能
  • セルベースLFアッセイのシングルモードリーダーにおける関心(1)
  • セルベースLFアッセイのシングルモードリーダーにおける関心(2)
  • マルチモード表現型・ターゲット型読み出しへの関心
  • マルチモードLF・マルチモード読み出しでのアプリケーションが望まれている
  • 調査結果のサマリー(2)
  • 最も望ましい特質を持つセルベースLFベンダー(1)
  • 最も望ましい特質を持つセルベースLFベンダー(2)
  • 回答者のセルベースLFアッセイ機器の使用経験
  • セルベースアッセイ用の新しいLF機器を購入する可能性
  • 回答者が購入に最も関心を持つセルベースLFアッセイベンダーの機器(1)
  • 回答者が購入に最も関心を持つセルベースLFアッセイベンダーの機器(2)
  • セルベースアッセイ用LFバイオセンサープレートの最大の価格帯
  • セルベースLFアッセイのアウトソーシングへの関心
  • セルベースLF技術のアンメットニーズに関する回答者のフィードバック
  • セルベースLF機器購入のCapex予算
  • セルベースLF機器市場の予測(1)
  • セルベースLF機器市場の予測(2)
  • セルベースLF消耗品予算
  • セルベースLF消耗品市場の予測(1)
  • セルベースLF消耗品市場の予測(2)
  • 調査結果のサマリー(3)

このページに掲載されている内容は最新版と異なる場合があります。詳細はお問い合わせください。

目次

This market report summarizes the results of HTStec's 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014.

