β遮断薬（片頭痛） - 予測と市場分析
Beta Blockers (Migraine) - Forecast and Market Analysis to 2023
|出版日||ページ情報||英文 43 Pages
|β遮断薬（片頭痛） - 予測と市場分析 Beta Blockers (Migraine) - Forecast and Market Analysis to 2023|
|出版日: 2014年03月31日||ページ情報: 英文 43 Pages||
The migraine market is saturated with generic drugs, and the remaining branded products already on the market are expected to lose exclusivity during the next few years, with the exception of Botox for chronic migraine, which is expected to maintain its leading position in terms of sales. However, reformulations of mature products as well as new classes of therapies are anticipated to launch during the forecast period and these will contribute to the market growth. By 2023, the migraine market will grow to $3.7 billion at a compound annual growth rate (CAGR) of 3.6%, with the US continuing to dominate the market as a result of higher drug prices and a large migraine population. Some of the new treatments are expected to target the key unmet needs but opportunities will remain for further treatment choices especially drugs that will offer an improved safety and side-effects profile.
Among the various prophylaxis therapy classes for migraine, beta blockers are highly effective and are the most widely used class of drugs for the prophylaxis of migraine. Beta blockers were primarily developed for controlling cardiac symptoms but were coincidentally found to have an effect on migraine prevention. They have been used as migraine treatment since the 1970s. Their mechanism of action for preventing migraine is not clear, but beta receptors have been shown to be present in the pial vessel of the brain. The possible mechanisms of action of beta blockers include reducing the neuronal firing rate of noradrenergic neurons in the locus coeruleus, regulation of PAG neurons firing rate and possible inhibition of 5-HT2C and 5-HT2B receptor subtypes.