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OpportunityAnalyzer:尋常性座瘡 - 機会分析と予測

OpportunityAnalyzer: Acne Vulgaris - Opportunity Analysis and Forecasts to 2018

発行 GlobalData 商品コード 306632
出版日 ページ情報 英文 177 Pages
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OpportunityAnalyzer:尋常性座瘡 - 機会分析と予測 OpportunityAnalyzer: Acne Vulgaris - Opportunity Analysis and Forecasts to 2018
出版日: 2014年06月20日 ページ情報: 英文 177 Pages
概要

主要6ヶ国(米国、フランス、ドイツ、イタリア、スペイン、英国)における尋常性座瘡(にきび)の治療薬市場は、2012年の23億米ドルから、2018年には28億米ドル規模まで拡大し、CAGRで3.9%の成長を遂げると予測されています。この成長の背景には、AndroScienceのASC-J9の発売、GaldermaのEpiduoの採用、PhotocureのVisonacの発売などが挙げられます。

当レポートでは、尋常性座瘡(にきび)の治療薬市場について調査分析し、疾患の概要、疫学、現在の治療選択肢、アンメットニーズ分析、機会分析、研究開発戦略、パイプライン評価などについて、体系的な情報を提供しています。

第1章 目次

第2章 イントロダクション

第3章 疾患の概要

  • 病因・病態生理
  • 予後
  • 生活の質
  • 症状

第4章 疫学

  • 危険因子と併存疾患
    • 家族歴はにきびの発症リスクを4倍に
    • 食生活はにきびの最も一般的な憎悪因子
    • 喫煙とにきびとの関係は不明瞭
    • 鬱病や不安はにきび患者の一般的な併存疾患
  • 世界の動向
    • 米国
    • EU5ヶ国
  • 予測手法
    • 利用した情報源
    • 利用しなかった情報源
  • 予測の前提条件・手法
    • 米国
    • フランス
    • ドイツ
    • イタリア・スペイン
    • 英国
  • 尋常性座瘡の疫学予測
    • 有病件数(合計)
    • 有病件数(合計):年齢別
    • 有病件数(合計):性別
    • 有病率(合計):年齢標準化
    • 有病件数(合計):重症度別
  • 議論
    • 疫学動向の考察
    • 分析の限界
    • 分析の強み

第5章 現在の治療選択肢

  • 概要
  • 製品プロファイル:主要ブランド

第6章 アンメットニーズ評価と機会分析

  • 概要
  • アンメットニーズ分析
  • 機会分析

第7章 研究開発(R&D)戦略

  • 概要:ライフサイクル管理戦略
  • 臨床試験設計

第8章 パイプライン評価

  • 概要
  • 臨床開発中の有望薬
  • 革新的な初期段階のアプローチ

第9章 パイプライン評価分析

  • 主要パイプライン薬の臨床ベンチマーク
  • 主要パイプライン薬の商業ベンチマーク
  • 競合評価
  • 売上の5ヶ年予測
    • 米国
    • EU5ヶ国

第10章 付録

図表

目次
Product Code: GDHC011POA

Despite its considerable patient population, the acne market has been overlooked and remained stagnant for the last decade. There has been a lack of research efforts due to the perception of a poor return on investment for topical treatments, the mainstay of acne therapy. There is an array of treatment options for acne, though with the exception of isotretinoin, most only provide symptomatic relief as opposed to a curative or disease-modifying solution. However, isotretinoin is unable to serve a significant proportion of the acne market owed to its teratogenic nature, making its prescription for women of child-bearing age problematic.

In the past decade, there has been a shift in the acne market, with greater appreciation of its patient pool and potential for a lucrative payoff. Furthermore, there has been greater stress put on the social and psychological implications of the disease, which impact patients' quality of life. As a result, R&D investments have been initiated by key pharmaceutical players.

Key strategies underway in the acne market include -

  • Drive for combination therapies, for example, Galderma's Epiduo (adapalene and benzoyl peroxide), which continues to experience rapid uptake.
  • Expansion of the market into the pediatric population and for late-onset acne in women.
  • A push towards disease-modifying therapies; for example, launch of AndroScience's ASC-J9 androgen receptor degradation enhancer is anticipated to be a game-changer and is expected to rival isotretinoin, the current market leader for severe acne.