  • The survey was initiated by HTStec as part of its tracking of this emerging life science marketplace and to update HTStec's previous report (dated March 2012).
  • The questionnaire was compiled to address the needs and interests of the cell-based LF binding analysis vendor community.
  • The main objectives were to comprehensively document current experience, practices and progress made in implementing cell-based assays using LF technologies. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
  • The report provides valuable intelligence for vendors developing and marketing cell-based LF systems, and details the latest market assessments regarding this changing area.
  • Equal emphasis was given to soliciting opinion from Pharma, Other Screening Labs and Academic Research segments, active in all cell application areas, from any geographic location.
  • The survey looked at the following aspects of cell-based LF as practiced today (2014) and in some cases as predicted for the future (2016): % of all the cell-based assays performed using LF technologies; vendor's instruments for cell-based LF detection currently used in respondent's lab; top 3 most recognizable LF instrument brands for cell-based assays; current perception of cell-based LF instrument suppliers; target classes and disease areas investigated with cell-based LF assays; applications of cell-based LF assays of greatest interest; application areas where LF provides unique benefits; time-frame of greatest interest when monitoring an in vitro cellular response; preferred approach to cell-based LF detection; areas where a cell-based LF platform has added value; typical throughput of the cell-based LF assays; % of cell-based LF assays performed in different biosensor formats; importance attached to the availability of coated plates for use in LF cell-based assays; microplate coatings most often required for optimum cell growth; the automation of cell-based LF detection instruments; most significant advantages and limitations of cell-based LF assays; features most-wanted in an LF-based cardiotoxicity/cardiac safety assay; functionalities most needed in a new cell-based LF detection system; interest in purchasing a single-mode benchtop LF plate reader; target-based response (multi-mode plate reader readout) most want to multiplex with a phenotypic/whole cell response (LF readout); specific applications where multiplexing LF with multi-mode readout is highly desirable; LF vendors most associated with desirable characteristics or attributes; actual experience of the instruments used for cell-based LF in respondent's lab; likelihood of purchasing a new LF instrument for cell-based over the coming years; budgets for cell-based LF detection instruments and consumables; maximum price points per well for LF biosensor plates; interest in using an outsourced fee-for-service provider for gain access to cell-based LF assay data; and any unmet needs in the area of cell-based LF assays.
  • The main questionnaire consisted of 30 relatively simple multi-choice questions and 1 open-ended question. In addition, there were 7 questions related solely to survey demographics.
  • The survey collected 52 validated responses, of these 81% provided comprehensive input.
  • Survey responses were geographically split: 42% Europe; 25% North America; 13% Asia (excluding Japan & China); 12% Japan; 6% China; and 2% Rest of World.
  • Survey respondents were mainly drawn from persons actively engaged (key end-users) in studying cell-based assays using LF technologies.
  • Respondents represented 24 University/Research Institute/Government Lab/Not-for-Profit Facilities; 8 Large Pharma; 6 Biotechs; 5 CROs; 4 Medium-Small Pharma; 4 Academic Screening Centers; and 1 Biopharma.
  • Respondent's main group activity was: 37% basic/academic research; 21% a combination of drug discovery roles; 13% primary screening (HTS); 13% assay development; 6% therapeutic areas; 6% other; 2% secondary screening; 2% hits-to-leads; and 2% leads-to-candidate.
  • Most survey respondents had a senior job role or position which was in descending order: 8 research scientists/associates; 7 senior scientists/researchers; 7 principal investigators; 6 section/group leaders; 6 directors; 4 others; 3 post-docs; 2 department heads; 1 lab manager; and 1 vice president.
  • Survey results were expressed as an average of all survey respondents. In addition, where appropriate the data was reanalyzed after sub-division into the following 6 survey groups: 1) Using LF; 2) Pharma; 3) Other Screening Labs; 4) Academic Research; 5) Europe; & 6) North America.
  • The majority of survey respondents had already applied LF approaches to cell-based assays today.
  • The median % of all cell-based assays undertaken using LF today was 6-10%.
  • The cell-based LF instruments most prevalent in the labs surveyed were from PerkinElmer.
  • The most recognizable LF instrument brand used for cell-based analysis was ACEA xCELLigence.
  • The current perception of vendors used for cell-based LF assays ranked PerkinElmer and ACEA Bioscience most positively.
  • The target class most investigated by cell-based LF assays was GPCRs.
  • The disease area most investigated/targeted with cell-based LF assays was oncology/cancer.
  • Phenotypic screening was rated the application of cell-based LF of greatest interest and the one where LF provides the most unique benefits.
  • The time frame of greatest interest when monitoring an in vitro cellular response with LF assays was short term (i.e. minutes to hours).
  • Most respondents preferred impedance-based over optical-based approaches to cell-based LF.
  • Basic/academic research was the area where a cell-based LF platform has added most value to date.
  • The median typical throughput for cell-based LF assays today was100-500 wells assayed per month.
  • The 96-well plate was the most used biosensor format for cell-based LF assays.
  • The requirement for coated plates was rated very important, with a median of 26-50% of assays needing coated plates, and respondents willing to pay a median 25% price increase (differential) for coated plates.
  • Poly-D-lysine was the microplate coating most often used for optimum cell growth.
  • The majority of respondents had not automated any cell-based LF detection devices.
  • Elimination of artefacts associated with labels was rated the most significant advantage of cell-based LF assays.
  • Consumable costs were rated the most significant limitation of cell-based LF assays.
  • Cost-efficient consumables in a 96-well format were rated the most wanted feature of an LF-based cardiotoxicity/cardiac safety assay.
  • Environmental control was rated the functionality most needed in a cell-based LF detection system.
  • Only a minority were interested in purchasing a single mode benchtop reader for cell-based LF assays. The reader's ability to also perform biochemical assays has limited influence on purchasing.
  • A majority of respondents see the benefits of combining (multiplexing) a phenotypic/whole cell response (LF readout) with a target-based response (multi-mode plate reader readout).
  • Fluorescence imaging (HCS) was the readout most would like to combine with LF for cell-based assays.
  • Only a few respondents were aware of specific applications where multiplexing LF with a multi-mode readout is highly desirable.
  • The cell-based LF instrument vendors most associated with a list of desirable characteristics or attributes was ACEA Biosciences, PerkinElmer and Molecular Devices.
  • Experience with instruments used for cell-based LF was tabulated with respect to satisfaction with the product and whether respondents would recommend it to others.
  • The median likelihood that respondents will purchase a new LF instrument for cell-based assays over the coming years (up to 2016) was unlikely (1-25% probability).
  • The vendors instruments respondents expressed most interest in purchasing came from Applied Biophysics, ACEA Bioscience and Molecular Devices.
  • The majority of respondents would not consider outsourcing to gain access to cell-based LF data.
  • The median capex budget for new cell-based LF instruments in 2014 was $75K-$100K.
  • A bottom up model developed to estimate the global market for cell-based LF instruments, using data derived from this survey, gave a value of around $50M.
  • The median budget for cell-based LF consumables in 2014 was $25K-$50K.
  • A bottom up model developed to estimate the global market for cell-based LF consumables, using data derived from this survey, gave a value of around $100M.
  • Some feedback on the unmet needs identified by survey respondents was documented.
  • The full report provides the data, details of the breakdown of the responses for each question, its segmentation and all the estimates for the future (2016). It also highlights some interesting differences between the survey groups.
  • PLEASE NOTE: This report is mainly about the application of LF technologies to cell-based assays, it does NOT cover protein-based biomolecular binding analysis/interactions.

