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Bulk Reagent Dispenser Trends 2012

発行 HTStec Ltd 商品コード 217775
出版日 ページ情報 英文 57 Pages
納期: 即日から翌営業日
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バルク試薬ディスペンサー(BRD)の利用動向 Bulk Reagent Dispenser Trends 2012
出版日: 2012年11月01日 ページ情報: 英文 57 Pages



  • エグゼクティブサマリー
  • 目次
  • 調査方法
  • 回答者の出身地域
  • 回答者の企業または組織
  • 回答者の役職
  • 回答者の事業分野
  • 現在のBRDの使用レベル
  • 回答者のラボにおけるBRD
  • 現在最も多く用いているBRD
  • ラボ当たりのBRDの数と平均寿命
  • プレート/ラックチューブフォーマットで行うバルクディスペンシングの割合
  • フォーマット別で最も多く用いるディスペンス量
  • 調査結果サマリー(1)
  • バルク試薬ディスペンシングの際のプレート・ラックチューブの一般的バッチサイズ
  • バルクディスペンシングの際の一般的処理量
  • 各種液体タイプのバルクディスペンシング
  • BRDを使う主な目的
  • BRDが用いられる応用分野
  • BRDの信頼性
  • 既存のBRDへの満足度
  • 回答者が修正できる主なBRDの問題
  • BRDによる特定の技術的問題の発生頻度
  • サポートを呼び出す必要があるBRDの主な問題
  • BRDのサービス&保守の管理
  • サポートを呼び出す頻度
  • BRDの購入決定におけるブランドの影響力
  • BRDの好みのブランド
  • 最近BRDの代替ブランドを購入した回答者
  • 最近BRDのブランドを変えた回答者
  • BRDブランドの変更における購入の意思決定の基準の影響
  • 新しいBRDの購入頻度 & 古いBRDの買換えの必要性
  • 改良型BRDの追加料金
  • 調査結果サマリー(2)
  • 新しいBRDの購入決定への影響因子
  • 新しいBRDの魅力:購買の観点から
  • 新しいBRDと関連の消耗品の購入に関連する動向
  • 代替BRDの購入シナリオを考える余地
  • BRDの買換えのための代替購入戦略への関心
  • 液体処理CAPEX予算の内訳
  • 異なるベンダーのBRDの将来の購入への関心
  • BRD関連消耗品の年間予算
  • BRD機器の世界市場推計
  • BRD関連消耗品の世界市場推計
  • 現在のBRDのアンメットニーズ
  • 調査結果サマリー(3)