Highlights

Key Questions Answered

  • How will the US and 5EU acne markets evolve over the forecast period from 2012 to 2018 in terms of sales and patient numbers?
  • How will the launch of late-stage pipeline therapies such as ASC-J9 and Visonac shape the future treatment landscape?
  • How do the clinical and commercial attributes of late-stage pipeline therapies compare to one another and against existing treatment options?
  • Why has there been a void of R&D interest from Big Pharma in this highly populated dermatology indication?
  • What are the remaining unmet needs and opportunities for drug developers within the acne space?

Key Findings

  • The main drivers of growth in the acne market during the 2012-2018 forecast period include the launch of AndroScience's ASC-J9, a therapeutic that is highly anticipated in the previously stagnant acne market and will make hormonal therapies available to males with acne, the continued success and uptake of Galderma's Epiduo, and the launch of Photocure's Visonac; potentially the first photodynamic therapy for use in acne.
  • The lack of dedicated R&D programs in acne has been attributed to pharmaceutical companies viewing topicals, the mainstay of acne therapy, as being inexpensive, with a poor return on investment. Instead, R&D strategies have centered on reformulations of existing products and/or fixed-dose combination therapies, acquisitions of key dermatology products by Big Pharma, and label expansions into the previously untapped pediatric market. Targeting the pediatric market is a strategy that GlobalData expects will be used by other dermatology companies during the coming decade.
  • A continued unmet need for acne is the need for new and innovative products to treat the underlying condition. Ideally, these products should be molecules that can specifically target critical pathways in the acne pathophysiology. Given the acne market's substantial patient pool (estimated to be 103.9 million patients in the US and 5EU) and increasing understanding of the disease's pathophysiology, GlobalData expects continued interest in the acne market from biotechs and pharmaceutical companies over the coming decade.

Scope

  • Overview of acne, including epidemiology, etiology, pathophysiology, symptoms, and current treatment options.
  • Annualized acne prescription therapeutics market revenue, annual cost of therapy and treatment usage pattern data from 2012 to 2018.
  • Key topics covered include strategic product assessment, market characterization, unmet needs, R&D strategies, clinical trial design, and benchmarking analysis for the acne prescription therapeutics market.
  • Pipeline analysis: comprehensive data split across different phases, emerging novel trends under development, and detailed analysis of late stage pipeline drugs. Accompanied by an interactive clinical and commercial benchmarking analysis tool.
  • Analysis of the current and future market competition in the US and 5EU acne prescription therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

Reasons to buy

  • Develop and design in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline.
  • Additionally a list of acquisition targets included in the early-stage pipeline products list.
  • Develop business strategies by understanding the trends shaping and driving the US and 5EU acne prescription therapeutics market.
  • Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the US and 5EU acne prescription therapeutics markets in the future.
  • Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.
  • Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.
  • Track therapy sales in the US and 5EU acne prescription therapeutics markets from 2012-2018.
  • Organize sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships.

Table of Contents

1. Table of Contents

  • 1.1. List of Tables
  • 1.2. List of Figures

2. Introduction

  • 2.1. Catalyst
  • 2.2. Related Reports

3. Disease Overview

  • 3.1. Etiology and Pathophysiology
  • 3.2. Prognosis
  • 3.3. Quality of Life
  • 3.4. Symptoms

4. Epidemiology

  • 4.1. Risk Factors and Comorbidities
    • 4.1.1. A family history of acne increases the risk of acne by four times
    • 4.1.2. Diet is the most common aggravating factor of acne
    • 4.1.3. The relationship between smoking and acne is unclear
    • 4.1.4. Depression and anxiety are common comorbidities in acne patients
  • 4.2. Global Trends
    • 4.2.1. US
    • 4.2.2. 5EU
  • 4.3. Forecast Methodology
    • 4.3.1. Sources Used
    • 4.3.2. Sources Not Used
  • 4.4. Forecast Assumptions and Methods
    • 4.4.1. US
    • 4.4.2. France
    • 4.4.3. Germany
    • 4.4.4. Italy and Spain
    • 4.4.5. UK
  • 4.5. Epidemiology Forecast for Acne (2012-2022)
    • 4.5.1. Total Prevalent Cases of Acne Vulgaris
    • 4.5.2. Age-Specific Total Prevalent Cases of Acne Vulgaris
    • 4.5.3. Sex-Specific Total Prevalent Cases of Acne Vulgaris
    • 4.5.4. Age-Standardized Total Prevalence of Acne Vulgaris
    • 4.5.5. Total Prevalent Cases of Acne Vulgaris by Severity
  • 4.6. Discussion
    • 4.6.1. Conclusions on Epidemiological Trends
    • 4.6.2. Limitations of the Analysis
    • 4.6.3. Strengths of the Analysis