Table of Contents

  • Executive Summary
  • Table Of Contents
  • Survey Respondents Organisation & Their Response To The Survey
  • Respondent's Company Or Organisational Origin
  • Respondent's Geographic Origin
  • Respondent's Job Role
  • Respondent's Main Group Activity
  • Respondent's Currently Applying LF Approaches To Cell-Based Assays
  • % Of All Cell-Based Assays Undertaken Using LF Technologies
  • Vendor's Instruments For Cell-Based LF Detection Found In Respondent's Lab Today
  • Current Makeup Of Instruments for Cell-Based LF Detection In Respondent's Lab Today
  • Most Recognizable LF Instrument Brands Used For Cell-Based Assays (1)
  • Most Recognizable LF Instrument Brands Used For Cell-Based Assays (2)
  • Current Perception Of Different LF Vendors For Cell-Based Assays (1)
  • Current Perception Of Different LF Vendors For Cell-Based Assays (2)
  • Target Classes Investigated With Cell-Based LF Assays
  • Disease Areas Investigated With LF Cell-Based Assays
  • Applications Of Cell-Based LF Assays That Are Of Greatest Interest
  • Applications Where Respondents Think LF Provides Unique Benefits
  • Time Frame Of Greatest Interest When Monitoring A Cellular LF Response (1)
  • Time Frame Of Greatest Interest When Monitoring A Cellular LF Response (2)
  • Preferred Approach To Cell-Based LF Detection (1)
  • Preferred Approach To Cell-Based LF Detection (2)
  • Summary Of Survey Findings (1)
  • Areas Where A Cell-Based LF Platform Has Added Value
  • Areas Where Cell-Based LF Adds Greatest Value
  • Typical Throughput Of Cell-Based LF Assays
  • % Of Cell-Based LF Assays Performed In Different Formats Today
  • Requirements For Coated Plates In Cell-Based LF Assays (1)
  • Requirements For Coated Plates In Cell-Based LF Assays (2)
  • Microplate Coatings Most Often Required For Cell-Based Assays
  • Respondents Who Have Automated Cell-Based LF Detection Devices
  • Most Significant Advantages Of Cell-Based LF Assays
  • Most Significant Limitations Of Cell-Based LF Assays
  • Most Important Features Of An LF-Based Cardiotoxicity Assay
  • Features & Functionalities Most Needed In A Cell-Based LF Detection System
  • Interest In A Single-Mode Reader For Cell-Based LF Assays (1)
  • Interest In A Single-Mode Reader For Cell-Based LF Assays (2)
  • Interest In Multiplexing Phenotypic & Target-Based Readouts
  • Applications Where Multiplexing LF And Multimode Readouts Is Desirable
  • Summary Of Survey Findings (2)
  • Cell-Based LF Vendor Most Associated With Desirable Attributes (1)
  • Cell-Based LF Vendor Most Associated With Desirable Attributes (2)
  • Respondent's Experience With Instruments Used For Cell-Based LF Assays
  • Likelihood Of Purchasing A New LF Instrument For Cell-Based Assays
  • Vendor's Instruments For Cell-Based LF Assays Respondents Are Most Interested In Purchasing (1)
  • Vendor's Instruments For Cell-Based LF Assays Respondents Are Most Interested In Purchasing (2)
  • Maximum PricePoints For LF Biosensors Plates Used For Cell-Based Assays
  • Interest In Outsourcing Cell-Based LF Assays
  • Respondent's Feedback On Unmet Needs In Cell-Based LF Technologies
  • Capex Budget For Purchasing Cell-Based LF Instruments
  • Cell-Based LF Instruments Market Estimate (1)
  • Cell-Based LF Instruments Market Estimate (2)
  • Budget For Purchasing Cell-Based LF Consumables
  • Cell-Based LF Consumables Market Estimate (1)
  • Cell-Based LF Consumables Market Estimate (2)
  • Summary Of Survey Findings (3)
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