Executive Summary

  • This market report summarizes the results of HTStecµs industry-wide global web-based benchmarking survey on bulk reagent dispensers (BRDs) carried out in October 2012.
  • The study was initiated by HTStec as part of its ongoing tracking of life science technologies and to update the previous report (March 2010). The main objectives were to comprehensively document current use of and experience with bulk reagent dispensers (e.g. Thermo Scientific Multidrop). The survey also investigated dispensing problems, instrument reliability, experience of BRD service and maintenance, influences on purchasing decisions, and interest in alternative purchasing scenarios. An additional objective was to estimate the current market size for BRD instruments and BRD-related consumables.
  • The survey looked at the following aspects of BRDs as practiced to date (2012) and in a few cases as predicted for the future (2015): current use of BRDs; makeup of vendor BRDs in respondentµs labs and which vendorµs BRDs are most used; how many BRDs are in respondentµs labs; % of BRD dispensing done in plate/racked tube formats; BRD dispensing volume ranges most used in various formats and final assay volume targeted; batch sizes processed and throughput requirements in various formats; types of liquids dispensed; main purpose and application areas of BRD dispensing; reliability of existing commercial BRDs; level of satisfaction with BRDs; frequency of occurrence of technical issues; main problems encountered day-to-day with BRDs which can be rectified by respondents or necessitate a service callout; how respondents currently manage the service and maintenance of their BRDs; frequency of service calls needed to support BRD functioning; influence of brand on the purchasing selection of a BRD; preferred brand of BRD and purchasing of another brand of BRD recently; influence of factors on a BRD purchasing decision; BRD purchasing frequency; paying a price premium for an improved BRD; whether respondents have experienced any trends related to the purchasing of new BRDs and related consumables; openness to consider alternative purchasing scenarios; interest in other purchasing strategies relative to the outright BRD purchase model; BRD capex budget allocation; future purchasing probability; vendorµs BRD system most likely to purchase; breakdown of total liquid handling capex budget; BRD-related consumables budget; and any unmet needs in BRD dispensing today.
  • The main questionnaire consisted of 28 multi-choice questions and 3 open-ended questions. In addition, there were 6 questions related solely to the administration of survey.
  • The survey collected 127 validated responses, of these 76% provided comprehensive input.
  • Survey responses were geographically split: 60% North America; 21% Europe; 13% Asia (excluding Japan); 5% Japan; and 1% Rest of World.
  • Respondents came from 58 University/Research Institute/Not-for-Profit Facilities; 29 Pharma; 16 Biotechs; 6 Medical Schools/Hospitals/Clinics; 6 Others; 4 CROs; 3 Academic Screening Centers; 3 Agrochemical/Agri-Biotech/Plant Genomics Companies; and 3 Diagnostics Companies.
  • Most survey respondents had a senior job role or position which was in descending order: 35 research scientists; 24 senior scientists/researchers; 12 principal investigators; 12 post-docs; 9 professors/ assistant professors; 8 directors; 7 section/group leaders; 7 graduates/PhD students; 6 lab managers; 5 others; and 2 department heads.
  • Respondents represented labs with the following main activities: 48 basic research; 19 assay development; 15 primary screening (HTS); 11 applied/other industry research; 11 with a combination of drug discovery roles; 9 other; 4 therapeutic areas (target ID/validation); 3 leads-to-candidate (ADME tox/preclinical research); 3 secondary screening; 2 hits-to-leads (lead optimization); and 2 compound management.
  • Survey results were expressed as an average of all survey respondents. In addition, were appropriate the data was reanalyzed after sub-division into the following 5 survey groups: 1) Pharma; 2) Applied Research; 3) Academic Research; 4) Europe; and 5) North America.
  • The current level of use of BRDs by most survey respondents was frequent.
  • BRDs from Thermo Scientific were the most prevalent in respondentµs labs today.
  • BRDs from Thermo Scientific were those used to the greatest extent in respondentµs labs today.
  • The median number of BRDs per lab was 2, with a median functional lifetime of 5 years.
  • Most BRD dispensing today (2012) was still done mainly into 96-well plates.
  • 5µL-50µL was the dispensing volume range most used in 96-well plates.
  • 25µL-100µL was the final assay volume range most targeted using a BRD in 96-well plates.
  • A median batch size of 5-10 96-well plates were typically processed when BRD dispensing.
  • A median throughput of 5-10 96-well plates/8h day were typically processed when BRD dispensing.
  • The majority of BRD dispensing today involves aqueous solutions, followed by media with cells.
  • Basic microplate filling was ranked the main purpose (irrespective of application area) of BRD dispensing.
  • Assay development was rated the main application area where BRDµs were used.
  • The reliability of the majority of respondentµs BRDs was rated >90% fully operational.
  • Most respondents were satisfied that existing BRD systems meet most of their current needs.
  • Feedback was documented on the main problems/issues encountered day-to-day with BRDs, which: a) can be rectified by respondents without the need to involve a service call; or b) have necessitated a service callout to restore full operation or functionality.
  • Of a list of technical problems encountered with BRDs blocked tips were encountered most often.
  • Most respondents currently manage service and maintenance of their BRD by purchasing a fixed term service/maintenance contract from the manufacturer.
  • A median frequency of 1 service call/year was needed to support BRDs between 2-3 years old.
  • Most respondents thought brand was important in the purchasing selection of a new BRD.
  • Most respondents had no preferred brand. Of those remaining with a brand preference most preferred Thermo Scientific and Beckman Coulter.
  • The majority of respondents had not purchased another brand to their preferred BRD brand recently.
  • In those cases where respondents have changed BRD brands recently (i.e. Have purchased another brand of BRD other than their preferred brand or the existing brand(s) in their lab) the brands switched were tabulated.
  • Access to new or enhanced BRD functionality or features (e.g. lower volumes) was ranked as the criteria that would most influence the purchasing decision to change BRD brands.
  • The median frequency of purchasing a new BRD over the past few years was every 3 years.
  • Respondents would pay a small price premium for a BRD with improved dispensing/cost efficiency.
  • Generation of improved and more consistent assay data was rated the most important influence on a purchasing decision for a new bulk dispenser.
  • The attractiveness of a new BRD able to make savings in volume reduction and/or ongoing running costs was rated µquite possiblyµ (i.e. Could tip the balance in favour of purchasing a particular system).
  • Of trends related to the purchasing a new BRD and related consumables most respondents had witnessed pressure to reduce spending on BRD-related consumables.
  • Openness to consider alternative BRD purchasing scenarios was moderately amenable (most respondentµs personal opinion) and indifferent (most respondentµs organizations buyer's likely viewpoint).
  • Receive fully supported BRD free-of-charge, pay-as-you-go through the purchase of consumables was rated the most attractive of a list of alternative BRD purchasing strategies.
  • The median capex budget in 2012 for BRD purchases was $15K-$20K.
  • The median probability of purchasing a new BRD over the coming years (2013-2015) was low (&<25%).
  • As a proportion of respondentµs total liquid handing budget today (2012) BRDs represented 20%.
  • Future interest in purchasing specific BRD models was highest for Beckman Coulterµs BioRAPTR FRD, PerkinElmerµs FlexDrop Plus Precision Reagent Dispenser and Thermo Scientificµs Multidrop Combi.
  • Overall the majority of future (up to 2015) purchasing preferences were for BRDµs from Thermo Scientific, followed by BioTek, Beckman Coulter and then PerkinElmer.
  • The median BRD-related consumable budget in 2012 was $5K-$10K.
  • Several bottom-up models were developed around respondentµs budgets identified in this survey, to estimate the global market for BRD instruments and BRD-related consumables. The total markets in 2012 were estimated to be around $25 million for BRD instruments and $50 million for BRD-related consumables. BRD instruments sales were estimated to be equivalent to at least 1,200 units per year. The markets were segmented between Pharma, Applied Research and Academic Research. CAGR estimates were made for the market segments.
  • Some respondents reported unmet needs in BRD dispensing today and these were documented.
  • The full report provides the data, details of the breakdown of the responses for each question, its segmentation and the estimates for the future (2015). It also highlights some interesting differences, particularly between Pharma and Europe versus the other survey groups.
  • PLEASE NOTE: This report is about BRDs (e.g. Thermo Scientific Multidrop) either used standalone or part of an automated system. These dispensers are mainly used for filling reagents into microplates, although they can also be used to fill some types of racked tubes. This report is focused on BRDs that do NOT use an aspirate function (i.e. are typically back-filled from a bottle) and do NOT have a washing capability