5. Current Treatment Options

  • 5.1. Overview
  • 5.2. Product Profiles - Major Brands
    • 5.2.1. Tretinoin (numerous brand and generic names)
    • 5.2.2. Isotretinoin
    • 5.2.3. Adapalene (numerous generic names)
    • 5.2.4. Benzoyl Peroxide (numerous generic names)
    • 5.2.5. Azelaic Acid (numerous generic names)
    • 5.2.6. Hormonal Therapy (numerous brand and generic names)
    • 5.2.7. Epiduo (adapalene and benzoyl peroxide)
    • 5.2.8. Tretinoin and Clindamycin Phosphate (numerous brand names)
    • 5.2.9. Benzoyl Peroxide and Clindamycin Phosphate (numerous brand and generic names)
    • 5.2.10. Benzoyl Peroxide and Erythromycin (numerous brand and generic names)
    • 5.2.11. Isotretinoin and Erythromycin (numerous brand and generic names)
    • 5.2.12. Zineryt (erythromycin and zinc acetate)

6. Unmet Needs Assessment and Opportunity Analysis

  • 6.1. Overview
  • 6.2. Unmet Needs Analysis
    • 6.2.1. Inadequate Investment in Innovative Drugs
    • 6.2.2. Improved Compliance
    • 6.2.3. Cost-Prohibitive Products
    • 6.2.4. Increased Patient and Caregiver Awareness
    • 6.2.5. Non-Teratogenic Treatment Options for Female Acne Patients of Childbearing Age
  • 6.3. Opportunity Analysis
    • 6.3.1. Investment in Novel Systemic Compounds
    • 6.3.2. Affordable and Accessible Combination Treatment Options
    • 6.3.3. Holistic Management of Acne Patients
    • 6.3.4. Exploring Photodynamic Therapy as a Potential Treatment for Acne

7. R&D Strategies

  • 7.1. Overview - Lifecycle Management Strategies
    • 7.1.1. Reformulation Strategies
    • 7.1.2. M&A in the Dermatology Market
    • 7.1.3. Label Expansion into Pediatric Population
  • 7.2. Clinical Trial Design
    • 7.2.1. Current Clinical Trial Design
    • 7.2.2. Limitations of Current Clinical Trial Design
    • 7.2.3. Future Outlook in Acne Clinical Trial Design

8. Pipeline Assessment

  • 8.1. Overview
  • 8.2. Promising Drugs in Clinical Development
    • 8.2.1. ASC-J9
    • 8.2.2. Visonac (methyl aminolevulinate)
  • 8.3. Innovative Early-Stage Approaches
    • 8.3.1. Anti-Inflammatory Drugs
    • 8.3.2. Vaccine Development
    • 8.3.3. Neuropeptides
    • 8.3.4. Phages

9. Pipeline Valuation Analysis

  • 9.1. Clinical Benchmark of Key Pipeline Drugs
  • 9.2. Commercial Benchmark of Key Pipeline Drugs
  • 9.3. Competitive Assessment
  • 9.4. Top-Line Five-Year Forecast
    • 9.4.1. US
    • 9.4.2. 5EU

10. Appendix

  • 10.1. Bibliography
  • 10.2. Abbreviations
  • 10.3. Methodology
  • 10.4. Forecasting Methodology
    • 10.4.1. Diagnosed Acne Vulgaris Patients
    • 10.4.2. Percent Drug-Treated Patients
    • 10.4.3. Drugs Included in Each Therapeutic Class
    • 10.4.4. Launch and Patent Expiry Dates
    • 10.4.5. General Pricing Assumptions
    • 10.4.6. Individual Drug Assumptions
    • 10.4.7. Pricing of Pipeline Agents
  • 10.5. Physicians and Specialists Included in this Study
  • 10.6. About the Authors
    • 10.6.1. Author
    • 10.6.2. Author/Reviewer
    • 10.6.3. Reviewer
    • 10.6.4. Epidemiologist
    • 10.6.5. Global Head of Healthcare
  • 10.7. About GlobalData
  • 10.8. Disclaimer

List of Tables

  • Table 1: Risk Factors and Comorbidities for Acne
  • Table 2: Classification of Acne Severity
  • Table 3: 6MM, Sources of Acne Prevalence Data
  • Table 4: 6MM, Sources of Acne Severity Data
  • Table 5: 6MM, Total Prevalent Cases of Acne Vulgaris, Ages 10-44 Years, Both Sexes, N (Millions), 2012-2022
  • Table 6: 6MM, Total Prevalent Cases of Acne Vulgaris, by Age, Both Sexes, N (Millions), (Row %), 2012
  • Table 7: 6MM, Total Prevalent Cases of Acne Vulgaris, by Sex, Ages 10-44 Years, N (Row %), 2012
  • Table 8: 6MM, Total Prevalent Cases of Acne Vulgaris by Severity, Ages 10-44 Years, Both Sexes, N (Millions) (Row %), 2012
  • Table 9: Commonly Used Treatments for the Management of Acne
  • Table 10: Product Profile - Tretinoin
  • Table 11: Tretinoin SWOT Analysis, 2014
  • Table 12: Product Profile - Isotretinoin
  • Table 13: Isotretinoin SWOT Analysis, 2014
  • Table 14: Product Profile - Adapalene
  • Table 15: Adapalene SWOT Analysis, 2014
  • Table 16: Product Profile - Benzoyl Peroxide
  • Table 17: Benzoyl Peroxide SWOT Analysis, 2014
  • Table 18: Product Profile - Azelaic Acid
  • Table 19: Azelaic Acid SWOT Analysis, 2014
  • Table 20: Product Profile - Hormonal Therapy
  • Table 21: Hormonal Therapy SWOT Analysis, 2014
  • Table 22: Product Profile - Epiduo
  • Table 23: Epiduo SWOT Analysis, 2014
  • Table 24: Product Profile -Tretinoin and Clindamycin Phosphate
  • Table 25: Tretinoin and Clindamycin Phosphate SWOT Analysis, 2014
  • Table 26: Product Profile - Benzoyl Peroxide and Clindamycin Phosphate
  • Table 27: Benzoyl Peroxide and Clindamycin Phosphate SWOT Analysis, 2014
  • Table 28: Product Profile - Benzoyl Peroxide and Erythromycin
  • Table 29: Benzoyl Peroxide and Erythromycin SWOT Analysis, 2014
  • Table 30: Product Profile - Isotretinoin and Erythromycin
  • Table 31: Isotretinoin and Erythromycin SWOT Analysis, 2014
  • Table 32: Product Profile - Zineryt
  • Table 33: Zineryt SWOT Analysis, 2014
  • Table 34: Overall Unmet Needs in Acne - Current Level of Attainment
  • Table 35: Acne - Late-Stage Pipeline, 2014
  • Table 36: Product Profile - ASC-J9
  • Table 37: ASC-J9 SWOT Analysis, 2014
  • Table 38: Product Profile - Visonac (methyl aminolevulinate)
  • Table 39: Visonac SWOT Analysis, 2014
  • Table 40: Early-Stage Pipeline Products in Acne, April 2014
  • Table 41: Clinical Benchmark for Acne, 2014
  • Table 42: Commercial Benchmark for Acne, 2014
  • Table 43: Top-Line Sales Forecasts ($m) for Acne, 2012-2018
  • Table 44: Key Events Impacting Sales for Acne, 2012-2018
  • Table 45: Acne Market - Drivers and Barriers, 2012-2018
  • Table 46: Key Launch Dates

List of Figures

  • Figure 1: Pathophysiology of Acne
  • Figure 2: Acne Grades and Correlation with Scarring
  • Figure 3: Acne Symptoms
  • Figure 4: Classification of Acne Severity
  • Figure 5: 6MM, Total Prevalent Cases of Acne Vulgaris, Ages 10-44 Years, Both Sexes, N (Millions), 2012-2022
  • Figure 6: 6MM, Total Prevalent Cases of Acne Vulgaris, by Age, Both Sexes, N (Millions), 2012
  • Figure 7: 6MM, Total Prevalent Cases of Acne Vulgaris, by Sex, Ages 10-44 Years, N (Millions), 2012
  • Figure 8: 6MM, Age-Standardized Total Prevalence of Acne Vulgaris, Ages 10-44 Years, 2012
  • Figure 9: 6MM, Total Prevalent Cases of Acne Vulgaris by Severity, Ages 10-44 Years, Both Sexes, N (Millions), 2012
  • Figure 10: Acne Treatment Algorithm
  • Figure 11: Competitive Assessment of Acne Therapies and Late-Stage Pipeline Agents in Acne, 2012-2018
  • Figure 12: Global Sales for Acne by Region, 2012-2018
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