Table of Contents

  • Executive Summary
  • Table of Contents
  • Survey Methodology
  • Respondentµs Organisational Origin and Response to Survey
  • Respondentµs Company or Organisational Origin
  • Respondentµs Geographic Origin
  • Respondentµs Job Role
  • Respondentµs Main Area of Activity
  • Current Level of Use of BRDs
  • BRDs in Survey Respondentµs Labs Today
  • BRDs Respondents Make Greatest Use of Today
  • Number of BRDs per Lab & Average Functional Lifetime (1)
  • Number of BRDs per Lab & Average Functional Lifetime (2)
  • % Bulk Dispensing Done in Plate/Racked Tube Formats Today (2012)
  • Most Used BRD Volume Ranges Associated With Formats Dispensed
  • Final Assay Volume Ranges Targeted Associated With Formats Dispensed
  • Summary of Survey Findings (1)
  • Typical Batch Sizes of Plates or Racked Tubes Used When Bulk Dispensing
  • Typical Throughput Achieved When Bulk Dispensing
  • Bulk Dispensing Done Using Various Liquid Types
  • Main Purpose Respondents BRDs are Used for
  • Main Application Areas Where BRDs are Used
  • BRD Reliability - % Fully Operational
  • Satisfaction with Existing BRDs
  • Main BRD Problems That Can be Rectified by Respondents
  • Frequency of Occurrence of Specific Technical Problems with BRDs
  • Main BRD Problems That Have Necessitated a Service Callout
  • Managing Service & Maintenance of BRDs
  • Frequency of Service Calls Needed to Support BRD Function
  • Influence of Brand on BRD Purchasing Selection
  • Preferred Brand of BRD
  • Respondents Who Have Purchased an Alternative Brand of BRD Recently
  • Respondents Who Have Changed BRD Brands Recently
  • Influence of Criteria on Purchasing Decision to Change BRD Brand
  • Frequency of Purchasing New BRDs & Need to Replace Old BRD
  • Additional Price Premium Commanded by an Improved BRD
  • Summary of Survey Findings (2)
  • Influence on a Purchasing Decision for a New BRD
  • Attractiveness of a New BRD from a Purchasing Perspective
  • Trends Related To Purchasing a New BRD & Related Consumables
  • Openness to Consider Alternative BRD Purchasing Scenarios
  • Interest in Alternative Purchasing Strategies for BRD Replacement (1)
  • Interest in Alternative Purchasing Strategies for BRD Replacement (2)
  • 2012 Capex Budget for BRDs (1)
  • 2012 Capex Budget for BRDs (2)
  • Breakdown of Total Liquid Handling Capex Budget Today (2012)
  • Future Purchasing Interest in Different Vendorµs BRDs (1)
  • Future Purchasing Interest in Different Vendorµs BRDs (2)
  • Current & Future Interest in Vendorµs BRDs
  • 2012 Annual Budget for BRD-Related Consumables (1)
  • BRD Instruments Global Market Estimate
  • BRD-Related Consumables Global Market Estimate
  • Unmet Needs in BRD Dispensing Today
  • Summary of Survey Findings (3)
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